ADF-H domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B127_LEIMU

TriTrypDb:

LmxM.29.2570

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0030863	cortical cytoskeleton	6	1
GO:0030864	cortical actin cytoskeleton	7	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B127

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B127

Function

Biological processes
Term	Name	Level	Count
GO:0008064	regulation of actin polymerization or depolymerization	6	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0030832	regulation of actin filament length	5	1
GO:0030833	regulation of actin filament polymerization	7	1
GO:0032271	regulation of protein polymerization	6	1
GO:0032535	regulation of cellular component size	4	1
GO:0032956	regulation of actin cytoskeleton organization	5	1
GO:0032970	regulation of actin filament-based process	4	1
GO:0033043	regulation of organelle organization	5	1
GO:0043254	regulation of protein-containing complex assembly	5	1
GO:0044087	regulation of cellular component biogenesis	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051493	regulation of cytoskeleton organization	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090066	regulation of anatomical structure size	3	1
GO:0110053	regulation of actin filament organization	6	1
GO:1902903	regulation of supramolecular fiber organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	10
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0008092	cytoskeletal protein binding	3	10
GO:0044877	protein-containing complex binding	2	1
GO:0051015	actin filament binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.458
CLV_NRD_NRD_1	147	149	PF00675	0.686
CLV_NRD_NRD_1	246	248	PF00675	0.339
CLV_NRD_NRD_1	310	312	PF00675	0.691
CLV_PCSK_FUR_1	145	149	PF00082	0.674
CLV_PCSK_KEX2_1	144	146	PF00082	0.653
CLV_PCSK_KEX2_1	147	149	PF00082	0.687
CLV_PCSK_KEX2_1	246	248	PF00082	0.339
CLV_PCSK_KEX2_1	41	43	PF00082	0.491
CLV_PCSK_KEX2_1	59	61	PF00082	0.396
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.637
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.519
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.364
CLV_PCSK_SKI1_1	121	125	PF00082	0.420
CLV_PCSK_SKI1_1	183	187	PF00082	0.473
CLV_PCSK_SKI1_1	247	251	PF00082	0.351
CLV_PCSK_SKI1_1	302	306	PF00082	0.461
DEG_Kelch_Keap1_1	237	242	PF01344	0.550
DEG_SCF_TRCP1_1	105	110	PF00400	0.602
DOC_CYCLIN_yCln2_LP_2	355	361	PF00134	0.701
DOC_MAPK_gen_1	167	177	PF00069	0.667
DOC_MAPK_gen_1	350	359	PF00069	0.716
DOC_MAPK_gen_1	41	48	PF00069	0.423
DOC_MAPK_MEF2A_6	147	156	PF00069	0.714
DOC_MAPK_MEF2A_6	170	179	PF00069	0.529
DOC_MAPK_RevD_3	231	247	PF00069	0.579
DOC_PP1_RVXF_1	233	239	PF00149	0.536
DOC_PP1_RVXF_1	245	252	PF00149	0.465
DOC_PP2B_LxvP_1	355	358	PF13499	0.705
DOC_USP7_MATH_1	34	38	PF00917	0.513
DOC_USP7_MATH_1	381	385	PF00917	0.662
DOC_USP7_MATH_1	53	57	PF00917	0.312
DOC_WW_Pin1_4	170	175	PF00397	0.751
DOC_WW_Pin1_4	275	280	PF00397	0.579
DOC_WW_Pin1_4	376	381	PF00397	0.691
LIG_14-3-3_CanoR_1	121	129	PF00244	0.341
LIG_14-3-3_CanoR_1	147	152	PF00244	0.692
LIG_14-3-3_CanoR_1	183	189	PF00244	0.484
LIG_14-3-3_CanoR_1	235	239	PF00244	0.490
LIG_14-3-3_CanoR_1	306	313	PF00244	0.624
LIG_14-3-3_CanoR_1	332	336	PF00244	0.594
LIG_14-3-3_CanoR_1	348	358	PF00244	0.588
LIG_APCC_ABBA_1	127	132	PF00400	0.571
LIG_BRCT_BRCA1_1	105	109	PF00533	0.579
LIG_BRCT_BRCA1_1	322	326	PF00533	0.577
LIG_BRCT_BRCA1_1	36	40	PF00533	0.568
LIG_BRCT_BRCA1_1	87	91	PF00533	0.513
LIG_deltaCOP1_diTrp_1	226	234	PF00928	0.530
LIG_FHA_1	179	185	PF00498	0.486
LIG_FHA_1	350	356	PF00498	0.733
LIG_FHA_1	388	394	PF00498	0.449
LIG_FHA_1	70	76	PF00498	0.604
LIG_FHA_2	305	311	PF00498	0.629
LIG_GBD_Chelix_1	401	409	PF00786	0.443
LIG_LIR_Gen_1	88	98	PF02991	0.544
LIG_LIR_Nem_3	228	234	PF02991	0.531
LIG_LIR_Nem_3	88	94	PF02991	0.539
LIG_LYPXL_S_1	269	273	PF13949	0.361
LIG_LYPXL_yS_3	270	273	PF13949	0.561
LIG_PDZ_Class_3	404	409	PF00595	0.448
LIG_Pex14_2	234	238	PF04695	0.561
LIG_SH2_PTP2	50	53	PF00017	0.504
LIG_SH2_STAP1	282	286	PF00017	0.510
LIG_SH2_STAT5	285	288	PF00017	0.490
LIG_SH2_STAT5	47	50	PF00017	0.436
LIG_SH3_3	157	163	PF00018	0.740
LIG_SH3_3	168	174	PF00018	0.779
LIG_SH3_3	355	361	PF00018	0.743
LIG_SUMO_SIM_anti_2	201	208	PF11976	0.384
LIG_SUMO_SIM_anti_2	388	395	PF11976	0.502
LIG_SUMO_SIM_par_1	172	178	PF11976	0.694
LIG_TRAF2_1	166	169	PF00917	0.657
LIG_TRAF2_1	225	228	PF00917	0.574
LIG_TRAF2_1	344	347	PF00917	0.589
LIG_TRAF2_1	386	389	PF00917	0.608
MOD_CK1_1	178	184	PF00069	0.561
MOD_CK1_1	370	376	PF00069	0.695
MOD_CK1_1	90	96	PF00069	0.427
MOD_CK2_1	170	176	PF00069	0.712
MOD_CK2_1	199	205	PF00069	0.590
MOD_CK2_1	236	242	PF00069	0.550
MOD_CK2_1	331	337	PF00069	0.529
MOD_CK2_1	383	389	PF00069	0.563
MOD_Cter_Amidation	145	148	PF01082	0.655
MOD_DYRK1A_RPxSP_1	170	174	PF00069	0.770
MOD_GlcNHglycan	105	108	PF01048	0.624
MOD_GlcNHglycan	302	305	PF01048	0.567
MOD_GlcNHglycan	307	310	PF01048	0.639
MOD_GlcNHglycan	36	39	PF01048	0.589
MOD_GlcNHglycan	367	370	PF01048	0.748
MOD_GSK3_1	103	110	PF00069	0.559
MOD_GSK3_1	300	307	PF00069	0.567
MOD_GSK3_1	320	327	PF00069	0.581
MOD_GSK3_1	349	356	PF00069	0.726
MOD_GSK3_1	361	368	PF00069	0.625
MOD_GSK3_1	383	390	PF00069	0.503
MOD_GSK3_1	65	72	PF00069	0.536
MOD_GSK3_1	81	88	PF00069	0.517
MOD_N-GLC_1	107	112	PF02516	0.542
MOD_N-GLC_1	68	73	PF02516	0.552
MOD_N-GLC_2	74	76	PF02516	0.412
MOD_NEK2_1	234	239	PF00069	0.472
MOD_NEK2_1	28	33	PF00069	0.438
MOD_NEK2_1	320	325	PF00069	0.596
MOD_NEK2_1	371	376	PF00069	0.704
MOD_NEK2_1	98	103	PF00069	0.588
MOD_NEK2_2	36	41	PF00069	0.518
MOD_PKA_1	147	153	PF00069	0.706
MOD_PKA_2	147	153	PF00069	0.672
MOD_PKA_2	169	175	PF00069	0.756
MOD_PKA_2	234	240	PF00069	0.472
MOD_PKA_2	305	311	PF00069	0.379
MOD_PKA_2	331	337	PF00069	0.588
MOD_PKA_2	353	359	PF00069	0.754
MOD_PKA_2	8	14	PF00069	0.440
MOD_PKA_2	98	104	PF00069	0.621
MOD_PKB_1	119	127	PF00069	0.341
MOD_PKB_1	145	153	PF00069	0.694
MOD_Plk_1	107	113	PF00069	0.541
MOD_Plk_1	175	181	PF00069	0.588
MOD_Plk_1	321	327	PF00069	0.588
MOD_Plk_1	387	393	PF00069	0.501
MOD_Plk_4	321	327	PF00069	0.539
MOD_Plk_4	331	337	PF00069	0.585
MOD_Plk_4	53	59	PF00069	0.579
MOD_Plk_4	90	96	PF00069	0.491
MOD_Plk_4	98	104	PF00069	0.570
MOD_ProDKin_1	170	176	PF00069	0.742
MOD_ProDKin_1	275	281	PF00069	0.579
MOD_ProDKin_1	376	382	PF00069	0.686
MOD_SUMO_for_1	166	169	PF00179	0.734
MOD_SUMO_rev_2	19	26	PF00179	0.483
MOD_SUMO_rev_2	308	313	PF00179	0.418
TRG_DiLeu_BaEn_1	389	394	PF01217	0.435
TRG_ENDOCYTIC_2	270	273	PF00928	0.536
TRG_ENDOCYTIC_2	30	33	PF00928	0.404
TRG_ER_diArg_1	145	148	PF00400	0.670
TRG_ER_diArg_1	246	248	PF00400	0.546
TRG_NES_CRM1_1	92	105	PF08389	0.540
TRG_NLS_MonoExtC_3	143	148	PF00514	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5G8	Leptomonas seymouri	66%	100%
A0A1X0P342	Trypanosomatidae	39%	100%
A0A3Q8IFZ1	Leishmania donovani	93%	100%
A4HII8	Leishmania braziliensis	83%	100%
A4I5T2	Leishmania infantum	94%	100%
C9ZR53	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	91%
Q4Q738	Leishmania major	92%	100%
V5BMX2	Trypanosoma cruzi	41%	100%