LeishMANIAdb
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Aminoacyl-tRNA hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Aminoacyl-tRNA hydrolase
Gene product:
peptidyl-tRNA hydrolase PTH2, putative
Species:
Leishmania mexicana
UniProt:
E9B115_LEIMU
TriTrypDb:
LmxM.29.2420
Length:
157

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 2
GO:0005829 cytosol 2 2
GO:0016020 membrane 2 4
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

E9B115
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B115

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0004045 aminoacyl-tRNA hydrolase activity 5 11
GO:0016787 hydrolase activity 2 11
GO:0016788 hydrolase activity, acting on ester bonds 3 11
GO:0052689 carboxylic ester hydrolase activity 4 11
GO:0140098 catalytic activity, acting on RNA 3 11
GO:0140101 catalytic activity, acting on a tRNA 4 11
GO:0140640 catalytic activity, acting on a nucleic acid 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 112 114 PF00675 0.252
CLV_PCSK_KEX2_1 112 114 PF00082 0.252
CLV_PCSK_SKI1_1 7 11 PF00082 0.400
DEG_Nend_UBRbox_2 1 3 PF02207 0.436
DOC_MAPK_HePTP_8 126 138 PF00069 0.436
DOC_MAPK_MEF2A_6 129 138 PF00069 0.475
DOC_MAPK_MEF2A_6 91 98 PF00069 0.591
DOC_MAPK_NFAT4_5 91 99 PF00069 0.452
DOC_USP7_MATH_1 111 115 PF00917 0.451
DOC_USP7_MATH_1 128 132 PF00917 0.505
DOC_USP7_MATH_1 140 144 PF00917 0.428
DOC_USP7_MATH_1 60 64 PF00917 0.519
DOC_WW_Pin1_4 54 59 PF00397 0.522
LIG_14-3-3_CanoR_1 105 111 PF00244 0.396
LIG_14-3-3_CanoR_1 45 53 PF00244 0.388
LIG_FHA_1 148 154 PF00498 0.580
LIG_FHA_1 91 97 PF00498 0.455
LIG_FHA_2 19 25 PF00498 0.470
LIG_NRBOX 35 41 PF00104 0.475
LIG_Pex14_1 69 73 PF04695 0.608
LIG_SH2_STAT5 73 76 PF00017 0.475
LIG_SH3_3 124 130 PF00018 0.454
LIG_SH3_3 142 148 PF00018 0.405
LIG_SH3_3 47 53 PF00018 0.452
LIG_SUMO_SIM_anti_2 131 137 PF11976 0.442
LIG_SUMO_SIM_anti_2 24 29 PF11976 0.452
LIG_TRAF2_1 21 24 PF00917 0.475
MOD_CK1_1 114 120 PF00069 0.389
MOD_CK2_1 18 24 PF00069 0.459
MOD_CMANNOS 69 72 PF00535 0.408
MOD_GlcNHglycan 30 33 PF01048 0.275
MOD_GlcNHglycan 46 49 PF01048 0.275
MOD_NEK2_1 10 15 PF00069 0.529
MOD_NEK2_1 28 33 PF00069 0.469
MOD_NEK2_2 82 87 PF00069 0.475
MOD_PIKK_1 60 66 PF00454 0.530
MOD_PKA_2 111 117 PF00069 0.475
MOD_PKA_2 44 50 PF00069 0.389
MOD_Plk_2-3 90 96 PF00069 0.452
MOD_ProDKin_1 54 60 PF00069 0.522

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IED2 Leishmania donovani 89% 95%
A0A3S7WPI5 Leishmania donovani 30% 100%
A4H4Q4 Leishmania braziliensis 28% 100%
A4HIH3 Leishmania braziliensis 72% 100%
A4HSY3 Leishmania infantum 31% 100%
A4I5S0 Leishmania infantum 89% 95%
C3MJ30 Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) 26% 100%
C3MYS2 Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) 26% 100%
C3MZS7 Sulfolobus islandicus (strain M.16.27) 26% 100%
C3N851 Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) 26% 100%
C3NF60 Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) 26% 100%
C4KJ09 Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) 26% 100%
E9AKW9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
Q4Q751 Leishmania major 87% 100%
Q4QIY6 Leishmania major 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS