Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B142_LEIMU

TriTrypDb:

LmxM.29.2700

Length:

391

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

E9B142

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B142

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.485
CLV_NRD_NRD_1	12	14	PF00675	0.485
CLV_NRD_NRD_1	177	179	PF00675	0.451
CLV_NRD_NRD_1	199	201	PF00675	0.685
CLV_NRD_NRD_1	261	263	PF00675	0.606
CLV_NRD_NRD_1	308	310	PF00675	0.817
CLV_NRD_NRD_1	33	35	PF00675	0.306
CLV_NRD_NRD_1	384	386	PF00675	0.719
CLV_PCSK_KEX2_1	12	14	PF00082	0.485
CLV_PCSK_KEX2_1	177	179	PF00082	0.454
CLV_PCSK_KEX2_1	199	201	PF00082	0.658
CLV_PCSK_KEX2_1	308	310	PF00082	0.817
CLV_PCSK_KEX2_1	33	35	PF00082	0.306
CLV_PCSK_KEX2_1	65	67	PF00082	0.441
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.441
CLV_PCSK_PC7_1	195	201	PF00082	0.667
CLV_PCSK_SKI1_1	183	187	PF00082	0.607
CLV_PCSK_SKI1_1	263	267	PF00082	0.748
CLV_PCSK_SKI1_1	370	374	PF00082	0.763
CLV_PCSK_SKI1_1	5	9	PF00082	0.606
DEG_COP1_1	276	284	PF00400	0.649
DEG_SCF_FBW7_1	300	307	PF00400	0.516
DEG_SPOP_SBC_1	274	278	PF00917	0.584
DEG_SPOP_SBC_1	329	333	PF00917	0.699
DOC_CDC14_PxL_1	220	228	PF14671	0.610
DOC_CYCLIN_yCln2_LP_2	272	275	PF00134	0.786
DOC_MAPK_RevD_3	162	178	PF00069	0.298
DOC_PP1_RVXF_1	96	102	PF00149	0.405
DOC_PP2B_LxvP_1	272	275	PF13499	0.786
DOC_SPAK_OSR1_1	86	90	PF12202	0.546
DOC_USP7_MATH_1	275	279	PF00917	0.567
DOC_USP7_MATH_1	286	290	PF00917	0.604
DOC_USP7_MATH_1	328	332	PF00917	0.605
DOC_WW_Pin1_4	230	235	PF00397	0.659
DOC_WW_Pin1_4	300	305	PF00397	0.698
DOC_WW_Pin1_4	310	315	PF00397	0.779
LIG_14-3-3_CanoR_1	21	29	PF00244	0.603
LIG_14-3-3_CanoR_1	362	369	PF00244	0.676
LIG_14-3-3_CanoR_1	98	102	PF00244	0.410
LIG_BIR_II_1	1	5	PF00653	0.542
LIG_BIR_III_2	231	235	PF00653	0.494
LIG_EVH1_1	203	207	PF00568	0.597
LIG_FHA_1	127	133	PF00498	0.546
LIG_FHA_1	150	156	PF00498	0.471
LIG_FHA_1	23	29	PF00498	0.475
LIG_FHA_1	267	273	PF00498	0.681
LIG_FHA_1	295	301	PF00498	0.645
LIG_FHA_1	349	355	PF00498	0.484
LIG_FHA_1	374	380	PF00498	0.666
LIG_FHA_2	123	129	PF00498	0.464
LIG_FHA_2	246	252	PF00498	0.691
LIG_FHA_2	319	325	PF00498	0.686
LIG_FHA_2	69	75	PF00498	0.389
LIG_FHA_2	98	104	PF00498	0.536
LIG_LIR_Gen_1	190	198	PF02991	0.530
LIG_LIR_Gen_1	40	47	PF02991	0.450
LIG_LIR_Nem_3	100	104	PF02991	0.432
LIG_LIR_Nem_3	190	196	PF02991	0.523
LIG_LIR_Nem_3	40	45	PF02991	0.435
LIG_LIR_Nem_3	82	88	PF02991	0.455
LIG_MYND_3	223	227	PF01753	0.612
LIG_RPA_C_Fungi	173	185	PF08784	0.587
LIG_SH2_CRK	193	197	PF00017	0.531
LIG_SH2_PTP2	88	91	PF00017	0.535
LIG_SH2_STAT5	193	196	PF00017	0.625
LIG_SH2_STAT5	247	250	PF00017	0.681
LIG_SH2_STAT5	338	341	PF00017	0.697
LIG_SH2_STAT5	35	38	PF00017	0.491
LIG_SH2_STAT5	88	91	PF00017	0.551
LIG_SH3_3	201	207	PF00018	0.624
LIG_SH3_3	231	237	PF00018	0.700
LIG_SH3_3	352	358	PF00018	0.760
LIG_SH3_3	4	10	PF00018	0.613
LIG_SH3_CIN85_PxpxPR_1	230	235	PF14604	0.762
LIG_TYR_ITIM	191	196	PF00017	0.471
LIG_WRC_WIRS_1	287	292	PF05994	0.491
MOD_CDK_SPK_2	230	235	PF00069	0.612
MOD_CK1_1	114	120	PF00069	0.479
MOD_CK1_1	233	239	PF00069	0.696
MOD_CK1_1	276	282	PF00069	0.689
MOD_CK1_1	288	294	PF00069	0.640
MOD_CK2_1	122	128	PF00069	0.462
MOD_CK2_1	133	139	PF00069	0.468
MOD_CK2_1	313	319	PF00069	0.796
MOD_CK2_1	68	74	PF00069	0.399
MOD_Cter_Amidation	260	263	PF01082	0.638
MOD_GlcNHglycan	112	116	PF01048	0.480
MOD_GlcNHglycan	187	190	PF01048	0.474
MOD_GlcNHglycan	282	285	PF01048	0.626
MOD_GlcNHglycan	290	293	PF01048	0.647
MOD_GSK3_1	122	129	PF00069	0.461
MOD_GSK3_1	150	157	PF00069	0.568
MOD_GSK3_1	187	194	PF00069	0.518
MOD_GSK3_1	273	280	PF00069	0.668
MOD_GSK3_1	291	298	PF00069	0.710
MOD_GSK3_1	300	307	PF00069	0.524
MOD_GSK3_1	346	353	PF00069	0.473
MOD_N-GLC_1	150	155	PF02516	0.474
MOD_NEK2_1	1	6	PF00069	0.536
MOD_NEK2_1	102	107	PF00069	0.310
MOD_NEK2_1	132	137	PF00069	0.458
MOD_NEK2_1	225	230	PF00069	0.486
MOD_NEK2_1	330	335	PF00069	0.695
MOD_NEK2_1	363	368	PF00069	0.761
MOD_NEK2_1	94	99	PF00069	0.404
MOD_PIKK_1	346	352	PF00454	0.472
MOD_PKA_1	370	376	PF00069	0.688
MOD_PKA_2	198	204	PF00069	0.638
MOD_PKA_2	361	367	PF00069	0.591
MOD_PKA_2	97	103	PF00069	0.335
MOD_Plk_1	318	324	PF00069	0.792
MOD_Plk_4	163	169	PF00069	0.478
MOD_Plk_4	318	324	PF00069	0.694
MOD_Plk_4	350	356	PF00069	0.636
MOD_ProDKin_1	230	236	PF00069	0.661
MOD_ProDKin_1	300	306	PF00069	0.702
MOD_ProDKin_1	310	316	PF00069	0.776
TRG_DiLeu_BaEn_1	59	64	PF01217	0.278
TRG_DiLeu_BaLyEn_6	221	226	PF01217	0.483
TRG_ENDOCYTIC_2	193	196	PF00928	0.528
TRG_ENDOCYTIC_2	42	45	PF00928	0.436
TRG_ENDOCYTIC_2	67	70	PF00928	0.281
TRG_ER_diArg_1	177	180	PF00400	0.465
TRG_ER_diArg_1	198	200	PF00400	0.668
TRG_ER_diArg_1	32	34	PF00400	0.290
TRG_NES_CRM1_1	159	173	PF08389	0.291
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB83	Leptomonas seymouri	45%	89%
A0A3Q8IFS9	Leishmania donovani	84%	100%
A4I5U7	Leishmania infantum	84%	100%
Q4Q724	Leishmania major	84%	100%