Putative heat shock 70-related protein 1, mitochondrial

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock 70-related protein 1, mitochondrial precursor, putative

Species:

Leishmania mexicana

UniProt:

E9B120_LEIMU

TriTrypDb:

LmxM.29.2470

Length:

344

Annotations

LeishMANIAdb annotations

ER-associated chaperone protein

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9B120

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B120

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0005488	binding	1	3
GO:0005524	ATP binding	5	3
GO:0017076	purine nucleotide binding	4	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0044183	protein folding chaperone	1	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:0140657	ATP-dependent activity	1	3
GO:0140662	ATP-dependent protein folding chaperone	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	264	266	PF00675	0.493
CLV_NRD_NRD_1	4	6	PF00675	0.725
CLV_NRD_NRD_1	99	101	PF00675	0.510
CLV_PCSK_KEX2_1	4	6	PF00082	0.725
CLV_PCSK_KEX2_1	79	81	PF00082	0.497
CLV_PCSK_KEX2_1	94	96	PF00082	0.289
CLV_PCSK_KEX2_1	99	101	PF00082	0.210
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.497
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.289
CLV_PCSK_PC7_1	95	101	PF00082	0.493
CLV_PCSK_SKI1_1	108	112	PF00082	0.493
CLV_PCSK_SKI1_1	176	180	PF00082	0.495
CLV_PCSK_SKI1_1	276	280	PF00082	0.493
DEG_APCC_DBOX_1	275	283	PF00400	0.493
DEG_Nend_Nbox_1	1	3	PF02207	0.737
DOC_MAPK_gen_1	208	216	PF00069	0.506
DOC_MAPK_gen_1	265	272	PF00069	0.493
DOC_USP7_MATH_1	10	14	PF00917	0.732
DOC_USP7_UBL2_3	68	72	PF12436	0.493
DOC_WW_Pin1_4	133	138	PF00397	0.511
DOC_WW_Pin1_4	58	63	PF00397	0.511
LIG_14-3-3_CanoR_1	265	272	PF00244	0.502
LIG_BRCT_BRCA1_1	54	58	PF00533	0.493
LIG_CtBP_PxDLS_1	269	274	PF00389	0.493
LIG_EH1_1	90	98	PF00400	0.493
LIG_eIF4E_1	91	97	PF01652	0.493
LIG_FHA_1	221	227	PF00498	0.511
LIG_FHA_1	265	271	PF00498	0.493
LIG_FHA_1	327	333	PF00498	0.493
LIG_FHA_1	59	65	PF00498	0.493
LIG_FHA_2	239	245	PF00498	0.511
LIG_LIR_Gen_1	36	44	PF02991	0.511
LIG_LIR_Nem_3	323	328	PF02991	0.493
LIG_LIR_Nem_3	36	41	PF02991	0.511
LIG_LIR_Nem_3	88	93	PF02991	0.493
LIG_LRP6_Inhibitor_1	186	192	PF00058	0.493
LIG_PTB_Apo_2	109	116	PF02174	0.493
LIG_PTB_Phospho_1	109	115	PF10480	0.493
LIG_SH2_CRK	115	119	PF00017	0.493
LIG_SH2_CRK	38	42	PF00017	0.511
LIG_SH2_GRB2like	170	173	PF00017	0.511
LIG_SH2_NCK_1	38	42	PF00017	0.511
LIG_SH2_STAP1	38	42	PF00017	0.493
LIG_SH2_STAT5	170	173	PF00017	0.497
LIG_SH2_STAT5	259	262	PF00017	0.493
LIG_SH3_3	162	168	PF00018	0.511
LIG_SH3_3	191	197	PF00018	0.493
LIG_SH3_3	298	304	PF00018	0.493
LIG_SUMO_SIM_anti_2	225	230	PF11976	0.511
LIG_SUMO_SIM_par_1	211	218	PF11976	0.494
LIG_TYR_ITIM	113	118	PF00017	0.493
LIG_TYR_ITSM	34	41	PF00017	0.511
MOD_CK2_1	224	230	PF00069	0.493
MOD_CK2_1	292	298	PF00069	0.493
MOD_CK2_1	320	326	PF00069	0.493
MOD_Cter_Amidation	97	100	PF01082	0.511
MOD_GlcNHglycan	12	15	PF01048	0.684
MOD_GlcNHglycan	267	270	PF01048	0.493
MOD_GlcNHglycan	294	297	PF01048	0.493
MOD_GlcNHglycan	8	11	PF01048	0.720
MOD_GSK3_1	220	227	PF00069	0.511
MOD_GSK3_1	238	245	PF00069	0.228
MOD_GSK3_1	292	299	PF00069	0.493
MOD_GSK3_1	36	43	PF00069	0.462
MOD_GSK3_1	6	13	PF00069	0.703
MOD_GSK3_1	81	88	PF00069	0.493
MOD_NEK2_1	224	229	PF00069	0.511
MOD_NEK2_1	264	269	PF00069	0.493
MOD_NEK2_1	318	323	PF00069	0.493
MOD_NEK2_1	34	39	PF00069	0.511
MOD_NEK2_2	86	91	PF00069	0.511
MOD_PIKK_1	135	141	PF00454	0.493
MOD_PIKK_1	19	25	PF00454	0.705
MOD_PIKK_1	326	332	PF00454	0.457
MOD_PKA_1	265	271	PF00069	0.493
MOD_PKA_2	264	270	PF00069	0.493
MOD_Plk_1	224	230	PF00069	0.511
MOD_Plk_1	333	339	PF00069	0.493
MOD_Plk_4	209	215	PF00069	0.495
MOD_Plk_4	60	66	PF00069	0.511
MOD_Plk_4	86	92	PF00069	0.511
MOD_ProDKin_1	133	139	PF00069	0.511
MOD_ProDKin_1	58	64	PF00069	0.511
MOD_SUMO_for_1	289	292	PF00179	0.493
MOD_SUMO_rev_2	103	113	PF00179	0.493
TRG_DiLeu_BaLyEn_6	328	333	PF01217	0.493
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.511
TRG_ENDOCYTIC_2	115	118	PF00928	0.493
TRG_ENDOCYTIC_2	38	41	PF00928	0.511
TRG_ER_diArg_1	4	6	PF00400	0.725
TRG_ER_diArg_1	99	101	PF00400	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4II73	Bodo saltans	36%	100%
A0A0S4IRP7	Bodo saltans	47%	67%
A4HGY0	Leishmania braziliensis	56%	100%
Q9ZIV1	Megasphaera elsdenii	53%	76%