Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B139_LEIMU

TriTrypDb:

LmxM.29.2670

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9B139

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B139

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.371
CLV_C14_Caspase3-7	259	263	PF00656	0.390
CLV_C14_Caspase3-7	274	278	PF00656	0.522
CLV_MEL_PAP_1	196	202	PF00089	0.509
CLV_NRD_NRD_1	10	12	PF00675	0.608
CLV_NRD_NRD_1	292	294	PF00675	0.534
CLV_NRD_NRD_1	351	353	PF00675	0.391
CLV_PCSK_KEX2_1	292	294	PF00082	0.482
CLV_PCSK_KEX2_1	319	321	PF00082	0.438
CLV_PCSK_KEX2_1	351	353	PF00082	0.481
CLV_PCSK_KEX2_1	9	11	PF00082	0.613
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.438
CLV_PCSK_SKI1_1	186	190	PF00082	0.556
CLV_PCSK_SKI1_1	292	296	PF00082	0.534
DEG_APCC_DBOX_1	292	300	PF00400	0.258
DOC_AGCK_PIF_1	143	148	PF00069	0.281
DOC_CKS1_1	286	291	PF01111	0.357
DOC_CYCLIN_RxL_1	289	298	PF00134	0.250
DOC_MAPK_gen_1	172	181	PF00069	0.397
DOC_MAPK_gen_1	292	299	PF00069	0.268
DOC_MAPK_gen_1	319	325	PF00069	0.634
DOC_MAPK_gen_1	9	19	PF00069	0.440
DOC_MAPK_MEF2A_6	172	181	PF00069	0.406
DOC_MAPK_MEF2A_6	292	301	PF00069	0.260
DOC_PP4_FxxP_1	165	168	PF00568	0.286
DOC_USP7_MATH_1	161	165	PF00917	0.328
DOC_USP7_MATH_1	266	270	PF00917	0.534
DOC_USP7_MATH_1	281	285	PF00917	0.467
DOC_USP7_MATH_1	307	311	PF00917	0.348
DOC_WW_Pin1_4	138	143	PF00397	0.449
DOC_WW_Pin1_4	149	154	PF00397	0.247
DOC_WW_Pin1_4	173	178	PF00397	0.412
DOC_WW_Pin1_4	285	290	PF00397	0.538
LIG_14-3-3_CanoR_1	100	107	PF00244	0.434
LIG_14-3-3_CanoR_1	134	143	PF00244	0.371
LIG_14-3-3_CanoR_1	144	149	PF00244	0.229
LIG_CtBP_PxDLS_1	82	86	PF00389	0.403
LIG_eIF4E_1	217	223	PF01652	0.350
LIG_FHA_1	174	180	PF00498	0.457
LIG_FHA_1	286	292	PF00498	0.470
LIG_FHA_1	336	342	PF00498	0.569
LIG_FHA_1	59	65	PF00498	0.422
LIG_FHA_1	96	102	PF00498	0.287
LIG_FHA_2	124	130	PF00498	0.314
LIG_IRF3_LxIS_1	291	298	PF10401	0.329
LIG_LIR_Apic_2	162	168	PF02991	0.305
LIG_LIR_Apic_2	58	63	PF02991	0.372
LIG_LIR_Gen_1	298	308	PF02991	0.385
LIG_LIR_Gen_1	355	363	PF02991	0.695
LIG_LIR_Nem_3	141	146	PF02991	0.378
LIG_LIR_Nem_3	182	188	PF02991	0.394
LIG_LIR_Nem_3	298	303	PF02991	0.329
LIG_LIR_Nem_3	355	360	PF02991	0.668
LIG_NRBOX	290	296	PF00104	0.344
LIG_Pex14_2	145	149	PF04695	0.342
LIG_Pex14_2	233	237	PF04695	0.245
LIG_Pex14_2	52	56	PF04695	0.420
LIG_Pex3_1	291	302	PF04882	0.291
LIG_PTB_Apo_2	93	100	PF02174	0.366
LIG_PTB_Phospho_1	93	99	PF10480	0.361
LIG_SH2_CRK	235	239	PF00017	0.337
LIG_SH2_CRK	357	361	PF00017	0.731
LIG_SH2_CRK	60	64	PF00017	0.304
LIG_SH2_GRB2like	94	97	PF00017	0.361
LIG_SH2_SRC	94	97	PF00017	0.361
LIG_SH2_STAT5	184	187	PF00017	0.310
LIG_SH2_STAT5	235	238	PF00017	0.382
LIG_SH2_STAT5	247	250	PF00017	0.302
LIG_SH2_STAT5	315	318	PF00017	0.680
LIG_SH2_STAT5	60	63	PF00017	0.299
LIG_SH2_STAT5	94	97	PF00017	0.361
LIG_SH3_1	174	180	PF00018	0.351
LIG_SH3_3	174	180	PF00018	0.350
LIG_SH3_3	185	191	PF00018	0.280
LIG_SH3_3	29	35	PF00018	0.525
LIG_SH3_3	360	366	PF00018	0.640
LIG_SH3_3	38	44	PF00018	0.447
LIG_SUMO_SIM_anti_2	21	27	PF11976	0.534
LIG_SUMO_SIM_anti_2	72	78	PF11976	0.271
LIG_SUMO_SIM_par_1	293	298	PF11976	0.401
LIG_WRC_WIRS_1	145	150	PF05994	0.291
MOD_CDK_SPxK_1	138	144	PF00069	0.328
MOD_CDK_SPxxK_3	285	292	PF00069	0.411
MOD_CK1_1	201	207	PF00069	0.283
MOD_CK1_1	269	275	PF00069	0.588
MOD_CK1_1	284	290	PF00069	0.440
MOD_CK2_1	123	129	PF00069	0.367
MOD_CK2_1	251	257	PF00069	0.397
MOD_Cter_Amidation	317	320	PF01082	0.439
MOD_GlcNHglycan	200	203	PF01048	0.620
MOD_GlcNHglycan	211	214	PF01048	0.628
MOD_GlcNHglycan	218	221	PF01048	0.541
MOD_GlcNHglycan	226	229	PF01048	0.587
MOD_GlcNHglycan	273	276	PF01048	0.781
MOD_GlcNHglycan	309	312	PF01048	0.420
MOD_GlcNHglycan	36	39	PF01048	0.651
MOD_GSK3_1	134	141	PF00069	0.482
MOD_GSK3_1	266	273	PF00069	0.478
MOD_GSK3_1	281	288	PF00069	0.474
MOD_GSK3_1	95	102	PF00069	0.410
MOD_N-GLC_1	269	274	PF02516	0.706
MOD_N-GLC_1	95	100	PF02516	0.469
MOD_NEK2_1	18	23	PF00069	0.463
MOD_NEK2_1	233	238	PF00069	0.324
MOD_NEK2_1	239	244	PF00069	0.377
MOD_NEK2_1	295	300	PF00069	0.317
MOD_PIKK_1	282	288	PF00454	0.488
MOD_PKA_2	198	204	PF00069	0.330
MOD_PKA_2	99	105	PF00069	0.422
MOD_Plk_1	161	167	PF00069	0.402
MOD_Plk_1	239	245	PF00069	0.312
MOD_Plk_1	95	101	PF00069	0.270
MOD_Plk_4	161	167	PF00069	0.338
MOD_Plk_4	179	185	PF00069	0.403
MOD_Plk_4	19	25	PF00069	0.501
MOD_Plk_4	27	33	PF00069	0.502
MOD_Plk_4	84	90	PF00069	0.390
MOD_ProDKin_1	138	144	PF00069	0.444
MOD_ProDKin_1	149	155	PF00069	0.247
MOD_ProDKin_1	173	179	PF00069	0.410
MOD_ProDKin_1	285	291	PF00069	0.531
MOD_SUMO_rev_2	201	210	PF00179	0.461
TRG_DiLeu_BaEn_1	72	77	PF01217	0.286
TRG_DiLeu_BaLyEn_6	290	295	PF01217	0.446
TRG_ENDOCYTIC_2	314	317	PF00928	0.608
TRG_ENDOCYTIC_2	357	360	PF00928	0.633
TRG_ER_diArg_1	133	136	PF00400	0.395
TRG_ER_diArg_1	291	293	PF00400	0.454
TRG_ER_diArg_1	350	352	PF00400	0.621
TRG_ER_diArg_1	9	11	PF00400	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVT9	Leptomonas seymouri	47%	97%
A0A1X0P1M4	Trypanosomatidae	33%	94%
A0A3S7X3V1	Leishmania donovani	89%	100%
A0A422NM26	Trypanosoma rangeli	33%	96%
A4HIK0	Leishmania braziliensis	69%	100%
A4I5U4	Leishmania infantum	89%	100%
C9ZR64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4Q727	Leishmania major	88%	100%
V5DNY7	Trypanosoma cruzi	33%	88%