RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA-binding protein

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania mexicana

UniProt:

E9B0Z1_LEIMU

TriTrypDb:

LmxM.29.2180

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9B0Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0Z1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	186	188	PF00675	0.522
CLV_NRD_NRD_1	404	406	PF00675	0.642
CLV_PCSK_FUR_1	181	185	PF00082	0.521
CLV_PCSK_KEX2_1	150	152	PF00082	0.284
CLV_PCSK_KEX2_1	180	182	PF00082	0.512
CLV_PCSK_KEX2_1	183	185	PF00082	0.525
CLV_PCSK_KEX2_1	186	188	PF00082	0.522
CLV_PCSK_KEX2_1	404	406	PF00082	0.642
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.284
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.512
CLV_PCSK_PC7_1	181	187	PF00082	0.523
CLV_PCSK_SKI1_1	14	18	PF00082	0.269
CLV_PCSK_SKI1_1	150	154	PF00082	0.292
CLV_PCSK_SKI1_1	34	38	PF00082	0.183
DEG_SCF_FBW7_1	353	360	PF00400	0.665
DEG_SCF_FBW7_1	422	428	PF00400	0.604
DEG_SCF_FBW7_1	435	441	PF00400	0.584
DEG_SIAH_1	418	426	PF03145	0.595
DEG_SPOP_SBC_1	425	429	PF00917	0.671
DOC_CKS1_1	163	168	PF01111	0.306
DOC_CKS1_1	362	367	PF01111	0.606
DOC_CKS1_1	399	404	PF01111	0.654
DOC_CKS1_1	422	427	PF01111	0.605
DOC_CKS1_1	435	440	PF01111	0.581
DOC_MAPK_gen_1	150	156	PF00069	0.484
DOC_MAPK_gen_1	43	52	PF00069	0.469
DOC_MAPK_gen_1	64	72	PF00069	0.469
DOC_PP2B_LxvP_1	225	228	PF13499	0.643
DOC_PP2B_LxvP_1	266	269	PF13499	0.609
DOC_PP2B_LxvP_1	468	471	PF13499	0.535
DOC_PP2B_LxvP_1	491	494	PF13499	0.629
DOC_PP2B_PxIxI_1	472	478	PF00149	0.605
DOC_PP4_FxxP_1	163	166	PF00568	0.318
DOC_PP4_FxxP_1	203	206	PF00568	0.586
DOC_USP7_MATH_1	152	156	PF00917	0.463
DOC_USP7_MATH_1	217	221	PF00917	0.613
DOC_USP7_MATH_1	239	243	PF00917	0.644
DOC_USP7_MATH_1	299	303	PF00917	0.625
DOC_USP7_MATH_1	357	361	PF00917	0.663
DOC_USP7_MATH_1	425	429	PF00917	0.640
DOC_USP7_MATH_1	438	442	PF00917	0.616
DOC_USP7_UBL2_3	85	89	PF12436	0.493
DOC_WW_Pin1_4	162	167	PF00397	0.313
DOC_WW_Pin1_4	202	207	PF00397	0.583
DOC_WW_Pin1_4	235	240	PF00397	0.590
DOC_WW_Pin1_4	319	324	PF00397	0.626
DOC_WW_Pin1_4	353	358	PF00397	0.598
DOC_WW_Pin1_4	361	366	PF00397	0.602
DOC_WW_Pin1_4	398	403	PF00397	0.588
DOC_WW_Pin1_4	421	426	PF00397	0.587
DOC_WW_Pin1_4	434	439	PF00397	0.584
DOC_WW_Pin1_4	461	466	PF00397	0.719
LIG_14-3-3_CanoR_1	14	21	PF00244	0.469
LIG_14-3-3_CanoR_1	151	157	PF00244	0.499
LIG_14-3-3_CanoR_1	243	249	PF00244	0.588
LIG_BRCT_BRCA1_1	274	278	PF00533	0.604
LIG_BRCT_BRCA1_1	326	330	PF00533	0.673
LIG_BRCT_BRCA1_1	43	47	PF00533	0.469
LIG_eIF4E_1	445	451	PF01652	0.562
LIG_EVH1_1	225	229	PF00568	0.610
LIG_FHA_1	205	211	PF00498	0.618
LIG_FHA_1	310	316	PF00498	0.684
LIG_FHA_1	435	441	PF00498	0.626
LIG_FHA_1	445	451	PF00498	0.545
LIG_FHA_2	139	145	PF00498	0.398
LIG_FHA_2	15	21	PF00498	0.469
LIG_FHA_2	177	183	PF00498	0.533
LIG_FHA_2	206	212	PF00498	0.533
LIG_FHA_2	493	499	PF00498	0.452
LIG_FHA_2	58	64	PF00498	0.507
LIG_IBAR_NPY_1	418	420	PF08397	0.584
LIG_LIR_Apic_2	161	166	PF02991	0.483
LIG_LIR_Gen_1	123	132	PF02991	0.469
LIG_LIR_Gen_1	141	149	PF02991	0.469
LIG_LIR_Gen_1	270	279	PF02991	0.603
LIG_LIR_Gen_1	327	337	PF02991	0.656
LIG_LIR_Gen_1	60	70	PF02991	0.516
LIG_LIR_Nem_3	135	140	PF02991	0.469
LIG_LIR_Nem_3	141	146	PF02991	0.469
LIG_LIR_Nem_3	22	28	PF02991	0.451
LIG_LIR_Nem_3	270	274	PF02991	0.602
LIG_LIR_Nem_3	327	333	PF02991	0.622
LIG_LIR_Nem_3	346	350	PF02991	0.466
LIG_LIR_Nem_3	44	50	PF02991	0.469
LIG_LIR_Nem_3	495	500	PF02991	0.503
LIG_LIR_Nem_3	60	65	PF02991	0.469
LIG_PCNA_PIPBox_1	1	10	PF02747	0.385
LIG_PCNA_PIPBox_1	109	118	PF02747	0.469
LIG_PCNA_yPIPBox_3	106	116	PF02747	0.469
LIG_Pex14_2	115	119	PF04695	0.469
LIG_Pex14_2	343	347	PF04695	0.649
LIG_PROFILIN_1	226	232	PF00235	0.595
LIG_PTAP_UEV_1	445	450	PF05743	0.615
LIG_PTB_Apo_2	329	336	PF02174	0.603
LIG_PTB_Apo_2	449	456	PF02174	0.570
LIG_PTB_Apo_2	476	483	PF02174	0.585
LIG_SH2_CRK	420	424	PF00017	0.601
LIG_SH2_GRB2like	162	165	PF00017	0.412
LIG_SH2_NCK_1	420	424	PF00017	0.601
LIG_SH2_SRC	173	176	PF00017	0.475
LIG_SH2_SRC	420	423	PF00017	0.601
LIG_SH2_STAT5	124	127	PF00017	0.483
LIG_SH2_STAT5	140	143	PF00017	0.469
LIG_SH2_STAT5	162	165	PF00017	0.460
LIG_SH2_STAT5	490	493	PF00017	0.639
LIG_SH2_STAT5	99	102	PF00017	0.485
LIG_SH3_1	359	365	PF00018	0.600
LIG_SH3_1	416	422	PF00018	0.592
LIG_SH3_2	231	236	PF14604	0.610
LIG_SH3_2	399	404	PF14604	0.611
LIG_SH3_3	221	227	PF00018	0.657
LIG_SH3_3	228	234	PF00018	0.585
LIG_SH3_3	359	365	PF00018	0.600
LIG_SH3_3	396	402	PF00018	0.610
LIG_SH3_3	416	422	PF00018	0.510
LIG_SH3_3	432	438	PF00018	0.585
LIG_SH3_3	443	449	PF00018	0.555
LIG_SH3_3	467	473	PF00018	0.574
LIG_SUMO_SIM_anti_2	165	171	PF11976	0.395
LIG_SUMO_SIM_par_1	390	395	PF11976	0.503
LIG_TRAF2_1	91	94	PF00917	0.479
MOD_CDK_SPxK_1	353	359	PF00069	0.601
MOD_CDK_SPxK_1	398	404	PF00069	0.613
MOD_CDK_SPxxK_3	398	405	PF00069	0.661
MOD_CK1_1	145	151	PF00069	0.477
MOD_CK1_1	176	182	PF00069	0.572
MOD_CK1_1	205	211	PF00069	0.620
MOD_CK1_1	251	257	PF00069	0.556
MOD_CK1_1	358	364	PF00069	0.699
MOD_CK1_1	407	413	PF00069	0.604
MOD_CK1_1	54	60	PF00069	0.398
MOD_CK2_1	105	111	PF00069	0.490
MOD_CK2_1	176	182	PF00069	0.526
MOD_CK2_1	205	211	PF00069	0.476
MOD_CK2_1	57	63	PF00069	0.507
MOD_GlcNHglycan	147	150	PF01048	0.269
MOD_GlcNHglycan	294	297	PF01048	0.566
MOD_GlcNHglycan	31	34	PF01048	0.247
MOD_GlcNHglycan	315	318	PF01048	0.688
MOD_GlcNHglycan	326	329	PF01048	0.584
MOD_GlcNHglycan	338	341	PF01048	0.581
MOD_GlcNHglycan	375	379	PF01048	0.769
MOD_GlcNHglycan	393	397	PF01048	0.764
MOD_GlcNHglycan	411	414	PF01048	0.500
MOD_GlcNHglycan	55	59	PF01048	0.209
MOD_GSK3_1	138	145	PF00069	0.433
MOD_GSK3_1	158	165	PF00069	0.495
MOD_GSK3_1	205	212	PF00069	0.640
MOD_GSK3_1	235	242	PF00069	0.660
MOD_GSK3_1	244	251	PF00069	0.587
MOD_GSK3_1	305	312	PF00069	0.648
MOD_GSK3_1	331	338	PF00069	0.536
MOD_GSK3_1	353	360	PF00069	0.665
MOD_GSK3_1	37	44	PF00069	0.469
MOD_GSK3_1	403	410	PF00069	0.653
MOD_GSK3_1	421	428	PF00069	0.603
MOD_GSK3_1	429	436	PF00069	0.600
MOD_GSK3_1	477	484	PF00069	0.545
MOD_LATS_1	241	247	PF00433	0.590
MOD_N-GLC_1	14	19	PF02516	0.269
MOD_N-GLC_1	158	163	PF02516	0.295
MOD_N-GLC_1	331	336	PF02516	0.606
MOD_N-GLC_1	366	371	PF02516	0.619
MOD_N-GLC_1	407	412	PF02516	0.672
MOD_N-GLC_1	430	435	PF02516	0.577
MOD_N-GLC_1	65	70	PF02516	0.269
MOD_N-GLC_2	213	215	PF02516	0.501
MOD_N-GLC_2	78	80	PF02516	0.345
MOD_NEK2_1	105	110	PF00069	0.463
MOD_NEK2_1	132	137	PF00069	0.462
MOD_NEK2_1	248	253	PF00069	0.773
MOD_NEK2_1	259	264	PF00069	0.625
MOD_NEK2_1	292	297	PF00069	0.574
MOD_NEK2_1	304	309	PF00069	0.544
MOD_NEK2_1	331	336	PF00069	0.627
MOD_NEK2_1	343	348	PF00069	0.629
MOD_NEK2_1	366	371	PF00069	0.636
MOD_NEK2_1	37	42	PF00069	0.469
MOD_NEK2_1	374	379	PF00069	0.649
MOD_NEK2_1	392	397	PF00069	0.559
MOD_NEK2_1	409	414	PF00069	0.587
MOD_NEK2_1	439	444	PF00069	0.648
MOD_NEK2_1	455	460	PF00069	0.502
MOD_NEK2_1	65	70	PF00069	0.469
MOD_NEK2_1	92	97	PF00069	0.510
MOD_NEK2_2	152	157	PF00069	0.463
MOD_PIKK_1	105	111	PF00454	0.469
MOD_PIKK_1	215	221	PF00454	0.557
MOD_PIKK_1	272	278	PF00454	0.541
MOD_PIKK_1	309	315	PF00454	0.638
MOD_PKA_1	404	410	PF00069	0.634
MOD_PKA_2	403	409	PF00069	0.679
MOD_Plk_1	158	164	PF00069	0.495
MOD_Plk_1	331	337	PF00069	0.567
MOD_Plk_1	366	372	PF00069	0.611
MOD_Plk_1	65	71	PF00069	0.476
MOD_Plk_2-3	142	148	PF00069	0.469
MOD_Plk_4	132	138	PF00069	0.472
MOD_Plk_4	299	305	PF00069	0.691
MOD_Plk_4	326	332	PF00069	0.664
MOD_ProDKin_1	162	168	PF00069	0.308
MOD_ProDKin_1	202	208	PF00069	0.587
MOD_ProDKin_1	235	241	PF00069	0.592
MOD_ProDKin_1	319	325	PF00069	0.621
MOD_ProDKin_1	353	359	PF00069	0.601
MOD_ProDKin_1	361	367	PF00069	0.605
MOD_ProDKin_1	398	404	PF00069	0.592
MOD_ProDKin_1	421	427	PF00069	0.589
MOD_ProDKin_1	434	440	PF00069	0.584
MOD_ProDKin_1	461	467	PF00069	0.719
MOD_SUMO_rev_2	84	91	PF00179	0.463
TRG_DiLeu_BaEn_2	110	116	PF01217	0.469
TRG_DiLeu_BaEn_4	93	99	PF01217	0.402
TRG_ENDOCYTIC_2	124	127	PF00928	0.478
TRG_ENDOCYTIC_2	140	143	PF00928	0.563
TRG_ENDOCYTIC_2	350	353	PF00928	0.669
TRG_ENDOCYTIC_2	420	423	PF00928	0.601
TRG_ENDOCYTIC_2	62	65	PF00928	0.469
TRG_ER_diArg_1	183	186	PF00400	0.525
TRG_ER_diArg_1	403	405	PF00400	0.641
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.269

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE63	Leptomonas seymouri	59%	100%
A0A3S7X3L2	Leishmania donovani	92%	100%
A4HIF0	Leishmania braziliensis	70%	98%
A4I5P7	Leishmania infantum	92%	100%
Q4Q775	Leishmania major	91%	100%