Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B161_LEIMU

TriTrypDb:

LmxM.29.2880

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B161

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B161

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	425	429	PF00656	0.511
CLV_C14_Caspase3-7	493	497	PF00656	0.465
CLV_C14_Caspase3-7	603	607	PF00656	0.465
CLV_NRD_NRD_1	28	30	PF00675	0.416
CLV_NRD_NRD_1	39	41	PF00675	0.508
CLV_NRD_NRD_1	640	642	PF00675	0.515
CLV_NRD_NRD_1	652	654	PF00675	0.428
CLV_PCSK_KEX2_1	28	30	PF00082	0.427
CLV_PCSK_KEX2_1	39	41	PF00082	0.508
CLV_PCSK_KEX2_1	640	642	PF00082	0.542
CLV_PCSK_KEX2_1	652	654	PF00082	0.528
CLV_PCSK_PC7_1	648	654	PF00082	0.298
CLV_PCSK_SKI1_1	28	32	PF00082	0.428
CLV_PCSK_SKI1_1	308	312	PF00082	0.477
CLV_PCSK_SKI1_1	39	43	PF00082	0.515
CLV_PCSK_SKI1_1	652	656	PF00082	0.438
CLV_Separin_Metazoa	155	159	PF03568	0.495
DEG_Nend_UBRbox_1	1	4	PF02207	0.599
DEG_SPOP_SBC_1	193	197	PF00917	0.488
DEG_SPOP_SBC_1	72	76	PF00917	0.612
DEG_SPOP_SBC_1	81	85	PF00917	0.571
DOC_CYCLIN_RxL_1	305	313	PF00134	0.526
DOC_CYCLIN_yCln2_LP_2	320	326	PF00134	0.431
DOC_MAPK_DCC_7	535	543	PF00069	0.490
DOC_MAPK_MEF2A_6	592	599	PF00069	0.512
DOC_PP4_FxxP_1	131	134	PF00568	0.599
DOC_USP7_MATH_1	386	390	PF00917	0.456
DOC_USP7_MATH_1	43	47	PF00917	0.567
DOC_USP7_MATH_1	431	435	PF00917	0.457
DOC_USP7_MATH_1	48	52	PF00917	0.701
DOC_USP7_MATH_1	565	569	PF00917	0.502
DOC_USP7_MATH_1	639	643	PF00917	0.545
DOC_USP7_MATH_1	81	85	PF00917	0.705
DOC_USP7_MATH_1	93	97	PF00917	0.597
DOC_WW_Pin1_4	221	226	PF00397	0.410
DOC_WW_Pin1_4	237	242	PF00397	0.335
DOC_WW_Pin1_4	370	375	PF00397	0.403
DOC_WW_Pin1_4	534	539	PF00397	0.327
DOC_WW_Pin1_4	641	646	PF00397	0.470
DOC_WW_Pin1_4	656	661	PF00397	0.451
LIG_14-3-3_CanoR_1	128	132	PF00244	0.519
LIG_14-3-3_CanoR_1	158	166	PF00244	0.584
LIG_14-3-3_CanoR_1	183	193	PF00244	0.594
LIG_14-3-3_CanoR_1	387	393	PF00244	0.551
LIG_14-3-3_CanoR_1	441	449	PF00244	0.504
LIG_14-3-3_CanoR_1	55	63	PF00244	0.626
LIG_14-3-3_CterR_2	668	673	PF00244	0.507
LIG_Actin_WH2_2	13	30	PF00022	0.432
LIG_BRCT_BRCA1_1	630	634	PF00533	0.476
LIG_eIF4E_1	289	295	PF01652	0.382
LIG_FHA_1	127	133	PF00498	0.688
LIG_FHA_1	193	199	PF00498	0.485
LIG_FHA_1	254	260	PF00498	0.417
LIG_FHA_1	331	337	PF00498	0.389
LIG_FHA_1	353	359	PF00498	0.525
LIG_FHA_1	395	401	PF00498	0.518
LIG_FHA_1	470	476	PF00498	0.490
LIG_FHA_1	653	659	PF00498	0.478
LIG_FHA_1	72	78	PF00498	0.600
LIG_FHA_2	32	38	PF00498	0.478
LIG_FHA_2	401	407	PF00498	0.501
LIG_FHA_2	474	480	PF00498	0.452
LIG_FHA_2	491	497	PF00498	0.380
LIG_FHA_2	601	607	PF00498	0.455
LIG_FHA_2	642	648	PF00498	0.398
LIG_LIR_Apic_2	129	134	PF02991	0.591
LIG_LIR_Gen_1	364	374	PF02991	0.440
LIG_LIR_Gen_1	434	443	PF02991	0.367
LIG_LIR_Gen_1	62	71	PF02991	0.447
LIG_LIR_LC3C_4	270	275	PF02991	0.411
LIG_LIR_Nem_3	364	369	PF02991	0.416
LIG_LIR_Nem_3	434	439	PF02991	0.391
LIG_LIR_Nem_3	442	446	PF02991	0.385
LIG_LIR_Nem_3	62	66	PF02991	0.446
LIG_NRBOX	229	235	PF00104	0.434
LIG_NRBOX	6	12	PF00104	0.426
LIG_Rb_LxCxE_1	278	290	PF01857	0.504
LIG_REV1ctd_RIR_1	363	372	PF16727	0.372
LIG_SH2_CRK	436	440	PF00017	0.344
LIG_SH2_STAP1	418	422	PF00017	0.417
LIG_SH2_STAP1	613	617	PF00017	0.417
LIG_SH2_STAT3	220	223	PF00017	0.435
LIG_SH2_STAT3	350	353	PF00017	0.568
LIG_SH2_STAT5	220	223	PF00017	0.515
LIG_SH2_STAT5	297	300	PF00017	0.465
LIG_SH3_3	219	225	PF00018	0.398
LIG_SH3_3	290	296	PF00018	0.365
LIG_SH3_3	571	577	PF00018	0.409
LIG_SUMO_SIM_anti_2	397	403	PF11976	0.453
LIG_SUMO_SIM_par_1	472	479	PF11976	0.346
LIG_SxIP_EBH_1	165	177	PF03271	0.505
LIG_TRAF2_1	34	37	PF00917	0.542
LIG_TRAF2_1	351	354	PF00917	0.529
LIG_UBA3_1	510	516	PF00899	0.353
LIG_WRC_WIRS_1	440	445	PF05994	0.354
MOD_CDK_SPxxK_3	237	244	PF00069	0.271
MOD_CDK_SPxxK_3	641	648	PF00069	0.466
MOD_CK1_1	159	165	PF00069	0.661
MOD_CK1_1	184	190	PF00069	0.547
MOD_CK1_1	301	307	PF00069	0.600
MOD_CK1_1	457	463	PF00069	0.481
MOD_CK1_1	489	495	PF00069	0.390
MOD_CK1_1	503	509	PF00069	0.486
MOD_CK1_1	59	65	PF00069	0.689
MOD_CK1_1	79	85	PF00069	0.715
MOD_CK1_1	87	93	PF00069	0.667
MOD_CK2_1	31	37	PF00069	0.495
MOD_CK2_1	348	354	PF00069	0.370
MOD_CK2_1	473	479	PF00069	0.455
MOD_DYRK1A_RPxSP_1	641	645	PF00069	0.536
MOD_DYRK1A_RPxSP_1	656	660	PF00069	0.562
MOD_GlcNHglycan	189	192	PF01048	0.658
MOD_GlcNHglycan	269	272	PF01048	0.376
MOD_GlcNHglycan	300	303	PF01048	0.399
MOD_GlcNHglycan	312	315	PF01048	0.384
MOD_GlcNHglycan	443	446	PF01048	0.475
MOD_GlcNHglycan	479	483	PF01048	0.450
MOD_GlcNHglycan	496	499	PF01048	0.419
MOD_GlcNHglycan	58	61	PF01048	0.660
MOD_GlcNHglycan	79	82	PF01048	0.747
MOD_GlcNHglycan	89	92	PF01048	0.767
MOD_GlcNHglycan	95	98	PF01048	0.670
MOD_GSK3_1	156	163	PF00069	0.781
MOD_GSK3_1	181	188	PF00069	0.451
MOD_GSK3_1	201	208	PF00069	0.293
MOD_GSK3_1	348	355	PF00069	0.347
MOD_GSK3_1	39	46	PF00069	0.622
MOD_GSK3_1	431	438	PF00069	0.436
MOD_GSK3_1	465	472	PF00069	0.418
MOD_GSK3_1	486	493	PF00069	0.471
MOD_GSK3_1	500	507	PF00069	0.570
MOD_GSK3_1	61	68	PF00069	0.630
MOD_GSK3_1	652	659	PF00069	0.470
MOD_GSK3_1	71	78	PF00069	0.706
MOD_GSK3_1	80	87	PF00069	0.646
MOD_N-GLC_1	237	242	PF02516	0.277
MOD_N-GLC_1	611	616	PF02516	0.355
MOD_N-GLC_2	21	23	PF02516	0.392
MOD_NEK2_1	11	16	PF00069	0.521
MOD_NEK2_1	127	132	PF00069	0.607
MOD_NEK2_1	181	186	PF00069	0.472
MOD_NEK2_1	192	197	PF00069	0.544
MOD_NEK2_1	201	206	PF00069	0.243
MOD_NEK2_1	228	233	PF00069	0.393
MOD_NEK2_1	253	258	PF00069	0.455
MOD_NEK2_1	298	303	PF00069	0.421
MOD_NEK2_1	31	36	PF00069	0.297
MOD_NEK2_1	310	315	PF00069	0.338
MOD_NEK2_1	426	431	PF00069	0.473
MOD_NEK2_1	439	444	PF00069	0.369
MOD_NEK2_1	494	499	PF00069	0.449
MOD_NEK2_1	501	506	PF00069	0.493
MOD_NEK2_1	600	605	PF00069	0.460
MOD_NEK2_1	77	82	PF00069	0.777
MOD_NEK2_1	86	91	PF00069	0.693
MOD_NEK2_1	92	97	PF00069	0.556
MOD_NEK2_2	48	53	PF00069	0.596
MOD_PIKK_1	349	355	PF00454	0.517
MOD_PIKK_1	400	406	PF00454	0.463
MOD_PIKK_1	566	572	PF00454	0.516
MOD_PIKK_1	611	617	PF00454	0.386
MOD_PKA_1	39	45	PF00069	0.532
MOD_PKA_1	652	658	PF00069	0.366
MOD_PKA_2	127	133	PF00069	0.657
MOD_PKA_2	160	166	PF00069	0.578
MOD_PKA_2	182	188	PF00069	0.577
MOD_PKA_2	386	392	PF00069	0.549
MOD_PKA_2	39	45	PF00069	0.582
MOD_PKA_2	639	645	PF00069	0.490
MOD_PKA_2	652	658	PF00069	0.406
MOD_Plk_1	394	400	PF00069	0.421
MOD_Plk_1	463	469	PF00069	0.516
MOD_Plk_1	628	634	PF00069	0.483
MOD_Plk_2-3	473	479	PF00069	0.489
MOD_Plk_4	11	17	PF00069	0.550
MOD_Plk_4	127	133	PF00069	0.519
MOD_Plk_4	229	235	PF00069	0.382
MOD_Plk_4	435	441	PF00069	0.397
MOD_Plk_4	454	460	PF00069	0.292
MOD_Plk_4	490	496	PF00069	0.422
MOD_ProDKin_1	221	227	PF00069	0.412
MOD_ProDKin_1	237	243	PF00069	0.332
MOD_ProDKin_1	370	376	PF00069	0.400
MOD_ProDKin_1	534	540	PF00069	0.322
MOD_ProDKin_1	641	647	PF00069	0.463
MOD_ProDKin_1	656	662	PF00069	0.442
MOD_SUMO_rev_2	389	393	PF00179	0.552
TRG_DiLeu_BaEn_1	354	359	PF01217	0.560
TRG_ENDOCYTIC_2	436	439	PF00928	0.388
TRG_ER_diArg_1	27	29	PF00400	0.413
TRG_ER_diArg_1	39	41	PF00400	0.508
TRG_ER_diArg_1	52	55	PF00400	0.644
TRG_ER_diArg_1	639	641	PF00400	0.548
TRG_ER_diArg_1	651	653	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I481	Leptomonas seymouri	70%	98%
A0A0S4IPG5	Bodo saltans	36%	100%
A0A1X0P1H7	Trypanosomatidae	49%	100%
A0A3Q8IG13	Leishmania donovani	95%	100%
A0A3R7JPV2	Trypanosoma rangeli	49%	100%
A4HIM2	Leishmania braziliensis	86%	100%
A4I5W7	Leishmania infantum	95%	100%
C9ZR90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
Q4Q704	Leishmania major	94%	100%
V5B7A2	Trypanosoma cruzi	49%	100%