Putative endosomal trafficking protein RME-8

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endosomal trafficking protein RME-8, putative

Species:

Leishmania mexicana

UniProt:

E9B0Z4_LEIMU

TriTrypDb:

LmxM.29.2210

Length:

2452

Annotations

LeishMANIAdb annotations

Contains a large alpha-helical solenoid domain. No trace of TM segments.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0010008	endosome membrane	5	1
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9B0Z4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0006898	receptor-mediated endocytosis	6	1
GO:0006996	organelle organization	4	11
GO:0007032	endosome organization	6	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0016050	vesicle organization	5	11
GO:0016192	vesicle-mediated transport	4	1
GO:0032386	regulation of intracellular transport	5	11

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1983	1987	PF00656	0.405
CLV_C14_Caspase3-7	2136	2140	PF00656	0.395
CLV_C14_Caspase3-7	380	384	PF00656	0.305
CLV_C14_Caspase3-7	464	468	PF00656	0.223
CLV_C14_Caspase3-7	495	499	PF00656	0.361
CLV_NRD_NRD_1	1401	1403	PF00675	0.210
CLV_NRD_NRD_1	1868	1870	PF00675	0.414
CLV_NRD_NRD_1	2101	2103	PF00675	0.535
CLV_NRD_NRD_1	2145	2147	PF00675	0.554
CLV_NRD_NRD_1	2148	2150	PF00675	0.504

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBN0	Leptomonas seymouri	69%	99%
A0A0S4IQD7	Bodo saltans	44%	100%
A0A1X0P2D1	Trypanosomatidae	45%	100%
A0A3Q8IF03	Leishmania donovani	94%	100%
A0A3R7KU28	Trypanosoma rangeli	44%	100%
A4HIF3	Leishmania braziliensis	85%	100%
C9ZR17	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AHK1	Leishmania infantum	94%	100%
F4IVL6	Arabidopsis thaliana	28%	96%
O75165	Homo sapiens	35%	100%

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