Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B154_LEIMU

TriTrypDb:

LmxM.29.2810

Length:

205

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B154

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B154

PDB structure(s): 7aih_Ar , 7am2_Ar , 7ane_Ar

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.370
CLV_NRD_NRD_1	155	157	PF00675	0.403
CLV_NRD_NRD_1	195	197	PF00675	0.348
CLV_NRD_NRD_1	92	94	PF00675	0.331
CLV_PCSK_KEX2_1	155	157	PF00082	0.403
CLV_PCSK_KEX2_1	187	189	PF00082	0.348
CLV_PCSK_KEX2_1	43	45	PF00082	0.445
CLV_PCSK_KEX2_1	94	96	PF00082	0.327
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.332
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.445
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.318
CLV_PCSK_PC7_1	151	157	PF00082	0.383
CLV_PCSK_SKI1_1	187	191	PF00082	0.326
CLV_PCSK_SKI1_1	26	30	PF00082	0.341
CLV_PCSK_SKI1_1	40	44	PF00082	0.357
DEG_Nend_Nbox_1	1	3	PF02207	0.542
DEG_SCF_FBW7_2	57	62	PF00400	0.424
DOC_MAPK_gen_1	187	195	PF00069	0.318
DOC_MAPK_gen_1	93	100	PF00069	0.312
DOC_MAPK_MEF2A_6	9	17	PF00069	0.399
DOC_PP1_RVXF_1	144	151	PF00149	0.363
DOC_PP2B_LxvP_1	169	172	PF13499	0.317
DOC_WW_Pin1_4	55	60	PF00397	0.404
LIG_14-3-3_CanoR_1	113	117	PF00244	0.343
LIG_14-3-3_CanoR_1	196	202	PF00244	0.428
LIG_FHA_1	104	110	PF00498	0.319
LIG_FHA_1	23	29	PF00498	0.325
LIG_LIR_Gen_1	74	85	PF02991	0.365
LIG_LIR_Gen_1	86	92	PF02991	0.284
LIG_LIR_Nem_3	106	111	PF02991	0.319
LIG_LIR_Nem_3	18	22	PF02991	0.331
LIG_LIR_Nem_3	199	204	PF02991	0.428
LIG_LIR_Nem_3	74	80	PF02991	0.371
LIG_LIR_Nem_3	86	90	PF02991	0.297
LIG_LIR_Nem_3	99	104	PF02991	0.229
LIG_Pex14_1	166	170	PF04695	0.302
LIG_Pex14_1	97	101	PF04695	0.297
LIG_SH2_CRK	201	205	PF00017	0.533
LIG_SH2_GRB2like	184	187	PF00017	0.357
LIG_SH2_PTP2	19	22	PF00017	0.355
LIG_SH2_SRC	170	173	PF00017	0.331
LIG_SH2_SRC	19	22	PF00017	0.389
LIG_SH2_STAP1	77	81	PF00017	0.364
LIG_SH2_STAT5	108	111	PF00017	0.312
LIG_SH2_STAT5	170	173	PF00017	0.358
LIG_SH2_STAT5	19	22	PF00017	0.355
LIG_TRAF2_1	36	39	PF00917	0.328
LIG_TYR_ITIM	17	22	PF00017	0.343
MOD_LATS_1	194	200	PF00433	0.392
MOD_N-GLC_2	165	167	PF02516	0.290
MOD_NEK2_1	2	7	PF00069	0.501
MOD_NEK2_1	24	29	PF00069	0.339
MOD_PKA_1	196	202	PF00069	0.422
MOD_PKA_2	112	118	PF00069	0.346
MOD_PKA_2	154	160	PF00069	0.341
MOD_PKA_2	2	8	PF00069	0.485
MOD_ProDKin_1	55	61	PF00069	0.410
MOD_SUMO_for_1	42	45	PF00179	0.381
MOD_SUMO_rev_2	182	189	PF00179	0.346
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.350
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.629
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.370
TRG_ENDOCYTIC_2	101	104	PF00928	0.307
TRG_ENDOCYTIC_2	108	111	PF00928	0.312
TRG_ENDOCYTIC_2	19	22	PF00928	0.321
TRG_ENDOCYTIC_2	201	204	PF00928	0.554
TRG_ENDOCYTIC_2	77	80	PF00928	0.371
TRG_Pf-PMV_PEXEL_1	6	10	PF00026	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIV5	Leptomonas seymouri	97%	100%
A0A0S4ITY2	Bodo saltans	81%	100%
A0A1X0P1S8	Trypanosomatidae	82%	100%
A0A3Q8IS65	Leishmania donovani	99%	100%
A0A3R7NR49	Trypanosoma rangeli	84%	100%
A4HIL4	Leishmania braziliensis	97%	100%
A4I5V9	Leishmania infantum	99%	100%
C9ZR78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	84%	100%
Q4Q712	Leishmania major	97%	100%
V5BSJ7	Trypanosoma cruzi	84%	100%