Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B135_LEIMU

TriTrypDb:

LmxM.29.2640

Length:

829

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B135

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B135

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	360	364	PF00656	0.411
CLV_NRD_NRD_1	396	398	PF00675	0.453
CLV_NRD_NRD_1	440	442	PF00675	0.451
CLV_NRD_NRD_1	625	627	PF00675	0.740
CLV_NRD_NRD_1	647	649	PF00675	0.581
CLV_NRD_NRD_1	743	745	PF00675	0.840
CLV_NRD_NRD_1	817	819	PF00675	0.665
CLV_PCSK_KEX2_1	22	24	PF00082	0.377
CLV_PCSK_KEX2_1	253	255	PF00082	0.506
CLV_PCSK_KEX2_1	295	297	PF00082	0.516
CLV_PCSK_KEX2_1	396	398	PF00082	0.453
CLV_PCSK_KEX2_1	625	627	PF00082	0.740
CLV_PCSK_KEX2_1	681	683	PF00082	0.836
CLV_PCSK_KEX2_1	742	744	PF00082	0.857
CLV_PCSK_KEX2_1	817	819	PF00082	0.665
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.377
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.607
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.516
CLV_PCSK_PC1ET2_1	681	683	PF00082	0.836
CLV_PCSK_PC7_1	18	24	PF00082	0.376
CLV_PCSK_SKI1_1	253	257	PF00082	0.501
CLV_PCSK_SKI1_1	296	300	PF00082	0.460
CLV_PCSK_SKI1_1	38	42	PF00082	0.324
CLV_PCSK_SKI1_1	381	385	PF00082	0.464
CLV_PCSK_SKI1_1	520	524	PF00082	0.721
CLV_PCSK_SKI1_1	539	543	PF00082	0.718
DEG_APCC_DBOX_1	295	303	PF00400	0.468
DEG_APCC_DBOX_1	380	388	PF00400	0.533
DEG_APCC_DBOX_1	396	404	PF00400	0.402
DEG_APCC_DBOX_1	519	527	PF00400	0.719
DEG_Nend_UBRbox_2	1	3	PF02207	0.540
DEG_SPOP_SBC_1	283	287	PF00917	0.470
DOC_CDC14_PxL_1	96	104	PF14671	0.554
DOC_CYCLIN_RxL_1	376	388	PF00134	0.462
DOC_CYCLIN_yCln2_LP_2	424	430	PF00134	0.464
DOC_MAPK_DCC_7	313	321	PF00069	0.453
DOC_MAPK_gen_1	119	129	PF00069	0.528
DOC_MAPK_gen_1	22	30	PF00069	0.354
DOC_MAPK_gen_1	253	262	PF00069	0.579
DOC_MAPK_gen_1	396	405	PF00069	0.431
DOC_MAPK_gen_1	417	424	PF00069	0.484
DOC_MAPK_HePTP_8	395	407	PF00069	0.406
DOC_MAPK_MEF2A_6	104	113	PF00069	0.633
DOC_MAPK_MEF2A_6	122	129	PF00069	0.440
DOC_MAPK_MEF2A_6	301	310	PF00069	0.539
DOC_MAPK_MEF2A_6	398	407	PF00069	0.399
DOC_PP2B_LxvP_1	759	762	PF13499	0.784
DOC_USP7_MATH_1	138	142	PF00917	0.489
DOC_USP7_MATH_1	226	230	PF00917	0.525
DOC_USP7_MATH_1	239	243	PF00917	0.509
DOC_USP7_MATH_1	283	287	PF00917	0.456
DOC_USP7_MATH_1	357	361	PF00917	0.482
DOC_USP7_MATH_1	370	374	PF00917	0.339
DOC_USP7_MATH_1	446	450	PF00917	0.420
DOC_USP7_MATH_1	460	464	PF00917	0.623
DOC_USP7_MATH_1	48	52	PF00917	0.339
DOC_USP7_MATH_1	537	541	PF00917	0.805
DOC_USP7_MATH_1	618	622	PF00917	0.828
DOC_USP7_MATH_1	680	684	PF00917	0.679
DOC_USP7_MATH_1	705	709	PF00917	0.665
DOC_USP7_MATH_1	796	800	PF00917	0.718
DOC_USP7_UBL2_3	136	140	PF12436	0.622
DOC_USP7_UBL2_3	572	576	PF12436	0.538
DOC_WW_Pin1_4	222	227	PF00397	0.569
DOC_WW_Pin1_4	312	317	PF00397	0.462
DOC_WW_Pin1_4	329	334	PF00397	0.528
DOC_WW_Pin1_4	435	440	PF00397	0.511
DOC_WW_Pin1_4	456	461	PF00397	0.594
DOC_WW_Pin1_4	592	597	PF00397	0.718
DOC_WW_Pin1_4	626	631	PF00397	0.762
DOC_WW_Pin1_4	632	637	PF00397	0.787
DOC_WW_Pin1_4	672	677	PF00397	0.830
DOC_WW_Pin1_4	685	690	PF00397	0.648
DOC_WW_Pin1_4	742	747	PF00397	0.839
DOC_WW_Pin1_4	792	797	PF00397	0.726
LIG_14-3-3_CanoR_1	122	126	PF00244	0.526
LIG_14-3-3_CanoR_1	254	264	PF00244	0.567
LIG_14-3-3_CanoR_1	326	336	PF00244	0.520
LIG_14-3-3_CanoR_1	445	451	PF00244	0.409
LIG_14-3-3_CanoR_1	50	54	PF00244	0.551
LIG_14-3-3_CanoR_1	511	515	PF00244	0.680
LIG_14-3-3_CanoR_1	590	596	PF00244	0.635
LIG_14-3-3_CanoR_1	610	618	PF00244	0.633
LIG_14-3-3_CanoR_1	625	629	PF00244	0.786
LIG_14-3-3_CanoR_1	648	657	PF00244	0.578
LIG_14-3-3_CanoR_1	696	700	PF00244	0.821
LIG_14-3-3_CanoR_1	811	817	PF00244	0.650
LIG_Actin_WH2_2	108	124	PF00022	0.515
LIG_Actin_WH2_2	240	258	PF00022	0.535
LIG_Actin_WH2_2	351	369	PF00022	0.455
LIG_AP2alpha_1	193	197	PF02296	0.795
LIG_CtBP_PxDLS_1	775	779	PF00389	0.721
LIG_FHA_1	122	128	PF00498	0.538
LIG_FHA_1	158	164	PF00498	0.595
LIG_FHA_1	250	256	PF00498	0.521
LIG_FHA_1	285	291	PF00498	0.443
LIG_FHA_1	610	616	PF00498	0.584
LIG_FHA_1	635	641	PF00498	0.640
LIG_FHA_1	645	651	PF00498	0.753
LIG_FHA_1	91	97	PF00498	0.375
LIG_FHA_2	190	196	PF00498	0.794
LIG_FHA_2	44	50	PF00498	0.528
LIG_GBD_Chelix_1	379	387	PF00786	0.463
LIG_LIR_Gen_1	147	156	PF02991	0.576
LIG_LIR_Gen_1	56	67	PF02991	0.493
LIG_LIR_Nem_3	147	151	PF02991	0.475
LIG_LIR_Nem_3	161	167	PF02991	0.504
LIG_LIR_Nem_3	56	62	PF02991	0.479
LIG_MAD2	452	460	PF02301	0.531
LIG_NRBOX	174	180	PF00104	0.546
LIG_NRBOX	420	426	PF00104	0.467
LIG_NRBOX	495	501	PF00104	0.486
LIG_PDZ_Class_2	824	829	PF00595	0.701
LIG_Pex14_2	193	197	PF04695	0.795
LIG_PTB_Apo_2	495	502	PF02174	0.514
LIG_SH2_GRB2like	148	151	PF00017	0.362
LIG_SH2_PTP2	114	117	PF00017	0.493
LIG_SH2_PTP2	352	355	PF00017	0.516
LIG_SH2_STAP1	164	168	PF00017	0.606
LIG_SH2_STAP1	663	667	PF00017	0.801
LIG_SH2_STAT3	272	275	PF00017	0.491
LIG_SH2_STAT5	114	117	PF00017	0.493
LIG_SH2_STAT5	148	151	PF00017	0.420
LIG_SH2_STAT5	272	275	PF00017	0.473
LIG_SH2_STAT5	352	355	PF00017	0.516
LIG_SH2_STAT5	402	405	PF00017	0.367
LIG_SH2_STAT5	432	435	PF00017	0.446
LIG_SH3_1	18	24	PF00018	0.664
LIG_SH3_3	18	24	PF00018	0.577
LIG_SH3_3	450	456	PF00018	0.483
LIG_SH3_3	612	618	PF00018	0.832
LIG_SH3_3	730	736	PF00018	0.710
LIG_SH3_3	755	761	PF00018	0.815
LIG_SH3_3	804	810	PF00018	0.644
LIG_SH3_4	572	579	PF00018	0.534
LIG_SUMO_SIM_anti_2	285	292	PF11976	0.450
LIG_SUMO_SIM_anti_2	305	310	PF11976	0.216
LIG_SUMO_SIM_anti_2	471	478	PF11976	0.629
LIG_TRAF2_1	684	687	PF00917	0.635
LIG_TRAF2_1	753	756	PF00917	0.790
LIG_TYR_ITIM	400	405	PF00017	0.421
LIG_UBA3_1	30	38	PF00899	0.458
LIG_Vh1_VBS_1	273	291	PF01044	0.438
LIG_WRC_WIRS_1	227	232	PF05994	0.512
LIG_WW_3	760	764	PF00397	0.714
MOD_CDC14_SPxK_1	438	441	PF00782	0.507
MOD_CDC14_SPxK_1	688	691	PF00782	0.767
MOD_CDK_SPK_2	456	461	PF00069	0.636
MOD_CDK_SPxK_1	435	441	PF00069	0.510
MOD_CDK_SPxK_1	685	691	PF00069	0.776
MOD_CDK_SPxxK_3	435	442	PF00069	0.506
MOD_CK1_1	174	180	PF00069	0.647
MOD_CK1_1	189	195	PF00069	0.545
MOD_CK1_1	198	204	PF00069	0.591
MOD_CK1_1	225	231	PF00069	0.629
MOD_CK1_1	242	248	PF00069	0.409
MOD_CK1_1	332	338	PF00069	0.447
MOD_CK1_1	359	365	PF00069	0.481
MOD_CK1_1	43	49	PF00069	0.604
MOD_CK1_1	509	515	PF00069	0.671
MOD_CK1_1	518	524	PF00069	0.696
MOD_CK1_1	571	577	PF00069	0.727
MOD_CK1_1	635	641	PF00069	0.756
MOD_CK1_1	695	701	PF00069	0.763
MOD_CK1_1	797	803	PF00069	0.691
MOD_CK2_1	138	144	PF00069	0.487
MOD_CK2_1	43	49	PF00069	0.514
MOD_CK2_1	680	686	PF00069	0.558
MOD_Cter_Amidation	623	626	PF01082	0.759
MOD_DYRK1A_RPxSP_1	626	630	PF00069	0.748
MOD_GlcNHglycan	188	191	PF01048	0.687
MOD_GlcNHglycan	247	250	PF01048	0.567
MOD_GlcNHglycan	296	299	PF01048	0.483
MOD_GlcNHglycan	329	332	PF01048	0.553
MOD_GlcNHglycan	336	339	PF01048	0.508
MOD_GlcNHglycan	359	362	PF01048	0.564
MOD_GlcNHglycan	387	390	PF01048	0.507
MOD_GlcNHglycan	514	517	PF01048	0.709
MOD_GlcNHglycan	538	542	PF01048	0.762
MOD_GlcNHglycan	620	623	PF01048	0.822
MOD_GlcNHglycan	630	633	PF01048	0.700
MOD_GlcNHglycan	677	680	PF01048	0.760
MOD_GlcNHglycan	682	685	PF01048	0.784
MOD_GlcNHglycan	707	710	PF01048	0.795
MOD_GlcNHglycan	714	717	PF01048	0.840
MOD_GlcNHglycan	739	742	PF01048	0.748
MOD_GlcNHglycan	799	802	PF01048	0.704
MOD_GSK3_1	134	141	PF00069	0.514
MOD_GSK3_1	182	189	PF00069	0.671
MOD_GSK3_1	193	200	PF00069	0.733
MOD_GSK3_1	218	225	PF00069	0.698
MOD_GSK3_1	239	246	PF00069	0.612
MOD_GSK3_1	325	332	PF00069	0.543
MOD_GSK3_1	334	341	PF00069	0.451
MOD_GSK3_1	456	463	PF00069	0.572
MOD_GSK3_1	502	509	PF00069	0.590
MOD_GSK3_1	568	575	PF00069	0.784
MOD_GSK3_1	594	601	PF00069	0.725
MOD_GSK3_1	624	631	PF00069	0.741
MOD_GSK3_1	63	70	PF00069	0.536
MOD_GSK3_1	644	651	PF00069	0.755
MOD_GSK3_1	668	675	PF00069	0.754
MOD_GSK3_1	792	799	PF00069	0.702
MOD_N-GLC_1	672	677	PF02516	0.746
MOD_NEK2_1	121	126	PF00069	0.516
MOD_NEK2_1	13	18	PF00069	0.513
MOD_NEK2_1	151	156	PF00069	0.406
MOD_NEK2_1	186	191	PF00069	0.682
MOD_NEK2_1	193	198	PF00069	0.703
MOD_NEK2_1	255	260	PF00069	0.581
MOD_NEK2_1	40	45	PF00069	0.294
MOD_NEK2_1	506	511	PF00069	0.617
MOD_NEK2_1	589	594	PF00069	0.724
MOD_NEK2_1	63	68	PF00069	0.476
MOD_NEK2_1	668	673	PF00069	0.526
MOD_PIKK_1	255	261	PF00454	0.575
MOD_PIKK_1	515	521	PF00454	0.785
MOD_PIKK_1	810	816	PF00454	0.778
MOD_PK_1	658	664	PF00069	0.728
MOD_PKA_1	648	654	PF00069	0.549
MOD_PKA_2	121	127	PF00069	0.520
MOD_PKA_2	325	331	PF00069	0.642
MOD_PKA_2	460	466	PF00069	0.630
MOD_PKA_2	49	55	PF00069	0.548
MOD_PKA_2	510	516	PF00069	0.679
MOD_PKA_2	589	595	PF00069	0.591
MOD_PKA_2	609	615	PF00069	0.685
MOD_PKA_2	624	630	PF00069	0.722
MOD_PKA_2	695	701	PF00069	0.819
MOD_PKA_2	810	816	PF00069	0.677
MOD_PKB_1	529	537	PF00069	0.619
MOD_PKB_1	646	654	PF00069	0.549
MOD_Plk_1	138	144	PF00069	0.440
MOD_Plk_1	182	188	PF00069	0.730
MOD_Plk_1	218	224	PF00069	0.411
MOD_Plk_1	242	248	PF00069	0.586
MOD_Plk_1	48	54	PF00069	0.339
MOD_Plk_1	537	543	PF00069	0.532
MOD_Plk_2-3	49	55	PF00069	0.548
MOD_Plk_4	174	180	PF00069	0.647
MOD_Plk_4	2	8	PF00069	0.530
MOD_Plk_4	226	232	PF00069	0.520
MOD_Plk_4	446	452	PF00069	0.425
MOD_Plk_4	502	508	PF00069	0.585
MOD_Plk_4	54	60	PF00069	0.493
MOD_Plk_4	658	664	PF00069	0.715
MOD_ProDKin_1	222	228	PF00069	0.570
MOD_ProDKin_1	312	318	PF00069	0.472
MOD_ProDKin_1	329	335	PF00069	0.522
MOD_ProDKin_1	435	441	PF00069	0.510
MOD_ProDKin_1	456	462	PF00069	0.592
MOD_ProDKin_1	592	598	PF00069	0.718
MOD_ProDKin_1	626	632	PF00069	0.762
MOD_ProDKin_1	672	678	PF00069	0.832
MOD_ProDKin_1	685	691	PF00069	0.650
MOD_ProDKin_1	742	748	PF00069	0.839
MOD_ProDKin_1	792	798	PF00069	0.726
MOD_SUMO_for_1	127	130	PF00179	0.557
MOD_SUMO_rev_2	130	138	PF00179	0.532
MOD_SUMO_rev_2	821	826	PF00179	0.662
TRG_DiLeu_BaEn_1	420	425	PF01217	0.472
TRG_DiLeu_BaEn_1	495	500	PF01217	0.524
TRG_DiLeu_BaEn_2	146	152	PF01217	0.496
TRG_DiLeu_BaEn_2	501	507	PF01217	0.563
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.601
TRG_ENDOCYTIC_2	114	117	PF00928	0.493
TRG_ENDOCYTIC_2	148	151	PF00928	0.497
TRG_ENDOCYTIC_2	352	355	PF00928	0.457
TRG_ENDOCYTIC_2	37	40	PF00928	0.293
TRG_ENDOCYTIC_2	402	405	PF00928	0.419
TRG_ER_diArg_1	395	397	PF00400	0.457
TRG_ER_diArg_1	526	529	PF00400	0.705
TRG_ER_diArg_1	553	556	PF00400	0.721
TRG_ER_diArg_1	742	744	PF00400	0.742
TRG_ER_diArg_1	816	818	PF00400	0.654
TRG_NES_CRM1_1	278	294	PF08389	0.458
TRG_NLS_Bipartite_1	235	257	PF00514	0.634
TRG_Pf-PMV_PEXEL_1	45	49	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	818	822	PF00026	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P525	Leptomonas seymouri	51%	96%
A0A3Q8II38	Leishmania donovani	90%	100%
A4HIJ6	Leishmania braziliensis	73%	100%
A4I5U0	Leishmania infantum	90%	100%
Q4Q731	Leishmania major	90%	100%