Tetratricopeptide repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B138_LEIMU

TriTrypDb:

LmxM.29.2660

Length:

518

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B138

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B138

PDB structure(s): 7aih_Aj , 7am2_Aj , 7ane_Aj

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.502
CLV_C14_Caspase3-7	315	319	PF00656	0.272
CLV_NRD_NRD_1	155	157	PF00675	0.484
CLV_NRD_NRD_1	210	212	PF00675	0.614
CLV_NRD_NRD_1	272	274	PF00675	0.436
CLV_NRD_NRD_1	353	355	PF00675	0.348
CLV_NRD_NRD_1	404	406	PF00675	0.345
CLV_NRD_NRD_1	432	434	PF00675	0.408
CLV_NRD_NRD_1	490	492	PF00675	0.404
CLV_PCSK_KEX2_1	210	212	PF00082	0.567
CLV_PCSK_KEX2_1	272	274	PF00082	0.423
CLV_PCSK_KEX2_1	353	355	PF00082	0.348
CLV_PCSK_KEX2_1	431	433	PF00082	0.409
CLV_PCSK_KEX2_1	490	492	PF00082	0.402
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.500
CLV_PCSK_PC7_1	427	433	PF00082	0.494
CLV_PCSK_SKI1_1	120	124	PF00082	0.412
CLV_PCSK_SKI1_1	411	415	PF00082	0.343
CLV_PCSK_SKI1_1	458	462	PF00082	0.394
CLV_Separin_Metazoa	445	449	PF03568	0.409
DEG_Nend_UBRbox_4	1	3	PF02207	0.424
DEG_SPOP_SBC_1	163	167	PF00917	0.708
DOC_AGCK_PIF_2	366	371	PF00069	0.311
DOC_CDC14_PxL_1	14	22	PF14671	0.406
DOC_CDC14_PxL_1	345	353	PF14671	0.328
DOC_MAPK_gen_1	210	216	PF00069	0.478
DOC_MAPK_gen_1	350	359	PF00069	0.380
DOC_MAPK_gen_1	392	401	PF00069	0.504
DOC_MAPK_MEF2A_6	33	41	PF00069	0.404
DOC_MAPK_RevD_3	396	412	PF00069	0.439
DOC_PP1_RVXF_1	360	367	PF00149	0.329
DOC_PP2B_LxvP_1	464	467	PF13499	0.405
DOC_PP4_FxxP_1	15	18	PF00568	0.385
DOC_USP7_MATH_1	162	166	PF00917	0.729
DOC_USP7_MATH_1	44	48	PF00917	0.400
DOC_USP7_MATH_1	78	82	PF00917	0.402
DOC_USP7_UBL2_3	505	509	PF12436	0.537
DOC_WW_Pin1_4	174	179	PF00397	0.667
DOC_WW_Pin1_4	33	38	PF00397	0.406
DOC_WW_Pin1_4	364	369	PF00397	0.318
DOC_WW_Pin1_4	439	444	PF00397	0.360
DOC_WW_Pin1_4	447	452	PF00397	0.393
DOC_WW_Pin1_4	72	77	PF00397	0.415
DOC_WW_Pin1_4	85	90	PF00397	0.396
LIG_14-3-3_CanoR_1	124	130	PF00244	0.400
LIG_14-3-3_CanoR_1	148	153	PF00244	0.556
LIG_14-3-3_CanoR_1	33	37	PF00244	0.410
LIG_14-3-3_CanoR_1	422	427	PF00244	0.376
LIG_14-3-3_CanoR_1	8	14	PF00244	0.407
LIG_BRCT_BRCA1_1	11	15	PF00533	0.407
LIG_BRCT_BRCA1_1	34	38	PF00533	0.402
LIG_EH1_1	341	349	PF00400	0.327
LIG_eIF4E_1	129	135	PF01652	0.511
LIG_FHA_1	187	193	PF00498	0.607
LIG_FHA_1	272	278	PF00498	0.419
LIG_FHA_2	180	186	PF00498	0.744
LIG_FHA_2	313	319	PF00498	0.436
LIG_FHA_2	321	327	PF00498	0.391
LIG_FHA_2	328	334	PF00498	0.371
LIG_FHA_2	440	446	PF00498	0.357
LIG_IBAR_NPY_1	487	489	PF08397	0.420
LIG_LIR_Apic_2	12	18	PF02991	0.390
LIG_LIR_Gen_1	182	191	PF02991	0.688
LIG_LIR_Gen_1	360	371	PF02991	0.325
LIG_LIR_Nem_3	12	17	PF02991	0.402
LIG_LIR_Nem_3	123	129	PF02991	0.369
LIG_LIR_Nem_3	182	186	PF02991	0.697
LIG_LIR_Nem_3	240	245	PF02991	0.344
LIG_LIR_Nem_3	35	41	PF02991	0.400
LIG_LIR_Nem_3	360	366	PF02991	0.332
LIG_LIR_Nem_3	370	374	PF02991	0.307
LIG_LIR_Nem_3	504	510	PF02991	0.408
LIG_LIR_Nem_3	77	82	PF02991	0.402
LIG_MAD2	480	488	PF02301	0.449
LIG_MLH1_MIPbox_1	11	15	PF16413	0.396
LIG_MYND_1	40	44	PF01753	0.403
LIG_PCNA_yPIPBox_3	470	482	PF02747	0.559
LIG_PDZ_Class_2	513	518	PF00595	0.560
LIG_Pex14_2	355	359	PF04695	0.384
LIG_REV1ctd_RIR_1	411	421	PF16727	0.367
LIG_SH2_CRK	242	246	PF00017	0.331
LIG_SH2_CRK	371	375	PF00017	0.509
LIG_SH2_NCK_1	249	253	PF00017	0.354
LIG_SH2_NCK_1	371	375	PF00017	0.369
LIG_SH2_PTP2	213	216	PF00017	0.375
LIG_SH2_STAP1	126	130	PF00017	0.400
LIG_SH2_STAP1	249	253	PF00017	0.373
LIG_SH2_STAP1	371	375	PF00017	0.305
LIG_SH2_STAP1	462	466	PF00017	0.422
LIG_SH2_STAT5	126	129	PF00017	0.409
LIG_SH2_STAT5	213	216	PF00017	0.390
LIG_SH2_STAT5	228	231	PF00017	0.364
LIG_SH2_STAT5	365	368	PF00017	0.311
LIG_SH2_STAT5	510	513	PF00017	0.412
LIG_SH3_3	102	108	PF00018	0.531
LIG_SH3_3	15	21	PF00018	0.402
LIG_SH3_3	158	164	PF00018	0.437
LIG_SH3_3	209	215	PF00018	0.447
LIG_SH3_3	292	298	PF00018	0.467
LIG_SH3_3	34	40	PF00018	0.378
LIG_SH3_3	60	66	PF00018	0.391
LIG_SH3_3	77	83	PF00018	0.386
LIG_SUMO_SIM_anti_2	326	333	PF11976	0.322
LIG_TYR_ITIM	239	244	PF00017	0.477
LIG_WRC_WIRS_1	10	15	PF05994	0.397
LIG_WRC_WIRS_1	82	87	PF05994	0.414
MOD_CK1_1	166	172	PF00069	0.671
MOD_CK1_1	338	344	PF00069	0.363
MOD_CK1_1	45	51	PF00069	0.410
MOD_CK1_1	493	499	PF00069	0.319
MOD_CK1_1	81	87	PF00069	0.559
MOD_CK2_1	320	326	PF00069	0.391
MOD_CK2_1	439	445	PF00069	0.359
MOD_Cter_Amidation	351	354	PF01082	0.334
MOD_GlcNHglycan	109	112	PF01048	0.487
MOD_GlcNHglycan	166	169	PF01048	0.712
MOD_GlcNHglycan	337	340	PF01048	0.362
MOD_GSK3_1	107	114	PF00069	0.483
MOD_GSK3_1	120	127	PF00069	0.402
MOD_GSK3_1	162	169	PF00069	0.677
MOD_GSK3_1	42	49	PF00069	0.404
MOD_GSK3_1	435	442	PF00069	0.376
MOD_GSK3_1	68	75	PF00069	0.415
MOD_GSK3_1	81	88	PF00069	0.472
MOD_NEK2_1	1	6	PF00069	0.423
MOD_NEK2_1	125	130	PF00069	0.379
MOD_NEK2_1	271	276	PF00069	0.358
MOD_NEK2_1	277	282	PF00069	0.356
MOD_NEK2_1	32	37	PF00069	0.407
MOD_NEK2_1	335	340	PF00069	0.468
MOD_NEK2_2	111	116	PF00069	0.380
MOD_NEK2_2	320	325	PF00069	0.453
MOD_PIKK_1	42	48	PF00454	0.404
MOD_PIKK_1	493	499	PF00454	0.494
MOD_PK_1	490	496	PF00069	0.318
MOD_PK_1	52	58	PF00069	0.413
MOD_PKA_1	490	496	PF00069	0.318
MOD_PKA_2	271	277	PF00069	0.398
MOD_PKA_2	32	38	PF00069	0.418
MOD_PKA_2	490	496	PF00069	0.397
MOD_Plk_2-3	179	185	PF00069	0.672
MOD_Plk_2-3	327	333	PF00069	0.411
MOD_Plk_4	125	131	PF00069	0.368
MOD_Plk_4	320	326	PF00069	0.423
MOD_Plk_4	327	333	PF00069	0.413
MOD_Plk_4	9	15	PF00069	0.400
MOD_ProDKin_1	174	180	PF00069	0.665
MOD_ProDKin_1	33	39	PF00069	0.406
MOD_ProDKin_1	364	370	PF00069	0.321
MOD_ProDKin_1	439	445	PF00069	0.359
MOD_ProDKin_1	447	453	PF00069	0.393
MOD_ProDKin_1	72	78	PF00069	0.410
MOD_ProDKin_1	85	91	PF00069	0.397
MOD_SUMO_for_1	130	133	PF00179	0.387
MOD_SUMO_for_1	220	223	PF00179	0.393
MOD_SUMO_for_1	460	463	PF00179	0.406
MOD_SUMO_rev_2	407	414	PF00179	0.355
TRG_DiLeu_BaEn_1	327	332	PF01217	0.388
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.327
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.403
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.400
TRG_ENDOCYTIC_2	213	216	PF00928	0.375
TRG_ENDOCYTIC_2	241	244	PF00928	0.348
TRG_ENDOCYTIC_2	371	374	PF00928	0.512
TRG_ER_diArg_1	210	212	PF00400	0.487
TRG_ER_diArg_1	271	273	PF00400	0.428
TRG_ER_diArg_1	353	355	PF00400	0.348
TRG_ER_diArg_1	389	392	PF00400	0.257
TRG_ER_diArg_1	489	491	PF00400	0.425
TRG_NES_CRM1_1	300	314	PF08389	0.299
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	498	502	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P524	Leptomonas seymouri	77%	100%
A0A0S4JJI8	Bodo saltans	53%	100%
A0A1X0P1I0	Trypanosomatidae	62%	100%
A0A3Q8IC59	Leishmania donovani	94%	100%
A0A3S5IRF5	Trypanosoma rangeli	65%	100%
A4HIJ9	Leishmania braziliensis	88%	100%
A4I5U3	Leishmania infantum	94%	100%
C9ZR63	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
Q4Q728	Leishmania major	94%	100%
V5BSI7	Trypanosoma cruzi	63%	100%