Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0Y9_LEIMU

TriTrypDb:

LmxM.29.2160

Length:

648

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0Y9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0Y9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	421	425	PF00656	0.488
CLV_C14_Caspase3-7	497	501	PF00656	0.476
CLV_C14_Caspase3-7	536	540	PF00656	0.663
CLV_C14_Caspase3-7	546	550	PF00656	0.698
CLV_C14_Caspase3-7	602	606	PF00656	0.567
CLV_NRD_NRD_1	159	161	PF00675	0.411
CLV_NRD_NRD_1	170	172	PF00675	0.556
CLV_NRD_NRD_1	333	335	PF00675	0.545
CLV_NRD_NRD_1	376	378	PF00675	0.482
CLV_NRD_NRD_1	396	398	PF00675	0.640
CLV_NRD_NRD_1	457	459	PF00675	0.594
CLV_NRD_NRD_1	469	471	PF00675	0.525
CLV_NRD_NRD_1	523	525	PF00675	0.604
CLV_PCSK_KEX2_1	333	335	PF00082	0.545
CLV_PCSK_KEX2_1	376	378	PF00082	0.482
CLV_PCSK_KEX2_1	413	415	PF00082	0.638
CLV_PCSK_KEX2_1	457	459	PF00082	0.594
CLV_PCSK_KEX2_1	469	471	PF00082	0.525
CLV_PCSK_KEX2_1	523	525	PF00082	0.604
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.632
CLV_PCSK_SKI1_1	151	155	PF00082	0.416
CLV_PCSK_SKI1_1	304	308	PF00082	0.485
CLV_PCSK_SKI1_1	410	414	PF00082	0.594
CLV_PCSK_SKI1_1	469	473	PF00082	0.530
CLV_PCSK_SKI1_1	51	55	PF00082	0.523
CLV_Separin_Metazoa	454	458	PF03568	0.481
DEG_APCC_DBOX_1	295	303	PF00400	0.527
DEG_Nend_UBRbox_2	1	3	PF02207	0.695
DEG_SCF_FBW7_1	613	620	PF00400	0.501
DEG_SIAH_1	246	254	PF03145	0.419
DEG_SPOP_SBC_1	438	442	PF00917	0.587
DOC_CKS1_1	554	559	PF01111	0.674
DOC_CYCLIN_yCln2_LP_2	116	122	PF00134	0.525
DOC_MAPK_MEF2A_6	55	63	PF00069	0.536
DOC_PP1_RVXF_1	361	367	PF00149	0.485
DOC_PP2B_LxvP_1	133	136	PF13499	0.462
DOC_PP2B_LxvP_1	240	243	PF13499	0.597
DOC_PP2B_LxvP_1	471	474	PF13499	0.560
DOC_PP4_FxxP_1	250	253	PF00568	0.593
DOC_USP7_MATH_1	229	233	PF00917	0.749
DOC_USP7_MATH_1	346	350	PF00917	0.558
DOC_USP7_MATH_1	446	450	PF00917	0.807
DOC_USP7_MATH_1	474	478	PF00917	0.651
DOC_WW_Pin1_4	243	248	PF00397	0.690
DOC_WW_Pin1_4	27	32	PF00397	0.615
DOC_WW_Pin1_4	34	39	PF00397	0.637
DOC_WW_Pin1_4	524	529	PF00397	0.646
DOC_WW_Pin1_4	553	558	PF00397	0.648
DOC_WW_Pin1_4	613	618	PF00397	0.506
LIG_14-3-3_CanoR_1	160	169	PF00244	0.391
LIG_14-3-3_CanoR_1	185	192	PF00244	0.532
LIG_14-3-3_CanoR_1	19	27	PF00244	0.497
LIG_14-3-3_CanoR_1	236	243	PF00244	0.529
LIG_14-3-3_CanoR_1	277	285	PF00244	0.433
LIG_14-3-3_CanoR_1	480	487	PF00244	0.557
LIG_14-3-3_CanoR_1	512	516	PF00244	0.661
LIG_Actin_WH2_2	183	201	PF00022	0.591
LIG_Actin_WH2_2	361	378	PF00022	0.481
LIG_Clathr_ClatBox_1	219	223	PF01394	0.615
LIG_eIF4E_1	305	311	PF01652	0.474
LIG_FHA_1	112	118	PF00498	0.577
LIG_FHA_1	152	158	PF00498	0.540
LIG_FHA_1	185	191	PF00498	0.627
LIG_FHA_1	236	242	PF00498	0.618
LIG_FHA_1	246	252	PF00498	0.586
LIG_FHA_1	273	279	PF00498	0.504
LIG_FHA_1	28	34	PF00498	0.530
LIG_FHA_1	306	312	PF00498	0.489
LIG_FHA_1	342	348	PF00498	0.539
LIG_FHA_1	363	369	PF00498	0.467
LIG_FHA_1	370	376	PF00498	0.456
LIG_FHA_1	440	446	PF00498	0.521
LIG_FHA_1	482	488	PF00498	0.525
LIG_FHA_1	549	555	PF00498	0.653
LIG_FHA_1	560	566	PF00498	0.598
LIG_FHA_1	614	620	PF00498	0.585
LIG_FHA_2	429	435	PF00498	0.602
LIG_FHA_2	52	58	PF00498	0.465
LIG_FHA_2	541	547	PF00498	0.672
LIG_FHA_2	556	562	PF00498	0.542
LIG_FHA_2	568	574	PF00498	0.510
LIG_FHA_2	618	624	PF00498	0.654
LIG_FHA_2	626	632	PF00498	0.582
LIG_FHA_2	640	646	PF00498	0.479
LIG_FHA_2	71	77	PF00498	0.474
LIG_HP1_1	383	387	PF01393	0.467
LIG_LIR_Apic_2	248	253	PF02991	0.555
LIG_LIR_Apic_2	514	518	PF02991	0.697
LIG_LIR_Gen_1	118	128	PF02991	0.662
LIG_LIR_Gen_1	284	289	PF02991	0.483
LIG_LIR_Nem_3	118	123	PF02991	0.664
LIG_LIR_Nem_3	279	285	PF02991	0.493
LIG_NRBOX	58	64	PF00104	0.557
LIG_Pex14_2	77	81	PF04695	0.510
LIG_SH2_CRK	285	289	PF00017	0.480
LIG_SH2_STAP1	285	289	PF00017	0.480
LIG_SH2_STAP1	89	93	PF00017	0.382
LIG_SH2_STAT5	169	172	PF00017	0.602
LIG_SH2_STAT5	294	297	PF00017	0.752
LIG_SH2_STAT5	305	308	PF00017	0.479
LIG_SH3_3	133	139	PF00018	0.526
LIG_SH3_3	186	192	PF00018	0.524
LIG_SH3_3	2	8	PF00018	0.529
LIG_SH3_3	212	218	PF00018	0.524
LIG_SH3_3	250	256	PF00018	0.419
LIG_SH3_3	292	298	PF00018	0.550
LIG_SH3_3	382	388	PF00018	0.632
LIG_SH3_3	551	557	PF00018	0.706
LIG_SUMO_SIM_anti_2	56	63	PF11976	0.639
LIG_SUMO_SIM_anti_2	570	576	PF11976	0.632
LIG_SUMO_SIM_par_1	121	126	PF11976	0.586
LIG_SUMO_SIM_par_1	343	349	PF11976	0.495
LIG_SUMO_SIM_par_1	59	66	PF11976	0.537
LIG_TRAF2_1	354	357	PF00917	0.571
LIG_TRAF2_1	54	57	PF00917	0.620
LIG_TRAF2_1	558	561	PF00917	0.621
LIG_TYR_ITIM	210	215	PF00017	0.509
MOD_CK1_1	276	282	PF00069	0.452
MOD_CK1_1	32	38	PF00069	0.513
MOD_CK1_1	329	335	PF00069	0.566
MOD_CK1_1	440	446	PF00069	0.817
MOD_CK1_1	449	455	PF00069	0.642
MOD_CK1_1	540	546	PF00069	0.690
MOD_CK1_1	548	554	PF00069	0.677
MOD_CK1_1	599	605	PF00069	0.643
MOD_CK2_1	123	129	PF00069	0.595
MOD_CK2_1	428	434	PF00069	0.695
MOD_CK2_1	479	485	PF00069	0.704
MOD_CK2_1	51	57	PF00069	0.546
MOD_CK2_1	531	537	PF00069	0.672
MOD_CK2_1	539	545	PF00069	0.605
MOD_CK2_1	555	561	PF00069	0.647
MOD_CK2_1	567	573	PF00069	0.495
MOD_CK2_1	625	631	PF00069	0.572
MOD_CK2_1	639	645	PF00069	0.653
MOD_DYRK1A_RPxSP_1	524	528	PF00069	0.644
MOD_GlcNHglycan	202	205	PF01048	0.400
MOD_GlcNHglycan	232	235	PF01048	0.564
MOD_GlcNHglycan	259	262	PF01048	0.468
MOD_GlcNHglycan	289	292	PF01048	0.697
MOD_GlcNHglycan	34	37	PF01048	0.570
MOD_GlcNHglycan	378	381	PF01048	0.452
MOD_GlcNHglycan	442	445	PF01048	0.773
MOD_GlcNHglycan	448	451	PF01048	0.599
MOD_GlcNHglycan	519	522	PF01048	0.576
MOD_GSK3_1	107	114	PF00069	0.516
MOD_GSK3_1	272	279	PF00069	0.516
MOD_GSK3_1	311	318	PF00069	0.559
MOD_GSK3_1	341	348	PF00069	0.508
MOD_GSK3_1	40	47	PF00069	0.721
MOD_GSK3_1	475	482	PF00069	0.636
MOD_GSK3_1	496	503	PF00069	0.557
MOD_GSK3_1	533	540	PF00069	0.724
MOD_GSK3_1	541	548	PF00069	0.797
MOD_GSK3_1	555	562	PF00069	0.597
MOD_GSK3_1	613	620	PF00069	0.712
MOD_N-GLC_1	532	537	PF02516	0.670
MOD_N-GLC_1	593	598	PF02516	0.532
MOD_N-GLC_2	130	132	PF02516	0.629
MOD_NEK2_1	123	128	PF00069	0.586
MOD_NEK2_1	162	167	PF00069	0.495
MOD_NEK2_1	287	292	PF00069	0.467
MOD_NEK2_1	362	367	PF00069	0.523
MOD_NEK2_1	531	536	PF00069	0.839
MOD_OFUCOSY	137	142	PF10250	0.457
MOD_PIKK_1	143	149	PF00454	0.606
MOD_PIKK_1	160	166	PF00454	0.467
MOD_PIKK_1	305	311	PF00454	0.550
MOD_PIKK_1	70	76	PF00454	0.500
MOD_PKA_1	160	166	PF00069	0.385
MOD_PKA_1	376	382	PF00069	0.443
MOD_PKA_2	184	190	PF00069	0.548
MOD_PKA_2	235	241	PF00069	0.667
MOD_PKA_2	276	282	PF00069	0.427
MOD_PKA_2	369	375	PF00069	0.452
MOD_PKA_2	376	382	PF00069	0.476
MOD_PKA_2	428	434	PF00069	0.594
MOD_PKA_2	479	485	PF00069	0.560
MOD_PKA_2	511	517	PF00069	0.689
MOD_PKA_2	537	543	PF00069	0.553
MOD_Plk_1	123	129	PF00069	0.606
MOD_Plk_1	273	279	PF00069	0.498
MOD_Plk_1	392	398	PF00069	0.639
MOD_Plk_2-3	418	424	PF00069	0.662
MOD_Plk_2-3	541	547	PF00069	0.679
MOD_Plk_4	29	35	PF00069	0.499
MOD_Plk_4	561	567	PF00069	0.603
MOD_ProDKin_1	243	249	PF00069	0.690
MOD_ProDKin_1	27	33	PF00069	0.620
MOD_ProDKin_1	34	40	PF00069	0.635
MOD_ProDKin_1	524	530	PF00069	0.647
MOD_ProDKin_1	553	559	PF00069	0.646
MOD_ProDKin_1	613	619	PF00069	0.505
MOD_SUMO_for_1	412	415	PF00179	0.629
TRG_AP2beta_CARGO_1	118	127	PF09066	0.587
TRG_DiLeu_BaEn_1	284	289	PF01217	0.438
TRG_DiLeu_BaEn_1	56	61	PF01217	0.532
TRG_DiLeu_BaEn_1	561	566	PF01217	0.655
TRG_ENDOCYTIC_2	212	215	PF00928	0.667
TRG_ENDOCYTIC_2	285	288	PF00928	0.481
TRG_ER_diArg_1	375	377	PF00400	0.438
TRG_ER_diArg_1	456	458	PF00400	0.669
TRG_ER_diArg_1	469	471	PF00400	0.486
TRG_NES_CRM1_1	563	577	PF08389	0.639
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8E3	Leptomonas seymouri	35%	97%
A0A3Q8IJH1	Leishmania donovani	82%	100%
A4HIE8	Leishmania braziliensis	68%	100%
A4I5P5	Leishmania infantum	82%	100%
Q4Q777	Leishmania major	84%	100%