DnaJ domain protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain protein-like protein

Species:

Leishmania mexicana

UniProt:

E9B118_LEIMU

TriTrypDb:

LmxM.29.2450

Length:

336

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0031207	Sec62/Sec63 complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1

Expansion

Sequence features

E9B118

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B118

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006613	cotranslational protein targeting to membrane	6	1
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	1
GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	6	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045047	protein targeting to ER	6	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070972	protein localization to endoplasmic reticulum	6	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0008320	protein transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022884	macromolecule transmembrane transporter activity	3	1
GO:0140318	protein transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	151	153	PF00675	0.686
CLV_NRD_NRD_1	198	200	PF00675	0.599
CLV_NRD_NRD_1	259	261	PF00675	0.466
CLV_NRD_NRD_1	8	10	PF00675	0.751
CLV_NRD_NRD_1	97	99	PF00675	0.752
CLV_PCSK_KEX2_1	151	153	PF00082	0.686
CLV_PCSK_KEX2_1	198	200	PF00082	0.599
CLV_PCSK_KEX2_1	250	252	PF00082	0.434
CLV_PCSK_KEX2_1	261	263	PF00082	0.391
CLV_PCSK_KEX2_1	8	10	PF00082	0.751
CLV_PCSK_KEX2_1	97	99	PF00082	0.764
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.434
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.391
CLV_PCSK_SKI1_1	173	177	PF00082	0.697
CLV_PCSK_SKI1_1	198	202	PF00082	0.658
CLV_PCSK_SKI1_1	24	28	PF00082	0.534
CLV_PCSK_SKI1_1	284	288	PF00082	0.315
CLV_PCSK_SKI1_1	321	325	PF00082	0.496
CLV_PCSK_SKI1_1	62	66	PF00082	0.562
CLV_PCSK_SKI1_1	8	12	PF00082	0.754
DEG_APCC_DBOX_1	97	105	PF00400	0.453
DEG_COP1_1	306	315	PF00400	0.696
DEG_Nend_Nbox_1	1	3	PF02207	0.534
DEG_SPOP_SBC_1	127	131	PF00917	0.542
DOC_ANK_TNKS_1	150	157	PF00023	0.466
DOC_CYCLIN_RxL_1	193	206	PF00134	0.443
DOC_CYCLIN_RxL_1	5	15	PF00134	0.542
DOC_CYCLIN_RxL_1	59	67	PF00134	0.362
DOC_MAPK_gen_1	282	289	PF00069	0.669
DOC_MAPK_MEF2A_6	235	244	PF00069	0.419
DOC_MAPK_RevD_3	238	251	PF00069	0.451
DOC_PP2B_LxvP_1	73	76	PF13499	0.489
DOC_USP7_MATH_1	76	80	PF00917	0.557
DOC_USP7_UBL2_3	28	32	PF12436	0.296
DOC_USP7_UBL2_3	62	66	PF12436	0.362
DOC_WW_Pin1_4	120	125	PF00397	0.555
DOC_WW_Pin1_4	150	155	PF00397	0.417
DOC_WW_Pin1_4	311	316	PF00397	0.694
LIG_14-3-3_CanoR_1	260	269	PF00244	0.525
LIG_Actin_WH2_2	50	68	PF00022	0.296
LIG_AP2alpha_2	15	17	PF02296	0.313
LIG_DCNL_PONY_1	1	4	PF03556	0.526
LIG_EVH1_2	315	319	PF00568	0.736
LIG_FHA_1	128	134	PF00498	0.423
LIG_FHA_2	133	139	PF00498	0.479
LIG_FHA_2	25	31	PF00498	0.334
LIG_FHA_2	304	310	PF00498	0.649
LIG_LIR_Gen_1	165	176	PF02991	0.395
LIG_LIR_Gen_1	327	334	PF02991	0.726
LIG_LIR_Gen_1	67	78	PF02991	0.399
LIG_LIR_Nem_3	15	20	PF02991	0.320
LIG_LIR_Nem_3	165	171	PF02991	0.385
LIG_LIR_Nem_3	263	269	PF02991	0.537
LIG_LIR_Nem_3	317	323	PF02991	0.650
LIG_LIR_Nem_3	327	333	PF02991	0.642
LIG_LIR_Nem_3	67	73	PF02991	0.389
LIG_SH2_CRK	237	241	PF00017	0.480
LIG_SH2_CRK	320	324	PF00017	0.714
LIG_SH2_CRK	330	334	PF00017	0.743
LIG_SH2_CRK	61	65	PF00017	0.296
LIG_SH2_NCK_1	330	334	PF00017	0.743
LIG_SH2_STAP1	237	241	PF00017	0.480
LIG_SH2_STAP1	330	334	PF00017	0.729
LIG_SH2_STAT3	158	161	PF00017	0.365
LIG_SH2_STAT5	158	161	PF00017	0.434
LIG_SH2_STAT5	246	249	PF00017	0.347
LIG_SH2_STAT5	330	333	PF00017	0.701
LIG_SH3_3	307	313	PF00018	0.638
LIG_SH3_3	320	326	PF00018	0.646
LIG_Sin3_3	293	300	PF02671	0.621
LIG_TRAF2_1	135	138	PF00917	0.476
LIG_TYR_ITIM	318	323	PF00017	0.684
LIG_WRC_WIRS_1	183	188	PF05994	0.454
MOD_CDK_SPxxK_3	150	157	PF00069	0.428
MOD_CK1_1	115	121	PF00069	0.616
MOD_CK1_1	123	129	PF00069	0.586
MOD_CK1_1	132	138	PF00069	0.473
MOD_CK1_1	48	54	PF00069	0.353
MOD_CK2_1	132	138	PF00069	0.454
MOD_CK2_1	164	170	PF00069	0.442
MOD_CK2_1	24	30	PF00069	0.313
MOD_CK2_1	311	317	PF00069	0.690
MOD_Cter_Amidation	95	98	PF01082	0.684
MOD_GlcNHglycan	115	118	PF01048	0.803
MOD_GlcNHglycan	125	128	PF01048	0.739
MOD_GlcNHglycan	186	189	PF01048	0.674
MOD_GlcNHglycan	222	225	PF01048	0.652
MOD_GlcNHglycan	24	27	PF01048	0.516
MOD_GlcNHglycan	47	50	PF01048	0.535
MOD_GlcNHglycan	86	89	PF01048	0.680
MOD_GSK3_1	115	122	PF00069	0.558
MOD_GSK3_1	123	130	PF00069	0.504
MOD_GSK3_1	146	153	PF00069	0.393
MOD_GSK3_1	20	27	PF00069	0.313
MOD_GSK3_1	249	256	PF00069	0.630
MOD_GSK3_1	324	331	PF00069	0.716
MOD_LATS_1	258	264	PF00433	0.584
MOD_NEK2_1	20	25	PF00069	0.298
MOD_NEK2_1	253	258	PF00069	0.659
MOD_NEK2_1	287	292	PF00069	0.562
MOD_NEK2_1	319	324	PF00069	0.747
MOD_NEK2_1	4	9	PF00069	0.508
MOD_PIKK_1	260	266	PF00454	0.712
MOD_PKA_1	260	266	PF00069	0.646
MOD_Plk_1	164	170	PF00069	0.442
MOD_Plk_1	208	214	PF00069	0.501
MOD_Plk_2-3	164	170	PF00069	0.442
MOD_Plk_4	129	135	PF00069	0.504
MOD_Plk_4	164	170	PF00069	0.412
MOD_Plk_4	328	334	PF00069	0.738
MOD_ProDKin_1	120	126	PF00069	0.554
MOD_ProDKin_1	150	156	PF00069	0.417
MOD_ProDKin_1	311	317	PF00069	0.695
MOD_SUMO_for_1	192	195	PF00179	0.432
MOD_SUMO_for_1	52	55	PF00179	0.362
MOD_SUMO_rev_2	150	159	PF00179	0.450
MOD_SUMO_rev_2	185	194	PF00179	0.460
MOD_SUMO_rev_2	25	33	PF00179	0.316
TRG_AP2beta_CARGO_1	15	24	PF09066	0.296
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.472
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.556
TRG_ENDOCYTIC_2	183	186	PF00928	0.464
TRG_ENDOCYTIC_2	237	240	PF00928	0.348
TRG_ENDOCYTIC_2	266	269	PF00928	0.588
TRG_ENDOCYTIC_2	320	323	PF00928	0.715
TRG_ENDOCYTIC_2	330	333	PF00928	0.740
TRG_ENDOCYTIC_2	35	38	PF00928	0.313
TRG_ENDOCYTIC_2	61	64	PF00928	0.284
TRG_ENDOCYTIC_2	70	73	PF00928	0.382
TRG_ER_diArg_1	8	10	PF00400	0.553
TRG_NLS_Bipartite_1	250	264	PF00514	0.704
TRG_Pf-PMV_PEXEL_1	199	204	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	8	13	PF00026	0.765

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCM1	Leptomonas seymouri	73%	100%
A0A0S4IL99	Bodo saltans	42%	100%
A0A1X0P2Q0	Trypanosomatidae	50%	100%
A0A3S7X3P0	Leishmania donovani	90%	100%
A4HIH6	Leishmania braziliensis	81%	100%
A4I5S3	Leishmania infantum	90%	100%
C9ZR42	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
Q4Q748	Leishmania major	92%	100%
V5AWW0	Trypanosoma cruzi	48%	100%