DUF155 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised ACR, YagE family COG1723, putative

Species:

Leishmania mexicana

UniProt:

E9B0Z5_LEIMU

TriTrypDb:

LmxM.29.2220

Length:

539

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	12
GO:0016020	membrane	2	11
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9B0Z5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0Z5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	48	52	PF00656	0.720
CLV_C14_Caspase3-7	5	9	PF00656	0.655
CLV_NRD_NRD_1	175	177	PF00675	0.386
CLV_NRD_NRD_1	190	192	PF00675	0.436
CLV_NRD_NRD_1	207	209	PF00675	0.467
CLV_NRD_NRD_1	223	225	PF00675	0.458
CLV_NRD_NRD_1	263	265	PF00675	0.358
CLV_NRD_NRD_1	299	301	PF00675	0.269
CLV_NRD_NRD_1	31	33	PF00675	0.494
CLV_NRD_NRD_1	436	438	PF00675	0.320
CLV_NRD_NRD_1	505	507	PF00675	0.319
CLV_PCSK_FUR_1	173	177	PF00082	0.457
CLV_PCSK_KEX2_1	175	177	PF00082	0.400
CLV_PCSK_KEX2_1	190	192	PF00082	0.448
CLV_PCSK_KEX2_1	207	209	PF00082	0.457
CLV_PCSK_KEX2_1	223	225	PF00082	0.462
CLV_PCSK_KEX2_1	263	265	PF00082	0.366
CLV_PCSK_KEX2_1	31	33	PF00082	0.494
CLV_PCSK_KEX2_1	435	437	PF00082	0.317
CLV_PCSK_KEX2_1	505	507	PF00082	0.319
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.329
CLV_PCSK_PC7_1	171	177	PF00082	0.374
CLV_PCSK_SKI1_1	175	179	PF00082	0.421
CLV_PCSK_SKI1_1	31	35	PF00082	0.451
CLV_PCSK_SKI1_1	368	372	PF00082	0.314
CLV_PCSK_SKI1_1	416	420	PF00082	0.261
DEG_APCC_DBOX_1	114	122	PF00400	0.652
DEG_APCC_DBOX_1	170	178	PF00400	0.650
DEG_APCC_DBOX_1	250	258	PF00400	0.577
DEG_APCC_DBOX_1	505	513	PF00400	0.451
DEG_Nend_UBRbox_2	1	3	PF02207	0.687
DEG_ODPH_VHL_1	88	101	PF01847	0.691
DEG_SCF_FBW7_1	64	71	PF00400	0.709
DOC_CDC14_PxL_1	462	470	PF14671	0.535
DOC_CKS1_1	349	354	PF01111	0.476
DOC_CKS1_1	419	424	PF01111	0.529
DOC_CYCLIN_RxL_1	114	124	PF00134	0.655
DOC_CYCLIN_RxL_1	171	182	PF00134	0.663
DOC_CYCLIN_yCln2_LP_2	419	425	PF00134	0.549
DOC_MAPK_gen_1	115	123	PF00069	0.655
DOC_MAPK_gen_1	435	447	PF00069	0.552
DOC_MAPK_MEF2A_6	115	123	PF00069	0.583
DOC_MAPK_MEF2A_6	387	394	PF00069	0.451
DOC_MAPK_RevD_3	162	176	PF00069	0.553
DOC_PP1_RVXF_1	482	488	PF00149	0.549
DOC_USP7_MATH_1	214	218	PF00917	0.747
DOC_USP7_MATH_1	385	389	PF00917	0.494
DOC_USP7_MATH_1	451	455	PF00917	0.527
DOC_USP7_MATH_1	489	493	PF00917	0.499
DOC_USP7_MATH_1	68	72	PF00917	0.745
DOC_WW_Pin1_4	163	168	PF00397	0.549
DOC_WW_Pin1_4	348	353	PF00397	0.496
DOC_WW_Pin1_4	418	423	PF00397	0.529
DOC_WW_Pin1_4	64	69	PF00397	0.758
DOC_WW_Pin1_4	71	76	PF00397	0.684
DOC_WW_Pin1_4	94	99	PF00397	0.762
LIG_14-3-3_CanoR_1	190	199	PF00244	0.723
LIG_14-3-3_CanoR_1	264	274	PF00244	0.582
LIG_14-3-3_CanoR_1	324	330	PF00244	0.388
LIG_14-3-3_CanoR_1	368	373	PF00244	0.421
LIG_14-3-3_CanoR_1	416	422	PF00244	0.552
LIG_14-3-3_CanoR_1	78	88	PF00244	0.786
LIG_BRCT_BRCA1_1	29	33	PF00533	0.676
LIG_BRCT_BRCA1_1	513	517	PF00533	0.301
LIG_Clathr_ClatBox_1	521	525	PF01394	0.386
LIG_deltaCOP1_diTrp_1	460	467	PF00928	0.462
LIG_EH1_1	516	524	PF00400	0.293
LIG_FHA_1	114	120	PF00498	0.684
LIG_FHA_1	125	131	PF00498	0.622
LIG_FHA_1	180	186	PF00498	0.673
LIG_FHA_1	424	430	PF00498	0.529
LIG_FHA_1	528	534	PF00498	0.466
LIG_FHA_1	94	100	PF00498	0.694
LIG_FHA_2	129	135	PF00498	0.605
LIG_FHA_2	419	425	PF00498	0.529
LIG_FHA_2	492	498	PF00498	0.594
LIG_LIR_Apic_2	376	381	PF02991	0.451
LIG_LIR_Apic_2	460	466	PF02991	0.454
LIG_LIR_Gen_1	158	167	PF02991	0.598
LIG_LIR_Gen_1	242	252	PF02991	0.496
LIG_LIR_Gen_1	280	288	PF02991	0.537
LIG_LIR_Gen_1	514	524	PF02991	0.309
LIG_LIR_LC3C_4	530	535	PF02991	0.228
LIG_LIR_Nem_3	148	152	PF02991	0.602
LIG_LIR_Nem_3	158	162	PF02991	0.590
LIG_LIR_Nem_3	242	248	PF02991	0.489
LIG_LIR_Nem_3	280	286	PF02991	0.557
LIG_LIR_Nem_3	354	360	PF02991	0.585
LIG_LIR_Nem_3	405	410	PF02991	0.517
LIG_LIR_Nem_3	424	428	PF02991	0.532
LIG_LIR_Nem_3	514	520	PF02991	0.309
LIG_MYND_1	86	90	PF01753	0.738
LIG_NRBOX	517	523	PF00104	0.329
LIG_PCNA_PIPBox_1	327	336	PF02747	0.451
LIG_PCNA_yPIPBox_3	315	324	PF02747	0.473
LIG_Pex14_1	141	145	PF04695	0.543
LIG_Pex14_1	467	471	PF04695	0.453
LIG_SH2_CRK	149	153	PF00017	0.551
LIG_SH2_CRK	159	163	PF00017	0.511
LIG_SH2_CRK	245	249	PF00017	0.493
LIG_SH2_NCK_1	325	329	PF00017	0.371
LIG_SH2_NCK_1	472	476	PF00017	0.549
LIG_SH2_STAP1	145	149	PF00017	0.646
LIG_SH2_STAT5	155	158	PF00017	0.519
LIG_SH2_STAT5	245	248	PF00017	0.399
LIG_SH2_STAT5	378	381	PF00017	0.460
LIG_SH2_STAT5	406	409	PF00017	0.517
LIG_SH3_3	105	111	PF00018	0.681
LIG_SH3_3	161	167	PF00018	0.602
LIG_SH3_3	225	231	PF00018	0.746
LIG_SH3_3	346	352	PF00018	0.529
LIG_SH3_3	84	90	PF00018	0.741
LIG_SH3_CIN85_PxpxPR_1	73	78	PF14604	0.674
LIG_SUMO_SIM_par_1	358	363	PF11976	0.529
LIG_SUMO_SIM_par_1	388	393	PF11976	0.467
LIG_SUMO_SIM_par_1	519	525	PF11976	0.309
LIG_SUMO_SIM_par_1	94	103	PF11976	0.588
LIG_TYR_ITIM	243	248	PF00017	0.486
LIG_UBA3_1	495	503	PF00899	0.521
LIG_WRC_WIRS_1	391	396	PF05994	0.549
MOD_CDK_SPxxK_3	71	78	PF00069	0.673
MOD_CK1_1	158	164	PF00069	0.644
MOD_CK1_1	179	185	PF00069	0.675
MOD_CK1_1	194	200	PF00069	0.684
MOD_CK1_1	229	235	PF00069	0.719
MOD_CK1_1	71	77	PF00069	0.737
MOD_CK2_1	128	134	PF00069	0.578
MOD_CK2_1	323	329	PF00069	0.392
MOD_CK2_1	418	424	PF00069	0.529
MOD_CK2_1	491	497	PF00069	0.592
MOD_Cter_Amidation	205	208	PF01082	0.459
MOD_Cter_Amidation	503	506	PF01082	0.414
MOD_GlcNHglycan	218	221	PF01048	0.561
MOD_GlcNHglycan	231	234	PF01048	0.454
MOD_GlcNHglycan	311	314	PF01048	0.299
MOD_GlcNHglycan	400	403	PF01048	0.357
MOD_GlcNHglycan	453	456	PF01048	0.306
MOD_GlcNHglycan	70	73	PF01048	0.544
MOD_GSK3_1	124	131	PF00069	0.593
MOD_GSK3_1	189	196	PF00069	0.757
MOD_GSK3_1	222	229	PF00069	0.716
MOD_GSK3_1	23	30	PF00069	0.723
MOD_GSK3_1	390	397	PF00069	0.488
MOD_GSK3_1	487	494	PF00069	0.617
MOD_GSK3_1	60	67	PF00069	0.774
MOD_GSK3_1	89	96	PF00069	0.684
MOD_N-GLC_1	124	129	PF02516	0.480
MOD_N-GLC_1	478	483	PF02516	0.294
MOD_NEK2_1	100	105	PF00069	0.605
MOD_NEK2_1	121	126	PF00069	0.666
MOD_NEK2_1	22	27	PF00069	0.691
MOD_NEK2_1	286	291	PF00069	0.555
MOD_NEK2_1	311	316	PF00069	0.460
MOD_NEK2_1	392	397	PF00069	0.451
MOD_NEK2_1	398	403	PF00069	0.451
MOD_NEK2_1	528	533	PF00069	0.436
MOD_NEK2_1	79	84	PF00069	0.704
MOD_NEK2_1	93	98	PF00069	0.707
MOD_NEK2_2	256	261	PF00069	0.591
MOD_PIKK_1	214	220	PF00454	0.741
MOD_PIKK_1	323	329	PF00454	0.400
MOD_PIKK_1	53	59	PF00454	0.799
MOD_PK_1	176	182	PF00069	0.673
MOD_PKA_1	190	196	PF00069	0.550
MOD_PKA_2	189	195	PF00069	0.710
MOD_PKA_2	222	228	PF00069	0.737
MOD_PKA_2	323	329	PF00069	0.388
MOD_Plk_1	60	66	PF00069	0.793
MOD_Plk_2-3	43	49	PF00069	0.660
MOD_Plk_4	158	164	PF00069	0.585
MOD_Plk_4	256	262	PF00069	0.551
MOD_Plk_4	368	374	PF00069	0.371
MOD_Plk_4	491	497	PF00069	0.573
MOD_ProDKin_1	163	169	PF00069	0.553
MOD_ProDKin_1	348	354	PF00069	0.496
MOD_ProDKin_1	418	424	PF00069	0.529
MOD_ProDKin_1	64	70	PF00069	0.757
MOD_ProDKin_1	71	77	PF00069	0.684
MOD_ProDKin_1	94	100	PF00069	0.762
TRG_DiLeu_BaEn_1	19	24	PF01217	0.617
TRG_DiLeu_BaEn_1	424	429	PF01217	0.545
TRG_DiLeu_BaLyEn_6	114	119	PF01217	0.656
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.741
TRG_ENDOCYTIC_2	149	152	PF00928	0.556
TRG_ENDOCYTIC_2	159	162	PF00928	0.523
TRG_ENDOCYTIC_2	245	248	PF00928	0.489
TRG_ENDOCYTIC_2	471	474	PF00928	0.462
TRG_ENDOCYTIC_2	507	510	PF00928	0.549
TRG_ER_diArg_1	101	104	PF00400	0.679
TRG_ER_diArg_1	114	117	PF00400	0.667
TRG_ER_diArg_1	171	174	PF00400	0.562
TRG_ER_diArg_1	175	177	PF00400	0.592
TRG_ER_diArg_1	189	191	PF00400	0.598
TRG_ER_diArg_1	202	205	PF00400	0.628
TRG_ER_diArg_1	31	33	PF00400	0.691
TRG_ER_diArg_1	436	438	PF00400	0.552
TRG_ER_diArg_1	505	507	PF00400	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P4	Leptomonas seymouri	63%	79%
A0A0S4IQM3	Bodo saltans	41%	100%
A0A1X0P1X6	Trypanosomatidae	48%	82%
A0A3Q8IS20	Leishmania donovani	94%	100%
A0A422NW98	Trypanosoma rangeli	44%	87%
A4HIF4	Leishmania braziliensis	79%	100%
A4I5Q0	Leishmania infantum	93%	100%
C9ZR20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	83%
Q4Q771	Leishmania major	91%	100%
V5BGV1	Trypanosoma cruzi	43%	86%