LeishMANIAdb
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Sphingosine phosphate lyase-like protein,putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Sphingosine phosphate lyase-like protein,putative
Gene product:
sphingosine phosphate lyase-like protein, putative
Species:
Leishmania mexicana
UniProt:
E9B108_LEIMU
TriTrypDb:
LmxM.29.2350
Length:
537

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005783 endoplasmic reticulum 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

E9B108
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B108

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0019752 carboxylic acid metabolic process 5 11
GO:0043436 oxoacid metabolic process 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044281 small molecule metabolic process 2 11
GO:0071704 organic substance metabolic process 2 11
GO:0006066 alcohol metabolic process 3 1
GO:0006576 biogenic amine metabolic process 5 1
GO:0006580 ethanolamine metabolic process 5 1
GO:0006629 lipid metabolic process 3 1
GO:0006643 membrane lipid metabolic process 4 1
GO:0006665 sphingolipid metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0009056 catabolic process 2 1
GO:0009058 biosynthetic process 2 1
GO:0009308 amine metabolic process 4 1
GO:0009309 amine biosynthetic process 5 1
GO:0016042 lipid catabolic process 4 1
GO:0030149 sphingolipid catabolic process 5 1
GO:0034308 primary alcohol metabolic process 4 1
GO:0034309 primary alcohol biosynthetic process 5 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0042401 biogenic amine biosynthetic process 6 1
GO:0042439 ethanolamine-containing compound metabolic process 4 1
GO:0044238 primary metabolic process 2 1
GO:0044242 cellular lipid catabolic process 4 1
GO:0044248 cellular catabolic process 3 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044255 cellular lipid metabolic process 3 1
GO:0044271 cellular nitrogen compound biosynthetic process 4 1
GO:0044283 small molecule biosynthetic process 3 1
GO:0046165 alcohol biosynthetic process 4 1
GO:0046335 ethanolamine biosynthetic process 6 1
GO:0046466 membrane lipid catabolic process 5 1
GO:1901160 primary amino compound metabolic process 4 1
GO:1901162 primary amino compound biosynthetic process 5 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901565 organonitrogen compound catabolic process 4 1
GO:1901566 organonitrogen compound biosynthetic process 4 1
GO:1901575 organic substance catabolic process 3 1
GO:1901576 organic substance biosynthetic process 3 1
GO:1901615 organic hydroxy compound metabolic process 3 1
GO:1901617 organic hydroxy compound biosynthetic process 4 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 11
GO:0008117 sphinganine-1-phosphate aldolase activity 5 8
GO:0016829 lyase activity 2 12
GO:0016830 carbon-carbon lyase activity 3 11
GO:0016832 aldehyde-lyase activity 4 8
GO:0019842 vitamin binding 3 11
GO:0030170 pyridoxal phosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0070279 vitamin B6 binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 154 156 PF00675 0.256
CLV_NRD_NRD_1 200 202 PF00675 0.237
CLV_NRD_NRD_1 63 65 PF00675 0.469
CLV_PCSK_SKI1_1 115 119 PF00082 0.328
CLV_PCSK_SKI1_1 318 322 PF00082 0.350
CLV_PCSK_SKI1_1 398 402 PF00082 0.342
CLV_PCSK_SKI1_1 500 504 PF00082 0.445
CLV_PCSK_SKI1_1 524 528 PF00082 0.347
CLV_PCSK_SKI1_1 65 69 PF00082 0.392
CLV_PCSK_SKI1_1 84 88 PF00082 0.475
DOC_CDC14_PxL_1 232 240 PF14671 0.342
DOC_CKS1_1 466 471 PF01111 0.407
DOC_MAPK_gen_1 13 22 PF00069 0.345
DOC_MAPK_gen_1 251 260 PF00069 0.274
DOC_MAPK_gen_1 305 315 PF00069 0.398
DOC_MAPK_MEF2A_6 308 315 PF00069 0.398
DOC_PP2B_LxvP_1 58 61 PF13499 0.500
DOC_PP2B_LxvP_1 86 89 PF13499 0.541
DOC_PP2B_PxIxI_1 413 419 PF00149 0.272
DOC_PP4_FxxP_1 298 301 PF00568 0.256
DOC_USP7_MATH_1 145 149 PF00917 0.343
DOC_USP7_MATH_1 366 370 PF00917 0.291
DOC_USP7_MATH_1 422 426 PF00917 0.293
DOC_USP7_MATH_1 428 432 PF00917 0.323
DOC_USP7_MATH_1 504 508 PF00917 0.374
DOC_USP7_MATH_1 89 93 PF00917 0.472
DOC_USP7_UBL2_3 247 251 PF12436 0.296
DOC_USP7_UBL2_3 65 69 PF12436 0.418
DOC_WW_Pin1_4 13 18 PF00397 0.507
DOC_WW_Pin1_4 362 367 PF00397 0.272
DOC_WW_Pin1_4 465 470 PF00397 0.398
LIG_14-3-3_CanoR_1 42 48 PF00244 0.575
LIG_14-3-3_CanoR_1 475 483 PF00244 0.353
LIG_APCC_ABBA_1 287 292 PF00400 0.272
LIG_APCC_ABBA_1 299 304 PF00400 0.272
LIG_BIR_III_4 176 180 PF00653 0.272
LIG_BRCT_BRCA1_1 147 151 PF00533 0.316
LIG_BRCT_BRCA1_1 348 352 PF00533 0.272
LIG_deltaCOP1_diTrp_1 447 455 PF00928 0.254
LIG_eIF4E_1 227 233 PF01652 0.256
LIG_FHA_1 128 134 PF00498 0.223
LIG_FHA_1 16 22 PF00498 0.477
LIG_FHA_1 184 190 PF00498 0.272
LIG_FHA_1 201 207 PF00498 0.351
LIG_FHA_1 239 245 PF00498 0.269
LIG_FHA_1 24 30 PF00498 0.446
LIG_FHA_1 255 261 PF00498 0.238
LIG_FHA_1 335 341 PF00498 0.261
LIG_FHA_1 405 411 PF00498 0.256
LIG_FHA_1 421 427 PF00498 0.282
LIG_FHA_1 428 434 PF00498 0.314
LIG_FHA_2 193 199 PF00498 0.376
LIG_FHA_2 399 405 PF00498 0.290
LIG_FHA_2 77 83 PF00498 0.360
LIG_FHA_2 85 91 PF00498 0.328
LIG_GBD_Chelix_1 101 109 PF00786 0.437
LIG_LIR_Gen_1 349 359 PF02991 0.256
LIG_LIR_Gen_1 380 389 PF02991 0.286
LIG_LIR_Gen_1 45 55 PF02991 0.409
LIG_LIR_Nem_3 226 230 PF02991 0.272
LIG_LIR_Nem_3 250 255 PF02991 0.316
LIG_LIR_Nem_3 349 355 PF02991 0.256
LIG_LIR_Nem_3 45 51 PF02991 0.415
LIG_LIR_Nem_3 80 86 PF02991 0.538
LIG_MAD2 69 77 PF02301 0.352
LIG_MYND_3 300 304 PF01753 0.398
LIG_PCNA_PIPBox_1 1 10 PF02747 0.497
LIG_PDZ_Class_2 532 537 PF00595 0.484
LIG_Pex14_2 298 302 PF04695 0.256
LIG_PTB_Apo_2 529 536 PF02174 0.346
LIG_PTB_Phospho_1 529 535 PF10480 0.342
LIG_SH2_CRK 255 259 PF00017 0.291
LIG_SH2_CRK 363 367 PF00017 0.272
LIG_SH2_GRB2like 7 10 PF00017 0.492
LIG_SH2_NCK_1 255 259 PF00017 0.291
LIG_SH2_PTP2 415 418 PF00017 0.291
LIG_SH2_STAP1 255 259 PF00017 0.316
LIG_SH2_STAT5 227 230 PF00017 0.272
LIG_SH2_STAT5 252 255 PF00017 0.272
LIG_SH2_STAT5 363 366 PF00017 0.272
LIG_SH2_STAT5 392 395 PF00017 0.256
LIG_SH2_STAT5 415 418 PF00017 0.291
LIG_SH2_STAT5 7 10 PF00017 0.588
LIG_SH3_3 208 214 PF00018 0.398
LIG_SH3_3 262 268 PF00018 0.256
LIG_SH3_3 71 77 PF00018 0.589
LIG_SUMO_SIM_anti_2 18 24 PF11976 0.444
LIG_SUMO_SIM_anti_2 462 468 PF11976 0.306
LIG_SUMO_SIM_par_1 18 24 PF11976 0.515
LIG_TRAF2_1 274 277 PF00917 0.350
LIG_TYR_ITIM 253 258 PF00017 0.291
LIG_TYR_ITIM 413 418 PF00017 0.291
LIG_UBA3_1 189 194 PF00899 0.291
LIG_UBA3_1 436 444 PF00899 0.402
LIG_WRC_WIRS_1 347 352 PF05994 0.316
MOD_CK1_1 183 189 PF00069 0.259
MOD_CK1_1 324 330 PF00069 0.256
MOD_CK1_1 506 512 PF00069 0.513
MOD_CK2_1 398 404 PF00069 0.443
MOD_CK2_1 76 82 PF00069 0.449
MOD_CK2_1 84 90 PF00069 0.455
MOD_Cter_Amidation 199 202 PF01082 0.321
MOD_Cter_Amidation 497 500 PF01082 0.492
MOD_GlcNHglycan 118 121 PF01048 0.332
MOD_GlcNHglycan 182 185 PF01048 0.259
MOD_GlcNHglycan 262 265 PF01048 0.256
MOD_GlcNHglycan 368 371 PF01048 0.297
MOD_GlcNHglycan 505 509 PF01048 0.514
MOD_GSK3_1 179 186 PF00069 0.262
MOD_GSK3_1 362 369 PF00069 0.270
MOD_GSK3_1 398 405 PF00069 0.353
MOD_GSK3_1 461 468 PF00069 0.321
MOD_GSK3_1 506 513 PF00069 0.446
MOD_NEK2_1 140 145 PF00069 0.271
MOD_NEK2_1 151 156 PF00069 0.269
MOD_NEK2_1 238 243 PF00069 0.398
MOD_NEK2_1 303 308 PF00069 0.398
MOD_NEK2_1 427 432 PF00069 0.378
MOD_NEK2_1 459 464 PF00069 0.300
MOD_NEK2_1 503 508 PF00069 0.585
MOD_NEK2_1 510 515 PF00069 0.521
MOD_NEK2_1 530 535 PF00069 0.491
MOD_NEK2_2 422 427 PF00069 0.272
MOD_PIKK_1 100 106 PF00454 0.456
MOD_PIKK_1 15 21 PF00454 0.449
MOD_PIKK_1 2 8 PF00454 0.511
MOD_PKA_2 200 206 PF00069 0.327
MOD_PKA_2 402 408 PF00069 0.366
MOD_PKA_2 41 47 PF00069 0.479
MOD_PKB_1 316 324 PF00069 0.350
MOD_Plk_1 109 115 PF00069 0.431
MOD_Plk_1 518 524 PF00069 0.363
MOD_Plk_4 160 166 PF00069 0.294
MOD_Plk_4 185 191 PF00069 0.272
MOD_Plk_4 207 213 PF00069 0.266
MOD_Plk_4 336 342 PF00069 0.257
MOD_Plk_4 422 428 PF00069 0.272
MOD_Plk_4 461 467 PF00069 0.287
MOD_Plk_4 483 489 PF00069 0.475
MOD_Plk_4 506 512 PF00069 0.428
MOD_Plk_4 530 536 PF00069 0.485
MOD_ProDKin_1 13 19 PF00069 0.506
MOD_ProDKin_1 362 368 PF00069 0.272
MOD_ProDKin_1 465 471 PF00069 0.404
MOD_SUMO_rev_2 441 445 PF00179 0.450
MOD_SUMO_rev_2 478 483 PF00179 0.456
MOD_SUMO_rev_2 491 501 PF00179 0.405
MOD_SUMO_rev_2 78 86 PF00179 0.429
TRG_DiLeu_BaEn_1 490 495 PF01217 0.490
TRG_DiLeu_BaEn_1 97 102 PF01217 0.417
TRG_ENDOCYTIC_2 227 230 PF00928 0.256
TRG_ENDOCYTIC_2 255 258 PF00928 0.274
TRG_ENDOCYTIC_2 415 418 PF00928 0.291
TRG_ENDOCYTIC_2 48 51 PF00928 0.428
TRG_ER_diArg_1 315 318 PF00400 0.350
TRG_NES_CRM1_1 100 114 PF08389 0.486
TRG_NES_CRM1_1 435 447 PF08389 0.200
TRG_Pf-PMV_PEXEL_1 475 479 PF00026 0.367

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IBN8 Leptomonas seymouri 76% 99%
A0A0S4JRW4 Bodo saltans 53% 99%
A0A1X0P362 Trypanosomatidae 65% 100%
A0A3Q8IS31 Leishmania donovani 94% 100%
A0A3R7KL89 Trypanosoma rangeli 63% 100%
A0B9M9 Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) 27% 100%
A4HIG7 Leishmania braziliensis 87% 100%
A4I5R3 Leishmania infantum 94% 100%
A6URB4 Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB) 26% 100%
C9ZR31 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 63% 100%
O95470 Homo sapiens 37% 95%
P54767 Solanum lycopersicum 25% 100%
Q05567 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 37% 91%
Q12VA2 Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) 27% 100%
Q2NHY7 Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3) 26% 100%
Q42472 Arabidopsis thaliana 24% 100%
Q46DU3 Methanosarcina barkeri (strain Fusaro / DSM 804) 29% 100%
Q4Q758 Leishmania major 91% 100%
Q52RG7 Oryza sativa subsp. japonica 40% 100%
Q54RV9 Dictyostelium discoideum 37% 100%
Q5R4G0 Pongo abelii 37% 95%
Q5WUR6 Legionella pneumophila (strain Lens) 33% 89%
Q5X3A8 Legionella pneumophila (strain Paris) 33% 89%
Q5ZTI6 Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) 32% 89%
Q8CHN6 Rattus norvegicus 39% 95%
Q8R0X7 Mus musculus 39% 95%
Q8U1P6 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 27% 100%
Q9C509 Arabidopsis thaliana 41% 99%
Q9UZD5 Pyrococcus abyssi (strain GE5 / Orsay) 28% 100%
Q9V7Y2 Drosophila melanogaster 38% 99%
Q9Y194 Caenorhabditis elegans 37% 97%
Q9ZPS3 Arabidopsis thaliana 25% 100%
Q9ZPS4 Arabidopsis thaliana 25% 100%
V5AWV1 Trypanosoma cruzi 62% 86%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS