Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0Y4_LEIMU

TriTrypDb:

LmxM.29.2110

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0Y4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0Y4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	9	13	PF00656	0.543
CLV_NRD_NRD_1	211	213	PF00675	0.483
CLV_NRD_NRD_1	414	416	PF00675	0.547
CLV_NRD_NRD_1	422	424	PF00675	0.592
CLV_PCSK_KEX2_1	211	213	PF00082	0.415
CLV_PCSK_KEX2_1	414	416	PF00082	0.547
CLV_PCSK_SKI1_1	127	131	PF00082	0.363
CLV_PCSK_SKI1_1	469	473	PF00082	0.569
DEG_APCC_DBOX_1	325	333	PF00400	0.630
DEG_APCC_DBOX_1	80	88	PF00400	0.457
DOC_CKS1_1	304	309	PF01111	0.589
DOC_CYCLIN_yCln2_LP_2	304	310	PF00134	0.659
DOC_MAPK_MEF2A_6	81	90	PF00069	0.375
DOC_PP1_RVXF_1	125	131	PF00149	0.350
DOC_PP4_FxxP_1	347	350	PF00568	0.586
DOC_PP4_FxxP_1	80	83	PF00568	0.425
DOC_USP7_MATH_1	159	163	PF00917	0.744
DOC_USP7_MATH_1	316	320	PF00917	0.732
DOC_USP7_MATH_1	352	356	PF00917	0.608
DOC_USP7_MATH_1	488	492	PF00917	0.589
DOC_USP7_UBL2_3	33	37	PF12436	0.534
DOC_WW_Pin1_4	157	162	PF00397	0.683
DOC_WW_Pin1_4	164	169	PF00397	0.627
DOC_WW_Pin1_4	181	186	PF00397	0.724
DOC_WW_Pin1_4	243	248	PF00397	0.680
DOC_WW_Pin1_4	26	31	PF00397	0.457
DOC_WW_Pin1_4	265	270	PF00397	0.684
DOC_WW_Pin1_4	271	276	PF00397	0.801
DOC_WW_Pin1_4	289	294	PF00397	0.509
DOC_WW_Pin1_4	303	308	PF00397	0.749
DOC_WW_Pin1_4	321	326	PF00397	0.690
DOC_WW_Pin1_4	327	332	PF00397	0.634
DOC_WW_Pin1_4	336	341	PF00397	0.508
DOC_WW_Pin1_4	366	371	PF00397	0.572
DOC_WW_Pin1_4	423	428	PF00397	0.622
DOC_WW_Pin1_4	429	434	PF00397	0.579
DOC_WW_Pin1_4	90	95	PF00397	0.380
LIG_14-3-3_CanoR_1	175	180	PF00244	0.703
LIG_14-3-3_CanoR_1	195	204	PF00244	0.308
LIG_14-3-3_CanoR_1	233	238	PF00244	0.591
LIG_14-3-3_CanoR_1	440	444	PF00244	0.679
LIG_14-3-3_CanoR_1	63	68	PF00244	0.545
LIG_Actin_WH2_2	519	535	PF00022	0.541
LIG_BRCT_BRCA1_1	217	221	PF00533	0.436
LIG_BRCT_BRCA1_1	354	358	PF00533	0.660
LIG_BRCT_BRCA1_1	374	378	PF00533	0.478
LIG_deltaCOP1_diTrp_1	229	237	PF00928	0.490
LIG_deltaCOP1_diTrp_1	59	67	PF00928	0.517
LIG_EH1_1	447	455	PF00400	0.606
LIG_FHA_1	203	209	PF00498	0.503
LIG_FHA_1	304	310	PF00498	0.587
LIG_FHA_1	312	318	PF00498	0.599
LIG_FHA_1	390	396	PF00498	0.600
LIG_FHA_2	146	152	PF00498	0.472
LIG_FHA_2	7	13	PF00498	0.494
LIG_FHA_2	97	103	PF00498	0.405
LIG_GBD_Chelix_1	125	133	PF00786	0.346
LIG_LIR_Apic_2	102	106	PF02991	0.458
LIG_LIR_Apic_2	236	240	PF02991	0.588
LIG_LIR_Apic_2	306	311	PF02991	0.780
LIG_LIR_Apic_2	345	350	PF02991	0.591
LIG_LIR_Gen_1	115	122	PF02991	0.429
LIG_LIR_Gen_1	218	228	PF02991	0.396
LIG_LIR_Nem_3	115	119	PF02991	0.458
LIG_LIR_Nem_3	137	142	PF02991	0.387
LIG_LIR_Nem_3	218	224	PF02991	0.412
LIG_LIR_Nem_3	41	47	PF02991	0.421
LIG_MYND_1	307	311	PF01753	0.586
LIG_NRBOX	16	22	PF00104	0.336
LIG_NRBOX	502	508	PF00104	0.489
LIG_SH2_CRK	139	143	PF00017	0.383
LIG_SH2_GRB2like	89	92	PF00017	0.384
LIG_SH2_NCK_1	55	59	PF00017	0.431
LIG_SH2_SRC	55	58	PF00017	0.404
LIG_SH2_SRC	89	92	PF00017	0.363
LIG_SH2_STAP1	391	395	PF00017	0.615
LIG_SH2_STAT5	214	217	PF00017	0.462
LIG_SH2_STAT5	308	311	PF00017	0.660
LIG_SH2_STAT5	391	394	PF00017	0.620
LIG_SH2_STAT5	89	92	PF00017	0.384
LIG_SH3_1	166	172	PF00018	0.572
LIG_SH3_3	155	161	PF00018	0.674
LIG_SH3_3	166	172	PF00018	0.655
LIG_SH3_3	182	188	PF00018	0.525
LIG_SH3_3	201	207	PF00018	0.315
LIG_SH3_3	244	250	PF00018	0.522
LIG_SH3_3	328	334	PF00018	0.679
LIG_SH3_3	516	522	PF00018	0.666
LIG_SUMO_SIM_par_1	313	319	PF11976	0.584
LIG_SUMO_SIM_par_1	93	99	PF11976	0.366
LIG_TRAF2_1	199	202	PF00917	0.427
LIG_TRAF2_1	54	57	PF00917	0.512
LIG_TRFH_1	347	351	PF08558	0.585
LIG_UBA3_1	506	514	PF00899	0.505
MOD_CDC14_SPxK_1	268	271	PF00782	0.633
MOD_CDK_SPK_2	321	326	PF00069	0.623
MOD_CDK_SPxK_1	265	271	PF00069	0.639
MOD_CDK_SPxxK_3	168	175	PF00069	0.622
MOD_CDK_SPxxK_3	26	33	PF00069	0.443
MOD_CDK_SPxxK_3	271	278	PF00069	0.621
MOD_CK1_1	145	151	PF00069	0.475
MOD_CK1_1	177	183	PF00069	0.589
MOD_CK1_1	3	9	PF00069	0.674
MOD_CK1_1	303	309	PF00069	0.787
MOD_CK1_1	319	325	PF00069	0.624
MOD_CK1_1	336	342	PF00069	0.478
MOD_CK1_1	363	369	PF00069	0.669
MOD_CK1_1	428	434	PF00069	0.699
MOD_CK1_1	439	445	PF00069	0.719
MOD_CK1_1	487	493	PF00069	0.672
MOD_CK1_1	65	71	PF00069	0.698
MOD_CK2_1	196	202	PF00069	0.455
MOD_CK2_1	51	57	PF00069	0.454
MOD_CK2_1	90	96	PF00069	0.375
MOD_Cter_Amidation	435	438	PF01082	0.675
MOD_GlcNHglycan	161	164	PF01048	0.584
MOD_GlcNHglycan	355	358	PF01048	0.514
MOD_GlcNHglycan	427	430	PF01048	0.649
MOD_GlcNHglycan	462	465	PF01048	0.651
MOD_GlcNHglycan	486	489	PF01048	0.708
MOD_GlcNHglycan	490	493	PF01048	0.696
MOD_GlcNHglycan	68	71	PF01048	0.569
MOD_GSK3_1	164	171	PF00069	0.701
MOD_GSK3_1	177	184	PF00069	0.726
MOD_GSK3_1	224	231	PF00069	0.454
MOD_GSK3_1	239	246	PF00069	0.517
MOD_GSK3_1	260	267	PF00069	0.670
MOD_GSK3_1	279	286	PF00069	0.611
MOD_GSK3_1	295	302	PF00069	0.721
MOD_GSK3_1	311	318	PF00069	0.597
MOD_GSK3_1	415	422	PF00069	0.631
MOD_GSK3_1	425	432	PF00069	0.577
MOD_GSK3_1	449	456	PF00069	0.639
MOD_GSK3_1	45	52	PF00069	0.488
MOD_GSK3_1	484	491	PF00069	0.731
MOD_GSK3_1	62	69	PF00069	0.559
MOD_N-GLC_1	175	180	PF02516	0.625
MOD_N-GLC_1	327	332	PF02516	0.633
MOD_N-GLC_1	90	95	PF02516	0.380
MOD_NEK2_1	174	179	PF00069	0.533
MOD_NEK2_1	228	233	PF00069	0.474
MOD_NEK2_1	299	304	PF00069	0.734
MOD_NEK2_1	315	320	PF00069	0.716
MOD_NEK2_1	378	383	PF00069	0.663
MOD_NEK2_1	419	424	PF00069	0.669
MOD_NEK2_1	49	54	PF00069	0.423
MOD_NEK2_1	526	531	PF00069	0.662
MOD_NEK2_2	45	50	PF00069	0.492
MOD_PIKK_1	239	245	PF00454	0.663
MOD_PIKK_1	285	291	PF00454	0.668
MOD_PK_1	287	293	PF00069	0.637
MOD_PKA_2	174	180	PF00069	0.650
MOD_PKA_2	197	203	PF00069	0.337
MOD_PKA_2	439	445	PF00069	0.623
MOD_PKA_2	49	55	PF00069	0.420
MOD_PKA_2	62	68	PF00069	0.536
MOD_Plk_1	108	114	PF00069	0.474
MOD_Plk_1	175	181	PF00069	0.641
MOD_Plk_1	224	230	PF00069	0.396
MOD_Plk_1	360	366	PF00069	0.533
MOD_Plk_2-3	51	57	PF00069	0.435
MOD_Plk_2-3	96	102	PF00069	0.378
MOD_Plk_4	121	127	PF00069	0.363
MOD_Plk_4	233	239	PF00069	0.598
MOD_Plk_4	415	421	PF00069	0.597
MOD_Plk_4	439	445	PF00069	0.553
MOD_Plk_4	449	455	PF00069	0.581
MOD_Plk_4	502	508	PF00069	0.514
MOD_ProDKin_1	157	163	PF00069	0.683
MOD_ProDKin_1	164	170	PF00069	0.629
MOD_ProDKin_1	181	187	PF00069	0.719
MOD_ProDKin_1	243	249	PF00069	0.683
MOD_ProDKin_1	26	32	PF00069	0.469
MOD_ProDKin_1	265	271	PF00069	0.686
MOD_ProDKin_1	289	295	PF00069	0.601
MOD_ProDKin_1	303	309	PF00069	0.749
MOD_ProDKin_1	321	327	PF00069	0.692
MOD_ProDKin_1	336	342	PF00069	0.511
MOD_ProDKin_1	366	372	PF00069	0.572
MOD_ProDKin_1	423	429	PF00069	0.624
MOD_ProDKin_1	90	96	PF00069	0.375
TRG_DiLeu_BaEn_1	449	454	PF01217	0.609
TRG_DiLeu_BaEn_4	56	62	PF01217	0.446
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.403
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.358
TRG_ENDOCYTIC_2	139	142	PF00928	0.376
TRG_ER_diArg_1	413	415	PF00400	0.541
TRG_NLS_Bipartite_1	423	441	PF00514	0.672
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.314

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9W6	Leptomonas seymouri	48%	98%
A0A3S7X3G8	Leishmania donovani	93%	100%
A4HIE3	Leishmania braziliensis	78%	100%
A4I5P0	Leishmania infantum	93%	100%
Q9NE60	Leishmania major	93%	100%