Putative superoxide dismutase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

superoxide dismutase, putative

Species:

Leishmania mexicana

UniProt:

E9B150_LEIMU

TriTrypDb:

LmxM.29.2770

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B150

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B150

PDB structure(s): 7ane_x

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0004784	superoxide dismutase activity	2	17
GO:0005488	binding	1	17
GO:0016209	antioxidant activity	1	17
GO:0016491	oxidoreductase activity	2	17
GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	3	17
GO:0043167	ion binding	2	17
GO:0043169	cation binding	3	17
GO:0046872	metal ion binding	4	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	73	75	PF00675	0.498
CLV_PCSK_SKI1_1	172	176	PF00082	0.269
CLV_PCSK_SKI1_1	247	251	PF00082	0.439
CLV_PCSK_SKI1_1	49	53	PF00082	0.476
DEG_Nend_UBRbox_1	1	4	PF02207	0.546
DOC_CKS1_1	25	30	PF01111	0.469
DOC_MAPK_gen_1	149	156	PF00069	0.478
DOC_PP4_FxxP_1	55	58	PF00568	0.311
DOC_USP7_MATH_1	124	128	PF00917	0.360
DOC_USP7_MATH_1	208	212	PF00917	0.323
DOC_USP7_MATH_1	70	74	PF00917	0.373
DOC_WW_Pin1_4	24	29	PF00397	0.498
LIG_14-3-3_CanoR_1	111	116	PF00244	0.422
LIG_14-3-3_CanoR_1	172	177	PF00244	0.401
LIG_14-3-3_CanoR_1	2	6	PF00244	0.487
LIG_BIR_III_4	50	54	PF00653	0.422
LIG_BRCT_BRCA1_1	126	130	PF00533	0.389
LIG_FHA_1	194	200	PF00498	0.277
LIG_FHA_1	204	210	PF00498	0.340
LIG_LIR_Gen_1	196	202	PF02991	0.206
LIG_LIR_Gen_1	78	89	PF02991	0.345
LIG_LIR_Nem_3	196	200	PF02991	0.237
LIG_LIR_Nem_3	252	258	PF02991	0.289
LIG_LIR_Nem_3	78	84	PF02991	0.337
LIG_PDZ_Class_1	263	268	PF00595	0.238
LIG_Pex14_2	130	134	PF04695	0.283
LIG_Pex14_2	245	249	PF04695	0.315
LIG_PTB_Apo_2	109	116	PF02174	0.484
LIG_REV1ctd_RIR_1	247	255	PF16727	0.377
LIG_SH2_CRK	136	140	PF00017	0.327
LIG_SH2_CRK	228	232	PF00017	0.417
LIG_SH2_SRC	228	231	PF00017	0.315
LIG_SH2_STAT3	261	264	PF00017	0.392
LIG_SH2_STAT5	132	135	PF00017	0.307
LIG_SH2_STAT5	189	192	PF00017	0.291
LIG_SH2_STAT5	261	264	PF00017	0.392
LIG_SH2_STAT5	56	59	PF00017	0.451
LIG_SH3_3	22	28	PF00018	0.460
LIG_SH3_5	58	62	PF00018	0.486
LIG_SUMO_SIM_par_1	215	221	PF11976	0.350
LIG_TRAF2_1	166	169	PF00917	0.279
MOD_CK1_1	180	186	PF00069	0.380
MOD_CK1_1	29	35	PF00069	0.495
MOD_CK2_1	96	102	PF00069	0.354
MOD_GlcNHglycan	182	185	PF01048	0.274
MOD_GlcNHglycan	223	226	PF01048	0.328
MOD_GlcNHglycan	28	31	PF01048	0.286
MOD_GSK3_1	111	118	PF00069	0.380
MOD_GSK3_1	156	163	PF00069	0.542
MOD_N-GLC_1	111	116	PF02516	0.493
MOD_N-GLC_1	160	165	PF02516	0.544
MOD_N-GLC_2	131	133	PF02516	0.272
MOD_NEK2_1	1	6	PF00069	0.503
MOD_NEK2_1	115	120	PF00069	0.390
MOD_NEK2_1	156	161	PF00069	0.530
MOD_NEK2_1	190	195	PF00069	0.269
MOD_NEK2_1	249	254	PF00069	0.380
MOD_NEK2_1	263	268	PF00069	0.343
MOD_NEK2_2	135	140	PF00069	0.444
MOD_PIKK_1	156	162	PF00454	0.466
MOD_PIKK_1	16	22	PF00454	0.612
MOD_PIKK_1	177	183	PF00454	0.413
MOD_PKA_2	1	7	PF00069	0.506
MOD_PKA_2	110	116	PF00069	0.435
MOD_PKA_2	35	41	PF00069	0.389
MOD_Plk_1	111	117	PF00069	0.469
MOD_Plk_4	1	7	PF00069	0.612
MOD_ProDKin_1	24	30	PF00069	0.489
MOD_SUMO_for_1	150	153	PF00179	0.500
MOD_SUMO_rev_2	46	54	PF00179	0.422
TRG_DiLeu_BaEn_2	240	246	PF01217	0.456
TRG_DiLeu_BaLyEn_6	212	217	PF01217	0.256
TRG_ENDOCYTIC_2	136	139	PF00928	0.333
TRG_ENDOCYTIC_2	81	84	PF00928	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4B5	Leptomonas seymouri	74%	100%
A0A0N0P8Z4	Leptomonas seymouri	28%	85%
A0A0N0P9F1	Leptomonas seymouri	26%	100%
A0A0S4IVC2	Bodo saltans	42%	95%
A0A0S4JBZ0	Bodo saltans	30%	100%
A0A0S4JFS7	Bodo saltans	29%	100%
A0A0S4JY21	Bodo saltans	30%	90%
A0A1X0NP16	Trypanosomatidae	27%	100%
A0A1X0NRJ7	Trypanosomatidae	31%	87%
A0A1X0P269	Trypanosomatidae	55%	100%
A0A3Q8II48	Leishmania donovani	95%	100%
A0A3R7MQ43	Trypanosoma rangeli	52%	100%
A0A3S5IRU3	Trypanosoma rangeli	26%	100%
A0A3S7X5U1	Leishmania donovani	28%	99%
A4H599	Leishmania braziliensis	27%	100%
A4HIL0	Leishmania braziliensis	85%	100%
A4HKH0	Leishmania braziliensis	26%	96%
A4HKH1	Leishmania braziliensis	26%	100%
A4HKQ4	Leishmania braziliensis	29%	100%
A4HTI0	Leishmania infantum	25%	100%
A4I5V5	Leishmania infantum	95%	100%
A4I884	Leishmania infantum	28%	99%
C9ZPK4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZR73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
D0AAF4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	87%
D3KVM5	Burkholderia sp.	24%	100%
E9AMA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B342	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	99%
O13401	Candida albicans	25%	100%
P0A0J1	Staphylococcus aureus (strain Mu50 / ATCC 700699)	22%	100%
P0A0J2	Staphylococcus aureus (strain MW2)	22%	100%
P0A0J3	Staphylococcus aureus (strain NCTC 8325 / PS 47)	22%	100%
P0A2F4	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	27%	100%
P0A2F5	Salmonella typhi	27%	100%
P0AGD3	Escherichia coli (strain K12)	26%	100%
P0AGD4	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	26%	100%
P0AGD5	Escherichia coli O157:H7	26%	100%
P0AGD6	Shigella flexneri	26%	100%
P18655	Synechococcus elongatus (strain PCC 7942 / FACHB-805)	25%	100%
P19685	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	24%	100%
P21276	Arabidopsis thaliana	23%	100%
P22302	Nicotiana plumbaginifolia	25%	100%
P34107	Entamoeba histolytica	22%	100%
P37369	Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)	24%	100%
P50061	Leptolyngbya boryana	27%	100%
P77968	Synechocystis sp. (strain PCC 6803 / Kazusa)	24%	100%
P99098	Staphylococcus aureus (strain N315)	22%	100%
Q1RH88	Rickettsia bellii (strain RML369-C)	26%	100%
Q2FGH0	Staphylococcus aureus (strain USA300)	22%	100%
Q2YT26	Staphylococcus aureus (strain bovine RF122 / ET3-1)	22%	100%
Q4Q512	Leishmania major	28%	100%
Q4Q716	Leishmania major	94%	100%
Q4QIE0	Leishmania major	25%	100%
Q4ULI1	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	28%	100%
Q5HFK7	Staphylococcus aureus (strain COL)	22%	100%
Q5VRL3	Oryza sativa subsp. japonica	29%	69%
Q68WK0	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	25%	100%
Q6G913	Staphylococcus aureus (strain MSSA476)	22%	100%
Q6GGE6	Staphylococcus aureus (strain MRSA252)	22%	100%
Q71S86	Leishmania donovani	25%	100%
Q88PD5	Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)	24%	100%
Q8VQ15	Staphylococcus epidermidis	21%	100%
Q92HJ3	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	27%	100%
Q9LU64	Arabidopsis thaliana	26%	88%
Q9ZD15	Rickettsia prowazekii (strain Madrid E)	26%	100%
V5AUS6	Trypanosoma cruzi	29%	89%
V5DNY0	Trypanosoma cruzi	54%	85%