Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B111_LEIMU

TriTrypDb:

LmxM.29.2380

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B111

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B111

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.474
CLV_NRD_NRD_1	124	126	PF00675	0.578
CLV_NRD_NRD_1	22	24	PF00675	0.499
CLV_NRD_NRD_1	296	298	PF00675	0.633
CLV_NRD_NRD_1	85	87	PF00675	0.574
CLV_PCSK_FUR_1	20	24	PF00082	0.611
CLV_PCSK_KEX2_1	124	126	PF00082	0.570
CLV_PCSK_KEX2_1	22	24	PF00082	0.491
CLV_PCSK_KEX2_1	231	233	PF00082	0.624
CLV_PCSK_KEX2_1	296	298	PF00082	0.659
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.624
CLV_PCSK_SKI1_1	105	109	PF00082	0.421
CLV_PCSK_SKI1_1	22	26	PF00082	0.542
CLV_PCSK_SKI1_1	35	39	PF00082	0.440
DOC_PP1_RVXF_1	33	39	PF00149	0.476
DOC_USP7_MATH_1	131	135	PF00917	0.538
DOC_USP7_MATH_1	200	204	PF00917	0.753
DOC_USP7_MATH_1	3	7	PF00917	0.665
DOC_USP7_UBL2_3	170	174	PF12436	0.508
LIG_14-3-3_CanoR_1	124	128	PF00244	0.624
LIG_14-3-3_CanoR_1	199	205	PF00244	0.745
LIG_14-3-3_CanoR_1	22	28	PF00244	0.547
LIG_14-3-3_CanoR_1	84	94	PF00244	0.494
LIG_Actin_WH2_2	72	88	PF00022	0.569
LIG_BIR_II_1	1	5	PF00653	0.712
LIG_FHA_1	260	266	PF00498	0.530
LIG_FHA_1	281	287	PF00498	0.509
LIG_FHA_1	80	86	PF00498	0.540
LIG_FHA_1	94	100	PF00498	0.478
LIG_FHA_2	153	159	PF00498	0.613
LIG_FHA_2	206	212	PF00498	0.691
LIG_FHA_2	214	220	PF00498	0.712
LIG_FHA_2	37	43	PF00498	0.560
LIG_FHA_2	86	92	PF00498	0.567
LIG_NRBOX	264	270	PF00104	0.559
LIG_SH2_NCK_1	235	239	PF00017	0.540
LIG_SUMO_SIM_anti_2	145	153	PF11976	0.496
LIG_SUMO_SIM_anti_2	5	13	PF11976	0.614
LIG_SUMO_SIM_anti_2	62	70	PF11976	0.608
LIG_TRAF2_1	126	129	PF00917	0.625
LIG_TRAF2_1	225	228	PF00917	0.613
LIG_TRAF2_1	275	278	PF00917	0.522
LIG_UBA3_1	146	154	PF00899	0.567
MOD_CK1_1	259	265	PF00069	0.421
MOD_CK2_1	123	129	PF00069	0.610
MOD_CK2_1	152	158	PF00069	0.523
MOD_CK2_1	25	31	PF00069	0.581
MOD_CK2_1	272	278	PF00069	0.533
MOD_CK2_1	36	42	PF00069	0.533
MOD_CK2_1	85	91	PF00069	0.500
MOD_GlcNHglycan	1	4	PF01048	0.716
MOD_GlcNHglycan	187	190	PF01048	0.685
MOD_GlcNHglycan	194	197	PF01048	0.729
MOD_GlcNHglycan	5	9	PF01048	0.607
MOD_GSK3_1	119	126	PF00069	0.584
MOD_GSK3_1	177	184	PF00069	0.567
MOD_GSK3_1	268	275	PF00069	0.564
MOD_NEK2_1	161	166	PF00069	0.543
MOD_NEK2_1	25	30	PF00069	0.617
MOD_NEK2_1	268	273	PF00069	0.476
MOD_NEK2_1	85	90	PF00069	0.610
MOD_PIKK_1	25	31	PF00454	0.616
MOD_PIKK_1	85	91	PF00454	0.629
MOD_PK_1	181	187	PF00069	0.413
MOD_PKA_2	123	129	PF00069	0.602
MOD_PKA_2	177	183	PF00069	0.653
MOD_PKA_2	85	91	PF00069	0.488
MOD_Plk_1	152	158	PF00069	0.611
MOD_Plk_1	4	10	PF00069	0.531
MOD_SUMO_for_1	53	56	PF00179	0.373
MOD_SUMO_rev_2	227	233	PF00179	0.632
MOD_SUMO_rev_2	28	37	PF00179	0.590
TRG_DiLeu_BaEn_1	145	150	PF01217	0.559
TRG_DiLeu_BaEn_1	264	269	PF01217	0.536
TRG_DiLeu_BaEn_1	42	47	PF01217	0.551
TRG_ER_diArg_1	123	125	PF00400	0.581
TRG_ER_diArg_1	20	23	PF00400	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDE9	Leptomonas seymouri	45%	96%
A0A1X0P1M8	Trypanosomatidae	29%	100%
A0A3S7X3N1	Leishmania donovani	88%	100%
A0A422NW57	Trypanosoma rangeli	32%	100%
A4HIG9	Leishmania braziliensis	76%	100%
A4I5R6	Leishmania infantum	88%	100%
C9ZR34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4Q755	Leishmania major	88%	100%
V5BGW1	Trypanosoma cruzi	33%	100%