Reticulon-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

reticulon domain protein, 22 kDa potentially aggravating protein (paple22)

Species:

Leishmania mexicana

UniProt:

E9B128_LEIMU

TriTrypDb:

LmxM.29.2580

Length:

197

Annotations

LeishMANIAdb annotations

Similar to reticulons (structural ER membrane proteins) of multicellular animals.. The toplology is difficult to assess, likely owing to the fact that these proteins are curvature-inducing. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	11
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B128

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B128

Function

Biological processes
Term	Name	Level	Count
GO:0009605	response to external stimulus	2	10
GO:0009607	response to biotic stimulus	2	10
GO:0009617	response to bacterium	3	10
GO:0043207	response to external biotic stimulus	3	10
GO:0044419	biological process involved in interspecies interaction between organisms	1	10
GO:0050896	response to stimulus	1	10
GO:0051707	response to other organism	2	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	193	195	PF00675	0.458
CLV_PCSK_KEX2_1	68	70	PF00082	0.355
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.351
CLV_PCSK_SKI1_1	6	10	PF00082	0.468
DEG_MDM2_SWIB_1	32	40	PF02201	0.296
DOC_PP4_FxxP_1	143	146	PF00568	0.273
DOC_USP7_MATH_1	22	26	PF00917	0.527
DOC_USP7_MATH_1	85	89	PF00917	0.530
DOC_WW_Pin1_4	71	76	PF00397	0.532
LIG_14-3-3_CanoR_1	21	31	PF00244	0.406
LIG_14-3-3_CanoR_1	69	75	PF00244	0.514
LIG_APCC_ABBA_1	38	43	PF00400	0.341
LIG_BIR_II_1	1	5	PF00653	0.607
LIG_BRCT_BRCA1_1	111	115	PF00533	0.386
LIG_BRCT_BRCA1_1	25	29	PF00533	0.400
LIG_EH1_1	114	122	PF00400	0.386
LIG_FHA_1	131	137	PF00498	0.258
LIG_FHA_1	142	148	PF00498	0.236
LIG_FHA_1	45	51	PF00498	0.384
LIG_FHA_1	92	98	PF00498	0.536
LIG_FHA_2	10	16	PF00498	0.571
LIG_FHA_2	103	109	PF00498	0.485
LIG_FHA_2	174	180	PF00498	0.591
LIG_FHA_2	71	77	PF00498	0.429
LIG_LIR_Apic_2	18	22	PF02991	0.519
LIG_LIR_Gen_1	26	37	PF02991	0.379
LIG_LIR_Gen_1	83	93	PF02991	0.543
LIG_LIR_Nem_3	105	109	PF02991	0.488
LIG_LIR_Nem_3	26	32	PF02991	0.374
LIG_LIR_Nem_3	34	39	PF02991	0.297
LIG_LIR_Nem_3	7	11	PF02991	0.604
LIG_LIR_Nem_3	83	89	PF02991	0.512
LIG_Pex14_2	124	128	PF04695	0.377
LIG_Pex14_2	29	33	PF04695	0.350
LIG_SH2_STAT5	109	112	PF00017	0.469
LIG_SH2_STAT5	166	169	PF00017	0.592
LIG_SH2_STAT5	44	47	PF00017	0.270
LIG_SH3_3	69	75	PF00018	0.525
LIG_SUMO_SIM_anti_2	100	105	PF11976	0.556
LIG_SUMO_SIM_anti_2	130	138	PF11976	0.323
LIG_SUMO_SIM_anti_2	55	60	PF11976	0.341
LIG_SUMO_SIM_par_1	98	105	PF11976	0.524
LIG_WRC_WIRS_1	46	51	PF05994	0.232
MOD_CK1_1	102	108	PF00069	0.448
MOD_CK1_1	130	136	PF00069	0.294
MOD_CK2_1	173	179	PF00069	0.587
MOD_GlcNHglycan	1	4	PF01048	0.404
MOD_GlcNHglycan	111	114	PF01048	0.292
MOD_GSK3_1	44	51	PF00069	0.261
MOD_GSK3_1	67	74	PF00069	0.523
MOD_NEK2_1	116	121	PF00069	0.334
MOD_NEK2_1	129	134	PF00069	0.269
MOD_NEK2_1	173	178	PF00069	0.628
MOD_NEK2_1	31	36	PF00069	0.266
MOD_NEK2_2	85	90	PF00069	0.454
MOD_PK_1	181	187	PF00069	0.585
MOD_PK_1	52	58	PF00069	0.341
MOD_PKA_1	181	187	PF00069	0.617
MOD_Plk_1	130	136	PF00069	0.294
MOD_Plk_1	42	48	PF00069	0.316
MOD_Plk_1	97	103	PF00069	0.544
MOD_Plk_4	116	122	PF00069	0.285
MOD_Plk_4	130	136	PF00069	0.229
MOD_Plk_4	23	29	PF00069	0.436
MOD_Plk_4	45	51	PF00069	0.347
MOD_Plk_4	52	58	PF00069	0.354
MOD_ProDKin_1	71	77	PF00069	0.532
MOD_SUMO_rev_2	190	196	PF00179	0.604
TRG_ENDOCYTIC_2	86	89	PF00928	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P527	Leptomonas seymouri	54%	100%
A0A0S4JFE7	Bodo saltans	28%	100%
A0A1X0P1J2	Trypanosomatidae	36%	100%
A0A3Q8IFS1	Leishmania donovani	88%	100%
A0A3R7L2P9	Trypanosoma rangeli	33%	100%
A4HII9	Leishmania braziliensis	74%	100%
C9ZR54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4Q737	Leishmania major	85%	100%
Q9NJS2	Leishmania infantum	88%	100%