Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic protein of unknown function (DUF872), putative

Species:

Leishmania mexicana

UniProt:

E9B152_LEIMU

TriTrypDb:

LmxM.29.2790

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9B152

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B152

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	63	65	PF00675	0.480
CLV_PCSK_KEX2_1	63	65	PF00082	0.498
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.453
CLV_PCSK_SKI1_1	118	122	PF00082	0.275
CLV_PCSK_SKI1_1	91	95	PF00082	0.365
DEG_Nend_UBRbox_1	1	4	PF02207	0.705
DOC_CKS1_1	14	19	PF01111	0.627
DOC_MAPK_gen_1	148	156	PF00069	0.275
DOC_MAPK_MEF2A_6	148	156	PF00069	0.260
DOC_MAPK_MEF2A_6	86	94	PF00069	0.579
DOC_PP1_RVXF_1	109	115	PF00149	0.560
DOC_PP1_RVXF_1	89	95	PF00149	0.576
DOC_PP2B_LxvP_1	161	164	PF13499	0.312
DOC_PP2B_LxvP_1	185	188	PF13499	0.475
DOC_USP7_UBL2_3	61	65	PF12436	0.643
DOC_WW_Pin1_4	13	18	PF00397	0.681
LIG_14-3-3_CanoR_1	179	185	PF00244	0.478
LIG_14-3-3_CanoR_1	31	40	PF00244	0.659
LIG_14-3-3_CanoR_1	47	56	PF00244	0.668
LIG_14-3-3_CanoR_1	64	69	PF00244	0.678
LIG_FHA_1	14	20	PF00498	0.662
LIG_FHA_2	46	52	PF00498	0.608
LIG_LIR_Gen_1	183	190	PF02991	0.475
LIG_LIR_Nem_3	168	173	PF02991	0.482
LIG_LIR_Nem_3	183	187	PF02991	0.397
LIG_LIR_Nem_3	75	81	PF02991	0.677
LIG_Pex14_2	120	124	PF04695	0.312
LIG_PTAP_UEV_1	10	15	PF05743	0.612
LIG_SH2_CRK	173	177	PF00017	0.531
LIG_SH2_CRK	182	186	PF00017	0.430
LIG_SH2_STAP1	167	171	PF00017	0.388
LIG_SH2_STAP1	88	92	PF00017	0.631
LIG_SH2_STAT5	144	147	PF00017	0.275
LIG_SH2_STAT5	175	178	PF00017	0.506
LIG_SH2_STAT5	182	185	PF00017	0.569
LIG_SH3_3	5	11	PF00018	0.730
LIG_SUMO_SIM_anti_2	131	137	PF11976	0.312
LIG_TRAF2_1	70	73	PF00917	0.603
LIG_TYR_ITIM	171	176	PF00017	0.388
MOD_CK1_1	38	44	PF00069	0.658
MOD_CK1_1	67	73	PF00069	0.636
MOD_CK1_1	9	15	PF00069	0.649
MOD_CK2_1	45	51	PF00069	0.615
MOD_CK2_1	67	73	PF00069	0.631
MOD_CMANNOS	114	117	PF00535	0.344
MOD_GlcNHglycan	126	129	PF01048	0.388
MOD_GlcNHglycan	36	40	PF01048	0.392
MOD_GlcNHglycan	8	11	PF01048	0.490
MOD_GSK3_1	124	131	PF00069	0.388
MOD_GSK3_1	35	42	PF00069	0.620
MOD_GSK3_1	9	16	PF00069	0.653
MOD_NEK2_1	124	129	PF00069	0.414
MOD_NEK2_1	174	179	PF00069	0.475
MOD_NEK2_2	165	170	PF00069	0.388
MOD_PKA_1	64	70	PF00069	0.580
MOD_PKA_2	57	63	PF00069	0.580
MOD_Plk_4	128	134	PF00069	0.388
MOD_Plk_4	165	171	PF00069	0.428
MOD_Plk_4	180	186	PF00069	0.415
MOD_ProDKin_1	13	19	PF00069	0.680
TRG_ENDOCYTIC_2	122	125	PF00928	0.312
TRG_ENDOCYTIC_2	166	169	PF00928	0.312
TRG_ENDOCYTIC_2	173	176	PF00928	0.475
TRG_ENDOCYTIC_2	182	185	PF00928	0.475
TRG_ENDOCYTIC_2	78	81	PF00928	0.675
TRG_ER_diArg_1	1	4	PF00400	0.720
TRG_ER_diArg_1	106	109	PF00400	0.552
TRG_NLS_MonoCore_2	62	67	PF00514	0.572
TRG_NLS_MonoExtC_3	63	69	PF00514	0.574
TRG_NLS_MonoExtN_4	61	68	PF00514	0.567
TRG_Pf-PMV_PEXEL_1	66	71	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Q7	Leptomonas seymouri	67%	100%
A0A3Q8IF42	Leishmania donovani	88%	100%
A4HIL2	Leishmania braziliensis	79%	98%
A4I5V7	Leishmania infantum	88%	100%
Q4Q714	Leishmania major	89%	98%