C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger C-x8-C-x5-C-x3-H type (and similar), putative

Species:

Leishmania mexicana

UniProt:

E9B151_LEIMU

TriTrypDb:

LmxM.29.2780

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0005689	U12-type spliceosomal complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9B151

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B151

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	173	175	PF00675	0.775
CLV_NRD_NRD_1	227	229	PF00675	0.762
CLV_PCSK_KEX2_1	173	175	PF00082	0.775
CLV_PCSK_KEX2_1	177	179	PF00082	0.563
CLV_PCSK_KEX2_1	227	229	PF00082	0.762
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.513
CLV_PCSK_PC7_1	173	179	PF00082	0.514
CLV_PCSK_SKI1_1	295	299	PF00082	0.507
DEG_COP1_1	179	187	PF00400	0.515
DEG_SPOP_SBC_1	142	146	PF00917	0.740
DEG_SPOP_SBC_1	279	283	PF00917	0.623
DOC_ANK_TNKS_1	137	144	PF00023	0.650
DOC_MAPK_DCC_7	268	278	PF00069	0.536
DOC_PP1_RVXF_1	217	224	PF00149	0.618
DOC_PP1_RVXF_1	226	233	PF00149	0.708
DOC_SPAK_OSR1_1	242	246	PF12202	0.496
DOC_USP7_MATH_1	150	154	PF00917	0.835
DOC_USP7_MATH_1	327	331	PF00917	0.646
DOC_WW_Pin1_4	256	261	PF00397	0.708
DOC_WW_Pin1_4	95	100	PF00397	0.738
LIG_14-3-3_CanoR_1	15	24	PF00244	0.557
LIG_14-3-3_CanoR_1	227	231	PF00244	0.724
LIG_14-3-3_CanoR_1	308	312	PF00244	0.499
LIG_14-3-3_CanoR_1	36	41	PF00244	0.367
LIG_APCC_ABBA_1	210	215	PF00400	0.749
LIG_BIR_II_1	1	5	PF00653	0.582
LIG_BRCT_BRCA1_1	219	223	PF00533	0.797
LIG_BRCT_BRCA1_1	228	232	PF00533	0.656
LIG_BRCT_BRCA1_1	34	38	PF00533	0.370
LIG_deltaCOP1_diTrp_1	235	243	PF00928	0.497
LIG_FHA_1	105	111	PF00498	0.783
LIG_FHA_1	11	17	PF00498	0.709
LIG_FHA_1	179	185	PF00498	0.628
LIG_FHA_1	279	285	PF00498	0.745
LIG_FHA_1	294	300	PF00498	0.422
LIG_FHA_2	100	106	PF00498	0.722
LIG_FHA_2	143	149	PF00498	0.845
LIG_FHA_2	21	27	PF00498	0.575
LIG_FHA_2	281	287	PF00498	0.632
LIG_FHA_2	64	70	PF00498	0.426
LIG_KLC1_Yacidic_2	211	215	PF13176	0.761
LIG_LIR_Apic_2	93	99	PF02991	0.629
LIG_LIR_Nem_3	23	27	PF02991	0.605
LIG_MYND_1	162	166	PF01753	0.710
LIG_SH2_NCK_1	193	197	PF00017	0.476
LIG_SH2_SRC	27	30	PF00017	0.540
LIG_SH2_STAP1	193	197	PF00017	0.476
LIG_SH2_STAT5	213	216	PF00017	0.766
LIG_SH2_STAT5	27	30	PF00017	0.618
LIG_SH3_3	136	142	PF00018	0.762
LIG_SH3_3	259	265	PF00018	0.685
LIG_SH3_3	271	277	PF00018	0.773
LIG_SH3_3	98	104	PF00018	0.676
LIG_WW_3	272	276	PF00397	0.512
MOD_CK1_1	128	134	PF00069	0.745
MOD_CK1_1	144	150	PF00069	0.587
MOD_CK1_1	176	182	PF00069	0.753
MOD_CK1_1	183	189	PF00069	0.639
MOD_CK1_1	2	8	PF00069	0.575
MOD_CK1_1	48	54	PF00069	0.522
MOD_CK2_1	142	148	PF00069	0.839
MOD_CK2_1	20	26	PF00069	0.592
MOD_CK2_1	280	286	PF00069	0.621
MOD_CK2_1	36	42	PF00069	0.363
MOD_CK2_1	63	69	PF00069	0.428
MOD_CK2_1	77	83	PF00069	0.616
MOD_CK2_1	99	105	PF00069	0.724
MOD_Cter_Amidation	171	174	PF01082	0.746
MOD_DYRK1A_RPxSP_1	256	260	PF00069	0.705
MOD_GlcNHglycan	1	4	PF01048	0.584
MOD_GlcNHglycan	107	110	PF01048	0.524
MOD_GlcNHglycan	157	161	PF01048	0.766
MOD_GlcNHglycan	178	181	PF01048	0.727
MOD_GlcNHglycan	29	32	PF01048	0.642
MOD_GlcNHglycan	47	50	PF01048	0.402
MOD_GSK3_1	10	17	PF00069	0.717
MOD_GSK3_1	156	163	PF00069	0.795
MOD_GSK3_1	176	183	PF00069	0.695
MOD_GSK3_1	191	198	PF00069	0.611
MOD_GSK3_1	254	261	PF00069	0.808
MOD_GSK3_1	303	310	PF00069	0.411
MOD_GSK3_1	32	39	PF00069	0.550
MOD_GSK3_1	64	71	PF00069	0.504
MOD_GSK3_1	95	102	PF00069	0.680
MOD_LATS_1	34	40	PF00433	0.359
MOD_N-GLC_1	237	242	PF02516	0.710
MOD_N-GLC_1	327	332	PF02516	0.589
MOD_NEK2_1	155	160	PF00069	0.604
MOD_NEK2_1	20	25	PF00069	0.510
MOD_NEK2_1	303	308	PF00069	0.411
MOD_PKA_1	173	179	PF00069	0.728
MOD_PKA_2	14	20	PF00069	0.592
MOD_PKA_2	173	179	PF00069	0.731
MOD_PKA_2	226	232	PF00069	0.684
MOD_PKA_2	307	313	PF00069	0.513
MOD_Plk_1	327	333	PF00069	0.661
MOD_Plk_1	68	74	PF00069	0.397
MOD_Plk_4	183	189	PF00069	0.637
MOD_Plk_4	2	8	PF00069	0.555
MOD_ProDKin_1	256	262	PF00069	0.708
MOD_ProDKin_1	95	101	PF00069	0.734
MOD_SUMO_rev_2	146	155	PF00179	0.757
MOD_SUMO_rev_2	170	179	PF00179	0.734
TRG_DiLeu_BaEn_1	42	47	PF01217	0.515
TRG_DiLeu_BaEn_2	285	291	PF01217	0.728

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD74	Leptomonas seymouri	30%	99%
A0A3S7X3N7	Leishmania donovani	86%	100%
A4HIL1	Leishmania braziliensis	67%	100%
A4I5V6	Leishmania infantum	86%	100%
Q4Q715	Leishmania major	85%	100%