Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B156_LEIMU

TriTrypDb:

LmxM.29.2830

Length:

798

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B156

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B156

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.454
CLV_C14_Caspase3-7	3	7	PF00656	0.581
CLV_C14_Caspase3-7	755	759	PF00656	0.561
CLV_NRD_NRD_1	14	16	PF00675	0.722
CLV_NRD_NRD_1	267	269	PF00675	0.471
CLV_NRD_NRD_1	277	279	PF00675	0.473
CLV_NRD_NRD_1	322	324	PF00675	0.434
CLV_NRD_NRD_1	330	332	PF00675	0.442
CLV_NRD_NRD_1	385	387	PF00675	0.474
CLV_NRD_NRD_1	412	414	PF00675	0.476
CLV_NRD_NRD_1	447	449	PF00675	0.644
CLV_NRD_NRD_1	455	457	PF00675	0.626
CLV_NRD_NRD_1	586	588	PF00675	0.480
CLV_NRD_NRD_1	607	609	PF00675	0.539
CLV_NRD_NRD_1	617	619	PF00675	0.409
CLV_NRD_NRD_1	735	737	PF00675	0.487
CLV_PCSK_FUR_1	264	268	PF00082	0.597
CLV_PCSK_FUR_1	320	324	PF00082	0.467
CLV_PCSK_FUR_1	328	332	PF00082	0.444
CLV_PCSK_FUR_1	383	387	PF00082	0.436
CLV_PCSK_KEX2_1	144	146	PF00082	0.532
CLV_PCSK_KEX2_1	264	266	PF00082	0.489
CLV_PCSK_KEX2_1	267	269	PF00082	0.465
CLV_PCSK_KEX2_1	277	279	PF00082	0.459
CLV_PCSK_KEX2_1	322	324	PF00082	0.450
CLV_PCSK_KEX2_1	330	332	PF00082	0.417
CLV_PCSK_KEX2_1	385	387	PF00082	0.435
CLV_PCSK_KEX2_1	412	414	PF00082	0.476
CLV_PCSK_KEX2_1	447	449	PF00082	0.646
CLV_PCSK_KEX2_1	470	472	PF00082	0.513
CLV_PCSK_KEX2_1	586	588	PF00082	0.469
CLV_PCSK_KEX2_1	607	609	PF00082	0.483
CLV_PCSK_KEX2_1	700	702	PF00082	0.429
CLV_PCSK_KEX2_1	735	737	PF00082	0.499
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.532
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.513
CLV_PCSK_PC1ET2_1	700	702	PF00082	0.404
CLV_PCSK_SKI1_1	297	301	PF00082	0.494
CLV_PCSK_SKI1_1	314	318	PF00082	0.477
CLV_PCSK_SKI1_1	342	346	PF00082	0.510
CLV_PCSK_SKI1_1	350	354	PF00082	0.399
CLV_PCSK_SKI1_1	366	370	PF00082	0.320
CLV_PCSK_SKI1_1	412	416	PF00082	0.572
CLV_PCSK_SKI1_1	608	612	PF00082	0.413
CLV_PCSK_SKI1_1	618	622	PF00082	0.399
CLV_PCSK_SKI1_1	710	714	PF00082	0.433
CLV_PCSK_SKI1_1	725	729	PF00082	0.415
CLV_PCSK_SKI1_1	791	795	PF00082	0.466
DEG_APCC_DBOX_1	439	447	PF00400	0.725
DEG_APCC_DBOX_1	607	615	PF00400	0.472
DEG_APCC_DBOX_1	790	798	PF00400	0.482
DEG_SPOP_SBC_1	74	78	PF00917	0.604
DOC_CDC14_PxL_1	4	12	PF14671	0.581
DOC_CYCLIN_RxL_1	615	622	PF00134	0.511
DOC_PP4_FxxP_1	104	107	PF00568	0.600
DOC_USP7_MATH_1	107	111	PF00917	0.720
DOC_USP7_MATH_1	217	221	PF00917	0.659
DOC_USP7_MATH_1	574	578	PF00917	0.469
DOC_USP7_MATH_1	651	655	PF00917	0.641
DOC_USP7_MATH_1	670	674	PF00917	0.323
DOC_USP7_MATH_1	74	78	PF00917	0.643
DOC_USP7_MATH_1	741	745	PF00917	0.520
DOC_USP7_UBL2_3	58	62	PF12436	0.695
DOC_USP7_UBL2_3	696	700	PF12436	0.451
DOC_WW_Pin1_4	117	122	PF00397	0.693
DOC_WW_Pin1_4	124	129	PF00397	0.699
LIG_14-3-3_CanoR_1	145	151	PF00244	0.583
LIG_14-3-3_CanoR_1	15	21	PF00244	0.605
LIG_14-3-3_CanoR_1	236	244	PF00244	0.471
LIG_14-3-3_CanoR_1	272	277	PF00244	0.559
LIG_14-3-3_CanoR_1	586	590	PF00244	0.404
LIG_BIR_II_1	1	5	PF00653	0.626
LIG_FHA_1	121	127	PF00498	0.748
LIG_FHA_1	427	433	PF00498	0.543
LIG_FHA_1	663	669	PF00498	0.537
LIG_FHA_2	135	141	PF00498	0.454
LIG_FHA_2	147	153	PF00498	0.536
LIG_FHA_2	238	244	PF00498	0.493
LIG_FHA_2	33	39	PF00498	0.610
LIG_FHA_2	365	371	PF00498	0.441
LIG_FHA_2	504	510	PF00498	0.565
LIG_FHA_2	514	520	PF00498	0.538
LIG_FHA_2	550	556	PF00498	0.333
LIG_FHA_2	586	592	PF00498	0.534
LIG_LIR_Apic_2	102	107	PF02991	0.737
LIG_LIR_Gen_1	19	25	PF02991	0.523
LIG_LIR_Gen_1	243	250	PF02991	0.467
LIG_LIR_Gen_1	298	308	PF02991	0.452
LIG_LIR_Gen_1	622	633	PF02991	0.401
LIG_LIR_Gen_1	729	738	PF02991	0.504
LIG_LIR_Nem_3	19	23	PF02991	0.532
LIG_LIR_Nem_3	243	247	PF02991	0.469
LIG_LIR_Nem_3	298	303	PF02991	0.459
LIG_LIR_Nem_3	362	368	PF02991	0.455
LIG_LIR_Nem_3	622	628	PF02991	0.400
LIG_LIR_Nem_3	729	734	PF02991	0.496
LIG_PCNA_yPIPBox_3	534	547	PF02747	0.467
LIG_SH2_CRK	147	151	PF00017	0.535
LIG_SH2_CRK	596	600	PF00017	0.524
LIG_SH2_NCK_1	147	151	PF00017	0.580
LIG_SH2_NCK_1	244	248	PF00017	0.472
LIG_SH2_SRC	113	116	PF00017	0.654
LIG_SH2_SRC	244	247	PF00017	0.472
LIG_SH2_SRC	29	32	PF00017	0.510
LIG_SH2_STAP1	100	104	PF00017	0.614
LIG_SH2_STAP1	25	29	PF00017	0.627
LIG_SH2_STAT3	439	442	PF00017	0.572
LIG_SH2_STAT5	113	116	PF00017	0.683
LIG_SH2_STAT5	29	32	PF00017	0.582
LIG_SH3_3	126	132	PF00018	0.685
LIG_SH3_3	247	253	PF00018	0.551
LIG_SH3_3	68	74	PF00018	0.595
LIG_SH3_3	87	93	PF00018	0.489
LIG_TRAF2_1	149	152	PF00917	0.557
LIG_TRAF2_1	279	282	PF00917	0.563
LIG_TRAF2_1	35	38	PF00917	0.620
LIG_TRAF2_1	416	419	PF00917	0.503
LIG_TRAF2_1	506	509	PF00917	0.600
LIG_TRAF2_1	552	555	PF00917	0.427
LIG_TRAF2_1	673	676	PF00917	0.412
LIG_TRAF2_1	743	746	PF00917	0.530
LIG_TYR_ITIM	242	247	PF00017	0.467
LIG_WRC_WIRS_1	365	370	PF05994	0.445
LIG_WRC_WIRS_1	575	580	PF05994	0.467
MOD_CDK_SPxxK_3	124	131	PF00069	0.579
MOD_CK1_1	11	17	PF00069	0.704
MOD_CK1_1	116	122	PF00069	0.625
MOD_CK1_1	32	38	PF00069	0.543
MOD_CK1_1	43	49	PF00069	0.639
MOD_CK1_1	553	559	PF00069	0.506
MOD_CK1_1	57	63	PF00069	0.539
MOD_CK1_1	576	582	PF00069	0.424
MOD_CK1_1	684	690	PF00069	0.483
MOD_CK1_1	76	82	PF00069	0.630
MOD_CK2_1	134	140	PF00069	0.635
MOD_CK2_1	146	152	PF00069	0.581
MOD_CK2_1	237	243	PF00069	0.527
MOD_CK2_1	255	261	PF00069	0.594
MOD_CK2_1	32	38	PF00069	0.620
MOD_CK2_1	364	370	PF00069	0.575
MOD_CK2_1	371	377	PF00069	0.485
MOD_CK2_1	495	501	PF00069	0.522
MOD_CK2_1	503	509	PF00069	0.539
MOD_CK2_1	513	519	PF00069	0.577
MOD_CK2_1	549	555	PF00069	0.333
MOD_CK2_1	585	591	PF00069	0.470
MOD_CK2_1	670	676	PF00069	0.531
MOD_CK2_1	726	732	PF00069	0.578
MOD_CK2_1	740	746	PF00069	0.394
MOD_GlcNHglycan	433	438	PF01048	0.517
MOD_GlcNHglycan	84	87	PF01048	0.639
MOD_GSK3_1	113	120	PF00069	0.657
MOD_GSK3_1	223	230	PF00069	0.733
MOD_GSK3_1	32	39	PF00069	0.652
MOD_GSK3_1	40	47	PF00069	0.670
MOD_GSK3_1	422	429	PF00069	0.639
MOD_GSK3_1	503	510	PF00069	0.596
MOD_GSK3_1	549	556	PF00069	0.389
MOD_GSK3_1	6	13	PF00069	0.603
MOD_GSK3_1	684	691	PF00069	0.483
MOD_GSK3_1	73	80	PF00069	0.636
MOD_LATS_1	270	276	PF00433	0.557
MOD_N-GLC_1	303	308	PF02516	0.405
MOD_N-GLC_1	495	500	PF02516	0.517
MOD_NEK2_1	10	15	PF00069	0.655
MOD_NEK2_1	146	151	PF00069	0.536
MOD_NEK2_1	303	308	PF00069	0.427
MOD_NEK2_1	426	431	PF00069	0.603
MOD_NEK2_1	503	508	PF00069	0.545
MOD_NEK2_1	511	516	PF00069	0.556
MOD_NEK2_1	573	578	PF00069	0.468
MOD_PIKK_1	189	195	PF00454	0.369
MOD_PIKK_1	210	216	PF00454	0.609
MOD_PIKK_1	550	556	PF00454	0.509
MOD_PIKK_1	741	747	PF00454	0.583
MOD_PIKK_1	8	14	PF00454	0.450
MOD_PK_1	681	687	PF00069	0.524
MOD_PKA_1	82	88	PF00069	0.636
MOD_PKA_2	202	208	PF00069	0.525
MOD_PKA_2	371	377	PF00069	0.436
MOD_PKA_2	390	396	PF00069	0.534
MOD_PKA_2	54	60	PF00069	0.788
MOD_PKA_2	585	591	PF00069	0.441
MOD_Plk_1	303	309	PF00069	0.441
MOD_Plk_1	495	501	PF00069	0.579
MOD_Plk_1	651	657	PF00069	0.545
MOD_Plk_2-3	585	591	PF00069	0.416
MOD_Plk_4	303	309	PF00069	0.448
MOD_Plk_4	422	428	PF00069	0.419
MOD_Plk_4	651	657	PF00069	0.545
MOD_ProDKin_1	117	123	PF00069	0.695
MOD_ProDKin_1	124	130	PF00069	0.700
MOD_SUMO_for_1	316	319	PF00179	0.439
MOD_SUMO_for_1	414	417	PF00179	0.686
MOD_SUMO_for_1	569	572	PF00179	0.454
MOD_SUMO_for_1	680	683	PF00179	0.433
MOD_SUMO_for_1	695	698	PF00179	0.438
MOD_SUMO_rev_2	138	146	PF00179	0.524
MOD_SUMO_rev_2	346	354	PF00179	0.487
MOD_SUMO_rev_2	359	365	PF00179	0.389
MOD_SUMO_rev_2	544	553	PF00179	0.464
MOD_SUMO_rev_2	613	621	PF00179	0.405
MOD_SUMO_rev_2	673	680	PF00179	0.527
MOD_SUMO_rev_2	697	702	PF00179	0.410
MOD_SUMO_rev_2	718	727	PF00179	0.461
TRG_AP2beta_CARGO_1	362	372	PF09066	0.469
TRG_DiLeu_BaEn_1	311	316	PF01217	0.411
TRG_DiLeu_BaEn_1	723	728	PF01217	0.437
TRG_DiLeu_LyEn_5	311	316	PF01217	0.411
TRG_ENDOCYTIC_2	147	150	PF00928	0.578
TRG_ENDOCYTIC_2	244	247	PF00928	0.472
TRG_ENDOCYTIC_2	568	571	PF00928	0.370
TRG_ENDOCYTIC_2	596	599	PF00928	0.404
TRG_ER_diArg_1	179	182	PF00400	0.654
TRG_ER_diArg_1	264	267	PF00400	0.485
TRG_ER_diArg_1	276	278	PF00400	0.468
TRG_ER_diArg_1	321	323	PF00400	0.493
TRG_ER_diArg_1	383	386	PF00400	0.532
TRG_ER_diArg_1	446	448	PF00400	0.669
TRG_ER_diArg_1	561	564	PF00400	0.393
TRG_ER_diArg_1	607	609	PF00400	0.483
TRG_ER_diArg_1	671	674	PF00400	0.529
TRG_ER_diArg_1	734	736	PF00400	0.494
TRG_ER_diArg_1	747	750	PF00400	0.666
TRG_NLS_Bipartite_1	50	65	PF00514	0.665
TRG_NLS_MonoExtC_3	57	62	PF00514	0.728
TRG_NLS_MonoExtN_4	48	54	PF00514	0.602
TRG_NLS_MonoExtN_4	55	62	PF00514	0.602
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	386	390	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	399	403	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	520	524	PF00026	0.695
TRG_Pf-PMV_PEXEL_1	534	538	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	618	622	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC64	Leptomonas seymouri	71%	100%
A0A1X0P1G0	Trypanosomatidae	43%	98%
A0A3R7M5L7	Trypanosoma rangeli	43%	100%
A0A3S7X3P7	Leishmania donovani	92%	100%
A4HIL6	Leishmania braziliensis	84%	100%
A4I5W1	Leishmania infantum	92%	100%
C9ZR81	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
Q4Q710	Leishmania major	92%	100%