Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9B131_LEIMU

TriTrypDb:

LmxM.29.2610

Length:

216

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B131

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B131

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	58	60	PF00675	0.561
CLV_PCSK_KEX2_1	150	152	PF00082	0.505
CLV_PCSK_KEX2_1	33	35	PF00082	0.624
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.472
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.581
CLV_PCSK_SKI1_1	143	147	PF00082	0.302
CLV_PCSK_SKI1_1	93	97	PF00082	0.268
DOC_PP1_RVXF_1	91	97	PF00149	0.468
DOC_USP7_MATH_1	65	69	PF00917	0.635
DOC_USP7_UBL2_3	146	150	PF12436	0.457
LIG_14-3-3_CanoR_1	104	108	PF00244	0.566
LIG_14-3-3_CanoR_1	86	94	PF00244	0.497
LIG_BIR_II_1	1	5	PF00653	0.639
LIG_BRCT_BRCA1_1	192	196	PF00533	0.644
LIG_FHA_1	116	122	PF00498	0.559
LIG_FHA_2	86	92	PF00498	0.468
LIG_IBAR_NPY_1	197	199	PF08397	0.667
LIG_LIR_Gen_1	118	126	PF02991	0.551
LIG_LIR_Nem_3	118	123	PF02991	0.570
LIG_LIR_Nem_3	193	199	PF02991	0.668
LIG_SH2_STAT5	120	123	PF00017	0.493
LIG_SUMO_SIM_anti_2	103	110	PF11976	0.551
LIG_TRAF2_1	38	41	PF00917	0.543
LIG_TRAF2_1	47	50	PF00917	0.508
MOD_CK1_1	69	75	PF00069	0.602
MOD_CK2_1	35	41	PF00069	0.538
MOD_GlcNHglycan	13	16	PF01048	0.712
MOD_GlcNHglycan	50	53	PF01048	0.659
MOD_GlcNHglycan	68	71	PF01048	0.710
MOD_GSK3_1	65	72	PF00069	0.657
MOD_GSK3_1	7	14	PF00069	0.686
MOD_N-GLC_1	74	79	PF02516	0.416
MOD_NEK2_1	192	197	PF00069	0.503
MOD_NEK2_1	48	53	PF00069	0.588
MOD_NEK2_1	95	100	PF00069	0.510
MOD_PIKK_1	190	196	PF00454	0.658
MOD_PKA_2	103	109	PF00069	0.517
MOD_PKA_2	58	64	PF00069	0.572
MOD_PKA_2	85	91	PF00069	0.487
MOD_Plk_1	74	80	PF00069	0.410
MOD_Plk_4	103	109	PF00069	0.495
MOD_Plk_4	74	80	PF00069	0.413
MOD_SUMO_for_1	53	56	PF00179	0.656
TRG_ENDOCYTIC_2	120	123	PF00928	0.468
TRG_ER_diArg_1	169	172	PF00400	0.641
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I450	Leptomonas seymouri	76%	100%
A0A0S4JLX4	Bodo saltans	51%	94%
A0A1X0P1L3	Trypanosomatidae	62%	100%
A0A3Q8IJK6	Leishmania donovani	98%	100%
A4HIJ2	Leishmania braziliensis	90%	100%
A4I5T6	Leishmania infantum	98%	100%
A6NDY0	Homo sapiens	31%	78%
B0BNE4	Rattus norvegicus	35%	80%
Q09295	Caenorhabditis elegans	31%	100%
Q28ZX3	Drosophila pseudoobscura pseudoobscura	33%	96%
Q4Q734	Leishmania major	97%	100%
Q54ZS8	Dictyostelium discoideum	28%	97%
Q7KNF2	Drosophila melanogaster	31%	96%
Q93VI4	Arabidopsis thaliana	32%	95%
Q9FJN9	Arabidopsis thaliana	33%	98%
V5B7C6	Trypanosoma cruzi	65%	94%