LeishMANIAdb
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Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Ubiquitin-like domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B137_LEIMU
TriTrypDb:
LmxM.29.2650
Length:
156

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005930 axoneme 2 1
GO:0016020 membrane 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

E9B137
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B137

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 147 151 PF00656 0.727
CLV_NRD_NRD_1 28 30 PF00675 0.357
CLV_PCSK_FUR_1 23 27 PF00082 0.309
CLV_PCSK_KEX2_1 25 27 PF00082 0.312
CLV_PCSK_KEX2_1 28 30 PF00082 0.352
CLV_PCSK_PC1ET2_1 25 27 PF00082 0.355
CLV_PCSK_SKI1_1 29 33 PF00082 0.375
DOC_MAPK_gen_1 23 33 PF00069 0.525
LIG_14-3-3_CanoR_1 55 61 PF00244 0.525
LIG_14-3-3_CanoR_1 68 76 PF00244 0.538
LIG_APCC_ABBA_1 31 36 PF00400 0.526
LIG_BRCT_BRCA1_1 53 57 PF00533 0.584
LIG_BRCT_BRCA1_1 72 76 PF00533 0.591
LIG_FHA_1 11 17 PF00498 0.464
LIG_FHA_1 147 153 PF00498 0.679
LIG_FHA_1 28 34 PF00498 0.457
LIG_FHA_1 57 63 PF00498 0.523
LIG_FHA_2 145 151 PF00498 0.724
LIG_FHA_2 99 105 PF00498 0.649
LIG_LIR_Gen_1 100 111 PF02991 0.565
LIG_LIR_Nem_3 100 106 PF02991 0.495
LIG_LIR_Nem_3 85 91 PF02991 0.555
LIG_PDZ_Class_2 151 156 PF00595 0.669
LIG_SH2_STAP1 58 62 PF00017 0.512
LIG_SH2_STAT3 64 67 PF00017 0.632
LIG_SH2_STAT5 21 24 PF00017 0.363
LIG_SH2_STAT5 34 37 PF00017 0.523
LIG_SH2_STAT5 58 61 PF00017 0.519
LIG_SUMO_SIM_anti_2 149 156 PF11976 0.672
MOD_CK1_1 70 76 PF00069 0.583
MOD_CK2_1 98 104 PF00069 0.670
MOD_GlcNHglycan 5 8 PF01048 0.411
MOD_GSK3_1 125 132 PF00069 0.718
MOD_GSK3_1 142 149 PF00069 0.754
MOD_GSK3_1 67 74 PF00069 0.597
MOD_GSK3_1 78 85 PF00069 0.615
MOD_GSK3_1 89 96 PF00069 0.583
MOD_NEK2_1 1 6 PF00069 0.479
MOD_NEK2_1 75 80 PF00069 0.664
MOD_PKA_2 27 33 PF00069 0.578
MOD_PKA_2 67 73 PF00069 0.586
MOD_Plk_1 70 76 PF00069 0.543
MOD_Plk_2-3 98 104 PF00069 0.648
MOD_Plk_4 71 77 PF00069 0.561
MOD_Plk_4 98 104 PF00069 0.655
TRG_ENDOCYTIC_2 21 24 PF00928 0.363
TRG_ENDOCYTIC_2 34 37 PF00928 0.523
TRG_ER_diArg_1 26 29 PF00400 0.546
TRG_NLS_MonoExtC_3 24 29 PF00514 0.568
TRG_NLS_MonoExtN_4 23 29 PF00514 0.568

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5G5 Leptomonas seymouri 72% 100%
A0A3Q8IS54 Leishmania donovani 90% 100%
A4HIJ8 Leishmania braziliensis 76% 100%
A4I5U2 Leishmania infantum 90% 100%
Q4Q729 Leishmania major 89% 100%
V5DP06 Trypanosoma cruzi 50% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS