CPSF_A domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0Y8_LEIMU

TriTrypDb:

LmxM.29.2150

Length:

855

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B0Y8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0Y8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.502
CLV_C14_Caspase3-7	558	562	PF00656	0.452
CLV_NRD_NRD_1	163	165	PF00675	0.453
CLV_NRD_NRD_1	223	225	PF00675	0.501
CLV_NRD_NRD_1	256	258	PF00675	0.707
CLV_NRD_NRD_1	367	369	PF00675	0.536
CLV_NRD_NRD_1	422	424	PF00675	0.727
CLV_NRD_NRD_1	441	443	PF00675	0.601
CLV_NRD_NRD_1	453	455	PF00675	0.538
CLV_NRD_NRD_1	56	58	PF00675	0.404
CLV_NRD_NRD_1	636	638	PF00675	0.393
CLV_PCSK_KEX2_1	163	165	PF00082	0.453
CLV_PCSK_KEX2_1	255	257	PF00082	0.673
CLV_PCSK_KEX2_1	367	369	PF00082	0.529
CLV_PCSK_KEX2_1	421	423	PF00082	0.706
CLV_PCSK_KEX2_1	443	445	PF00082	0.617
CLV_PCSK_KEX2_1	55	57	PF00082	0.419
CLV_PCSK_KEX2_1	636	638	PF00082	0.393
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.599
CLV_PCSK_SKI1_1	131	135	PF00082	0.420
CLV_PCSK_SKI1_1	413	417	PF00082	0.786
CLV_PCSK_SKI1_1	486	490	PF00082	0.410
CLV_PCSK_SKI1_1	623	627	PF00082	0.353
CLV_PCSK_SKI1_1	724	728	PF00082	0.457
CLV_PCSK_SKI1_1	761	765	PF00082	0.441
CLV_PCSK_SKI1_1	833	837	PF00082	0.398
DEG_APCC_DBOX_1	256	264	PF00400	0.508
DEG_COP1_1	770	780	PF00400	0.370
DEG_SPOP_SBC_1	12	16	PF00917	0.420
DEG_SPOP_SBC_1	250	254	PF00917	0.430
DOC_MAPK_MEF2A_6	45	52	PF00069	0.355
DOC_PP1_RVXF_1	528	535	PF00149	0.385
DOC_PP1_RVXF_1	64	71	PF00149	0.372
DOC_PP2B_LxvP_1	269	272	PF13499	0.716
DOC_PP2B_PxIxI_1	785	791	PF00149	0.402
DOC_SPAK_OSR1_1	668	672	PF12202	0.416
DOC_USP7_MATH_1	11	15	PF00917	0.405
DOC_USP7_MATH_1	250	254	PF00917	0.643
DOC_USP7_MATH_1	274	278	PF00917	0.739
DOC_USP7_MATH_1	335	339	PF00917	0.647
DOC_USP7_MATH_1	384	388	PF00917	0.609
DOC_USP7_MATH_1	466	470	PF00917	0.621
DOC_USP7_MATH_1	612	616	PF00917	0.430
DOC_USP7_MATH_1	649	653	PF00917	0.689
DOC_USP7_MATH_1	792	796	PF00917	0.325
DOC_WW_Pin1_4	169	174	PF00397	0.575
DOC_WW_Pin1_4	25	30	PF00397	0.635
DOC_WW_Pin1_4	392	397	PF00397	0.503
DOC_WW_Pin1_4	581	586	PF00397	0.425
DOC_WW_Pin1_4	587	592	PF00397	0.425
LIG_14-3-3_CanoR_1	192	197	PF00244	0.429
LIG_14-3-3_CanoR_1	244	251	PF00244	0.562
LIG_14-3-3_CanoR_1	379	385	PF00244	0.414
LIG_14-3-3_CanoR_1	486	491	PF00244	0.591
LIG_14-3-3_CanoR_1	668	672	PF00244	0.455
LIG_BIR_III_4	38	42	PF00653	0.579
LIG_BRCT_BRCA1_1	13	17	PF00533	0.421
LIG_BRCT_BRCA1_1	27	31	PF00533	0.557
LIG_BRCT_BRCA1_1	614	618	PF00533	0.387
LIG_BRCT_BRCA1_1	88	92	PF00533	0.530
LIG_Clathr_ClatBox_1	133	137	PF01394	0.441
LIG_Clathr_ClatBox_1	20	24	PF01394	0.377
LIG_CSL_BTD_1	582	585	PF09270	0.410
LIG_CSL_BTD_1	828	831	PF09270	0.453
LIG_EH1_1	684	692	PF00400	0.294
LIG_eIF4E_1	620	626	PF01652	0.335
LIG_FHA_1	188	194	PF00498	0.454
LIG_FHA_1	215	221	PF00498	0.349
LIG_FHA_1	229	235	PF00498	0.335
LIG_FHA_1	237	243	PF00498	0.392
LIG_FHA_1	309	315	PF00498	0.399
LIG_FHA_1	317	323	PF00498	0.382
LIG_FHA_1	335	341	PF00498	0.655
LIG_FHA_1	373	379	PF00498	0.600
LIG_FHA_1	503	509	PF00498	0.422
LIG_FHA_1	540	546	PF00498	0.495
LIG_FHA_1	717	723	PF00498	0.416
LIG_FHA_1	752	758	PF00498	0.339
LIG_FHA_2	283	289	PF00498	0.487
LIG_FHA_2	384	390	PF00498	0.493
LIG_FHA_2	489	495	PF00498	0.519
LIG_FHA_2	556	562	PF00498	0.437
LIG_FHA_2	59	65	PF00498	0.516
LIG_Integrin_isoDGR_2	222	224	PF01839	0.332
LIG_Integrin_isoDGR_2	350	352	PF01839	0.438
LIG_LIR_Gen_1	14	23	PF02991	0.485
LIG_LIR_Gen_1	28	39	PF02991	0.716
LIG_LIR_Gen_1	315	326	PF02991	0.511
LIG_LIR_Gen_1	478	485	PF02991	0.552
LIG_LIR_LC3C_4	206	210	PF02991	0.383
LIG_LIR_Nem_3	14	20	PF02991	0.488
LIG_LIR_Nem_3	315	321	PF02991	0.562
LIG_LIR_Nem_3	356	362	PF02991	0.425
LIG_LIR_Nem_3	478	482	PF02991	0.551
LIG_LIR_Nem_3	615	621	PF02991	0.311
LIG_LIR_Nem_3	826	832	PF02991	0.350
LIG_NRBOX	321	327	PF00104	0.311
LIG_NRBOX	620	626	PF00104	0.335
LIG_PDZ_Class_2	850	855	PF00595	0.372
LIG_Pex14_2	475	479	PF04695	0.502
LIG_PTB_Apo_2	686	693	PF02174	0.286
LIG_SH2_CRK	318	322	PF00017	0.418
LIG_SH2_CRK	355	359	PF00017	0.479
LIG_SH2_GRB2like	355	358	PF00017	0.389
LIG_SH2_NCK_1	355	359	PF00017	0.522
LIG_SH2_NCK_1	431	435	PF00017	0.571
LIG_SH2_STAP1	318	322	PF00017	0.499
LIG_SH2_STAP1	355	359	PF00017	0.470
LIG_SH2_STAT5	318	321	PF00017	0.570
LIG_SH2_STAT5	355	358	PF00017	0.488
LIG_SH2_STAT5	364	367	PF00017	0.418
LIG_SH2_STAT5	431	434	PF00017	0.662
LIG_SH2_STAT5	620	623	PF00017	0.346
LIG_SH2_STAT5	823	826	PF00017	0.428
LIG_SH3_1	606	612	PF00018	0.413
LIG_SH3_3	162	168	PF00018	0.504
LIG_SH3_3	601	607	PF00018	0.539
LIG_SH3_3	828	834	PF00018	0.481
LIG_SUMO_SIM_anti_2	14	22	PF11976	0.362
LIG_SUMO_SIM_anti_2	206	212	PF11976	0.543
LIG_SUMO_SIM_anti_2	46	54	PF11976	0.412
LIG_SUMO_SIM_anti_2	81	89	PF11976	0.441
LIG_SUMO_SIM_par_1	132	138	PF11976	0.376
LIG_SUMO_SIM_par_1	280	285	PF11976	0.524
LIG_SUMO_SIM_par_1	294	301	PF11976	0.423
LIG_SUMO_SIM_par_1	374	382	PF11976	0.427
LIG_SUMO_SIM_par_1	46	54	PF11976	0.510
LIG_SUMO_SIM_par_1	568	573	PF11976	0.430
LIG_SUMO_SIM_par_1	789	795	PF11976	0.317
LIG_SUMO_SIM_par_1	81	89	PF11976	0.371
LIG_TRAF2_1	149	152	PF00917	0.339
LIG_WRC_WIRS_1	107	112	PF05994	0.392
LIG_WRC_WIRS_1	307	312	PF05994	0.251
MOD_CDK_SPxxK_3	581	588	PF00069	0.447
MOD_CK1_1	214	220	PF00069	0.375
MOD_CK1_1	258	264	PF00069	0.667
MOD_CK1_1	308	314	PF00069	0.573
MOD_CK1_1	316	322	PF00069	0.537
MOD_CK1_1	338	344	PF00069	0.467
MOD_CK1_1	429	435	PF00069	0.636
MOD_CK1_1	5	11	PF00069	0.517
MOD_CK1_1	645	651	PF00069	0.689
MOD_CK1_1	652	658	PF00069	0.640
MOD_CK1_1	670	676	PF00069	0.332
MOD_CK1_1	72	78	PF00069	0.501
MOD_CK1_1	822	828	PF00069	0.477
MOD_CK2_1	146	152	PF00069	0.300
MOD_CK2_1	242	248	PF00069	0.467
MOD_CK2_1	41	47	PF00069	0.528
MOD_CK2_1	466	472	PF00069	0.515
MOD_CK2_1	488	494	PF00069	0.507
MOD_CK2_1	693	699	PF00069	0.487
MOD_Cter_Amidation	222	225	PF01082	0.279
MOD_GlcNHglycan	257	260	PF01048	0.732
MOD_GlcNHglycan	315	318	PF01048	0.493
MOD_GlcNHglycan	337	340	PF01048	0.579
MOD_GlcNHglycan	406	409	PF01048	0.700
MOD_GlcNHglycan	428	431	PF01048	0.574
MOD_GlcNHglycan	462	465	PF01048	0.657
MOD_GlcNHglycan	497	500	PF01048	0.532
MOD_GlcNHglycan	513	516	PF01048	0.360
MOD_GlcNHglycan	572	575	PF01048	0.393
MOD_GlcNHglycan	599	602	PF01048	0.720
MOD_GlcNHglycan	614	617	PF01048	0.433
MOD_GlcNHglycan	678	681	PF01048	0.366
MOD_GlcNHglycan	739	742	PF01048	0.566
MOD_GlcNHglycan	747	750	PF01048	0.404
MOD_GlcNHglycan	82	85	PF01048	0.506
MOD_GlcNHglycan	841	844	PF01048	0.500
MOD_GSK3_1	1	8	PF00069	0.566
MOD_GSK3_1	106	113	PF00069	0.564
MOD_GSK3_1	116	123	PF00069	0.556
MOD_GSK3_1	187	194	PF00069	0.484
MOD_GSK3_1	23	30	PF00069	0.543
MOD_GSK3_1	251	258	PF00069	0.693
MOD_GSK3_1	294	301	PF00069	0.448
MOD_GSK3_1	316	323	PF00069	0.479
MOD_GSK3_1	330	337	PF00069	0.545
MOD_GSK3_1	462	469	PF00069	0.700
MOD_GSK3_1	593	600	PF00069	0.514
MOD_GSK3_1	641	648	PF00069	0.606
MOD_GSK3_1	724	731	PF00069	0.447
MOD_GSK3_1	747	754	PF00069	0.515
MOD_GSK3_1	772	779	PF00069	0.464
MOD_GSK3_1	819	826	PF00069	0.420
MOD_N-GLC_1	169	174	PF02516	0.652
MOD_N-GLC_1	214	219	PF02516	0.550
MOD_N-GLC_1	562	567	PF02516	0.431
MOD_NEK2_1	115	120	PF00069	0.421
MOD_NEK2_1	196	201	PF00069	0.535
MOD_NEK2_1	211	216	PF00069	0.511
MOD_NEK2_1	282	287	PF00069	0.333
MOD_NEK2_1	321	326	PF00069	0.466
MOD_NEK2_1	363	368	PF00069	0.459
MOD_NEK2_1	570	575	PF00069	0.341
MOD_NEK2_1	624	629	PF00069	0.432
MOD_NEK2_1	745	750	PF00069	0.422
MOD_NEK2_1	751	756	PF00069	0.308
MOD_NEK2_1	86	91	PF00069	0.412
MOD_NEK2_2	122	127	PF00069	0.430
MOD_PIKK_1	116	122	PF00454	0.558
MOD_PIKK_1	23	29	PF00454	0.327
MOD_PIKK_1	316	322	PF00454	0.571
MOD_PIKK_1	369	375	PF00454	0.572
MOD_PIKK_1	659	665	PF00454	0.501
MOD_PIKK_1	767	773	PF00454	0.499
MOD_PIKK_1	792	798	PF00454	0.407
MOD_PKA_1	255	261	PF00069	0.559
MOD_PKA_2	191	197	PF00069	0.443
MOD_PKA_2	243	249	PF00069	0.591
MOD_PKA_2	255	261	PF00069	0.697
MOD_PKA_2	378	384	PF00069	0.483
MOD_PKA_2	539	545	PF00069	0.414
MOD_PKA_2	667	673	PF00069	0.532
MOD_PKA_2	728	734	PF00069	0.570
MOD_Plk_1	5	11	PF00069	0.424
MOD_Plk_1	593	599	PF00069	0.477
MOD_Plk_1	72	78	PF00069	0.520
MOD_Plk_4	13	19	PF00069	0.461
MOD_Plk_4	204	210	PF00069	0.553
MOD_Plk_4	27	33	PF00069	0.569
MOD_Plk_4	282	288	PF00069	0.406
MOD_Plk_4	321	327	PF00069	0.347
MOD_Plk_4	478	484	PF00069	0.601
MOD_Plk_4	5	11	PF00069	0.463
MOD_Plk_4	706	712	PF00069	0.500
MOD_Plk_4	819	825	PF00069	0.438
MOD_ProDKin_1	169	175	PF00069	0.560
MOD_ProDKin_1	25	31	PF00069	0.643
MOD_ProDKin_1	392	398	PF00069	0.497
MOD_ProDKin_1	581	587	PF00069	0.438
MOD_SUMO_for_1	602	605	PF00179	0.455
TRG_DiLeu_BaLyEn_6	566	571	PF01217	0.399
TRG_ENDOCYTIC_2	307	310	PF00928	0.532
TRG_ENDOCYTIC_2	318	321	PF00928	0.309
TRG_ENDOCYTIC_2	355	358	PF00928	0.514
TRG_ER_diArg_1	163	165	PF00400	0.453
TRG_ER_diArg_1	255	257	PF00400	0.675
TRG_ER_diArg_1	421	423	PF00400	0.589
TRG_ER_diArg_1	55	57	PF00400	0.421
TRG_ER_diArg_1	635	637	PF00400	0.383
TRG_NLS_MonoExtN_4	442	447	PF00514	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P916	Leptomonas seymouri	44%	92%
A0A0S4ILJ2	Bodo saltans	26%	100%
A0A1X0P1Y6	Trypanosomatidae	25%	100%
A0A3S5IQN0	Trypanosoma rangeli	27%	100%
A0A3S7X3K9	Leishmania donovani	88%	100%
A4HIE7	Leishmania braziliensis	74%	100%
A4I5P4	Leishmania infantum	88%	100%
C9ZR12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q4Q778	Leishmania major	90%	100%
V5BC72	Trypanosoma cruzi	25%	96%