AAA family ATPase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AAA family ATPase-like protein

Species:

Leishmania mexicana

UniProt:

E9B124_LEIMU

TriTrypDb:

LmxM.29.2540

Length:

786

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9B124

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B124

Function

Biological processes
Term	Name	Level	Count
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0022613	ribonucleoprotein complex biogenesis	4	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0042254	ribosome biogenesis	5	1
GO:0043085	positive regulation of catalytic activity	4	1
GO:0044085	cellular component biogenesis	3	1
GO:0044093	positive regulation of molecular function	3	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051052	regulation of DNA metabolic process	5	1
GO:0051054	positive regulation of DNA metabolic process	6	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051338	regulation of transferase activity	4	1
GO:0051347	positive regulation of transferase activity	5	1
GO:0051972	regulation of telomerase activity	5	1
GO:0051973	positive regulation of telomerase activity	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:2000278	regulation of DNA biosynthetic process	6	1
GO:2000573	positive regulation of DNA biosynthetic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003824	catalytic activity	1	16
GO:0005488	binding	1	16
GO:0005524	ATP binding	5	16
GO:0016462	pyrophosphatase activity	5	16
GO:0016787	hydrolase activity	2	16
GO:0016817	hydrolase activity, acting on acid anhydrides	3	16
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	16
GO:0016887	ATP hydrolysis activity	7	16
GO:0017076	purine nucleotide binding	4	16
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0044877	protein-containing complex binding	2	1
GO:1990275	preribosome binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.608
CLV_C14_Caspase3-7	617	621	PF00656	0.324
CLV_C14_Caspase3-7	641	645	PF00656	0.324
CLV_C14_Caspase3-7	667	671	PF00656	0.397
CLV_C14_Caspase3-7	717	721	PF00656	0.422
CLV_NRD_NRD_1	157	159	PF00675	0.431
CLV_NRD_NRD_1	301	303	PF00675	0.548
CLV_NRD_NRD_1	382	384	PF00675	0.524
CLV_NRD_NRD_1	681	683	PF00675	0.248
CLV_NRD_NRD_1	778	780	PF00675	0.422
CLV_PCSK_KEX2_1	157	159	PF00082	0.406
CLV_PCSK_KEX2_1	301	303	PF00082	0.548
CLV_PCSK_KEX2_1	382	384	PF00082	0.444
CLV_PCSK_KEX2_1	504	506	PF00082	0.573
CLV_PCSK_KEX2_1	681	683	PF00082	0.308
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.573
CLV_PCSK_SKI1_1	121	125	PF00082	0.579
CLV_PCSK_SKI1_1	174	178	PF00082	0.439
CLV_PCSK_SKI1_1	179	183	PF00082	0.385
CLV_PCSK_SKI1_1	552	556	PF00082	0.310
CLV_PCSK_SKI1_1	564	568	PF00082	0.194
CLV_PCSK_SKI1_1	600	604	PF00082	0.309
CLV_PCSK_SKI1_1	654	658	PF00082	0.392
CLV_PCSK_SKI1_1	88	92	PF00082	0.458
DEG_APCC_DBOX_1	178	186	PF00400	0.411
DEG_APCC_DBOX_1	428	436	PF00400	0.462
DEG_SCF_TRCP1_1	249	254	PF00400	0.471
DOC_CDC14_PxL_1	684	692	PF14671	0.472
DOC_CYCLIN_yClb1_LxF_4	654	660	PF00134	0.369
DOC_MAPK_DCC_7	23	32	PF00069	0.417
DOC_MAPK_gen_1	23	32	PF00069	0.539
DOC_MAPK_gen_1	301	311	PF00069	0.408
DOC_MAPK_gen_1	382	388	PF00069	0.379
DOC_MAPK_gen_1	504	510	PF00069	0.543
DOC_MAPK_gen_1	653	660	PF00069	0.392
DOC_MAPK_gen_1	675	685	PF00069	0.324
DOC_MAPK_MEF2A_6	163	171	PF00069	0.492
DOC_MAPK_MEF2A_6	25	34	PF00069	0.521
DOC_MAPK_MEF2A_6	607	615	PF00069	0.324
DOC_MAPK_MEF2A_6	678	687	PF00069	0.324
DOC_PP1_RVXF_1	302	309	PF00149	0.509
DOC_PP1_RVXF_1	765	772	PF00149	0.386
DOC_PP2B_LxvP_1	415	418	PF13499	0.504
DOC_PP2B_LxvP_1	548	551	PF13499	0.358
DOC_SPAK_OSR1_1	505	509	PF12202	0.543
DOC_USP7_MATH_1	200	204	PF00917	0.715
DOC_USP7_MATH_1	21	25	PF00917	0.640
DOC_USP7_MATH_1	335	339	PF00917	0.463
DOC_USP7_MATH_1	444	448	PF00917	0.453
DOC_USP7_MATH_1	480	484	PF00917	0.408
DOC_USP7_MATH_1	560	564	PF00917	0.290
DOC_USP7_MATH_1	572	576	PF00917	0.373
DOC_USP7_MATH_1	743	747	PF00917	0.302
DOC_USP7_MATH_1	8	12	PF00917	0.650
DOC_USP7_MATH_1	83	87	PF00917	0.513
DOC_WW_Pin1_4	195	200	PF00397	0.610
DOC_WW_Pin1_4	224	229	PF00397	0.757
DOC_WW_Pin1_4	234	239	PF00397	0.719
DOC_WW_Pin1_4	546	551	PF00397	0.394
DOC_WW_Pin1_4	607	612	PF00397	0.392
LIG_14-3-3_CanoR_1	121	126	PF00244	0.395
LIG_14-3-3_CanoR_1	157	161	PF00244	0.424
LIG_14-3-3_CanoR_1	170	176	PF00244	0.303
LIG_14-3-3_CanoR_1	234	238	PF00244	0.551
LIG_14-3-3_CanoR_1	276	282	PF00244	0.449
LIG_14-3-3_CanoR_1	334	340	PF00244	0.520
LIG_14-3-3_CanoR_1	362	368	PF00244	0.402
LIG_14-3-3_CanoR_1	387	393	PF00244	0.346
LIG_14-3-3_CanoR_1	481	486	PF00244	0.395
LIG_14-3-3_CanoR_1	499	504	PF00244	0.494
LIG_14-3-3_CanoR_1	628	636	PF00244	0.285
LIG_14-3-3_CanoR_1	693	701	PF00244	0.432
LIG_14-3-3_CanoR_1	779	786	PF00244	0.556
LIG_BIR_II_1	1	5	PF00653	0.422
LIG_BRCT_BRCA1_1	539	543	PF00533	0.425
LIG_deltaCOP1_diTrp_1	151	156	PF00928	0.520
LIG_deltaCOP1_diTrp_1	533	541	PF00928	0.495
LIG_deltaCOP1_diTrp_1	768	775	PF00928	0.380
LIG_FHA_1	137	143	PF00498	0.520
LIG_FHA_1	170	176	PF00498	0.527
LIG_FHA_1	258	264	PF00498	0.464
LIG_FHA_1	301	307	PF00498	0.487
LIG_FHA_1	470	476	PF00498	0.395
LIG_FHA_2	460	466	PF00498	0.344
LIG_FHA_2	485	491	PF00498	0.551
LIG_FHA_2	512	518	PF00498	0.377
LIG_FHA_2	525	531	PF00498	0.305
LIG_FHA_2	639	645	PF00498	0.324
LIG_FHA_2	687	693	PF00498	0.559
LIG_FHA_2	721	727	PF00498	0.331
LIG_FHA_2	747	753	PF00498	0.278
LIG_Integrin_RGD_1	14	16	PF01839	0.454
LIG_LIR_Gen_1	149	160	PF02991	0.453
LIG_LIR_Gen_1	307	315	PF02991	0.430
LIG_LIR_Gen_1	514	522	PF02991	0.418
LIG_LIR_Gen_1	540	551	PF02991	0.474
LIG_LIR_Gen_1	698	708	PF02991	0.367
LIG_LIR_Gen_1	733	743	PF02991	0.260
LIG_LIR_LC3C_4	260	263	PF02991	0.450
LIG_LIR_Nem_3	149	155	PF02991	0.469
LIG_LIR_Nem_3	253	258	PF02991	0.575
LIG_LIR_Nem_3	307	311	PF02991	0.407
LIG_LIR_Nem_3	514	518	PF02991	0.397
LIG_LIR_Nem_3	540	546	PF02991	0.435
LIG_LIR_Nem_3	67	72	PF02991	0.512
LIG_LIR_Nem_3	698	704	PF02991	0.342
LIG_LIR_Nem_3	733	739	PF02991	0.260
LIG_MYND_1	109	113	PF01753	0.440
LIG_PCNA_yPIPBox_3	457	470	PF02747	0.379
LIG_Pex14_1	152	156	PF04695	0.513
LIG_SH2_CRK	557	561	PF00017	0.324
LIG_SH2_CRK	73	77	PF00017	0.410
LIG_SH2_PTP2	166	169	PF00017	0.510
LIG_SH2_PTP2	684	687	PF00017	0.324
LIG_SH2_STAT5	166	169	PF00017	0.461
LIG_SH2_STAT5	305	308	PF00017	0.401
LIG_SH2_STAT5	684	687	PF00017	0.324
LIG_SH2_STAT5	714	717	PF00017	0.260
LIG_SH2_STAT5	722	725	PF00017	0.260
LIG_SH3_2	688	693	PF14604	0.370
LIG_SH3_3	107	113	PF00018	0.395
LIG_SH3_3	505	511	PF00018	0.411
LIG_SH3_3	579	585	PF00018	0.260
LIG_SH3_3	670	676	PF00018	0.290
LIG_SH3_3	682	688	PF00018	0.373
LIG_SUMO_SIM_anti_2	726	733	PF11976	0.260
LIG_SUMO_SIM_par_1	183	188	PF11976	0.507
LIG_SUMO_SIM_par_1	259	266	PF11976	0.330
LIG_SUMO_SIM_par_1	375	381	PF11976	0.518
LIG_SUMO_SIM_par_1	411	416	PF11976	0.432
LIG_SUMO_SIM_par_1	447	456	PF11976	0.483
LIG_SUMO_SIM_par_1	98	104	PF11976	0.532
LIG_TRAF2_1	420	423	PF00917	0.283
LIG_TRFH_1	546	550	PF08558	0.360
LIG_TYR_ITIM	164	169	PF00017	0.491
LIG_TYR_ITSM	65	72	PF00017	0.529
MOD_CDK_SPxK_1	546	552	PF00069	0.417
MOD_CK1_1	145	151	PF00069	0.617
MOD_CK1_1	250	256	PF00069	0.544
MOD_CK1_1	320	326	PF00069	0.469
MOD_CK1_1	354	360	PF00069	0.501
MOD_CK1_1	391	397	PF00069	0.328
MOD_CK1_1	400	406	PF00069	0.369
MOD_CK1_1	411	417	PF00069	0.336
MOD_CK1_1	746	752	PF00069	0.407
MOD_CK2_1	145	151	PF00069	0.620
MOD_CK2_1	417	423	PF00069	0.414
MOD_CK2_1	435	441	PF00069	0.388
MOD_CK2_1	686	692	PF00069	0.475
MOD_CK2_1	720	726	PF00069	0.266
MOD_DYRK1A_RPxSP_1	234	238	PF00069	0.551
MOD_DYRK1A_RPxSP_1	607	611	PF00069	0.392
MOD_GlcNHglycan	10	13	PF01048	0.576
MOD_GlcNHglycan	202	205	PF01048	0.407
MOD_GlcNHglycan	220	223	PF01048	0.645
MOD_GlcNHglycan	228	231	PF01048	0.691
MOD_GlcNHglycan	249	252	PF01048	0.638
MOD_GlcNHglycan	295	298	PF01048	0.517
MOD_GlcNHglycan	337	340	PF01048	0.524
MOD_GlcNHglycan	357	360	PF01048	0.330
MOD_GlcNHglycan	390	393	PF01048	0.318
MOD_GlcNHglycan	4	7	PF01048	0.506
MOD_GlcNHglycan	403	406	PF01048	0.390
MOD_GlcNHglycan	419	422	PF01048	0.394
MOD_GlcNHglycan	437	440	PF01048	0.390
MOD_GlcNHglycan	520	523	PF01048	0.455
MOD_GlcNHglycan	81	84	PF01048	0.662
MOD_GSK3_1	142	149	PF00069	0.496
MOD_GSK3_1	247	254	PF00069	0.667
MOD_GSK3_1	293	300	PF00069	0.687
MOD_GSK3_1	317	324	PF00069	0.438
MOD_GSK3_1	335	342	PF00069	0.380
MOD_GSK3_1	351	358	PF00069	0.309
MOD_GSK3_1	397	404	PF00069	0.272
MOD_GSK3_1	480	487	PF00069	0.522
MOD_GSK3_1	634	641	PF00069	0.270
MOD_GSK3_1	716	723	PF00069	0.260
MOD_GSK3_1	79	86	PF00069	0.444
MOD_LATS_1	777	783	PF00433	0.492
MOD_N-GLC_1	511	516	PF02516	0.449
MOD_N-GLC_1	546	551	PF02516	0.509
MOD_N-GLC_1	572	577	PF02516	0.324
MOD_NEK2_1	156	161	PF00069	0.572
MOD_NEK2_1	169	174	PF00069	0.334
MOD_NEK2_1	218	223	PF00069	0.586
MOD_NEK2_1	293	298	PF00069	0.504
MOD_NEK2_1	408	413	PF00069	0.506
MOD_NEK2_1	435	440	PF00069	0.537
MOD_NEK2_1	46	51	PF00069	0.550
MOD_NEK2_1	469	474	PF00069	0.357
MOD_NEK2_1	506	511	PF00069	0.395
MOD_NEK2_1	79	84	PF00069	0.428
MOD_OFUCOSY	431	437	PF10250	0.373
MOD_PIKK_1	169	175	PF00454	0.447
MOD_PIKK_1	459	465	PF00454	0.361
MOD_PIKK_1	634	640	PF00454	0.260
MOD_PKA_1	779	785	PF00069	0.684
MOD_PKA_2	156	162	PF00069	0.421
MOD_PKA_2	169	175	PF00069	0.275
MOD_PKA_2	233	239	PF00069	0.750
MOD_PKA_2	300	306	PF00069	0.380
MOD_PKA_2	335	341	PF00069	0.501
MOD_PKA_2	480	486	PF00069	0.501
MOD_PKA_2	498	504	PF00069	0.298
MOD_PKA_2	778	784	PF00069	0.590
MOD_PKA_2	79	85	PF00069	0.601
MOD_Plk_1	100	106	PF00069	0.473
MOD_Plk_1	185	191	PF00069	0.537
MOD_Plk_1	506	512	PF00069	0.482
MOD_Plk_1	572	578	PF00069	0.392
MOD_Plk_4	257	263	PF00069	0.426
MOD_Plk_4	339	345	PF00069	0.506
MOD_Plk_4	363	369	PF00069	0.420
MOD_Plk_4	403	409	PF00069	0.443
MOD_Plk_4	537	543	PF00069	0.472
MOD_Plk_4	562	568	PF00069	0.324
MOD_ProDKin_1	195	201	PF00069	0.608
MOD_ProDKin_1	224	230	PF00069	0.759
MOD_ProDKin_1	234	240	PF00069	0.716
MOD_ProDKin_1	546	552	PF00069	0.393
MOD_ProDKin_1	607	613	PF00069	0.392
MOD_SUMO_rev_2	517	527	PF00179	0.398
MOD_SUMO_rev_2	651	656	PF00179	0.251
TRG_ENDOCYTIC_2	166	169	PF00928	0.379
TRG_ENDOCYTIC_2	684	687	PF00928	0.324
TRG_ENDOCYTIC_2	69	72	PF00928	0.535
TRG_ENDOCYTIC_2	73	76	PF00928	0.493
TRG_ER_diArg_1	156	158	PF00400	0.396
TRG_ER_diArg_1	301	304	PF00400	0.386
TRG_ER_diArg_1	382	384	PF00400	0.449
TRG_ER_diArg_1	681	683	PF00400	0.392
TRG_ER_diArg_1	760	763	PF00400	0.399
TRG_NLS_MonoExtC_3	757	762	PF00514	0.272
TRG_Pf-PMV_PEXEL_1	600	604	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	634	638	PF00026	0.260
TRG_PTS1	783	786	PF00515	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2H1	Leptomonas seymouri	66%	85%
A0A1X0P1J4	Trypanosomatidae	48%	100%
A0A3Q8IS46	Leishmania donovani	91%	81%
A0A3R7M308	Trypanosoma rangeli	49%	100%
A0A3S7X0L3	Leishmania donovani	32%	100%
A4HFM9	Leishmania braziliensis	33%	100%
A4HII5	Leishmania braziliensis	81%	100%
A4I2Q7	Leishmania infantum	32%	100%
A4I5S8	Leishmania infantum	91%	75%
C9ZR48	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	99%
E9AD83	Leishmania major	33%	100%
E9AZ07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q07844	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	94%
Q4Q741	Leishmania major	91%	100%
Q8RY16	Arabidopsis thaliana	31%	84%
V5AUZ1	Trypanosoma cruzi	49%	100%