N-acetyltransferase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B129_LEIMU

TriTrypDb:

LmxM.29.2590

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9B129

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B129

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0019538	protein metabolic process	3	12
GO:0030163	protein catabolic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008914	leucyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016755	aminoacyltransferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.714
CLV_C14_Caspase3-7	66	70	PF00656	0.687
CLV_NRD_NRD_1	106	108	PF00675	0.701
CLV_NRD_NRD_1	289	291	PF00675	0.393
CLV_NRD_NRD_1	455	457	PF00675	0.468
CLV_PCSK_KEX2_1	289	291	PF00082	0.364
CLV_PCSK_KEX2_1	323	325	PF00082	0.622
CLV_PCSK_KEX2_1	455	457	PF00082	0.468
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.622
CLV_PCSK_SKI1_1	179	183	PF00082	0.578
CLV_PCSK_SKI1_1	188	192	PF00082	0.422
CLV_PCSK_SKI1_1	273	277	PF00082	0.677
CLV_PCSK_SKI1_1	450	454	PF00082	0.470
CLV_PCSK_SKI1_1	48	52	PF00082	0.714
CLV_PCSK_SKI1_1	68	72	PF00082	0.761
CLV_PCSK_SKI1_1	90	94	PF00082	0.685
DEG_SPOP_SBC_1	255	259	PF00917	0.743
DOC_CKS1_1	3	8	PF01111	0.675
DOC_PP4_FxxP_1	191	194	PF00568	0.523
DOC_PP4_FxxP_1	216	219	PF00568	0.343
DOC_PP4_FxxP_1	233	236	PF00568	0.451
DOC_USP7_MATH_1	254	258	PF00917	0.765
DOC_USP7_MATH_1	275	279	PF00917	0.621
DOC_USP7_MATH_1	77	81	PF00917	0.638
DOC_WW_Pin1_4	2	7	PF00397	0.676
DOC_WW_Pin1_4	247	252	PF00397	0.671
DOC_WW_Pin1_4	350	355	PF00397	0.542
DOC_WW_Pin1_4	484	489	PF00397	0.376
LIG_14-3-3_CanoR_1	159	164	PF00244	0.585
LIG_14-3-3_CanoR_1	241	245	PF00244	0.503
LIG_14-3-3_CanoR_1	314	319	PF00244	0.540
LIG_14-3-3_CanoR_1	324	328	PF00244	0.514
LIG_14-3-3_CanoR_1	421	427	PF00244	0.521
LIG_14-3-3_CanoR_1	455	464	PF00244	0.426
LIG_14-3-3_CanoR_1	90	97	PF00244	0.702
LIG_14-3-3_CanoR_1	98	105	PF00244	0.657
LIG_APCC_ABBA_1	479	484	PF00400	0.542
LIG_BIR_III_2	462	466	PF00653	0.559
LIG_BRCT_BRCA1_1	169	173	PF00533	0.498
LIG_BRCT_BRCA1_1	41	45	PF00533	0.648
LIG_Clathr_ClatBox_1	366	370	PF01394	0.474
LIG_CtBP_PxDLS_1	155	159	PF00389	0.659
LIG_CtBP_PxDLS_1	219	223	PF00389	0.477
LIG_FHA_1	140	146	PF00498	0.610
LIG_FHA_1	176	182	PF00498	0.561
LIG_FHA_1	199	205	PF00498	0.483
LIG_FHA_1	241	247	PF00498	0.545
LIG_FHA_1	274	280	PF00498	0.662
LIG_FHA_1	303	309	PF00498	0.478
LIG_FHA_1	374	380	PF00498	0.477
LIG_FHA_1	410	416	PF00498	0.362
LIG_FHA_1	49	55	PF00498	0.720
LIG_FHA_2	10	16	PF00498	0.718
LIG_LIR_Apic_2	149	155	PF02991	0.638
LIG_LIR_Gen_1	330	336	PF02991	0.422
LIG_LIR_Nem_3	187	192	PF02991	0.431
LIG_LIR_Nem_3	330	335	PF02991	0.432
LIG_LIR_Nem_3	394	398	PF02991	0.371
LIG_LIR_Nem_3	425	431	PF02991	0.479
LIG_LIR_Nem_3	440	446	PF02991	0.462
LIG_PCNA_TLS_4	404	413	PF02747	0.494
LIG_PCNA_yPIPBox_3	283	292	PF02747	0.473
LIG_PCNA_yPIPBox_3	68	82	PF02747	0.701
LIG_Pex14_1	427	431	PF04695	0.392
LIG_Pex14_2	173	177	PF04695	0.499
LIG_Pex14_2	439	443	PF04695	0.516
LIG_Pex14_2	453	457	PF04695	0.306
LIG_SH2_CRK	212	216	PF00017	0.353
LIG_SH2_PTP2	192	195	PF00017	0.505
LIG_SH2_SRC	192	195	PF00017	0.583
LIG_SH2_STAP1	242	246	PF00017	0.539
LIG_SH2_STAP1	424	428	PF00017	0.404
LIG_SH2_STAT3	318	321	PF00017	0.525
LIG_SH2_STAT5	124	127	PF00017	0.542
LIG_SH2_STAT5	192	195	PF00017	0.521
LIG_SH2_STAT5	242	245	PF00017	0.456
LIG_SH2_STAT5	297	300	PF00017	0.469
LIG_SH2_STAT5	395	398	PF00017	0.473
LIG_SH2_STAT5	424	427	PF00017	0.500
LIG_SH2_STAT5	472	475	PF00017	0.388
LIG_SH3_2	3	8	PF14604	0.597
LIG_SH3_3	169	175	PF00018	0.536
LIG_SH3_3	191	197	PF00018	0.585
LIG_SH3_3	245	251	PF00018	0.633
LIG_SH3_3	443	449	PF00018	0.522
LIG_SUMO_SIM_par_1	297	305	PF11976	0.440
LIG_TRAF2_1	354	357	PF00917	0.582
LIG_TYR_ITIM	210	215	PF00017	0.348
LIG_UBA3_1	366	374	PF00899	0.477
LIG_WRC_WIRS_1	407	412	PF05994	0.444
MOD_CDK_SPxK_1	2	8	PF00069	0.600
MOD_CDK_SPxxK_3	484	491	PF00069	0.386
MOD_CK1_1	137	143	PF00069	0.612
MOD_CK1_1	14	20	PF00069	0.497
MOD_CK1_1	269	275	PF00069	0.504
MOD_CK1_1	341	347	PF00069	0.686
MOD_CK1_1	80	86	PF00069	0.662
MOD_CK2_1	214	220	PF00069	0.493
MOD_CK2_1	350	356	PF00069	0.415
MOD_CK2_1	56	62	PF00069	0.644
MOD_GlcNHglycan	136	139	PF01048	0.609
MOD_GlcNHglycan	268	271	PF01048	0.732
MOD_GlcNHglycan	293	296	PF01048	0.486
MOD_GlcNHglycan	39	42	PF01048	0.522
MOD_GlcNHglycan	457	460	PF01048	0.504
MOD_GlcNHglycan	83	86	PF01048	0.691
MOD_GlcNHglycan	99	102	PF01048	0.514
MOD_GSK3_1	11	18	PF00069	0.790
MOD_GSK3_1	124	131	PF00069	0.474
MOD_GSK3_1	132	139	PF00069	0.611
MOD_GSK3_1	214	221	PF00069	0.485
MOD_GSK3_1	269	276	PF00069	0.544
MOD_GSK3_1	304	311	PF00069	0.389
MOD_GSK3_1	337	344	PF00069	0.601
MOD_GSK3_1	35	42	PF00069	0.609
MOD_GSK3_1	77	84	PF00069	0.711
MOD_NEK2_1	198	203	PF00069	0.489
MOD_NEK2_1	345	350	PF00069	0.583
MOD_NEK2_1	39	44	PF00069	0.593
MOD_NEK2_1	489	494	PF00069	0.710
MOD_NEK2_1	92	97	PF00069	0.598
MOD_NEK2_2	275	280	PF00069	0.577
MOD_PKA_1	323	329	PF00069	0.572
MOD_PKA_1	455	461	PF00069	0.450
MOD_PKA_2	167	173	PF00069	0.613
MOD_PKA_2	240	246	PF00069	0.511
MOD_PKA_2	323	329	PF00069	0.581
MOD_PKA_2	341	347	PF00069	0.378
MOD_PKA_2	455	461	PF00069	0.448
MOD_PKA_2	97	103	PF00069	0.553
MOD_Plk_1	393	399	PF00069	0.354
MOD_Plk_4	111	117	PF00069	0.438
MOD_Plk_4	167	173	PF00069	0.531
MOD_Plk_4	275	281	PF00069	0.659
MOD_Plk_4	304	310	PF00069	0.373
MOD_Plk_4	323	329	PF00069	0.414
MOD_Plk_4	393	399	PF00069	0.399
MOD_Plk_4	406	412	PF00069	0.266
MOD_Plk_4	422	428	PF00069	0.383
MOD_Plk_4	49	55	PF00069	0.640
MOD_Plk_4	77	83	PF00069	0.712
MOD_Plk_4	92	98	PF00069	0.466
MOD_ProDKin_1	2	8	PF00069	0.678
MOD_ProDKin_1	247	253	PF00069	0.681
MOD_ProDKin_1	350	356	PF00069	0.538
MOD_ProDKin_1	484	490	PF00069	0.380
MOD_SUMO_for_1	7	10	PF00179	0.623
MOD_SUMO_rev_2	40	50	PF00179	0.711
TRG_DiLeu_BaEn_1	67	72	PF01217	0.756
TRG_DiLeu_BaLyEn_6	362	367	PF01217	0.540
TRG_ENDOCYTIC_2	212	215	PF00928	0.350
TRG_ENDOCYTIC_2	428	431	PF00928	0.379
TRG_ER_diArg_1	288	290	PF00400	0.407
TRG_ER_diArg_1	454	456	PF00400	0.469
TRG_Pf-PMV_PEXEL_1	365	370	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBI6	Leptomonas seymouri	47%	99%
A0A1X0P1I4	Trypanosomatidae	34%	100%
A0A1X0P1L0	Trypanosomatidae	34%	100%
A0A3R7NR23	Trypanosoma rangeli	33%	100%
A0A3S5H7N5	Leishmania donovani	88%	100%
A4HIJ0	Leishmania braziliensis	73%	99%
A4I5T4	Leishmania infantum	88%	100%
C9ZR56	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4Q736	Leishmania major	89%	100%
V5DNZ0	Trypanosoma cruzi	33%	100%