Pre-mRNA cleavage complex II Clp1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-mRNA cleavage complex II Clp1-like protein

Species:

Leishmania mexicana

UniProt:

E9B114_LEIMU

TriTrypDb:

LmxM.29.2410

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B114

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B114

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation	8	1
GO:0006378	mRNA polyadenylation	7	1
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	9	1
GO:0006397	mRNA processing	7	2
GO:0006399	tRNA metabolic process	7	1
GO:0008033	tRNA processing	8	1
GO:0008380	RNA splicing	7	1
GO:0016071	mRNA metabolic process	6	2
GO:0031123	RNA 3'-end processing	7	2
GO:0031124	mRNA 3'-end processing	8	2
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043631	RNA polyadenylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0019205	nucleobase-containing compound kinase activity	5	12
GO:0051731	polynucleotide 5'-hydroxyl-kinase activity	5	12
GO:0046404	polydeoxyribonucleotide 5'-hydroxyl-kinase activity	7	1
GO:0051733	polydeoxyribonucleotide kinase activity	6	1
GO:0051734	polynucleotide kinase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.646
CLV_NRD_NRD_1	3	5	PF00675	0.659
CLV_NRD_NRD_1	311	313	PF00675	0.391
CLV_PCSK_KEX2_1	210	212	PF00082	0.322
CLV_PCSK_KEX2_1	310	312	PF00082	0.387
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.322
CLV_PCSK_SKI1_1	108	112	PF00082	0.540
CLV_PCSK_SKI1_1	141	145	PF00082	0.427
CLV_PCSK_SKI1_1	317	321	PF00082	0.417
CLV_PCSK_SKI1_1	403	407	PF00082	0.470
CLV_PCSK_SKI1_1	49	53	PF00082	0.508
DEG_APCC_DBOX_1	323	331	PF00400	0.548
DEG_COP1_1	348	358	PF00400	0.452
DEG_Nend_UBRbox_3	1	3	PF02207	0.746
DEG_ODPH_VHL_1	394	407	PF01847	0.518
DEG_SCF_FBW7_1	76	83	PF00400	0.249
DEG_SPOP_SBC_1	110	114	PF00917	0.486
DOC_CDC14_PxL_1	290	298	PF14671	0.453
DOC_CKS1_1	320	325	PF01111	0.417
DOC_CKS1_1	77	82	PF01111	0.501
DOC_CYCLIN_yCln2_LP_2	401	407	PF00134	0.392
DOC_CYCLIN_yCln2_LP_2	418	424	PF00134	0.564
DOC_MAPK_DCC_7	416	424	PF00069	0.614
DOC_MAPK_gen_1	210	217	PF00069	0.322
DOC_MAPK_gen_1	4	12	PF00069	0.597
DOC_MAPK_MEF2A_6	141	148	PF00069	0.427
DOC_MAPK_MEF2A_6	210	217	PF00069	0.365
DOC_MAPK_MEF2A_6	353	360	PF00069	0.512
DOC_MAPK_MEF2A_6	416	424	PF00069	0.614
DOC_MAPK_NFAT4_5	141	149	PF00069	0.427
DOC_MAPK_NFAT4_5	210	218	PF00069	0.375
DOC_PP1_RVXF_1	284	291	PF00149	0.371
DOC_PP2B_LxvP_1	412	415	PF13499	0.429
DOC_PP2B_LxvP_1	418	421	PF13499	0.478
DOC_PP4_FxxP_1	320	323	PF00568	0.514
DOC_PP4_FxxP_1	393	396	PF00568	0.368
DOC_USP7_MATH_1	110	114	PF00917	0.666
DOC_USP7_MATH_1	222	226	PF00917	0.349
DOC_USP7_MATH_1	334	338	PF00917	0.459
DOC_USP7_MATH_1	80	84	PF00917	0.384
DOC_WW_Pin1_4	149	154	PF00397	0.427
DOC_WW_Pin1_4	241	246	PF00397	0.415
DOC_WW_Pin1_4	298	303	PF00397	0.391
DOC_WW_Pin1_4	319	324	PF00397	0.391
DOC_WW_Pin1_4	406	411	PF00397	0.405
DOC_WW_Pin1_4	76	81	PF00397	0.483
LIG_14-3-3_CanoR_1	335	342	PF00244	0.477
LIG_14-3-3_CanoR_1	4	12	PF00244	0.615
LIG_14-3-3_CanoR_1	41	45	PF00244	0.479
LIG_APCC_ABBA_1	340	345	PF00400	0.498
LIG_BRCT_BRCA1_1	174	178	PF00533	0.427
LIG_BRCT_BRCA1_1	224	228	PF00533	0.427
LIG_deltaCOP1_diTrp_1	272	278	PF00928	0.278
LIG_FHA_1	112	118	PF00498	0.491
LIG_FHA_1	199	205	PF00498	0.366
LIG_FHA_1	262	268	PF00498	0.356
LIG_FHA_1	43	49	PF00498	0.531
LIG_FHA_1	92	98	PF00498	0.521
LIG_FHA_2	182	188	PF00498	0.441
LIG_FHA_2	267	273	PF00498	0.448
LIG_LIR_Apic_2	119	124	PF02991	0.557
LIG_LIR_Apic_2	392	396	PF02991	0.369
LIG_LIR_Gen_1	248	258	PF02991	0.177
LIG_LIR_Gen_1	287	297	PF02991	0.431
LIG_LIR_Nem_3	248	254	PF02991	0.177
LIG_LIR_Nem_3	287	293	PF02991	0.460
LIG_LIR_Nem_3	345	350	PF02991	0.485
LIG_LIR_Nem_3	351	355	PF02991	0.376
LIG_PCNA_TLS_4	312	319	PF02747	0.375
LIG_PTB_Apo_2	227	234	PF02174	0.427
LIG_RPA_C_Fungi	91	103	PF08784	0.462
LIG_SH2_CRK	251	255	PF00017	0.276
LIG_SH2_CRK	280	284	PF00017	0.337
LIG_SH2_CRK	50	54	PF00017	0.431
LIG_SH2_PTP2	158	161	PF00017	0.453
LIG_SH2_SRC	158	161	PF00017	0.356
LIG_SH2_STAT5	158	161	PF00017	0.433
LIG_SH2_STAT5	212	215	PF00017	0.306
LIG_SH2_STAT5	318	321	PF00017	0.306
LIG_SH3_2	326	331	PF14604	0.412
LIG_SH3_3	160	166	PF00018	0.417
LIG_SH3_3	176	182	PF00018	0.310
LIG_SH3_3	188	194	PF00018	0.374
LIG_SH3_3	288	294	PF00018	0.370
LIG_SH3_3	296	302	PF00018	0.299
LIG_SH3_3	320	326	PF00018	0.420
LIG_SH3_3	404	410	PF00018	0.508
LIG_SH3_3	74	80	PF00018	0.541
LIG_SUMO_SIM_anti_2	29	34	PF11976	0.422
LIG_SUMO_SIM_anti_2	337	343	PF11976	0.410
LIG_SUMO_SIM_par_1	125	131	PF11976	0.395
LIG_SUMO_SIM_par_1	29	34	PF11976	0.371
LIG_SUMO_SIM_par_1	98	105	PF11976	0.547
LIG_TRAF2_1	113	116	PF00917	0.661
LIG_TYR_ITIM	156	161	PF00017	0.375
LIG_TYR_ITIM	249	254	PF00017	0.276
LIG_UBA3_1	100	108	PF00899	0.569
LIG_WRC_WIRS_1	390	395	PF05994	0.368
MOD_CDK_SPK_2	319	324	PF00069	0.511
MOD_CK1_1	203	209	PF00069	0.394
MOD_CK1_1	244	250	PF00069	0.394
MOD_CK1_1	42	48	PF00069	0.528
MOD_CK2_1	109	115	PF00069	0.589
MOD_CK2_1	181	187	PF00069	0.441
MOD_CK2_1	228	234	PF00069	0.462
MOD_CK2_1	348	354	PF00069	0.453
MOD_CK2_1	368	374	PF00069	0.205
MOD_CK2_1	394	400	PF00069	0.510
MOD_Cter_Amidation	106	109	PF01082	0.316
MOD_GlcNHglycan	174	177	PF01048	0.427
MOD_GlcNHglycan	205	208	PF01048	0.375
MOD_GlcNHglycan	33	36	PF01048	0.440
MOD_GlcNHglycan	370	373	PF01048	0.466
MOD_GlcNHglycan	396	399	PF01048	0.473
MOD_GSK3_1	198	205	PF00069	0.269
MOD_GSK3_1	239	246	PF00069	0.443
MOD_GSK3_1	252	259	PF00069	0.308
MOD_GSK3_1	6	13	PF00069	0.529
MOD_GSK3_1	76	83	PF00069	0.415
MOD_N-GLC_1	21	26	PF02516	0.269
MOD_NEK2_1	117	122	PF00069	0.596
MOD_NEK2_1	198	203	PF00069	0.454
MOD_NEK2_1	228	233	PF00069	0.391
MOD_NEK2_1	239	244	PF00069	0.304
MOD_NEK2_1	261	266	PF00069	0.382
MOD_NEK2_1	284	289	PF00069	0.371
MOD_NEK2_1	31	36	PF00069	0.462
MOD_NEK2_1	39	44	PF00069	0.419
MOD_NEK2_1	91	96	PF00069	0.433
MOD_PIKK_1	21	27	PF00454	0.343
MOD_PKA_2	3	9	PF00069	0.636
MOD_PKA_2	334	340	PF00069	0.487
MOD_PKA_2	40	46	PF00069	0.495
MOD_Plk_2-3	348	354	PF00069	0.416
MOD_Plk_4	193	199	PF00069	0.319
MOD_Plk_4	256	262	PF00069	0.325
MOD_Plk_4	26	32	PF00069	0.391
MOD_Plk_4	389	395	PF00069	0.424
MOD_Plk_4	80	86	PF00069	0.422
MOD_ProDKin_1	149	155	PF00069	0.427
MOD_ProDKin_1	241	247	PF00069	0.415
MOD_ProDKin_1	298	304	PF00069	0.391
MOD_ProDKin_1	319	325	PF00069	0.393
MOD_ProDKin_1	406	412	PF00069	0.401
MOD_ProDKin_1	76	82	PF00069	0.484
MOD_SUMO_rev_2	112	120	PF00179	0.637
TRG_DiLeu_BaEn_1	87	92	PF01217	0.489
TRG_DiLeu_BaEn_2	233	239	PF01217	0.453
TRG_DiLeu_BaEn_2	273	279	PF01217	0.457
TRG_ENDOCYTIC_2	158	161	PF00928	0.453
TRG_ENDOCYTIC_2	212	215	PF00928	0.306
TRG_ENDOCYTIC_2	251	254	PF00928	0.276
TRG_ENDOCYTIC_2	280	283	PF00928	0.337
TRG_ER_diArg_1	310	312	PF00400	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT73	Leptomonas seymouri	70%	99%
A0A0S4IVZ6	Bodo saltans	33%	98%
A0A1X0P2B1	Trypanosomatidae	39%	100%
A0A3R7KU37	Trypanosoma rangeli	36%	100%
A0A3S5H7N4	Leishmania donovani	92%	100%
A1DE49	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	23%	76%
A2RAW3	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	24%	89%
A2VE01	Bos taurus	25%	100%
A4HEC1	Leishmania braziliensis	25%	100%
A4HIH2	Leishmania braziliensis	86%	100%
A4I5R9	Leishmania infantum	92%	100%
A6S936	Botryotinia fuckeliana (strain B05.10)	25%	92%
A7RG82	Nematostella vectensis	27%	99%
A8PB32	Brugia malayi	28%	98%
A8X9U4	Caenorhabditis briggsae	27%	99%
B0VZR4	Culex quinquefasciatus	25%	100%
B3MGZ0	Drosophila ananassae	26%	100%
B3NRK6	Drosophila erecta	26%	100%
B4GGT6	Drosophila persimilis	25%	100%
B4HQJ2	Drosophila sechellia	25%	100%
B4JVN0	Drosophila grimshawi	24%	100%
B4KML2	Drosophila mojavensis	26%	100%
B4MCL6	Drosophila virilis	25%	100%
B4MRZ9	Drosophila willistoni	25%	100%
B4P4H2	Drosophila yakuba	26%	100%
B4QEE3	Drosophila simulans	25%	100%
C9ZKC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	96%
C9ZR38	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E7F3I6	Danio rerio	30%	96%
P52874	Caenorhabditis elegans	26%	99%
Q0CEZ9	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	24%	76%
Q0U2G5	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	23%	91%
Q16WA6	Aedes aegypti	24%	100%
Q1DKL9	Coccidioides immitis (strain RS)	22%	76%
Q28ZT4	Drosophila pseudoobscura pseudoobscura	25%	100%
Q2H1L0	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	24%	86%
Q4Q752	Leishmania major	93%	100%
Q4R7R3	Macaca fascicularis	26%	100%
Q54N48	Dictyostelium discoideum	23%	93%
Q5BH19	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	24%	78%
Q5PQL4	Rattus norvegicus	26%	100%
Q5ZJL4	Gallus gallus	26%	100%
Q66JK4	Xenopus tropicalis	30%	97%
Q6NS21	Xenopus laevis	27%	97%
Q7K284	Drosophila melanogaster	25%	100%
Q7QJW7	Anopheles gambiae	26%	100%
Q92989	Homo sapiens	26%	100%
Q99LI9	Mus musculus	26%	100%
Q9FLE2	Arabidopsis thaliana	24%	100%
Q9SR06	Arabidopsis thaliana	27%	96%
V5DD01	Trypanosoma cruzi	39%	92%