Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9B0Z2_LEIMU

TriTrypDb:

LmxM.29.2190

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9B0Z2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0Z2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	185	187	PF00675	0.535
CLV_NRD_NRD_1	251	253	PF00675	0.536
CLV_NRD_NRD_1	65	67	PF00675	0.222
CLV_PCSK_FUR_1	182	186	PF00082	0.537
CLV_PCSK_KEX2_1	182	184	PF00082	0.534
CLV_PCSK_KEX2_1	185	187	PF00082	0.537
CLV_PCSK_KEX2_1	251	253	PF00082	0.536
CLV_PCSK_SKI1_1	113	117	PF00082	0.190
CLV_PCSK_SKI1_1	149	153	PF00082	0.258
CLV_PCSK_SKI1_1	33	37	PF00082	0.258
CLV_PCSK_SKI1_1	414	418	PF00082	0.519
CLV_PCSK_SKI1_1	56	60	PF00082	0.333
CLV_PCSK_SKI1_1	66	70	PF00082	0.254
CLV_PCSK_SKI1_1	88	92	PF00082	0.566
DEG_SPOP_SBC_1	240	244	PF00917	0.481
DOC_CKS1_1	304	309	PF01111	0.607
DOC_CYCLIN_RxL_1	411	421	PF00134	0.520
DOC_CYCLIN_yClb3_PxF_3	274	280	PF00134	0.485
DOC_MAPK_gen_1	42	51	PF00069	0.458
DOC_PP2B_LxvP_1	348	351	PF13499	0.615
DOC_PP4_FxxP_1	200	203	PF00568	0.589
DOC_PP4_FxxP_1	296	299	PF00568	0.581
DOC_PP4_FxxP_1	327	330	PF00568	0.593
DOC_PP4_FxxP_1	397	400	PF00568	0.702
DOC_USP7_MATH_1	226	230	PF00917	0.559
DOC_USP7_MATH_1	240	244	PF00917	0.698
DOC_USP7_MATH_1	261	265	PF00917	0.733
DOC_USP7_MATH_1	323	327	PF00917	0.632
DOC_USP7_MATH_1	330	334	PF00917	0.645
DOC_USP7_MATH_1	339	343	PF00917	0.717
DOC_USP7_MATH_1	481	485	PF00917	0.501
DOC_USP7_MATH_1	487	491	PF00917	0.476
DOC_USP7_UBL2_3	241	245	PF12436	0.590
DOC_WW_Pin1_4	263	268	PF00397	0.668
DOC_WW_Pin1_4	288	293	PF00397	0.630
DOC_WW_Pin1_4	303	308	PF00397	0.581
DOC_WW_Pin1_4	326	331	PF00397	0.634
DOC_WW_Pin1_4	364	369	PF00397	0.521
DOC_WW_Pin1_4	396	401	PF00397	0.605
LIG_14-3-3_CanoR_1	113	119	PF00244	0.430
LIG_APCC_ABBA_1	21	26	PF00400	0.497
LIG_APCC_ABBA_1	452	457	PF00400	0.429
LIG_APCC_ABBA_1	48	53	PF00400	0.497
LIG_BIR_II_1	1	5	PF00653	0.387
LIG_BRCT_BRCA1_1	332	336	PF00533	0.444
LIG_BRCT_BRCA1_1	42	46	PF00533	0.440
LIG_FHA_1	253	259	PF00498	0.627
LIG_FHA_1	371	377	PF00498	0.500
LIG_FHA_1	444	450	PF00498	0.558
LIG_FHA_1	75	81	PF00498	0.428
LIG_FHA_2	142	148	PF00498	0.499
LIG_FHA_2	310	316	PF00498	0.588
LIG_FHA_2	483	489	PF00498	0.440
LIG_LIR_Apic_2	128	134	PF02991	0.431
LIG_LIR_Apic_2	293	299	PF02991	0.593
LIG_LIR_Apic_2	326	330	PF02991	0.638
LIG_LIR_Apic_2	395	400	PF02991	0.626
LIG_LIR_Apic_2	442	448	PF02991	0.545
LIG_LIR_Gen_1	141	148	PF02991	0.483
LIG_LIR_Gen_1	75	82	PF02991	0.527
LIG_LIR_Nem_3	117	121	PF02991	0.450
LIG_LIR_Nem_3	141	145	PF02991	0.454
LIG_LIR_Nem_3	43	49	PF02991	0.447
LIG_LIR_Nem_3	75	79	PF02991	0.505
LIG_MYND_1	263	267	PF01753	0.584
LIG_MYND_1	275	279	PF01753	0.498
LIG_PCNA_PIPBox_1	108	117	PF02747	0.483
LIG_PCNA_yPIPBox_3	108	116	PF02747	0.519
LIG_Pex14_2	114	118	PF04695	0.458
LIG_PROFILIN_1	271	277	PF00235	0.502
LIG_PTB_Apo_2	117	124	PF02174	0.497
LIG_PTB_Phospho_1	117	123	PF10480	0.497
LIG_SH2_CRK	131	135	PF00017	0.441
LIG_SH2_CRK	61	65	PF00017	0.450
LIG_SH2_GRB2like	426	429	PF00017	0.543
LIG_SH2_NCK_1	142	146	PF00017	0.497
LIG_SH2_STAT5	123	126	PF00017	0.458
LIG_SH2_STAT5	161	164	PF00017	0.525
LIG_SH2_STAT5	309	312	PF00017	0.575
LIG_SH2_STAT5	426	429	PF00017	0.648
LIG_SH2_STAT5	445	448	PF00017	0.540
LIG_SH2_STAT5	98	101	PF00017	0.440
LIG_SH3_3	268	274	PF00018	0.605
LIG_SH3_3	276	282	PF00018	0.655
LIG_SH3_3	448	454	PF00018	0.530
LIG_SH3_3	465	471	PF00018	0.609
LIG_SH3_3	76	82	PF00018	0.347
LIG_TRAF2_2	351	356	PF00917	0.670
LIG_TRFH_1	383	387	PF08558	0.549
LIG_WRC_WIRS_1	115	120	PF05994	0.446
LIG_WRC_WIRS_1	434	439	PF05994	0.512
LIG_WW_1	453	456	PF00397	0.422
LIG_WW_2	275	278	PF00397	0.458
MOD_CK1_1	212	218	PF00069	0.707
MOD_CK1_1	234	240	PF00069	0.607
MOD_CK1_1	243	249	PF00069	0.573
MOD_CK1_1	326	332	PF00069	0.614
MOD_CK1_1	364	370	PF00069	0.432
MOD_CK1_1	399	405	PF00069	0.595
MOD_CK1_1	430	436	PF00069	0.682
MOD_CK1_1	490	496	PF00069	0.527
MOD_CK2_1	202	208	PF00069	0.760
MOD_CK2_1	309	315	PF00069	0.594
MOD_CK2_1	482	488	PF00069	0.442
MOD_GlcNHglycan	164	167	PF01048	0.458
MOD_GlcNHglycan	195	198	PF01048	0.668
MOD_GlcNHglycan	208	212	PF01048	0.712
MOD_GlcNHglycan	268	271	PF01048	0.570
MOD_GlcNHglycan	30	33	PF01048	0.301
MOD_GlcNHglycan	315	318	PF01048	0.581
MOD_GlcNHglycan	341	344	PF01048	0.623
MOD_GlcNHglycan	401	404	PF01048	0.632
MOD_GlcNHglycan	485	488	PF01048	0.498
MOD_GSK3_1	209	216	PF00069	0.639
MOD_GSK3_1	226	233	PF00069	0.583
MOD_GSK3_1	239	246	PF00069	0.547
MOD_GSK3_1	257	264	PF00069	0.535
MOD_GSK3_1	290	297	PF00069	0.729
MOD_GSK3_1	309	316	PF00069	0.556
MOD_GSK3_1	326	333	PF00069	0.737
MOD_GSK3_1	366	373	PF00069	0.478
MOD_GSK3_1	395	402	PF00069	0.621
MOD_GSK3_1	408	415	PF00069	0.595
MOD_GSK3_1	424	431	PF00069	0.663
MOD_GSK3_1	483	490	PF00069	0.559
MOD_N-GLC_1	157	162	PF02516	0.417
MOD_N-GLC_1	234	239	PF02516	0.676
MOD_N-GLC_1	252	257	PF02516	0.490
MOD_N-GLC_1	361	366	PF02516	0.682
MOD_N-GLC_1	370	375	PF02516	0.661
MOD_N-GLC_1	427	432	PF02516	0.644
MOD_NEK2_1	114	119	PF00069	0.479
MOD_NEK2_1	162	167	PF00069	0.522
MOD_NEK2_1	213	218	PF00069	0.607
MOD_NEK2_1	408	413	PF00069	0.711
MOD_NEK2_1	417	422	PF00069	0.664
MOD_NEK2_1	482	487	PF00069	0.440
MOD_PIKK_1	337	343	PF00454	0.544
MOD_PIKK_1	408	414	PF00454	0.654
MOD_PKA_1	66	72	PF00069	0.407
MOD_Plk_1	157	163	PF00069	0.622
MOD_Plk_1	234	240	PF00069	0.718
MOD_Plk_1	361	367	PF00069	0.670
MOD_Plk_1	370	376	PF00069	0.644
MOD_Plk_1	464	470	PF00069	0.580
MOD_Plk_2-3	141	147	PF00069	0.522
MOD_Plk_4	157	163	PF00069	0.597
MOD_Plk_4	370	376	PF00069	0.646
MOD_Plk_4	412	418	PF00069	0.629
MOD_Plk_4	487	493	PF00069	0.530
MOD_ProDKin_1	263	269	PF00069	0.669
MOD_ProDKin_1	288	294	PF00069	0.633
MOD_ProDKin_1	303	309	PF00069	0.575
MOD_ProDKin_1	326	332	PF00069	0.632
MOD_ProDKin_1	364	370	PF00069	0.519
MOD_ProDKin_1	396	402	PF00069	0.606
MOD_SUMO_for_1	170	173	PF00179	0.372
MOD_SUMO_for_1	178	181	PF00179	0.441
MOD_SUMO_rev_2	141	151	PF00179	0.497
MOD_SUMO_rev_2	233	243	PF00179	0.619
MOD_SUMO_rev_2	52	58	PF00179	0.503
TRG_DiLeu_BaEn_4	92	98	PF01217	0.490
TRG_ENDOCYTIC_2	123	126	PF00928	0.473
TRG_ENDOCYTIC_2	142	145	PF00928	0.439
TRG_ENDOCYTIC_2	61	64	PF00928	0.440
TRG_ER_diArg_1	182	185	PF00400	0.534
TRG_ER_diArg_1	250	252	PF00400	0.521
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.283

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Q0	Leptomonas seymouri	63%	100%
A0A3Q8II02	Leishmania donovani	91%	100%
A0A3Q8IIS4	Leishmania donovani	24%	100%
A0A3R7M093	Trypanosoma rangeli	40%	92%
A4HIF1	Leishmania braziliensis	68%	98%
A4I4J6	Leishmania infantum	23%	100%
A4I5P8	Leishmania infantum	91%	100%
C9ZR15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
P42731	Arabidopsis thaliana	22%	80%
Q4Q774	Leishmania major	84%	99%
V5BLA5	Trypanosoma cruzi	42%	100%