Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B165_LEIMU

TriTrypDb:

LmxM.29.2920

Length:

453

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B165

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B165

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.803
CLV_NRD_NRD_1	149	151	PF00675	0.582
CLV_NRD_NRD_1	152	154	PF00675	0.554
CLV_NRD_NRD_1	227	229	PF00675	0.576
CLV_NRD_NRD_1	312	314	PF00675	0.500
CLV_NRD_NRD_1	386	388	PF00675	0.568
CLV_PCSK_FUR_1	383	387	PF00082	0.533
CLV_PCSK_KEX2_1	104	106	PF00082	0.803
CLV_PCSK_KEX2_1	149	151	PF00082	0.669
CLV_PCSK_KEX2_1	385	387	PF00082	0.565
CLV_PCSK_SKI1_1	10	14	PF00082	0.533
CLV_PCSK_SKI1_1	369	373	PF00082	0.633
CLV_PCSK_SKI1_1	425	429	PF00082	0.748
DEG_APCC_DBOX_1	159	167	PF00400	0.474
DOC_CKS1_1	42	47	PF01111	0.553
DOC_CKS1_1	426	431	PF01111	0.737
DOC_CYCLIN_RxL_1	236	246	PF00134	0.552
DOC_CYCLIN_yCln2_LP_2	413	419	PF00134	0.569
DOC_MAPK_gen_1	149	159	PF00069	0.584
DOC_PP2B_LxvP_1	413	416	PF13499	0.565
DOC_PP4_FxxP_1	42	45	PF00568	0.625
DOC_USP7_MATH_1	179	183	PF00917	0.649
DOC_USP7_MATH_1	211	215	PF00917	0.655
DOC_USP7_MATH_1	268	272	PF00917	0.722
DOC_USP7_MATH_1	285	289	PF00917	0.538
DOC_USP7_MATH_1	88	92	PF00917	0.632
DOC_WW_Pin1_4	175	180	PF00397	0.526
DOC_WW_Pin1_4	264	269	PF00397	0.717
DOC_WW_Pin1_4	283	288	PF00397	0.702
DOC_WW_Pin1_4	41	46	PF00397	0.552
DOC_WW_Pin1_4	411	416	PF00397	0.772
DOC_WW_Pin1_4	425	430	PF00397	0.677
DOC_WW_Pin1_4	433	438	PF00397	0.732
DOC_WW_Pin1_4	447	452	PF00397	0.660
LIG_14-3-3_CanoR_1	187	194	PF00244	0.633
LIG_14-3-3_CanoR_1	244	248	PF00244	0.716
LIG_14-3-3_CanoR_1	278	285	PF00244	0.728
LIG_14-3-3_CanoR_1	361	368	PF00244	0.467
LIG_14-3-3_CanoR_1	438	448	PF00244	0.791
LIG_14-3-3_CanoR_1	52	58	PF00244	0.727
LIG_APCC_ABBA_1	12	17	PF00400	0.591
LIG_BIR_II_1	1	5	PF00653	0.597
LIG_BIR_III_4	260	264	PF00653	0.742
LIG_CaM_IQ_9	308	323	PF13499	0.549
LIG_FHA_1	303	309	PF00498	0.471
LIG_FHA_1	340	346	PF00498	0.557
LIG_FHA_1	426	432	PF00498	0.610
LIG_FHA_1	440	446	PF00498	0.716
LIG_FHA_2	26	32	PF00498	0.587
LIG_FHA_2	77	83	PF00498	0.724
LIG_GBD_Chelix_1	216	224	PF00786	0.596
LIG_Integrin_isoDGR_2	185	187	PF01839	0.737
LIG_LIR_Apic_2	41	45	PF02991	0.702
LIG_LIR_Gen_1	169	179	PF02991	0.500
LIG_LIR_Gen_1	80	90	PF02991	0.620
LIG_LIR_Nem_3	169	175	PF02991	0.487
LIG_LIR_Nem_3	51	57	PF02991	0.461
LIG_LIR_Nem_3	80	86	PF02991	0.621
LIG_SH2_CRK	172	176	PF00017	0.516
LIG_SH2_NCK_1	172	176	PF00017	0.516
LIG_SH2_STAP1	83	87	PF00017	0.618
LIG_SH2_STAT5	172	175	PF00017	0.513
LIG_SH3_3	118	124	PF00018	0.710
LIG_SH3_3	262	268	PF00018	0.720
LIG_SH3_3	409	415	PF00018	0.790
LIG_SH3_3	431	437	PF00018	0.754
LIG_SUMO_SIM_anti_2	155	160	PF11976	0.580
LIG_SUMO_SIM_par_1	43	49	PF11976	0.551
LIG_TRAF2_1	21	24	PF00917	0.584
LIG_WRC_WIRS_1	39	44	PF05994	0.697
MOD_CDC14_SPxK_1	450	453	PF00782	0.718
MOD_CDK_SPK_2	264	269	PF00069	0.717
MOD_CDK_SPK_2	433	438	PF00069	0.744
MOD_CDK_SPxK_1	447	453	PF00069	0.724
MOD_CDK_SPxxK_3	433	440	PF00069	0.744
MOD_CK1_1	180	186	PF00069	0.613
MOD_CK1_1	246	252	PF00069	0.760
MOD_CK1_1	277	283	PF00069	0.762
MOD_CK1_1	379	385	PF00069	0.572
MOD_CK1_1	38	44	PF00069	0.694
MOD_CK1_1	392	398	PF00069	0.683
MOD_CK1_1	436	442	PF00069	0.588
MOD_CK1_1	59	65	PF00069	0.603
MOD_CK2_1	18	24	PF00069	0.587
MOD_CK2_1	206	212	PF00069	0.704
MOD_CK2_1	25	31	PF00069	0.593
MOD_CK2_1	76	82	PF00069	0.621
MOD_GlcNHglycan	168	171	PF01048	0.594
MOD_GlcNHglycan	179	182	PF01048	0.577
MOD_GlcNHglycan	20	23	PF01048	0.576
MOD_GlcNHglycan	212	216	PF01048	0.642
MOD_GlcNHglycan	248	251	PF01048	0.680
MOD_GlcNHglycan	260	264	PF01048	0.703
MOD_GlcNHglycan	287	290	PF01048	0.773
MOD_GlcNHglycan	391	394	PF01048	0.665
MOD_GlcNHglycan	61	64	PF01048	0.625
MOD_GSK3_1	162	169	PF00069	0.630
MOD_GSK3_1	173	180	PF00069	0.662
MOD_GSK3_1	189	196	PF00069	0.736
MOD_GSK3_1	206	213	PF00069	0.733
MOD_GSK3_1	259	266	PF00069	0.728
MOD_GSK3_1	274	281	PF00069	0.672
MOD_GSK3_1	40	47	PF00069	0.589
MOD_GSK3_1	425	432	PF00069	0.673
MOD_GSK3_1	53	60	PF00069	0.629
MOD_N-GLC_1	387	392	PF02516	0.560
MOD_NEK2_1	16	21	PF00069	0.579
MOD_NEK2_1	193	198	PF00069	0.657
MOD_NEK2_1	243	248	PF00069	0.611
MOD_NEK2_1	25	30	PF00069	0.489
MOD_NEK2_1	339	344	PF00069	0.536
MOD_NEK2_1	40	45	PF00069	0.431
MOD_NEK2_1	5	10	PF00069	0.591
MOD_NEK2_1	67	72	PF00069	0.667
MOD_PIKK_1	215	221	PF00454	0.702
MOD_PIKK_1	344	350	PF00454	0.533
MOD_PIKK_1	360	366	PF00454	0.551
MOD_PIKK_1	376	382	PF00454	0.598
MOD_PIKK_1	387	393	PF00454	0.647
MOD_PIKK_1	398	404	PF00454	0.604
MOD_PK_1	278	284	PF00069	0.725
MOD_PKA_2	100	106	PF00069	0.712
MOD_PKA_2	243	249	PF00069	0.619
MOD_PKA_2	268	274	PF00069	0.664
MOD_PKA_2	277	283	PF00069	0.638
MOD_PKA_2	35	41	PF00069	0.598
MOD_PKA_2	360	366	PF00069	0.367
MOD_PKA_2	398	404	PF00069	0.655
MOD_PKB_1	374	382	PF00069	0.558
MOD_PKB_1	385	393	PF00069	0.641
MOD_Plk_1	16	22	PF00069	0.584
MOD_Plk_1	170	176	PF00069	0.686
MOD_Plk_1	211	217	PF00069	0.614
MOD_Plk_1	302	308	PF00069	0.513
MOD_Plk_1	339	345	PF00069	0.496
MOD_Plk_4	189	195	PF00069	0.580
MOD_Plk_4	35	41	PF00069	0.640
MOD_ProDKin_1	175	181	PF00069	0.528
MOD_ProDKin_1	264	270	PF00069	0.716
MOD_ProDKin_1	283	289	PF00069	0.699
MOD_ProDKin_1	41	47	PF00069	0.552
MOD_ProDKin_1	411	417	PF00069	0.772
MOD_ProDKin_1	425	431	PF00069	0.676
MOD_ProDKin_1	433	439	PF00069	0.731
MOD_ProDKin_1	447	453	PF00069	0.663
MOD_SUMO_for_1	300	303	PF00179	0.574
MOD_SUMO_for_1	332	335	PF00179	0.578
MOD_SUMO_rev_2	365	371	PF00179	0.559
TRG_DiLeu_BaEn_1	236	241	PF01217	0.565
TRG_DiLeu_BaEn_1	303	308	PF01217	0.552
TRG_DiLeu_BaEn_1	367	372	PF01217	0.650
TRG_DiLeu_BaEn_1	82	87	PF01217	0.613
TRG_DiLeu_LyEn_5	236	241	PF01217	0.539
TRG_ENDOCYTIC_2	172	175	PF00928	0.513
TRG_ENDOCYTIC_2	83	86	PF00928	0.619
TRG_ER_diArg_1	104	106	PF00400	0.628
TRG_ER_diArg_1	374	377	PF00400	0.596
TRG_ER_diArg_1	383	386	PF00400	0.538
TRG_NES_CRM1_1	366	381	PF08389	0.648
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	369	373	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	421	426	PF00026	0.739

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUI5	Leptomonas seymouri	46%	71%
A0A3Q8IEH0	Leishmania donovani	88%	100%
A4HIM6	Leishmania braziliensis	69%	100%
A4I5X1	Leishmania infantum	87%	100%
Q4Q700	Leishmania major	87%	100%