DnaJ domain protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain protein-like protein

Species:

Leishmania mexicana

UniProt:

E9B118_LEIMU

TriTrypDb:

LmxM.29.2450

Length:

336

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0031207	Sec62/Sec63 complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0110165	cellular anatomical entity	1	7
GO:0140534	endoplasmic reticulum protein-containing complex	2	1

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Expansion

Sequence features

E9B118

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B118

Function

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Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006613	cotranslational protein targeting to membrane	6	1
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	1
GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	6	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0008320	protein transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022884	macromolecule transmembrane transporter activity	3	1
GO:0140318	protein transporter activity	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	151	153	PF00675	0.686
CLV_NRD_NRD_1	198	200	PF00675	0.599
CLV_NRD_NRD_1	259	261	PF00675	0.466
CLV_NRD_NRD_1	8	10	PF00675	0.751
CLV_NRD_NRD_1	97	99	PF00675	0.752
CLV_PCSK_KEX2_1	151	153	PF00082	0.686
CLV_PCSK_KEX2_1	198	200	PF00082	0.599
CLV_PCSK_KEX2_1	250	252	PF00082	0.434
CLV_PCSK_KEX2_1	261	263	PF00082	0.391
CLV_PCSK_KEX2_1	8	10	PF00082	0.751

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCM1	Leptomonas seymouri	73%	100%
A0A0S4IL99	Bodo saltans	42%	100%
A0A1X0P2Q0	Trypanosomatidae	50%	100%
A0A3S7X3P0	Leishmania donovani	90%	100%
A4HIH6	Leishmania braziliensis	81%	100%
A4I5S3	Leishmania infantum	90%	100%
C9ZR42	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
Q4Q748	Leishmania major	92%	100%
V5AWW0	Trypanosoma cruzi	48%	100%

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