Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B143_LEIMU

TriTrypDb:

LmxM.29.2710

Length:

925

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B143

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B143

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	691	695	PF00656	0.506
CLV_C14_Caspase3-7	902	906	PF00656	0.509
CLV_NRD_NRD_1	118	120	PF00675	0.638
CLV_NRD_NRD_1	170	172	PF00675	0.693
CLV_NRD_NRD_1	226	228	PF00675	0.634
CLV_NRD_NRD_1	288	290	PF00675	0.683
CLV_NRD_NRD_1	306	308	PF00675	0.513
CLV_NRD_NRD_1	477	479	PF00675	0.531
CLV_NRD_NRD_1	498	500	PF00675	0.671
CLV_NRD_NRD_1	524	526	PF00675	0.609
CLV_NRD_NRD_1	642	644	PF00675	0.724
CLV_NRD_NRD_1	772	774	PF00675	0.478
CLV_NRD_NRD_1	829	831	PF00675	0.576
CLV_PCSK_FUR_1	168	172	PF00082	0.707
CLV_PCSK_KEX2_1	170	172	PF00082	0.735
CLV_PCSK_KEX2_1	226	228	PF00082	0.634
CLV_PCSK_KEX2_1	288	290	PF00082	0.700
CLV_PCSK_KEX2_1	306	308	PF00082	0.570
CLV_PCSK_KEX2_1	449	451	PF00082	0.791
CLV_PCSK_KEX2_1	477	479	PF00082	0.404
CLV_PCSK_KEX2_1	524	526	PF00082	0.609
CLV_PCSK_KEX2_1	59	61	PF00082	0.578
CLV_PCSK_KEX2_1	829	831	PF00082	0.576
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.653
CLV_PCSK_PC1ET2_1	477	479	PF00082	0.383
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.671
CLV_PCSK_SKI1_1	20	24	PF00082	0.488
CLV_PCSK_SKI1_1	25	29	PF00082	0.496
CLV_PCSK_SKI1_1	288	292	PF00082	0.670
CLV_PCSK_SKI1_1	30	34	PF00082	0.430
CLV_PCSK_SKI1_1	492	496	PF00082	0.487
CLV_PCSK_SKI1_1	595	599	PF00082	0.561
CLV_PCSK_SKI1_1	683	687	PF00082	0.487
CLV_PCSK_SKI1_1	830	834	PF00082	0.399
CLV_Separin_Metazoa	919	923	PF03568	0.491
DEG_Nend_UBRbox_2	1	3	PF02207	0.610
DEG_SCF_FBW7_2	418	423	PF00400	0.597
DEG_SCF_TRCP1_1	876	882	PF00400	0.649
DEG_SPOP_SBC_1	69	73	PF00917	0.641
DOC_ANK_TNKS_1	501	508	PF00023	0.601
DOC_CKS1_1	139	144	PF01111	0.518
DOC_CKS1_1	290	295	PF01111	0.686
DOC_CKS1_1	818	823	PF01111	0.536
DOC_CYCLIN_yCln2_LP_2	818	824	PF00134	0.471
DOC_CYCLIN_yCln2_LP_2	844	850	PF00134	0.600
DOC_MAPK_gen_1	306	314	PF00069	0.509
DOC_MAPK_gen_1	773	780	PF00069	0.555
DOC_MAPK_HePTP_8	770	782	PF00069	0.478
DOC_MAPK_MEF2A_6	773	782	PF00069	0.547
DOC_PP2B_LxvP_1	294	297	PF13499	0.742
DOC_PP2B_LxvP_1	610	613	PF13499	0.620
DOC_PP2B_LxvP_1	687	690	PF13499	0.567
DOC_PP4_FxxP_1	139	142	PF00568	0.516
DOC_PP4_FxxP_1	809	812	PF00568	0.628
DOC_USP7_MATH_1	108	112	PF00917	0.729
DOC_USP7_MATH_1	184	188	PF00917	0.596
DOC_USP7_MATH_1	194	198	PF00917	0.492
DOC_USP7_MATH_1	283	287	PF00917	0.623
DOC_USP7_MATH_1	439	443	PF00917	0.594
DOC_USP7_MATH_1	553	557	PF00917	0.522
DOC_USP7_MATH_1	631	635	PF00917	0.648
DOC_USP7_MATH_1	70	74	PF00917	0.685
DOC_USP7_MATH_1	745	749	PF00917	0.559
DOC_USP7_MATH_1	772	776	PF00917	0.471
DOC_USP7_UBL2_3	500	504	PF12436	0.578
DOC_USP7_UBL2_3	508	512	PF12436	0.693
DOC_WW_Pin1_4	127	132	PF00397	0.623
DOC_WW_Pin1_4	138	143	PF00397	0.575
DOC_WW_Pin1_4	289	294	PF00397	0.649
DOC_WW_Pin1_4	307	312	PF00397	0.611
DOC_WW_Pin1_4	319	324	PF00397	0.646
DOC_WW_Pin1_4	338	343	PF00397	0.748
DOC_WW_Pin1_4	352	357	PF00397	0.528
DOC_WW_Pin1_4	370	375	PF00397	0.594
DOC_WW_Pin1_4	382	387	PF00397	0.566
DOC_WW_Pin1_4	416	421	PF00397	0.605
DOC_WW_Pin1_4	435	440	PF00397	0.600
DOC_WW_Pin1_4	451	456	PF00397	0.599
DOC_WW_Pin1_4	460	465	PF00397	0.485
DOC_WW_Pin1_4	608	613	PF00397	0.744
DOC_WW_Pin1_4	651	656	PF00397	0.668
DOC_WW_Pin1_4	811	816	PF00397	0.646
DOC_WW_Pin1_4	817	822	PF00397	0.656
DOC_WW_Pin1_4	82	87	PF00397	0.794
DOC_WW_Pin1_4	856	861	PF00397	0.558
DOC_WW_Pin1_4	93	98	PF00397	0.699
LIG_14-3-3_CanoR_1	113	119	PF00244	0.598
LIG_14-3-3_CanoR_1	134	140	PF00244	0.623
LIG_14-3-3_CanoR_1	301	305	PF00244	0.612
LIG_14-3-3_CanoR_1	450	455	PF00244	0.681
LIG_14-3-3_CanoR_1	595	600	PF00244	0.562
LIG_14-3-3_CanoR_1	683	688	PF00244	0.491
LIG_BIR_III_4	247	251	PF00653	0.663
LIG_deltaCOP1_diTrp_1	720	726	PF00928	0.402
LIG_FHA_1	122	128	PF00498	0.712
LIG_FHA_1	201	207	PF00498	0.629
LIG_FHA_1	260	266	PF00498	0.634
LIG_FHA_1	314	320	PF00498	0.700
LIG_FHA_1	387	393	PF00498	0.632
LIG_FHA_1	41	47	PF00498	0.483
LIG_FHA_1	684	690	PF00498	0.706
LIG_FHA_1	775	781	PF00498	0.654
LIG_FHA_1	818	824	PF00498	0.633
LIG_FHA_1	87	93	PF00498	0.828
LIG_FHA_2	139	145	PF00498	0.656
LIG_FHA_2	155	161	PF00498	0.701
LIG_FHA_2	400	406	PF00498	0.525
LIG_FHA_2	452	458	PF00498	0.818
LIG_FHA_2	526	532	PF00498	0.603
LIG_FHA_2	596	602	PF00498	0.608
LIG_FHA_2	637	643	PF00498	0.655
LIG_FHA_2	667	673	PF00498	0.592
LIG_FHA_2	793	799	PF00498	0.592
LIG_FHA_2	893	899	PF00498	0.690
LIG_FHA_2	914	920	PF00498	0.643
LIG_Integrin_RGD_1	763	765	PF01839	0.626
LIG_LIR_Apic_2	137	142	PF02991	0.513
LIG_LIR_Apic_2	58	64	PF02991	0.602
LIG_LIR_Gen_1	421	430	PF02991	0.660
LIG_LIR_Gen_1	720	730	PF02991	0.472
LIG_LIR_Gen_1	915	924	PF02991	0.652
LIG_LIR_Nem_3	341	347	PF02991	0.639
LIG_LIR_Nem_3	421	427	PF02991	0.619
LIG_LIR_Nem_3	592	597	PF02991	0.591
LIG_LIR_Nem_3	604	610	PF02991	0.639
LIG_LIR_Nem_3	720	726	PF02991	0.402
LIG_LIR_Nem_3	915	920	PF02991	0.669
LIG_MYND_1	352	356	PF01753	0.632
LIG_MYND_1	614	618	PF01753	0.604
LIG_SH2_CRK	424	428	PF00017	0.626
LIG_SH2_CRK	8	12	PF00017	0.495
LIG_SH2_CRK	848	852	PF00017	0.642
LIG_SH2_NCK_1	424	428	PF00017	0.626
LIG_SH2_PTP2	383	386	PF00017	0.660
LIG_SH2_SRC	6	9	PF00017	0.539
LIG_SH2_STAT3	260	263	PF00017	0.665
LIG_SH2_STAT5	383	386	PF00017	0.660
LIG_SH2_STAT5	6	9	PF00017	0.599
LIG_SH2_STAT5	606	609	PF00017	0.648
LIG_SH3_2	534	539	PF14604	0.680
LIG_SH3_3	279	285	PF00018	0.666
LIG_SH3_3	287	293	PF00018	0.687
LIG_SH3_3	462	468	PF00018	0.622
LIG_SH3_3	531	537	PF00018	0.613
LIG_SH3_3	611	617	PF00018	0.630
LIG_SH3_3	63	69	PF00018	0.658
LIG_SH3_3	649	655	PF00018	0.530
LIG_SH3_3	809	815	PF00018	0.633
LIG_SH3_3	820	826	PF00018	0.645
LIG_SH3_3	844	850	PF00018	0.638
LIG_SH3_3	89	95	PF00018	0.680
LIG_SH3_3	918	924	PF00018	0.490
LIG_SUMO_SIM_anti_2	779	785	PF11976	0.522
LIG_SUMO_SIM_par_1	363	369	PF11976	0.494
LIG_SUMO_SIM_par_1	9	17	PF11976	0.467
LIG_TRAF2_1	670	673	PF00917	0.585
LIG_TRAF2_1	837	840	PF00917	0.551
LIG_WRC_WIRS_1	661	666	PF05994	0.641
LIG_WRC_WIRS_1	914	919	PF05994	0.675
MOD_CDK_SPK_2	382	387	PF00069	0.654
MOD_CDK_SPxK_1	289	295	PF00069	0.673
MOD_CDK_SPxK_1	416	422	PF00069	0.607
MOD_CDK_SPxxK_3	127	134	PF00069	0.629
MOD_CDK_SPxxK_3	370	377	PF00069	0.647
MOD_CDK_SPxxK_3	451	458	PF00069	0.682
MOD_CK1_1	187	193	PF00069	0.647
MOD_CK1_1	246	252	PF00069	0.798
MOD_CK1_1	264	270	PF00069	0.516
MOD_CK1_1	322	328	PF00069	0.657
MOD_CK1_1	435	441	PF00069	0.662
MOD_CK1_1	666	672	PF00069	0.550
MOD_CK1_1	679	685	PF00069	0.476
MOD_CK1_1	747	753	PF00069	0.772
MOD_CK1_1	96	102	PF00069	0.671
MOD_CK2_1	138	144	PF00069	0.664
MOD_CK2_1	154	160	PF00069	0.698
MOD_CK2_1	194	200	PF00069	0.492
MOD_CK2_1	451	457	PF00069	0.681
MOD_CK2_1	595	601	PF00069	0.579
MOD_CK2_1	636	642	PF00069	0.624
MOD_CK2_1	666	672	PF00069	0.618
MOD_CK2_1	834	840	PF00069	0.665
MOD_CK2_1	892	898	PF00069	0.686
MOD_CK2_1	913	919	PF00069	0.643
MOD_Cter_Amidation	217	220	PF01082	0.641
MOD_DYRK1A_RPxSP_1	289	293	PF00069	0.642
MOD_GlcNHglycan	179	182	PF01048	0.704
MOD_GlcNHglycan	196	199	PF01048	0.492
MOD_GlcNHglycan	238	241	PF01048	0.703
MOD_GlcNHglycan	247	251	PF01048	0.819
MOD_GlcNHglycan	298	301	PF01048	0.681
MOD_GlcNHglycan	319	322	PF01048	0.661
MOD_GlcNHglycan	368	371	PF01048	0.616
MOD_GlcNHglycan	410	414	PF01048	0.755
MOD_GlcNHglycan	441	444	PF01048	0.793
MOD_GlcNHglycan	550	553	PF01048	0.685
MOD_GlcNHglycan	563	566	PF01048	0.623
MOD_GlcNHglycan	669	672	PF01048	0.643
MOD_GlcNHglycan	726	729	PF01048	0.487
MOD_GlcNHglycan	73	76	PF01048	0.745
MOD_GlcNHglycan	737	740	PF01048	0.541
MOD_GlcNHglycan	752	755	PF01048	0.569
MOD_GlcNHglycan	774	777	PF01048	0.472
MOD_GlcNHglycan	860	863	PF01048	0.696
MOD_GlcNHglycan	876	879	PF01048	0.622
MOD_GlcNHglycan	881	884	PF01048	0.562
MOD_GSK3_1	134	141	PF00069	0.755
MOD_GSK3_1	172	179	PF00069	0.691
MOD_GSK3_1	190	197	PF00069	0.573
MOD_GSK3_1	232	239	PF00069	0.656
MOD_GSK3_1	296	303	PF00069	0.656
MOD_GSK3_1	313	320	PF00069	0.524
MOD_GSK3_1	366	373	PF00069	0.666
MOD_GSK3_1	382	389	PF00069	0.502
MOD_GSK3_1	399	406	PF00069	0.523
MOD_GSK3_1	418	425	PF00069	0.645
MOD_GSK3_1	428	435	PF00069	0.665
MOD_GSK3_1	444	451	PF00069	0.564
MOD_GSK3_1	460	467	PF00069	0.622
MOD_GSK3_1	561	568	PF00069	0.523
MOD_GSK3_1	608	615	PF00069	0.667
MOD_GSK3_1	632	639	PF00069	0.811
MOD_GSK3_1	647	654	PF00069	0.641
MOD_GSK3_1	660	667	PF00069	0.683
MOD_GSK3_1	679	686	PF00069	0.674
MOD_GSK3_1	78	85	PF00069	0.649
MOD_GSK3_1	813	820	PF00069	0.593
MOD_GSK3_1	830	837	PF00069	0.554
MOD_GSK3_1	874	881	PF00069	0.789
MOD_GSK3_1	96	103	PF00069	0.656
MOD_N-GLC_1	114	119	PF02516	0.632
MOD_N-GLC_1	208	213	PF02516	0.660
MOD_N-GLC_1	451	456	PF02516	0.640
MOD_N-GLC_1	78	83	PF02516	0.650
MOD_NEK2_1	100	105	PF00069	0.660
MOD_NEK2_1	135	140	PF00069	0.641
MOD_NEK2_1	331	336	PF00069	0.510
MOD_NEK2_1	498	503	PF00069	0.562
MOD_NEK2_1	664	669	PF00069	0.685
MOD_NEK2_1	913	918	PF00069	0.678
MOD_NEK2_2	114	119	PF00069	0.670
MOD_NEK2_2	121	126	PF00069	0.582
MOD_NEK2_2	671	676	PF00069	0.571
MOD_OFUCOSY	231	236	PF10250	0.635
MOD_PIKK_1	259	265	PF00454	0.660
MOD_PIKK_1	78	84	PF00454	0.650
MOD_PIKK_1	813	819	PF00454	0.653
MOD_PIKK_1	830	836	PF00454	0.502
MOD_PK_1	422	428	PF00069	0.658
MOD_PKA_1	226	232	PF00069	0.636
MOD_PKA_1	830	836	PF00069	0.562
MOD_PKA_2	184	190	PF00069	0.695
MOD_PKA_2	226	232	PF00069	0.674
MOD_PKA_2	300	306	PF00069	0.620
MOD_PKA_2	386	392	PF00069	0.633
MOD_PKA_2	40	46	PF00069	0.357
MOD_PKA_2	498	504	PF00069	0.689
MOD_PKA_2	51	57	PF00069	0.371
MOD_PKA_2	631	637	PF00069	0.681
MOD_PKA_2	772	778	PF00069	0.473
MOD_PKA_2	879	885	PF00069	0.582
MOD_Plk_1	109	115	PF00069	0.803
MOD_Plk_1	208	214	PF00069	0.641
MOD_Plk_1	409	415	PF00069	0.655
MOD_Plk_1	422	428	PF00069	0.645
MOD_Plk_1	601	607	PF00069	0.570
MOD_Plk_1	671	677	PF00069	0.571
MOD_Plk_4	422	428	PF00069	0.658
MOD_Plk_4	602	608	PF00069	0.576
MOD_ProDKin_1	127	133	PF00069	0.625
MOD_ProDKin_1	138	144	PF00069	0.577
MOD_ProDKin_1	289	295	PF00069	0.653
MOD_ProDKin_1	307	313	PF00069	0.608
MOD_ProDKin_1	319	325	PF00069	0.646
MOD_ProDKin_1	338	344	PF00069	0.751
MOD_ProDKin_1	352	358	PF00069	0.528
MOD_ProDKin_1	370	376	PF00069	0.594
MOD_ProDKin_1	382	388	PF00069	0.565
MOD_ProDKin_1	416	422	PF00069	0.607
MOD_ProDKin_1	435	441	PF00069	0.601
MOD_ProDKin_1	451	457	PF00069	0.602
MOD_ProDKin_1	460	466	PF00069	0.485
MOD_ProDKin_1	608	614	PF00069	0.743
MOD_ProDKin_1	651	657	PF00069	0.666
MOD_ProDKin_1	811	817	PF00069	0.646
MOD_ProDKin_1	82	88	PF00069	0.797
MOD_ProDKin_1	856	862	PF00069	0.558
MOD_ProDKin_1	93	99	PF00069	0.701
MOD_SUMO_for_1	46	49	PF00179	0.511
MOD_SUMO_for_1	494	497	PF00179	0.460
MOD_SUMO_for_1	511	514	PF00179	0.586
MOD_SUMO_rev_2	58	66	PF00179	0.548
MOD_SUMO_rev_2	72	81	PF00179	0.568
TRG_DiLeu_BaEn_4	672	678	PF01217	0.581
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.505
TRG_ENDOCYTIC_2	424	427	PF00928	0.663
TRG_ENDOCYTIC_2	606	609	PF00928	0.657
TRG_ENDOCYTIC_2	848	851	PF00928	0.640
TRG_ER_diArg_1	167	170	PF00400	0.695
TRG_ER_diArg_1	226	228	PF00400	0.634
TRG_ER_diArg_1	287	289	PF00400	0.684
TRG_ER_diArg_1	305	307	PF00400	0.502
TRG_ER_diArg_1	523	525	PF00400	0.607
TRG_ER_diArg_1	828	830	PF00400	0.580
TRG_ER_FFAT_2	720	731	PF00635	0.392
TRG_NLS_MonoExtC_3	476	482	PF00514	0.376
TRG_Pf-PMV_PEXEL_1	830	834	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXH7	Leptomonas seymouri	41%	99%
A0A1X0P323	Trypanosomatidae	28%	100%
A0A3S5H7N6	Leishmania donovani	89%	99%
A4HIK3	Leishmania braziliensis	67%	98%
A4I5U8	Leishmania infantum	89%	99%
Q4Q723	Leishmania major	87%	100%