GTPase activator-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTPase activator-like protein

Species:

Leishmania mexicana

UniProt:

E9B157_LEIMU

TriTrypDb:

LmxM.29.2840

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B157

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B157

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0043085	positive regulation of catalytic activity	4	1
GO:0043087	regulation of GTPase activity	5	1
GO:0043547	positive regulation of GTPase activity	6	1
GO:0044093	positive regulation of molecular function	3	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0050790	regulation of catalytic activity	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051336	regulation of hydrolase activity	4	1
GO:0051345	positive regulation of hydrolase activity	5	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0090630	activation of GTPase activity	7	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0003924	GTPase activity	7	4
GO:0003925	G protein activity	2	4
GO:0005096	GTPase activator activity	4	1
GO:0008047	enzyme activator activity	3	1
GO:0016462	pyrophosphatase activity	5	4
GO:0016787	hydrolase activity	2	4
GO:0016817	hydrolase activity, acting on acid anhydrides	3	4
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	4
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	4
GO:0030234	enzyme regulator activity	2	1
GO:0030695	GTPase regulator activity	4	1
GO:0060589	nucleoside-triphosphatase regulator activity	3	1
GO:0098772	molecular function regulator activity	1	4
GO:0140677	molecular function activator activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	301	303	PF00675	0.442
CLV_NRD_NRD_1	66	68	PF00675	0.320
CLV_NRD_NRD_1	90	92	PF00675	0.310
CLV_PCSK_KEX2_1	301	303	PF00082	0.442
CLV_PCSK_KEX2_1	66	68	PF00082	0.320
CLV_PCSK_KEX2_1	90	92	PF00082	0.310
CLV_PCSK_SKI1_1	272	276	PF00082	0.428
CLV_PCSK_SKI1_1	90	94	PF00082	0.339
DEG_APCC_DBOX_1	271	279	PF00400	0.467
DOC_CYCLIN_yClb1_LxF_4	171	177	PF00134	0.424
DOC_MAPK_MEF2A_6	198	205	PF00069	0.213
DOC_MAPK_MEF2A_6	53	60	PF00069	0.407
DOC_MAPK_NFAT4_5	198	206	PF00069	0.213
DOC_PP4_FxxP_1	176	179	PF00568	0.340
DOC_USP7_MATH_1	33	37	PF00917	0.580
DOC_USP7_UBL2_3	276	280	PF12436	0.494
DOC_WW_Pin1_4	290	295	PF00397	0.459
DOC_WW_Pin1_4	80	85	PF00397	0.357
LIG_14-3-3_CanoR_1	91	99	PF00244	0.241
LIG_Actin_WH2_2	285	303	PF00022	0.286
LIG_BRCT_BRCA1_1	153	157	PF00533	0.391
LIG_BRCT_BRCA1_1	228	232	PF00533	0.260
LIG_BRCT_BRCA1_1	56	60	PF00533	0.362
LIG_FHA_1	127	133	PF00498	0.385
LIG_FHA_1	164	170	PF00498	0.438
LIG_FHA_1	74	80	PF00498	0.461
LIG_FHA_1	94	100	PF00498	0.181
LIG_IRF3_LxIS_1	185	191	PF10401	0.280
LIG_LIR_Gen_1	180	190	PF02991	0.364
LIG_LIR_Gen_1	44	52	PF02991	0.325
LIG_LIR_Gen_1	8	19	PF02991	0.443
LIG_LIR_Nem_3	111	115	PF02991	0.435
LIG_LIR_Nem_3	135	140	PF02991	0.300
LIG_LIR_Nem_3	180	185	PF02991	0.348
LIG_LIR_Nem_3	186	190	PF02991	0.316
LIG_LIR_Nem_3	191	197	PF02991	0.284
LIG_LIR_Nem_3	21	25	PF02991	0.392
LIG_LIR_Nem_3	282	286	PF02991	0.454
LIG_LIR_Nem_3	44	49	PF02991	0.446
LIG_LIR_Nem_3	8	14	PF02991	0.469
LIG_PDZ_Class_1	319	324	PF00595	0.608
LIG_Pex14_1	277	281	PF04695	0.386
LIG_Pex14_2	151	155	PF04695	0.430
LIG_Pex14_2	204	208	PF04695	0.312
LIG_Pex14_2	219	223	PF04695	0.321
LIG_SH2_CRK	22	26	PF00017	0.495
LIG_SH2_STAP1	195	199	PF00017	0.303
LIG_SH2_STAT5	105	108	PF00017	0.304
LIG_SH2_STAT5	112	115	PF00017	0.306
LIG_SH2_STAT5	146	149	PF00017	0.331
LIG_SH2_STAT5	187	190	PF00017	0.440
LIG_SH3_3	46	52	PF00018	0.338
LIG_TYR_ITIM	185	190	PF00017	0.325
LIG_UBA3_1	285	290	PF00899	0.382
LIG_WRC_WIRS_1	220	225	PF05994	0.321
MOD_CK1_1	126	132	PF00069	0.422
MOD_CK1_1	245	251	PF00069	0.466
MOD_CK1_1	41	47	PF00069	0.378
MOD_CK2_1	72	78	PF00069	0.374
MOD_GlcNHglycan	190	193	PF01048	0.276
MOD_GlcNHglycan	228	231	PF01048	0.238
MOD_GlcNHglycan	247	250	PF01048	0.528
MOD_GSK3_1	241	248	PF00069	0.414
MOD_GSK3_1	315	322	PF00069	0.503
MOD_GSK3_1	68	75	PF00069	0.352
MOD_N-GLC_1	126	131	PF02516	0.384
MOD_N-GLC_1	99	104	PF02516	0.434
MOD_NEK2_1	163	168	PF00069	0.417
MOD_NEK2_1	219	224	PF00069	0.336
MOD_NEK2_1	242	247	PF00069	0.367
MOD_NEK2_1	270	275	PF00069	0.387
MOD_NEK2_1	300	305	PF00069	0.484
MOD_NEK2_1	93	98	PF00069	0.397
MOD_PIKK_1	5	11	PF00454	0.346
MOD_PIKK_1	82	88	PF00454	0.362
MOD_PKA_2	242	248	PF00069	0.393
MOD_PKA_2	300	306	PF00069	0.480
MOD_Plk_1	41	47	PF00069	0.402
MOD_Plk_1	99	105	PF00069	0.388
MOD_Plk_4	133	139	PF00069	0.333
MOD_Plk_4	177	183	PF00069	0.456
MOD_Plk_4	242	248	PF00069	0.375
MOD_Plk_4	315	321	PF00069	0.513
MOD_ProDKin_1	290	296	PF00069	0.455
MOD_ProDKin_1	80	86	PF00069	0.357
MOD_SUMO_rev_2	282	292	PF00179	0.382
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.468
TRG_ENDOCYTIC_2	187	190	PF00928	0.384
TRG_ENDOCYTIC_2	194	197	PF00928	0.403
TRG_ENDOCYTIC_2	22	25	PF00928	0.397
TRG_ER_diArg_1	300	302	PF00400	0.425
TRG_ER_diArg_1	66	68	PF00400	0.150
TRG_ER_diArg_1	89	91	PF00400	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1N7	Leptomonas seymouri	68%	100%
A0A0S4ITU5	Bodo saltans	41%	79%
A0A1X0P1K5	Trypanosomatidae	47%	81%
A0A1X0P2Z0	Trypanosomatidae	23%	72%
A0A3S7X3S6	Leishmania donovani	94%	100%
A0A422NB36	Trypanosoma rangeli	26%	66%
A0A422NJ84	Trypanosoma rangeli	27%	77%
A4HIL7	Leishmania braziliensis	83%	100%
A4HQC7	Leishmania braziliensis	25%	76%
A4I5W2	Leishmania infantum	94%	100%
C9ZR83	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	82%
Q4Q0F2	Leishmania major	24%	78%
Q4Q709	Leishmania major	92%	100%
Q6PBU5	Danio rerio	24%	91%
V5B7A5	Trypanosoma cruzi	50%	100%
V5BT66	Trypanosoma cruzi	27%	79%
V5BU55	Trypanosoma cruzi	23%	71%