Tubulin-tyrosine ligase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin-tyrosine ligase-like protein

Species:

Leishmania mexicana

UniProt:

E9B101_LEIMU

TriTrypDb:

LmxM.29.2280

Length:

705

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9B101

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B101

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0019538	protein metabolic process	3	14
GO:0036211	protein modification process	4	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043412	macromolecule modification	4	14
GO:0044238	primary metabolic process	2	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0018095	protein polyglutamylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018200	peptidyl-glutamic acid modification	6	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	14
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016874	ligase activity	2	14
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	1
GO:0016881	acid-amino acid ligase activity	4	1
GO:0070739	protein-glutamic acid ligase activity	3	1
GO:0070740	tubulin-glutamic acid ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	357	361	PF00656	0.496
CLV_C14_Caspase3-7	454	458	PF00656	0.374
CLV_NRD_NRD_1	110	112	PF00675	0.404
CLV_NRD_NRD_1	191	193	PF00675	0.340
CLV_NRD_NRD_1	206	208	PF00675	0.228
CLV_NRD_NRD_1	286	288	PF00675	0.261
CLV_NRD_NRD_1	3	5	PF00675	0.502
CLV_NRD_NRD_1	306	308	PF00675	0.195
CLV_NRD_NRD_1	414	416	PF00675	0.384
CLV_NRD_NRD_1	474	476	PF00675	0.298
CLV_NRD_NRD_1	504	506	PF00675	0.314
CLV_NRD_NRD_1	56	58	PF00675	0.439
CLV_PCSK_KEX2_1	110	112	PF00082	0.345
CLV_PCSK_KEX2_1	183	185	PF00082	0.240
CLV_PCSK_KEX2_1	191	193	PF00082	0.352
CLV_PCSK_KEX2_1	286	288	PF00082	0.321
CLV_PCSK_KEX2_1	3	5	PF00082	0.502
CLV_PCSK_KEX2_1	414	416	PF00082	0.405
CLV_PCSK_KEX2_1	474	476	PF00082	0.298
CLV_PCSK_KEX2_1	504	506	PF00082	0.311
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.255
CLV_PCSK_SKI1_1	191	195	PF00082	0.258
CLV_PCSK_SKI1_1	254	258	PF00082	0.264
CLV_PCSK_SKI1_1	286	290	PF00082	0.234
CLV_PCSK_SKI1_1	405	409	PF00082	0.307
CLV_PCSK_SKI1_1	424	428	PF00082	0.503
CLV_PCSK_SKI1_1	595	599	PF00082	0.556
CLV_Separin_Metazoa	133	137	PF03568	0.597
DEG_Nend_Nbox_1	1	3	PF02207	0.592
DOC_ANK_TNKS_1	567	574	PF00023	0.439
DOC_CKS1_1	139	144	PF01111	0.434
DOC_CYCLIN_yCln2_LP_2	586	592	PF00134	0.501
DOC_MAPK_FxFP_2	61	64	PF00069	0.475
DOC_MAPK_gen_1	183	190	PF00069	0.470
DOC_MAPK_gen_1	307	315	PF00069	0.426
DOC_MAPK_gen_1	651	660	PF00069	0.508
DOC_MAPK_MEF2A_6	183	190	PF00069	0.408
DOC_MAPK_MEF2A_6	307	315	PF00069	0.436
DOC_MAPK_MEF2A_6	618	625	PF00069	0.380
DOC_MAPK_NFAT4_5	308	316	PF00069	0.435
DOC_PP2B_LxvP_1	100	103	PF13499	0.313
DOC_PP2B_LxvP_1	427	430	PF13499	0.513
DOC_PP2B_LxvP_1	663	666	PF13499	0.571
DOC_PP4_FxxP_1	61	64	PF00568	0.463
DOC_USP7_MATH_1	148	152	PF00917	0.525
DOC_USP7_MATH_1	201	205	PF00917	0.434
DOC_USP7_MATH_1	209	213	PF00917	0.512
DOC_USP7_MATH_1	21	25	PF00917	0.640
DOC_USP7_MATH_1	236	240	PF00917	0.501
DOC_USP7_MATH_1	316	320	PF00917	0.418
DOC_USP7_MATH_1	38	42	PF00917	0.655
DOC_USP7_MATH_1	672	676	PF00917	0.488
DOC_USP7_MATH_1	688	692	PF00917	0.267
DOC_USP7_MATH_2	224	230	PF00917	0.434
DOC_USP7_UBL2_3	279	283	PF12436	0.401
DOC_WW_Pin1_4	138	143	PF00397	0.485
DOC_WW_Pin1_4	234	239	PF00397	0.392
DOC_WW_Pin1_4	388	393	PF00397	0.704
DOC_WW_Pin1_4	40	45	PF00397	0.617
DOC_WW_Pin1_4	51	56	PF00397	0.556
LIG_14-3-3_CanoR_1	162	170	PF00244	0.427
LIG_14-3-3_CanoR_1	213	217	PF00244	0.504
LIG_14-3-3_CanoR_1	286	294	PF00244	0.514
LIG_14-3-3_CanoR_1	424	430	PF00244	0.674
LIG_14-3-3_CanoR_1	57	62	PF00244	0.441
LIG_Actin_WH2_2	35	52	PF00022	0.624
LIG_BIR_III_4	457	461	PF00653	0.345
LIG_BRCT_BRCA1_1	127	131	PF00533	0.540
LIG_BRCT_BRCA1_1	541	545	PF00533	0.511
LIG_BRCT_BRCA1_1	59	63	PF00533	0.417
LIG_deltaCOP1_diTrp_1	444	453	PF00928	0.301
LIG_EH_1	526	530	PF12763	0.434
LIG_eIF4E_1	297	303	PF01652	0.418
LIG_eIF4E_1	689	695	PF01652	0.369
LIG_FHA_1	139	145	PF00498	0.591
LIG_FHA_1	283	289	PF00498	0.554
LIG_FHA_1	431	437	PF00498	0.679
LIG_FHA_1	487	493	PF00498	0.516
LIG_FHA_1	549	555	PF00498	0.424
LIG_FHA_1	698	704	PF00498	0.323
LIG_FHA_2	201	207	PF00498	0.498
LIG_FHA_2	615	621	PF00498	0.557
LIG_GBD_Chelix_1	484	492	PF00786	0.218
LIG_GBD_Chelix_1	554	562	PF00786	0.258
LIG_LIR_Apic_2	220	224	PF02991	0.434
LIG_LIR_Apic_2	60	64	PF02991	0.471
LIG_LIR_Gen_1	128	135	PF02991	0.450
LIG_LIR_Gen_1	212	222	PF02991	0.433
LIG_LIR_Gen_1	268	276	PF02991	0.511
LIG_LIR_Nem_3	212	217	PF02991	0.343
LIG_LIR_Nem_3	268	272	PF02991	0.438
LIG_LIR_Nem_3	318	323	PF02991	0.437
LIG_LIR_Nem_3	402	407	PF02991	0.375
LIG_LIR_Nem_3	511	516	PF02991	0.477
LIG_LIR_Nem_3	94	100	PF02991	0.334
LIG_MLH1_MIPbox_1	59	63	PF16413	0.515
LIG_MYND_3	536	540	PF01753	0.475
LIG_Pex14_2	635	639	PF04695	0.284
LIG_SH2_CRK	214	218	PF00017	0.343
LIG_SH2_CRK	320	324	PF00017	0.441
LIG_SH2_PTP2	314	317	PF00017	0.408
LIG_SH2_SRC	455	458	PF00017	0.455
LIG_SH2_STAP1	98	102	PF00017	0.313
LIG_SH2_STAT3	292	295	PF00017	0.435
LIG_SH2_STAT3	689	692	PF00017	0.367
LIG_SH2_STAT3	74	77	PF00017	0.574
LIG_SH2_STAT5	216	219	PF00017	0.335
LIG_SH2_STAT5	292	295	PF00017	0.428
LIG_SH2_STAT5	297	300	PF00017	0.423
LIG_SH2_STAT5	314	317	PF00017	0.426
LIG_SH2_STAT5	395	398	PF00017	0.400
LIG_SH2_STAT5	416	419	PF00017	0.508
LIG_SH2_STAT5	455	458	PF00017	0.482
LIG_SH2_STAT5	48	51	PF00017	0.539
LIG_SH2_STAT5	512	515	PF00017	0.475
LIG_SH2_STAT5	62	65	PF00017	0.403
LIG_SH2_STAT5	682	685	PF00017	0.460
LIG_SH3_3	503	509	PF00018	0.511
LIG_SUMO_SIM_anti_2	605	610	PF11976	0.492
LIG_SUMO_SIM_par_1	299	305	PF11976	0.455
LIG_SUMO_SIM_par_1	425	433	PF11976	0.516
LIG_SUMO_SIM_par_1	529	535	PF11976	0.444
LIG_UBA3_1	272	279	PF00899	0.499
LIG_WW_1	71	74	PF00397	0.480
MOD_CDC14_SPxK_1	54	57	PF00782	0.547
MOD_CDK_SPxK_1	51	57	PF00069	0.571
MOD_CDK_SPxxK_3	234	241	PF00069	0.392
MOD_CDK_SPxxK_3	51	58	PF00069	0.566
MOD_CK1_1	212	218	PF00069	0.498
MOD_CK1_1	229	235	PF00069	0.515
MOD_CK1_1	24	30	PF00069	0.653
MOD_CK1_1	248	254	PF00069	0.454
MOD_CK1_1	282	288	PF00069	0.522
MOD_CK1_1	341	347	PF00069	0.533
MOD_CK1_1	376	382	PF00069	0.780
MOD_CK1_1	425	431	PF00069	0.647
MOD_CK1_1	538	544	PF00069	0.435
MOD_CK1_1	548	554	PF00069	0.435
MOD_CK1_1	645	651	PF00069	0.623
MOD_CK1_1	656	662	PF00069	0.643
MOD_CK1_1	80	86	PF00069	0.552
MOD_CK1_1	89	95	PF00069	0.427
MOD_CK2_1	200	206	PF00069	0.499
MOD_CK2_1	508	514	PF00069	0.475
MOD_CK2_1	90	96	PF00069	0.423
MOD_Cter_Amidation	305	308	PF01082	0.243
MOD_Cter_Amidation	412	415	PF01082	0.355
MOD_GlcNHglycan	203	206	PF01048	0.159
MOD_GlcNHglycan	23	26	PF01048	0.722
MOD_GlcNHglycan	370	373	PF01048	0.582
MOD_GlcNHglycan	375	378	PF01048	0.780
MOD_GlcNHglycan	386	389	PF01048	0.648
MOD_GlcNHglycan	392	395	PF01048	0.639
MOD_GlcNHglycan	644	647	PF01048	0.592
MOD_GlcNHglycan	662	666	PF01048	0.425
MOD_GlcNHglycan	695	698	PF01048	0.319
MOD_GSK3_1	23	30	PF00069	0.618
MOD_GSK3_1	256	263	PF00069	0.543
MOD_GSK3_1	340	347	PF00069	0.523
MOD_GSK3_1	364	371	PF00069	0.697
MOD_GSK3_1	384	391	PF00069	0.725
MOD_GSK3_1	459	466	PF00069	0.451
MOD_GSK3_1	535	542	PF00069	0.444
MOD_GSK3_1	572	579	PF00069	0.581
MOD_GSK3_1	642	649	PF00069	0.541
MOD_GSK3_1	654	661	PF00069	0.623
MOD_GSK3_1	693	700	PF00069	0.447
MOD_GSK3_1	76	83	PF00069	0.651
MOD_GSK3_1	86	93	PF00069	0.518
MOD_N-GLC_1	344	349	PF02516	0.392
MOD_N-GLC_1	384	389	PF02516	0.493
MOD_N-GLC_1	408	413	PF02516	0.358
MOD_N-GLC_1	577	582	PF02516	0.588
MOD_NEK2_1	163	168	PF00069	0.279
MOD_NEK2_1	288	293	PF00069	0.481
MOD_NEK2_1	29	34	PF00069	0.463
MOD_NEK2_1	368	373	PF00069	0.673
MOD_NEK2_1	445	450	PF00069	0.349
MOD_NEK2_1	522	527	PF00069	0.465
MOD_NEK2_1	539	544	PF00069	0.425
MOD_NEK2_1	545	550	PF00069	0.418
MOD_NEK2_1	576	581	PF00069	0.566
MOD_NEK2_1	88	93	PF00069	0.375
MOD_NEK2_2	125	130	PF00069	0.362
MOD_NEK2_2	460	465	PF00069	0.305
MOD_PIKK_1	256	262	PF00454	0.436
MOD_PIKK_1	646	652	PF00454	0.660
MOD_PIKK_1	688	694	PF00454	0.330
MOD_PK_1	654	660	PF00069	0.435
MOD_PKA_1	474	480	PF00069	0.323
MOD_PKA_1	57	63	PF00069	0.408
MOD_PKA_2	212	218	PF00069	0.502
MOD_PKA_2	226	232	PF00069	0.514
MOD_PKA_2	248	254	PF00069	0.427
MOD_PKA_2	474	480	PF00069	0.305
MOD_PKA_2	653	659	PF00069	0.672
MOD_PKB_1	403	411	PF00069	0.480
MOD_Plk_1	30	36	PF00069	0.517
MOD_Plk_1	408	414	PF00069	0.365
MOD_Plk_1	460	466	PF00069	0.571
MOD_Plk_1	522	528	PF00069	0.513
MOD_Plk_1	577	583	PF00069	0.576
MOD_Plk_1	654	660	PF00069	0.435
MOD_Plk_1	697	703	PF00069	0.321
MOD_Plk_4	212	218	PF00069	0.453
MOD_Plk_4	226	232	PF00069	0.435
MOD_Plk_4	288	294	PF00069	0.527
MOD_Plk_4	31	37	PF00069	0.531
MOD_Plk_4	321	327	PF00069	0.421
MOD_Plk_4	508	514	PF00069	0.475
MOD_Plk_4	57	63	PF00069	0.424
MOD_Plk_4	572	578	PF00069	0.613
MOD_Plk_4	678	684	PF00069	0.429
MOD_ProDKin_1	138	144	PF00069	0.480
MOD_ProDKin_1	234	240	PF00069	0.392
MOD_ProDKin_1	388	394	PF00069	0.701
MOD_ProDKin_1	40	46	PF00069	0.611
MOD_ProDKin_1	51	57	PF00069	0.546
MOD_SUMO_rev_2	204	210	PF00179	0.484
MOD_SUMO_rev_2	274	281	PF00179	0.480
MOD_SUMO_rev_2	439	448	PF00179	0.422
TRG_DiLeu_BaEn_1	226	231	PF01217	0.450
TRG_DiLeu_BaEn_1	299	304	PF01217	0.432
TRG_DiLeu_BaEn_1	31	36	PF01217	0.407
TRG_DiLeu_BaEn_1	483	488	PF01217	0.515
TRG_DiLeu_BaEn_1	690	695	PF01217	0.341
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.317
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.471
TRG_DiLeu_BaLyEn_6	298	303	PF01217	0.418
TRG_ENDOCYTIC_2	170	173	PF00928	0.446
TRG_ENDOCYTIC_2	214	217	PF00928	0.432
TRG_ENDOCYTIC_2	314	317	PF00928	0.414
TRG_ENDOCYTIC_2	320	323	PF00928	0.445
TRG_ENDOCYTIC_2	416	419	PF00928	0.477
TRG_ENDOCYTIC_2	512	515	PF00928	0.475
TRG_ENDOCYTIC_2	97	100	PF00928	0.303
TRG_ER_diArg_1	109	111	PF00400	0.404
TRG_ER_diArg_1	190	192	PF00400	0.552
TRG_ER_diArg_1	2	4	PF00400	0.499
TRG_ER_diArg_1	286	288	PF00400	0.521
TRG_ER_diArg_1	414	416	PF00400	0.461
TRG_ER_diArg_1	464	467	PF00400	0.489
TRG_ER_diArg_1	503	505	PF00400	0.434
TRG_ER_diArg_1	623	626	PF00400	0.532
TRG_ER_diArg_1	64	67	PF00400	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Q6	Leptomonas seymouri	57%	98%
A0A0S4ISF0	Bodo saltans	37%	100%
A0A1X0P1M0	Trypanosomatidae	41%	100%
A0A3Q8IDL7	Leishmania donovani	25%	97%
A0A3Q8IEC1	Leishmania donovani	90%	100%
A0A3R7LAU2	Trypanosoma rangeli	25%	75%
A0A3S5IS28	Trypanosoma rangeli	43%	100%
A4HIG0	Leishmania braziliensis	76%	100%
A4HYN9	Leishmania infantum	25%	97%
A4I5Q6	Leishmania infantum	90%	100%
A4Q9F0	Mus musculus	23%	77%
A8X9V4	Caenorhabditis briggsae	25%	100%
C9ZR25	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZYH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AUL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q09647	Caenorhabditis elegans	24%	100%
Q4Q765	Leishmania major	89%	100%
Q4QCW7	Leishmania major	25%	100%
Q6ZT98	Homo sapiens	25%	79%
V5BLC0	Trypanosoma cruzi	42%	100%