SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B105_LEIMU

TriTrypDb:

LmxM.29.2320

Length:

357

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B105

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B105

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	330	334	PF00656	0.463
CLV_NRD_NRD_1	20	22	PF00675	0.399
CLV_NRD_NRD_1	294	296	PF00675	0.293
CLV_NRD_NRD_1	303	305	PF00675	0.304
CLV_NRD_NRD_1	326	328	PF00675	0.479
CLV_NRD_NRD_1	337	339	PF00675	0.623
CLV_NRD_NRD_1	77	79	PF00675	0.215
CLV_PCSK_KEX2_1	19	21	PF00082	0.388
CLV_PCSK_KEX2_1	294	296	PF00082	0.291
CLV_PCSK_KEX2_1	303	305	PF00082	0.293
CLV_PCSK_KEX2_1	326	328	PF00082	0.615
CLV_PCSK_KEX2_1	337	339	PF00082	0.547
CLV_PCSK_KEX2_1	77	79	PF00082	0.215
CLV_PCSK_PC7_1	16	22	PF00082	0.385
CLV_PCSK_PC7_1	322	328	PF00082	0.467
CLV_PCSK_SKI1_1	26	30	PF00082	0.292
DEG_APCC_DBOX_1	185	193	PF00400	0.365
DEG_SPOP_SBC_1	255	259	PF00917	0.365
DOC_CDC14_PxL_1	228	236	PF14671	0.451
DOC_MAPK_gen_1	247	255	PF00069	0.467
DOC_MAPK_gen_1	303	313	PF00069	0.569
DOC_MAPK_gen_1	77	85	PF00069	0.508
DOC_MAPK_MEF2A_6	36	45	PF00069	0.450
DOC_PP2B_LxvP_1	251	254	PF13499	0.532
DOC_PP2B_LxvP_1	53	56	PF13499	0.539
DOC_USP7_MATH_1	125	129	PF00917	0.405
DOC_USP7_MATH_1	293	297	PF00917	0.435
DOC_WW_Pin1_4	129	134	PF00397	0.436
DOC_WW_Pin1_4	280	285	PF00397	0.545
LIG_14-3-3_CanoR_1	104	108	PF00244	0.427
LIG_14-3-3_CanoR_1	174	180	PF00244	0.416
LIG_14-3-3_CanoR_1	294	298	PF00244	0.487
LIG_14-3-3_CanoR_1	316	324	PF00244	0.552
LIG_14-3-3_CanoR_1	61	65	PF00244	0.509
LIG_Actin_WH2_2	172	188	PF00022	0.396
LIG_APCC_ABBA_1	83	88	PF00400	0.482
LIG_BIR_II_1	1	5	PF00653	0.427
LIG_BIR_III_2	114	118	PF00653	0.365
LIG_BRCT_BRCA1_1	171	175	PF00533	0.482
LIG_BRCT_BRCA1_1	177	181	PF00533	0.442
LIG_deltaCOP1_diTrp_1	88	97	PF00928	0.531
LIG_FHA_1	174	180	PF00498	0.456
LIG_FHA_1	235	241	PF00498	0.542
LIG_FHA_2	49	55	PF00498	0.529
LIG_FHA_2	67	73	PF00498	0.450
LIG_LIR_Gen_1	233	243	PF02991	0.550
LIG_LIR_Gen_1	88	98	PF02991	0.531
LIG_LIR_LC3C_4	38	41	PF02991	0.365
LIG_LIR_Nem_3	178	184	PF02991	0.459
LIG_LIR_Nem_3	224	228	PF02991	0.471
LIG_LIR_Nem_3	233	238	PF02991	0.472
LIG_LIR_Nem_3	88	93	PF02991	0.531
LIG_Pex14_1	92	96	PF04695	0.531
LIG_Pex14_2	86	90	PF04695	0.482
LIG_RPA_C_Fungi	289	301	PF08784	0.226
LIG_SH2_CRK	47	51	PF00017	0.404
LIG_SH2_NCK_1	193	197	PF00017	0.292
LIG_SH2_SRC	148	151	PF00017	0.335
LIG_SH2_STAP1	148	152	PF00017	0.335
LIG_SH2_STAT5	146	149	PF00017	0.271
LIG_SH2_STAT5	184	187	PF00017	0.314
LIG_SH2_STAT5	244	247	PF00017	0.271
LIG_SH2_STAT5	351	354	PF00017	0.456
LIG_SH2_STAT5	47	50	PF00017	0.289
LIG_SH3_3	266	272	PF00018	0.289
LIG_SH3_3	38	44	PF00018	0.171
LIG_Sin3_3	285	292	PF02671	0.213
LIG_SUMO_SIM_par_1	236	242	PF11976	0.292
LIG_TRAF2_1	180	183	PF00917	0.233
LIG_TYR_ITIM	45	50	PF00017	0.404
MOD_CK1_1	106	112	PF00069	0.270
MOD_CK1_1	155	161	PF00069	0.410
MOD_CK1_1	191	197	PF00069	0.363
MOD_CK1_1	257	263	PF00069	0.335
MOD_CK2_1	129	135	PF00069	0.271
MOD_CK2_1	194	200	PF00069	0.318
MOD_CK2_1	66	72	PF00069	0.369
MOD_GlcNHglycan	154	157	PF01048	0.414
MOD_GlcNHglycan	197	200	PF01048	0.404
MOD_GlcNHglycan	290	293	PF01048	0.449
MOD_GSK3_1	103	110	PF00069	0.261
MOD_GSK3_1	125	132	PF00069	0.180
MOD_GSK3_1	169	176	PF00069	0.384
MOD_GSK3_1	191	198	PF00069	0.438
MOD_GSK3_1	230	237	PF00069	0.396
MOD_GSK3_1	327	334	PF00069	0.642
MOD_N-GLC_1	331	336	PF02516	0.584
MOD_N-GLC_2	278	280	PF02516	0.335
MOD_NEK2_1	107	112	PF00069	0.212
MOD_NEK2_1	127	132	PF00069	0.320
MOD_NEK2_1	152	157	PF00069	0.469
MOD_NEK2_1	175	180	PF00069	0.391
MOD_NEK2_1	234	239	PF00069	0.352
MOD_NEK2_1	39	44	PF00069	0.331
MOD_NEK2_1	66	71	PF00069	0.255
MOD_NEK2_2	188	193	PF00069	0.404
MOD_PIKK_1	48	54	PF00454	0.335
MOD_PKA_2	103	109	PF00069	0.248
MOD_PKA_2	173	179	PF00069	0.292
MOD_PKA_2	293	299	PF00069	0.402
MOD_PKA_2	315	321	PF00069	0.554
MOD_PKA_2	60	66	PF00069	0.439
MOD_Plk_1	134	140	PF00069	0.261
MOD_Plk_1	309	315	PF00069	0.289
MOD_Plk_1	331	337	PF00069	0.670
MOD_Plk_2-3	230	236	PF00069	0.376
MOD_Plk_2-3	309	315	PF00069	0.314
MOD_Plk_4	188	194	PF00069	0.414
MOD_Plk_4	230	236	PF00069	0.370
MOD_Plk_4	239	245	PF00069	0.319
MOD_Plk_4	265	271	PF00069	0.370
MOD_ProDKin_1	129	135	PF00069	0.271
MOD_ProDKin_1	280	286	PF00069	0.424
TRG_ENDOCYTIC_2	47	50	PF00928	0.317
TRG_ER_diArg_1	19	21	PF00400	0.413
TRG_ER_diArg_1	246	249	PF00400	0.271
TRG_ER_diArg_1	302	304	PF00400	0.373
TRG_ER_diArg_1	336	338	PF00400	0.460
TRG_ER_diArg_1	76	78	PF00400	0.241
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	350	354	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDQ4	Leptomonas seymouri	50%	98%
A0A1X0P1P8	Trypanosomatidae	41%	100%
A0A3Q8IEW5	Leishmania donovani	87%	100%
A0A3R7MQP1	Trypanosoma rangeli	40%	100%
A4HIG4	Leishmania braziliensis	77%	100%
A4I5R0	Leishmania infantum	87%	100%
C9ZR29	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
Q4Q761	Leishmania major	88%	100%
V5BLC5	Trypanosoma cruzi	39%	72%