LeishMANIAdb
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TPR_REGION domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TPR_REGION domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B117_LEIMU
TriTrypDb:
LmxM.29.2440
Length:
774

Annotations

LeishMANIAdb annotations

Might be a conserved chaperone protein, probably not transmembrane.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B117
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B117

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 10
GO:0009987 cellular process 1 10
Molecular functions
Term Name Level Count
GO:0005488 binding 1 10
GO:0005515 protein binding 2 10
GO:0030544 Hsp70 protein binding 4 10
GO:0031072 heat shock protein binding 3 10
GO:0051879 Hsp90 protein binding 4 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 218 222 PF00656 0.447
CLV_C14_Caspase3-7 233 237 PF00656 0.596
CLV_C14_Caspase3-7 243 247 PF00656 0.450
CLV_C14_Caspase3-7 25 29 PF00656 0.567
CLV_C14_Caspase3-7 729 733 PF00656 0.690
CLV_NRD_NRD_1 357 359 PF00675 0.596
CLV_NRD_NRD_1 506 508 PF00675 0.395
CLV_NRD_NRD_1 512 514 PF00675 0.403
CLV_NRD_NRD_1 519 521 PF00675 0.418
CLV_NRD_NRD_1 567 569 PF00675 0.414
CLV_NRD_NRD_1 670 672 PF00675 0.592
CLV_NRD_NRD_1 757 759 PF00675 0.520
CLV_PCSK_FUR_1 668 672 PF00082 0.525
CLV_PCSK_KEX2_1 359 361 PF00082 0.551
CLV_PCSK_KEX2_1 506 508 PF00082 0.394
CLV_PCSK_KEX2_1 511 513 PF00082 0.403
CLV_PCSK_KEX2_1 519 521 PF00082 0.419
CLV_PCSK_KEX2_1 567 569 PF00082 0.414
CLV_PCSK_KEX2_1 668 670 PF00082 0.583
CLV_PCSK_PC1ET2_1 359 361 PF00082 0.552
CLV_PCSK_PC1ET2_1 511 513 PF00082 0.429
CLV_PCSK_PC7_1 507 513 PF00082 0.403
CLV_PCSK_SKI1_1 211 215 PF00082 0.463
CLV_PCSK_SKI1_1 496 500 PF00082 0.314
CLV_PCSK_SKI1_1 603 607 PF00082 0.406
CLV_Separin_Metazoa 98 102 PF03568 0.358
DEG_APCC_DBOX_1 464 472 PF00400 0.438
DEG_APCC_DBOX_1 495 503 PF00400 0.417
DEG_Nend_Nbox_1 1 3 PF02207 0.460
DEG_SPOP_SBC_1 229 233 PF00917 0.401
DEG_SPOP_SBC_1 402 406 PF00917 0.334
DEG_SPOP_SBC_1 699 703 PF00917 0.747
DOC_ANK_TNKS_1 518 525 PF00023 0.528
DOC_CKS1_1 413 418 PF01111 0.597
DOC_CKS1_1 621 626 PF01111 0.640
DOC_CYCLIN_RxL_1 469 477 PF00134 0.367
DOC_CYCLIN_yCln2_LP_2 456 462 PF00134 0.420
DOC_MAPK_gen_1 112 120 PF00069 0.361
DOC_MAPK_gen_1 261 268 PF00069 0.286
DOC_MAPK_gen_1 287 295 PF00069 0.313
DOC_MAPK_gen_1 343 353 PF00069 0.472
DOC_MAPK_gen_1 738 748 PF00069 0.559
DOC_MAPK_gen_1 756 765 PF00069 0.698
DOC_MAPK_MEF2A_6 261 268 PF00069 0.343
DOC_MAPK_MEF2A_6 478 485 PF00069 0.474
DOC_MAPK_MEF2A_6 496 504 PF00069 0.335
DOC_MAPK_MEF2A_6 758 767 PF00069 0.697
DOC_MAPK_RevD_3 497 512 PF00069 0.438
DOC_PP2B_LxvP_1 122 125 PF13499 0.304
DOC_PP2B_LxvP_1 35 38 PF13499 0.431
DOC_PP2B_LxvP_1 630 633 PF13499 0.611
DOC_PP4_FxxP_1 646 649 PF00568 0.582
DOC_USP7_MATH_1 136 140 PF00917 0.407
DOC_USP7_MATH_1 212 216 PF00917 0.426
DOC_USP7_MATH_1 227 231 PF00917 0.510
DOC_USP7_MATH_1 23 27 PF00917 0.589
DOC_USP7_MATH_1 382 386 PF00917 0.401
DOC_USP7_MATH_1 547 551 PF00917 0.733
DOC_USP7_MATH_1 616 620 PF00917 0.669
DOC_USP7_MATH_1 633 637 PF00917 0.638
DOC_USP7_MATH_1 692 696 PF00917 0.724
DOC_USP7_MATH_1 726 730 PF00917 0.674
DOC_USP7_MATH_1 768 772 PF00917 0.714
DOC_WW_Pin1_4 223 228 PF00397 0.468
DOC_WW_Pin1_4 375 380 PF00397 0.471
DOC_WW_Pin1_4 412 417 PF00397 0.546
DOC_WW_Pin1_4 418 423 PF00397 0.553
DOC_WW_Pin1_4 425 430 PF00397 0.558
DOC_WW_Pin1_4 552 557 PF00397 0.732
DOC_WW_Pin1_4 620 625 PF00397 0.636
DOC_WW_Pin1_4 636 641 PF00397 0.739
LIG_14-3-3_CanoR_1 112 122 PF00244 0.406
LIG_14-3-3_CanoR_1 193 198 PF00244 0.390
LIG_14-3-3_CanoR_1 290 296 PF00244 0.382
LIG_14-3-3_CanoR_1 401 409 PF00244 0.468
LIG_14-3-3_CanoR_1 453 457 PF00244 0.333
LIG_14-3-3_CanoR_1 506 514 PF00244 0.605
LIG_14-3-3_CanoR_1 603 609 PF00244 0.609
LIG_14-3-3_CanoR_1 687 694 PF00244 0.766
LIG_Actin_WH2_2 745 763 PF00022 0.652
LIG_APCC_ABBA_1 264 269 PF00400 0.385
LIG_APCC_ABBAyCdc20_2 263 269 PF00400 0.386
LIG_BIR_III_2 221 225 PF00653 0.397
LIG_BIR_III_2 246 250 PF00653 0.418
LIG_BRCT_BRCA1_1 261 265 PF00533 0.359
LIG_BRCT_BRCA1_1 618 622 PF00533 0.662
LIG_CtBP_PxDLS_1 487 491 PF00389 0.262
LIG_FHA_1 119 125 PF00498 0.363
LIG_FHA_1 223 229 PF00498 0.343
LIG_FHA_1 376 382 PF00498 0.479
LIG_FHA_1 422 428 PF00498 0.589
LIG_FHA_1 480 486 PF00498 0.479
LIG_FHA_1 492 498 PF00498 0.320
LIG_FHA_1 574 580 PF00498 0.625
LIG_FHA_1 64 70 PF00498 0.356
LIG_FHA_1 655 661 PF00498 0.751
LIG_FHA_1 764 770 PF00498 0.757
LIG_FHA_2 193 199 PF00498 0.437
LIG_FHA_2 229 235 PF00498 0.591
LIG_FHA_2 241 247 PF00498 0.447
LIG_FHA_2 435 441 PF00498 0.532
LIG_FHA_2 534 540 PF00498 0.686
LIG_FHA_2 621 627 PF00498 0.650
LIG_Integrin_isoDGR_2 92 94 PF01839 0.491
LIG_LIR_Apic_2 619 624 PF02991 0.691
LIG_LIR_Apic_2 644 649 PF02991 0.589
LIG_LIR_Gen_1 188 197 PF02991 0.449
LIG_LIR_Gen_1 262 271 PF02991 0.331
LIG_LIR_Gen_1 348 357 PF02991 0.361
LIG_LIR_Gen_1 607 616 PF02991 0.572
LIG_LIR_Nem_3 116 122 PF02991 0.462
LIG_LIR_Nem_3 151 157 PF02991 0.514
LIG_LIR_Nem_3 188 192 PF02991 0.468
LIG_LIR_Nem_3 202 208 PF02991 0.383
LIG_LIR_Nem_3 262 268 PF02991 0.327
LIG_LIR_Nem_3 348 353 PF02991 0.440
LIG_LIR_Nem_3 455 460 PF02991 0.401
LIG_LIR_Nem_3 534 540 PF02991 0.757
LIG_LIR_Nem_3 607 611 PF02991 0.535
LIG_LIR_Nem_3 612 618 PF02991 0.513
LIG_LIR_Nem_3 619 625 PF02991 0.520
LIG_LIR_Nem_3 84 90 PF02991 0.343
LIG_LYPXL_yS_3 87 90 PF13949 0.380
LIG_MLH1_MIPbox_1 618 622 PF16413 0.587
LIG_PDZ_Class_3 769 774 PF00595 0.727
LIG_Pex14_1 288 292 PF04695 0.335
LIG_Pex14_2 204 208 PF04695 0.377
LIG_REV1ctd_RIR_1 206 215 PF16727 0.234
LIG_RPA_C_Fungi 501 513 PF08784 0.467
LIG_SH2_CRK 154 158 PF00017 0.678
LIG_SH2_CRK 591 595 PF00017 0.391
LIG_SH2_CRK 615 619 PF00017 0.449
LIG_SH2_NCK_1 137 141 PF00017 0.609
LIG_SH2_SRC 219 222 PF00017 0.534
LIG_SH2_SRC 615 618 PF00017 0.384
LIG_SH2_SRC 647 650 PF00017 0.525
LIG_SH2_STAP1 321 325 PF00017 0.554
LIG_SH2_STAT5 119 122 PF00017 0.512
LIG_SH2_STAT5 219 222 PF00017 0.477
LIG_SH2_STAT5 292 295 PF00017 0.392
LIG_SH2_STAT5 337 340 PF00017 0.558
LIG_SH2_STAT5 350 353 PF00017 0.314
LIG_SH2_STAT5 445 448 PF00017 0.469
LIG_SH2_STAT5 617 620 PF00017 0.404
LIG_SH2_STAT5 621 624 PF00017 0.432
LIG_SH2_STAT5 647 650 PF00017 0.449
LIG_SH2_STAT5 651 654 PF00017 0.483
LIG_SH2_STAT5 663 666 PF00017 0.575
LIG_SH3_2 556 561 PF14604 0.471
LIG_SH3_3 130 136 PF00018 0.417
LIG_SH3_3 221 227 PF00018 0.569
LIG_SH3_3 34 40 PF00018 0.605
LIG_SH3_3 410 416 PF00018 0.468
LIG_SH3_3 428 434 PF00018 0.601
LIG_SH3_3 553 559 PF00018 0.655
LIG_SUMO_SIM_anti_2 747 753 PF11976 0.575
LIG_SUMO_SIM_par_1 623 629 PF11976 0.522
LIG_SUMO_SIM_par_1 744 750 PF11976 0.635
LIG_SUMO_SIM_par_1 765 772 PF11976 0.629
LIG_TRAF2_1 672 675 PF00917 0.573
LIG_TYR_ITIM 589 594 PF00017 0.427
MOD_CDK_SPxxK_3 418 425 PF00069 0.602
MOD_CDK_SPxxK_3 554 561 PF00069 0.487
MOD_CK1_1 113 119 PF00069 0.644
MOD_CK1_1 127 133 PF00069 0.227
MOD_CK1_1 230 236 PF00069 0.726
MOD_CK1_1 636 642 PF00069 0.578
MOD_CK1_1 662 668 PF00069 0.565
MOD_CK1_1 686 692 PF00069 0.595
MOD_CK1_1 695 701 PF00069 0.746
MOD_CK1_1 702 708 PF00069 0.762
MOD_CK1_1 710 716 PF00069 0.772
MOD_CK2_1 192 198 PF00069 0.489
MOD_CK2_1 212 218 PF00069 0.525
MOD_CK2_1 401 407 PF00069 0.551
MOD_CK2_1 669 675 PF00069 0.675
MOD_CK2_1 690 696 PF00069 0.613
MOD_GlcNHglycan 138 141 PF01048 0.444
MOD_GlcNHglycan 150 153 PF01048 0.650
MOD_GlcNHglycan 236 240 PF01048 0.723
MOD_GlcNHglycan 243 246 PF01048 0.725
MOD_GlcNHglycan 25 28 PF01048 0.650
MOD_GlcNHglycan 508 511 PF01048 0.566
MOD_GlcNHglycan 618 621 PF01048 0.529
MOD_GlcNHglycan 634 638 PF01048 0.613
MOD_GlcNHglycan 674 678 PF01048 0.796
MOD_GlcNHglycan 83 86 PF01048 0.514
MOD_GSK3_1 100 107 PF00069 0.385
MOD_GSK3_1 123 130 PF00069 0.405
MOD_GSK3_1 223 230 PF00069 0.646
MOD_GSK3_1 368 375 PF00069 0.480
MOD_GSK3_1 382 389 PF00069 0.479
MOD_GSK3_1 408 415 PF00069 0.600
MOD_GSK3_1 421 428 PF00069 0.797
MOD_GSK3_1 430 437 PF00069 0.768
MOD_GSK3_1 444 451 PF00069 0.553
MOD_GSK3_1 470 477 PF00069 0.515
MOD_GSK3_1 548 555 PF00069 0.627
MOD_GSK3_1 616 623 PF00069 0.614
MOD_GSK3_1 632 639 PF00069 0.529
MOD_GSK3_1 659 666 PF00069 0.699
MOD_GSK3_1 669 676 PF00069 0.742
MOD_GSK3_1 686 693 PF00069 0.522
MOD_GSK3_1 695 702 PF00069 0.690
MOD_GSK3_1 703 710 PF00069 0.633
MOD_GSK3_1 712 719 PF00069 0.676
MOD_GSK3_1 726 733 PF00069 0.654
MOD_GSK3_1 77 84 PF00069 0.581
MOD_LATS_1 531 537 PF00433 0.580
MOD_N-GLC_1 81 86 PF02516 0.507
MOD_NEK2_1 1 6 PF00069 0.673
MOD_NEK2_1 118 123 PF00069 0.465
MOD_NEK2_1 42 47 PF00069 0.556
MOD_NEK2_1 474 479 PF00069 0.538
MOD_NEK2_1 500 505 PF00069 0.368
MOD_NEK2_1 548 553 PF00069 0.664
MOD_NEK2_1 63 68 PF00069 0.463
MOD_NEK2_1 683 688 PF00069 0.690
MOD_NEK2_1 83 88 PF00069 0.262
MOD_NEK2_2 382 387 PF00069 0.513
MOD_NEK2_2 491 496 PF00069 0.394
MOD_NEK2_2 641 646 PF00069 0.477
MOD_OFUCOSY 123 128 PF10250 0.470
MOD_OFUCOSY 163 170 PF10250 0.575
MOD_PIKK_1 337 343 PF00454 0.498
MOD_PIKK_1 448 454 PF00454 0.535
MOD_PIKK_1 54 60 PF00454 0.511
MOD_PIKK_1 548 554 PF00454 0.680
MOD_PIKK_1 609 615 PF00454 0.475
MOD_PIKK_1 700 706 PF00454 0.492
MOD_PIKK_1 74 80 PF00454 0.274
MOD_PKA_1 506 512 PF00069 0.598
MOD_PKA_1 669 675 PF00069 0.779
MOD_PKA_2 100 106 PF00069 0.380
MOD_PKA_2 192 198 PF00069 0.557
MOD_PKA_2 452 458 PF00069 0.400
MOD_PKA_2 506 512 PF00069 0.546
MOD_PKA_2 669 675 PF00069 0.755
MOD_PKA_2 686 692 PF00069 0.640
MOD_Plk_1 143 149 PF00069 0.663
MOD_Plk_1 42 48 PF00069 0.682
MOD_Plk_1 562 568 PF00069 0.584
MOD_Plk_1 695 701 PF00069 0.494
MOD_Plk_2-3 690 696 PF00069 0.731
MOD_Plk_4 104 110 PF00069 0.477
MOD_Plk_4 368 374 PF00069 0.585
MOD_Plk_4 382 388 PF00069 0.463
MOD_Plk_4 408 414 PF00069 0.451
MOD_Plk_4 452 458 PF00069 0.417
MOD_Plk_4 63 69 PF00069 0.530
MOD_Plk_4 641 647 PF00069 0.595
MOD_Plk_4 747 753 PF00069 0.743
MOD_ProDKin_1 223 229 PF00069 0.603
MOD_ProDKin_1 375 381 PF00069 0.599
MOD_ProDKin_1 412 418 PF00069 0.708
MOD_ProDKin_1 425 431 PF00069 0.727
MOD_ProDKin_1 552 558 PF00069 0.683
MOD_ProDKin_1 620 626 PF00069 0.557
MOD_ProDKin_1 636 642 PF00069 0.696
MOD_SUMO_for_1 598 601 PF00179 0.535
MOD_SUMO_rev_2 585 590 PF00179 0.501
MOD_SUMO_rev_2 592 600 PF00179 0.471
TRG_ENDOCYTIC_2 119 122 PF00928 0.411
TRG_ENDOCYTIC_2 154 157 PF00928 0.678
TRG_ENDOCYTIC_2 292 295 PF00928 0.408
TRG_ENDOCYTIC_2 350 353 PF00928 0.467
TRG_ENDOCYTIC_2 457 460 PF00928 0.491
TRG_ENDOCYTIC_2 591 594 PF00928 0.397
TRG_ENDOCYTIC_2 608 611 PF00928 0.366
TRG_ENDOCYTIC_2 615 618 PF00928 0.381
TRG_ENDOCYTIC_2 87 90 PF00928 0.396
TRG_ER_diArg_1 260 263 PF00400 0.336
TRG_ER_diArg_1 357 360 PF00400 0.503
TRG_ER_diArg_1 506 508 PF00400 0.497
TRG_ER_diArg_1 512 514 PF00400 0.528
TRG_ER_diArg_1 566 568 PF00400 0.518
TRG_ER_diArg_1 668 671 PF00400 0.768
TRG_Pf-PMV_PEXEL_1 512 516 PF00026 0.523

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3V6 Leptomonas seymouri 55% 90%
A0A0S4IQF5 Bodo saltans 29% 100%
A0A1X0P352 Trypanosomatidae 32% 100%
A0A3Q8IJJ7 Leishmania donovani 92% 99%
A0A3R7NPX7 Trypanosoma rangeli 32% 100%
A4HIH5 Leishmania braziliensis 77% 100%
A4I5S2 Leishmania infantum 92% 99%
C9ZR41 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
Q4Q749 Leishmania major 89% 99%
V5BC99 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS