PNPLA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF3336)/Patatin-like phospholipase, putative

Species:

Leishmania mexicana

UniProt:

E9B0Y7_LEIMU

TriTrypDb:

LmxM.29.2140

Length:

765

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9B0Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0Y7

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	6
GO:0016042	lipid catabolic process	4	6
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901575	organic substance catabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0004806	triglyceride lipase activity	5	4
GO:0016298	lipase activity	4	4
GO:0016788	hydrolase activity, acting on ester bonds	3	4
GO:0052689	carboxylic ester hydrolase activity	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.711
CLV_C14_Caspase3-7	93	97	PF00656	0.558
CLV_MEL_PAP_1	671	677	PF00089	0.413
CLV_NRD_NRD_1	196	198	PF00675	0.500
CLV_NRD_NRD_1	397	399	PF00675	0.348
CLV_NRD_NRD_1	607	609	PF00675	0.268
CLV_PCSK_KEX2_1	489	491	PF00082	0.492
CLV_PCSK_KEX2_1	607	609	PF00082	0.268
CLV_PCSK_KEX2_1	69	71	PF00082	0.349
CLV_PCSK_PC1ET2_1	489	491	PF00082	0.546
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.349
CLV_PCSK_SKI1_1	257	261	PF00082	0.473
CLV_PCSK_SKI1_1	398	402	PF00082	0.390
CLV_PCSK_SKI1_1	406	410	PF00082	0.269
CLV_PCSK_SKI1_1	489	493	PF00082	0.468
CLV_PCSK_SKI1_1	543	547	PF00082	0.473
CLV_PCSK_SKI1_1	579	583	PF00082	0.224
CLV_PCSK_SKI1_1	607	611	PF00082	0.344
CLV_PCSK_SKI1_1	739	743	PF00082	0.341
DEG_APCC_DBOX_1	606	614	PF00400	0.511
DEG_Nend_UBRbox_3	1	3	PF02207	0.636
DOC_ANK_TNKS_1	34	41	PF00023	0.509
DOC_CKS1_1	366	371	PF01111	0.612
DOC_MAPK_gen_1	138	147	PF00069	0.656
DOC_MAPK_gen_1	489	500	PF00069	0.268
DOC_MAPK_gen_1	607	613	PF00069	0.649
DOC_MAPK_gen_1	674	682	PF00069	0.602
DOC_MAPK_gen_1	750	760	PF00069	0.541
DOC_MAPK_MEF2A_6	35	43	PF00069	0.548
DOC_PP1_RVXF_1	255	262	PF00149	0.633
DOC_PP1_RVXF_1	648	654	PF00149	0.558
DOC_PP2B_LxvP_1	632	635	PF13499	0.570
DOC_PP4_FxxP_1	631	634	PF00568	0.564
DOC_PP4_FxxP_1	678	681	PF00568	0.481
DOC_USP7_MATH_1	13	17	PF00917	0.607
DOC_USP7_MATH_1	170	174	PF00917	0.694
DOC_USP7_MATH_1	272	276	PF00917	0.743
DOC_USP7_MATH_1	280	284	PF00917	0.711
DOC_USP7_MATH_1	315	319	PF00917	0.819
DOC_USP7_MATH_1	321	325	PF00917	0.697
DOC_USP7_MATH_1	364	368	PF00917	0.663
DOC_USP7_MATH_1	697	701	PF00917	0.594
DOC_USP7_UBL2_3	395	399	PF12436	0.546
DOC_USP7_UBL2_3	489	493	PF12436	0.292
DOC_WW_Pin1_4	160	165	PF00397	0.695
DOC_WW_Pin1_4	297	302	PF00397	0.686
DOC_WW_Pin1_4	324	329	PF00397	0.681
DOC_WW_Pin1_4	335	340	PF00397	0.659
DOC_WW_Pin1_4	362	367	PF00397	0.611
DOC_WW_Pin1_4	452	457	PF00397	0.312
DOC_WW_Pin1_4	473	478	PF00397	0.280
LIG_14-3-3_CanoR_1	197	201	PF00244	0.635
LIG_14-3-3_CanoR_1	347	356	PF00244	0.650
LIG_14-3-3_CanoR_1	379	387	PF00244	0.726
LIG_14-3-3_CanoR_1	82	88	PF00244	0.628
LIG_Actin_WH2_2	181	199	PF00022	0.653
LIG_Actin_WH2_2	383	400	PF00022	0.548
LIG_APCC_ABBA_1	475	480	PF00400	0.268
LIG_BIR_III_2	285	289	PF00653	0.647
LIG_BIR_III_2	29	33	PF00653	0.660
LIG_BRCT_BRCA1_1	315	319	PF00533	0.652
LIG_eIF4E_1	404	410	PF01652	0.609
LIG_FHA_1	183	189	PF00498	0.626
LIG_FHA_1	241	247	PF00498	0.656
LIG_FHA_1	312	318	PF00498	0.692
LIG_FHA_1	405	411	PF00498	0.480
LIG_FHA_1	483	489	PF00498	0.307
LIG_FHA_1	492	498	PF00498	0.303
LIG_FHA_1	52	58	PF00498	0.571
LIG_FHA_1	6	12	PF00498	0.596
LIG_FHA_1	729	735	PF00498	0.532
LIG_FHA_1	93	99	PF00498	0.512
LIG_FHA_2	280	286	PF00498	0.667
LIG_FHA_2	513	519	PF00498	0.407
LIG_FHA_2	549	555	PF00498	0.345
LIG_FHA_2	7	13	PF00498	0.624
LIG_FHA_2	740	746	PF00498	0.506
LIG_GBD_Chelix_1	740	748	PF00786	0.346
LIG_IBAR_NPY_1	625	627	PF08397	0.523
LIG_LIR_Gen_1	291	299	PF02991	0.690
LIG_LIR_Gen_1	679	689	PF02991	0.589
LIG_LIR_Gen_1	707	715	PF02991	0.571
LIG_LIR_Nem_3	18	23	PF02991	0.625
LIG_LIR_Nem_3	291	295	PF02991	0.693
LIG_LIR_Nem_3	586	590	PF02991	0.468
LIG_LIR_Nem_3	679	685	PF02991	0.603
LIG_LIR_Nem_3	707	711	PF02991	0.574
LIG_LIR_Nem_3	716	722	PF02991	0.557
LIG_LIR_Nem_3	729	735	PF02991	0.532
LIG_LIR_Nem_3	79	84	PF02991	0.582
LIG_MYND_1	630	634	PF01753	0.558
LIG_NRBOX	63	69	PF00104	0.529
LIG_Pex14_2	492	496	PF04695	0.268
LIG_Pex14_2	678	682	PF04695	0.546
LIG_REV1ctd_RIR_1	489	497	PF16727	0.268
LIG_SH2_CRK	20	24	PF00017	0.595
LIG_SH2_GRB2like	708	711	PF00017	0.555
LIG_SH2_GRB2like	83	86	PF00017	0.592
LIG_SH2_NCK_1	84	88	PF00017	0.589
LIG_SH2_PTP2	627	630	PF00017	0.528
LIG_SH2_SRC	590	593	PF00017	0.501
LIG_SH2_SRC	618	621	PF00017	0.531
LIG_SH2_SRC	627	630	PF00017	0.490
LIG_SH2_STAP1	94	98	PF00017	0.509
LIG_SH2_STAT5	20	23	PF00017	0.596
LIG_SH2_STAT5	549	552	PF00017	0.301
LIG_SH2_STAT5	590	593	PF00017	0.468
LIG_SH2_STAT5	618	621	PF00017	0.505
LIG_SH2_STAT5	627	630	PF00017	0.591
LIG_SH2_STAT5	708	711	PF00017	0.582
LIG_SH2_STAT5	719	722	PF00017	0.583
LIG_SH2_STAT5	94	97	PF00017	0.535
LIG_SH3_3	152	158	PF00018	0.674
LIG_SH3_3	292	298	PF00018	0.662
LIG_SH3_3	322	328	PF00018	0.695
LIG_SH3_3	363	369	PF00018	0.599
LIG_SH3_3	547	553	PF00018	0.257
LIG_SH3_3	586	592	PF00018	0.468
LIG_SH3_3	709	715	PF00018	0.552
LIG_SH3_5	715	719	PF00018	0.590
LIG_TRAF2_1	534	537	PF00917	0.268
LIG_TYR_ITIM	616	621	PF00017	0.493
LIG_UBA3_1	446	454	PF00899	0.272
LIG_WRC_WIRS_1	60	65	PF05994	0.561
LIG_WW_1	370	373	PF00397	0.632
MOD_CDK_SPxxK_3	297	304	PF00069	0.720
MOD_CK1_1	114	120	PF00069	0.682
MOD_CK1_1	173	179	PF00069	0.676
MOD_CK1_1	230	236	PF00069	0.703
MOD_CK1_1	242	248	PF00069	0.729
MOD_CK1_1	293	299	PF00069	0.657
MOD_CK1_1	324	330	PF00069	0.698
MOD_CK1_1	352	358	PF00069	0.653
MOD_CK1_1	365	371	PF00069	0.668
MOD_CK1_1	412	418	PF00069	0.312
MOD_CK1_1	442	448	PF00069	0.270
MOD_CK1_1	482	488	PF00069	0.201
MOD_CK1_1	559	565	PF00069	0.316
MOD_CK1_1	6	12	PF00069	0.624
MOD_CK2_1	452	458	PF00069	0.268
MOD_CK2_1	512	518	PF00069	0.406
MOD_CK2_1	531	537	PF00069	0.301
MOD_CK2_1	6	12	PF00069	0.668
MOD_CK2_1	739	745	PF00069	0.508
MOD_CMANNOS	652	655	PF00535	0.384
MOD_GlcNHglycan	113	116	PF01048	0.477
MOD_GlcNHglycan	131	134	PF01048	0.364
MOD_GlcNHglycan	148	152	PF01048	0.421
MOD_GlcNHglycan	160	163	PF01048	0.462
MOD_GlcNHglycan	168	171	PF01048	0.516
MOD_GlcNHglycan	172	175	PF01048	0.490
MOD_GlcNHglycan	220	223	PF01048	0.544
MOD_GlcNHglycan	229	232	PF01048	0.476
MOD_GlcNHglycan	264	268	PF01048	0.410
MOD_GlcNHglycan	329	332	PF01048	0.562
MOD_GlcNHglycan	380	383	PF01048	0.459
MOD_GlcNHglycan	411	414	PF01048	0.335
MOD_GlcNHglycan	441	444	PF01048	0.500
MOD_GlcNHglycan	522	525	PF01048	0.479
MOD_GlcNHglycan	558	561	PF01048	0.393
MOD_GlcNHglycan	643	646	PF01048	0.488
MOD_GlcNHglycan	689	692	PF01048	0.364
MOD_GlcNHglycan	715	718	PF01048	0.351
MOD_GlcNHglycan	85	88	PF01048	0.389
MOD_GSK3_1	1	8	PF00069	0.641
MOD_GSK3_1	124	131	PF00069	0.735
MOD_GSK3_1	166	173	PF00069	0.727
MOD_GSK3_1	208	215	PF00069	0.682
MOD_GSK3_1	216	223	PF00069	0.694
MOD_GSK3_1	226	233	PF00069	0.661
MOD_GSK3_1	236	243	PF00069	0.619
MOD_GSK3_1	245	252	PF00069	0.618
MOD_GSK3_1	293	300	PF00069	0.711
MOD_GSK3_1	302	309	PF00069	0.715
MOD_GSK3_1	311	318	PF00069	0.743
MOD_GSK3_1	348	355	PF00069	0.646
MOD_GSK3_1	400	407	PF00069	0.521
MOD_GSK3_1	409	416	PF00069	0.302
MOD_GSK3_1	438	445	PF00069	0.281
MOD_GSK3_1	462	469	PF00069	0.320
MOD_GSK3_1	527	534	PF00069	0.268
MOD_GSK3_1	59	66	PF00069	0.564
MOD_GSK3_1	634	641	PF00069	0.599
MOD_GSK3_1	661	668	PF00069	0.546
MOD_GSK3_1	687	694	PF00069	0.608
MOD_GSK3_1	718	725	PF00069	0.538
MOD_N-GLC_1	1	6	PF02516	0.459
MOD_N-GLC_1	311	316	PF02516	0.504
MOD_N-GLC_1	527	532	PF02516	0.468
MOD_NEK2_1	147	152	PF00069	0.638
MOD_NEK2_1	196	201	PF00069	0.704
MOD_NEK2_1	227	232	PF00069	0.700
MOD_NEK2_1	238	243	PF00069	0.622
MOD_NEK2_1	349	354	PF00069	0.655
MOD_NEK2_1	409	414	PF00069	0.413
MOD_NEK2_1	438	443	PF00069	0.294
MOD_NEK2_1	450	455	PF00069	0.317
MOD_NEK2_1	462	467	PF00069	0.385
MOD_NEK2_1	491	496	PF00069	0.274
MOD_NEK2_1	51	56	PF00069	0.602
MOD_NEK2_1	527	532	PF00069	0.277
MOD_NEK2_1	619	624	PF00069	0.492
MOD_NEK2_1	63	68	PF00069	0.480
MOD_NEK2_1	76	81	PF00069	0.572
MOD_PIKK_1	531	537	PF00454	0.268
MOD_PIKK_1	619	625	PF00454	0.533
MOD_PK_1	216	222	PF00069	0.643
MOD_PKA_2	196	202	PF00069	0.675
MOD_PKA_2	349	355	PF00069	0.636
MOD_PKA_2	378	384	PF00069	0.743
MOD_PKB_1	737	745	PF00069	0.509
MOD_Plk_1	124	130	PF00069	0.649
MOD_Plk_1	263	269	PF00069	0.647
MOD_Plk_1	290	296	PF00069	0.747
MOD_Plk_1	512	518	PF00069	0.306
MOD_Plk_1	527	533	PF00069	0.306
MOD_Plk_1	691	697	PF00069	0.505
MOD_Plk_1	76	82	PF00069	0.621
MOD_Plk_4	442	448	PF00069	0.296
MOD_Plk_4	512	518	PF00069	0.268
MOD_Plk_4	59	65	PF00069	0.532
MOD_Plk_4	6	12	PF00069	0.643
MOD_Plk_4	643	649	PF00069	0.569
MOD_Plk_4	661	667	PF00069	0.639
MOD_Plk_4	697	703	PF00069	0.616
MOD_Plk_4	76	82	PF00069	0.507
MOD_ProDKin_1	160	166	PF00069	0.697
MOD_ProDKin_1	297	303	PF00069	0.688
MOD_ProDKin_1	324	330	PF00069	0.683
MOD_ProDKin_1	335	341	PF00069	0.659
MOD_ProDKin_1	362	368	PF00069	0.616
MOD_ProDKin_1	452	458	PF00069	0.312
MOD_ProDKin_1	473	479	PF00069	0.280
MOD_SUMO_rev_2	283	289	PF00179	0.664
TRG_DiLeu_BaEn_2	457	463	PF01217	0.268
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.720
TRG_DiLeu_BaLyEn_6	298	303	PF01217	0.685
TRG_DiLeu_BaLyEn_6	605	610	PF01217	0.468
TRG_ENDOCYTIC_2	20	23	PF00928	0.620
TRG_ENDOCYTIC_2	618	621	PF00928	0.488
TRG_ENDOCYTIC_2	708	711	PF00928	0.589
TRG_ER_diArg_1	606	608	PF00400	0.468
TRG_ER_diArg_1	737	740	PF00400	0.520
TRG_NES_CRM1_1	751	762	PF08389	0.507
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	607	612	PF00026	0.319
TRG_Pf-PMV_PEXEL_1	746	751	PF00026	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P1	Leptomonas seymouri	54%	93%
A4HB80	Leishmania braziliensis	27%	100%
A4HIE6	Leishmania braziliensis	77%	100%
A4I5P3	Leishmania infantum	91%	86%
Q4Q779	Leishmania major	91%	100%