Conserved TPR domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR domain protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B146_LEIMU

TriTrypDb:

LmxM.29.2740

Length:

402

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0032991	protein-containing complex	1	1
GO:0072379	ER membrane insertion complex	2	1
GO:0072380	TRC complex	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B146

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B146

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006950	response to stress	2	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0015031	protein transport	4	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0030433	ubiquitin-dependent ERAD pathway	6	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0045047	protein targeting to ER	6	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0050896	response to stimulus	1	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0051716	cellular response to stimulus	2	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070972	protein localization to endoplasmic reticulum	6	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901698	response to nitrogen compound	3	1

Molecular functions
Term	Name	Level	Count
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.536
CLV_NRD_NRD_1	24	26	PF00675	0.540
CLV_NRD_NRD_1	353	355	PF00675	0.580
CLV_NRD_NRD_1	75	77	PF00675	0.662
CLV_PCSK_KEX2_1	24	26	PF00082	0.619
CLV_PCSK_KEX2_1	240	242	PF00082	0.597
CLV_PCSK_KEX2_1	75	77	PF00082	0.671
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.597
CLV_PCSK_PC7_1	71	77	PF00082	0.664
CLV_PCSK_SKI1_1	14	18	PF00082	0.423
CLV_PCSK_SKI1_1	67	71	PF00082	0.611
DEG_Nend_UBRbox_2	1	3	PF02207	0.760
DOC_CKS1_1	333	338	PF01111	0.517
DOC_PP1_RVXF_1	11	18	PF00149	0.436
DOC_PP1_RVXF_1	82	89	PF00149	0.571
DOC_PP4_FxxP_1	395	398	PF00568	0.678
DOC_USP7_MATH_1	398	402	PF00917	0.546
DOC_USP7_MATH_1	49	53	PF00917	0.566
DOC_USP7_UBL2_3	114	118	PF12436	0.356
DOC_USP7_UBL2_3	236	240	PF12436	0.480
DOC_USP7_UBL2_3	95	99	PF12436	0.541
DOC_WW_Pin1_4	332	337	PF00397	0.513
LIG_FHA_1	153	159	PF00498	0.351
LIG_FHA_2	232	238	PF00498	0.599
LIG_FHA_2	56	62	PF00498	0.535
LIG_IBAR_NPY_1	124	126	PF08397	0.472
LIG_LIR_Gen_1	18	23	PF02991	0.431
LIG_LIR_Gen_1	199	210	PF02991	0.358
LIG_LIR_Gen_1	293	302	PF02991	0.628
LIG_LIR_Gen_1	82	92	PF02991	0.478
LIG_LIR_Nem_3	199	205	PF02991	0.358
LIG_LIR_Nem_3	293	297	PF02991	0.609
LIG_LIR_Nem_3	335	340	PF02991	0.504
LIG_LIR_Nem_3	82	88	PF02991	0.463
LIG_PTB_Apo_2	192	199	PF02174	0.384
LIG_PTB_Apo_2	275	282	PF02174	0.532
LIG_PTB_Apo_2	288	295	PF02174	0.516
LIG_PTB_Apo_2	389	396	PF02174	0.609
LIG_PTB_Phospho_1	192	198	PF10480	0.384
LIG_REV1ctd_RIR_1	165	175	PF16727	0.324
LIG_SH2_CRK	202	206	PF00017	0.339
LIG_SH2_STAP1	108	112	PF00017	0.511
LIG_SH2_STAP1	154	158	PF00017	0.324
LIG_SH2_STAP1	198	202	PF00017	0.333
LIG_SH2_STAP1	215	219	PF00017	0.276
LIG_SH2_STAT5	154	157	PF00017	0.331
LIG_SH2_STAT5	377	380	PF00017	0.545
LIG_SH2_STAT5	97	100	PF00017	0.458
LIG_SH3_3	330	336	PF00018	0.588
LIG_SUMO_SIM_anti_2	57	64	PF11976	0.514
LIG_SUMO_SIM_anti_2	87	93	PF11976	0.417
LIG_WRC_WIRS_1	16	21	PF05994	0.425
LIG_WRC_WIRS_1	85	90	PF05994	0.427
MOD_CDK_SPxxK_3	332	339	PF00069	0.592
MOD_CK1_1	303	309	PF00069	0.678
MOD_CK2_1	23	29	PF00069	0.592
MOD_CK2_1	231	237	PF00069	0.573
MOD_CK2_1	74	80	PF00069	0.637
MOD_CK2_1	84	90	PF00069	0.415
MOD_GlcNHglycan	251	254	PF01048	0.484
MOD_GlcNHglycan	51	54	PF01048	0.706
MOD_GlcNHglycan	76	79	PF01048	0.673
MOD_GSK3_1	196	203	PF00069	0.331
MOD_N-GLC_1	213	218	PF02516	0.487
MOD_N-GLC_1	231	236	PF02516	0.503
MOD_NEK2_1	15	20	PF00069	0.461
MOD_NEK2_1	23	28	PF00069	0.546
MOD_NEK2_1	281	286	PF00069	0.628
MOD_NEK2_1	393	398	PF00069	0.629
MOD_PIKK_1	140	146	PF00454	0.467
MOD_PIKK_1	23	29	PF00454	0.521
MOD_PIKK_1	303	309	PF00454	0.686
MOD_PKA_2	23	29	PF00069	0.586
MOD_PKA_2	74	80	PF00069	0.595
MOD_Plk_2-3	102	108	PF00069	0.462
MOD_Plk_4	84	90	PF00069	0.441
MOD_ProDKin_1	332	338	PF00069	0.517
MOD_SUMO_rev_2	237	246	PF00179	0.505
MOD_SUMO_rev_2	77	86	PF00179	0.528
TRG_DiLeu_BaEn_1	293	298	PF01217	0.579
TRG_ENDOCYTIC_2	126	129	PF00928	0.488
TRG_ENDOCYTIC_2	202	205	PF00928	0.339
TRG_ENDOCYTIC_2	371	374	PF00928	0.651
TRG_ER_diArg_1	23	25	PF00400	0.601
TRG_NES_CRM1_1	314	328	PF08389	0.682

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5L1	Leptomonas seymouri	85%	100%
A0A0S4ITV7	Bodo saltans	60%	100%
A0A1X0P1H3	Trypanosomatidae	61%	100%
A0A3R7KEN1	Trypanosoma rangeli	60%	97%
A0A3S7X3N8	Leishmania donovani	96%	99%
A4HIK6	Leishmania braziliensis	91%	100%
A4I5V1	Leishmania infantum	96%	99%
C9ZR70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	97%
Q4Q720	Leishmania major	96%	100%
V5BX66	Trypanosoma cruzi	61%	97%