Conserved zinc-finger protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B109_LEIMU

TriTrypDb:

LmxM.29.2360

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9B109

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B109

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	13
GO:0008270	zinc ion binding	6	13
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0046914	transition metal ion binding	5	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	254	258	PF00656	0.443
CLV_C14_Caspase3-7	472	476	PF00656	0.557
CLV_NRD_NRD_1	246	248	PF00675	0.478
CLV_NRD_NRD_1	264	266	PF00675	0.439
CLV_NRD_NRD_1	33	35	PF00675	0.283
CLV_NRD_NRD_1	486	488	PF00675	0.527
CLV_PCSK_KEX2_1	119	121	PF00082	0.419
CLV_PCSK_KEX2_1	246	248	PF00082	0.524
CLV_PCSK_KEX2_1	264	266	PF00082	0.522
CLV_PCSK_KEX2_1	295	297	PF00082	0.600
CLV_PCSK_KEX2_1	33	35	PF00082	0.283
CLV_PCSK_KEX2_1	486	488	PF00082	0.514
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.419
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.600
CLV_PCSK_SKI1_1	247	251	PF00082	0.511
CLV_PCSK_SKI1_1	33	37	PF00082	0.373
CLV_PCSK_SKI1_1	4	8	PF00082	0.415
CLV_PCSK_SKI1_1	417	421	PF00082	0.579
DEG_APCC_DBOX_1	245	253	PF00400	0.462
DEG_APCC_DBOX_1	264	272	PF00400	0.539
DEG_SPOP_SBC_1	259	263	PF00917	0.389
DOC_ANK_TNKS_1	119	126	PF00023	0.414
DOC_CKS1_1	375	380	PF01111	0.609
DOC_CYCLIN_RxL_1	30	38	PF00134	0.163
DOC_CYCLIN_yClb1_LxF_4	378	383	PF00134	0.452
DOC_CYCLIN_yCln2_LP_2	15	21	PF00134	0.275
DOC_CYCLIN_yCln2_LP_2	375	381	PF00134	0.521
DOC_MAPK_MEF2A_6	170	179	PF00069	0.534
DOC_PP1_RVXF_1	378	384	PF00149	0.453
DOC_PP1_RVXF_1	494	500	PF00149	0.396
DOC_PP4_FxxP_1	44	47	PF00568	0.254
DOC_USP7_MATH_1	537	541	PF00917	0.412
DOC_USP7_UBL2_3	115	119	PF12436	0.287
DOC_WW_Pin1_4	365	370	PF00397	0.521
DOC_WW_Pin1_4	374	379	PF00397	0.580
DOC_WW_Pin1_4	80	85	PF00397	0.318
LIG_14-3-3_CanoR_1	211	215	PF00244	0.485
LIG_14-3-3_CanoR_1	246	250	PF00244	0.495
LIG_14-3-3_CanoR_1	296	304	PF00244	0.567
LIG_14-3-3_CanoR_1	347	353	PF00244	0.671
LIG_14-3-3_CanoR_1	380	384	PF00244	0.395
LIG_14-3-3_CanoR_1	4	12	PF00244	0.324
LIG_14-3-3_CanoR_1	431	437	PF00244	0.459
LIG_14-3-3_CanoR_1	480	488	PF00244	0.374
LIG_Actin_WH2_2	386	403	PF00022	0.396
LIG_Actin_WH2_2	493	511	PF00022	0.410
LIG_APCC_ABBA_1	102	107	PF00400	0.340
LIG_APCC_ABBA_1	166	171	PF00400	0.417
LIG_BRCT_BRCA1_1	130	134	PF00533	0.517
LIG_BRCT_BRCA1_1	443	447	PF00533	0.437
LIG_FHA_1	174	180	PF00498	0.516
LIG_FHA_1	27	33	PF00498	0.347
LIG_FHA_1	380	386	PF00498	0.455
LIG_FHA_1	480	486	PF00498	0.429
LIG_FHA_1	5	11	PF00498	0.290
LIG_FHA_1	505	511	PF00498	0.367
LIG_FHA_2	287	293	PF00498	0.480
LIG_FHA_2	325	331	PF00498	0.591
LIG_KLC1_Yacidic_2	70	74	PF13176	0.426
LIG_LIR_Gen_1	217	227	PF02991	0.446
LIG_LIR_Gen_1	228	239	PF02991	0.441
LIG_LIR_Gen_1	418	428	PF02991	0.453
LIG_LIR_Gen_1	51	61	PF02991	0.321
LIG_LIR_Gen_1	70	78	PF02991	0.603
LIG_LIR_Nem_3	217	223	PF02991	0.447
LIG_LIR_Nem_3	228	234	PF02991	0.437
LIG_LIR_Nem_3	314	319	PF02991	0.518
LIG_LIR_Nem_3	418	423	PF02991	0.460
LIG_LIR_Nem_3	444	450	PF02991	0.355
LIG_LIR_Nem_3	51	56	PF02991	0.269
LIG_LIR_Nem_3	70	75	PF02991	0.543
LIG_PDZ_Class_2	540	545	PF00595	0.375
LIG_Rb_pABgroove_1	495	503	PF01858	0.336
LIG_SH2_CRK	501	505	PF00017	0.557
LIG_SH2_NCK_1	220	224	PF00017	0.419
LIG_SH2_PTP2	72	75	PF00017	0.389
LIG_SH2_SRC	64	67	PF00017	0.437
LIG_SH2_SRC	72	75	PF00017	0.471
LIG_SH2_STAP1	216	220	PF00017	0.557
LIG_SH2_STAP1	481	485	PF00017	0.416
LIG_SH2_STAT3	162	165	PF00017	0.325
LIG_SH2_STAT5	105	108	PF00017	0.376
LIG_SH2_STAT5	162	165	PF00017	0.344
LIG_SH2_STAT5	267	270	PF00017	0.503
LIG_SH2_STAT5	481	484	PF00017	0.497
LIG_SH2_STAT5	53	56	PF00017	0.308
LIG_SH2_STAT5	72	75	PF00017	0.480
LIG_SH3_2	136	141	PF14604	0.217
LIG_SH3_3	133	139	PF00018	0.376
LIG_SH3_3	340	346	PF00018	0.546
LIG_SUMO_SIM_anti_2	539	545	PF11976	0.324
LIG_SUMO_SIM_par_1	317	323	PF11976	0.607
LIG_SUMO_SIM_par_1	74	81	PF11976	0.313
LIG_TYR_ITSM	49	56	PF00017	0.238
MOD_CDK_SPK_2	80	85	PF00069	0.318
MOD_CDK_SPxK_1	374	380	PF00069	0.565
MOD_CK1_1	128	134	PF00069	0.612
MOD_CK1_1	26	32	PF00069	0.355
MOD_CK1_1	355	361	PF00069	0.718
MOD_CK1_1	432	438	PF00069	0.402
MOD_CK1_1	455	461	PF00069	0.482
MOD_CK2_1	191	197	PF00069	0.513
MOD_CK2_1	270	276	PF00069	0.530
MOD_CK2_1	286	292	PF00069	0.495
MOD_CK2_1	317	323	PF00069	0.497
MOD_CK2_1	49	55	PF00069	0.494
MOD_GlcNHglycan	116	119	PF01048	0.433
MOD_GlcNHglycan	254	257	PF01048	0.450
MOD_GlcNHglycan	313	316	PF01048	0.461
MOD_GlcNHglycan	404	407	PF01048	0.438
MOD_GlcNHglycan	92	95	PF01048	0.553
MOD_GSK3_1	210	217	PF00069	0.564
MOD_GSK3_1	270	277	PF00069	0.554
MOD_GSK3_1	348	355	PF00069	0.588
MOD_GSK3_1	439	446	PF00069	0.435
MOD_GSK3_1	451	458	PF00069	0.523
MOD_GSK3_1	51	58	PF00069	0.297
MOD_N-GLC_1	274	279	PF02516	0.494
MOD_N-GLC_1	348	353	PF02516	0.688
MOD_N-GLC_1	358	363	PF02516	0.709
MOD_N-GLC_1	512	517	PF02516	0.469
MOD_NEK2_1	127	132	PF00069	0.606
MOD_NEK2_1	150	155	PF00069	0.367
MOD_NEK2_1	173	178	PF00069	0.553
MOD_NEK2_1	260	265	PF00069	0.480
MOD_NEK2_1	324	329	PF00069	0.502
MOD_NEK2_1	348	353	PF00069	0.713
MOD_NEK2_1	379	384	PF00069	0.408
MOD_NEK2_1	419	424	PF00069	0.487
MOD_NEK2_1	48	53	PF00069	0.437
MOD_NEK2_1	78	83	PF00069	0.331
MOD_PIKK_1	150	156	PF00454	0.384
MOD_PIKK_1	295	301	PF00454	0.649
MOD_PIKK_1	407	413	PF00454	0.469
MOD_PIKK_1	452	458	PF00454	0.508
MOD_PK_1	270	276	PF00069	0.470
MOD_PK_1	439	445	PF00069	0.438
MOD_PKA_1	295	301	PF00069	0.454
MOD_PKA_2	210	216	PF00069	0.474
MOD_PKA_2	245	251	PF00069	0.453
MOD_PKA_2	252	258	PF00069	0.390
MOD_PKA_2	295	301	PF00069	0.610
MOD_PKA_2	352	358	PF00069	0.745
MOD_PKA_2	379	385	PF00069	0.409
MOD_PKA_2	407	413	PF00069	0.319
MOD_PKA_2	479	485	PF00069	0.352
MOD_Plk_1	274	280	PF00069	0.504
MOD_Plk_1	322	328	PF00069	0.583
MOD_Plk_1	348	354	PF00069	0.458
MOD_Plk_1	358	364	PF00069	0.585
MOD_Plk_1	389	395	PF00069	0.413
MOD_Plk_1	429	435	PF00069	0.348
MOD_Plk_2-3	191	197	PF00069	0.547
MOD_Plk_2-3	334	340	PF00069	0.610
MOD_Plk_4	191	197	PF00069	0.481
MOD_Plk_4	210	216	PF00069	0.348
MOD_Plk_4	274	280	PF00069	0.550
MOD_Plk_4	389	395	PF00069	0.494
MOD_Plk_4	419	425	PF00069	0.410
MOD_Plk_4	443	449	PF00069	0.376
MOD_Plk_4	539	545	PF00069	0.375
MOD_ProDKin_1	365	371	PF00069	0.520
MOD_ProDKin_1	374	380	PF00069	0.565
MOD_ProDKin_1	80	86	PF00069	0.302
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.163
TRG_ENDOCYTIC_2	220	223	PF00928	0.457
TRG_ENDOCYTIC_2	501	504	PF00928	0.552
TRG_ENDOCYTIC_2	53	56	PF00928	0.254
TRG_ENDOCYTIC_2	72	75	PF00928	0.576
TRG_ER_diArg_1	245	247	PF00400	0.566
TRG_ER_diArg_1	32	34	PF00400	0.327
TRG_ER_diArg_1	398	401	PF00400	0.567
TRG_ER_diArg_1	485	487	PF00400	0.515
TRG_ER_diArg_1	496	499	PF00400	0.453
TRG_Pf-PMV_PEXEL_1	33	38	PF00026	0.277
TRG_Pf-PMV_PEXEL_1	498	502	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9X5	Leptomonas seymouri	67%	99%
A0A0S4IQV6	Bodo saltans	43%	97%
A0A0S4JR35	Bodo saltans	25%	91%
A0A1X0P2R0	Trypanosomatidae	51%	95%
A0A3Q8IC39	Leishmania donovani	93%	100%
A0A3R7M632	Trypanosoma rangeli	52%	96%
A4HIG8	Leishmania braziliensis	81%	100%
A4I5R4	Leishmania infantum	93%	100%
C9ZR32	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	97%
Q4Q757	Leishmania major	92%	100%
V5DCZ6	Trypanosoma cruzi	52%	96%