Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0Y3_LEIMU

TriTrypDb:

LmxM.29.2100

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0Y3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0Y3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.510
CLV_C14_Caspase3-7	226	230	PF00656	0.429
CLV_MEL_PAP_1	172	178	PF00089	0.446
CLV_NRD_NRD_1	207	209	PF00675	0.422
CLV_NRD_NRD_1	342	344	PF00675	0.647
CLV_PCSK_KEX2_1	342	344	PF00082	0.647
CLV_PCSK_KEX2_1	422	424	PF00082	0.403
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.403
CLV_PCSK_SKI1_1	241	245	PF00082	0.526
CLV_PCSK_SKI1_1	274	278	PF00082	0.492
CLV_PCSK_SKI1_1	422	426	PF00082	0.377
CLV_PCSK_SKI1_1	469	473	PF00082	0.476
DEG_APCC_DBOX_1	500	508	PF00400	0.454
DEG_MDM2_SWIB_1	257	264	PF02201	0.427
DEG_SPOP_SBC_1	559	563	PF00917	0.370
DOC_CYCLIN_RxL_1	419	427	PF00134	0.460
DOC_CYCLIN_yCln2_LP_2	201	207	PF00134	0.422
DOC_MAPK_DCC_7	358	366	PF00069	0.494
DOC_MAPK_RevD_3	328	343	PF00069	0.475
DOC_MIT_MIM_1	497	507	PF04212	0.486
DOC_PP1_RVXF_1	325	332	PF00149	0.407
DOC_PP1_RVXF_1	410	417	PF00149	0.415
DOC_PP2B_LxvP_1	246	249	PF13499	0.413
DOC_PP4_FxxP_1	122	125	PF00568	0.573
DOC_PP4_FxxP_1	308	311	PF00568	0.576
DOC_PP4_FxxP_1	416	419	PF00568	0.376
DOC_SPAK_OSR1_1	327	331	PF12202	0.342
DOC_USP7_MATH_1	108	112	PF00917	0.657
DOC_USP7_MATH_1	213	217	PF00917	0.571
DOC_USP7_MATH_1	369	373	PF00917	0.649
DOC_USP7_MATH_1	398	402	PF00917	0.699
DOC_USP7_MATH_1	407	411	PF00917	0.661
DOC_USP7_MATH_1	559	563	PF00917	0.395
DOC_USP7_MATH_1	610	614	PF00917	0.543
DOC_USP7_MATH_1	87	91	PF00917	0.618
DOC_WW_Pin1_4	104	109	PF00397	0.669
DOC_WW_Pin1_4	125	130	PF00397	0.542
DOC_WW_Pin1_4	162	167	PF00397	0.538
DOC_WW_Pin1_4	187	192	PF00397	0.573
DOC_WW_Pin1_4	200	205	PF00397	0.332
DOC_WW_Pin1_4	365	370	PF00397	0.588
DOC_WW_Pin1_4	38	43	PF00397	0.498
DOC_WW_Pin1_4	394	399	PF00397	0.514
DOC_WW_Pin1_4	415	420	PF00397	0.452
DOC_WW_Pin1_4	58	63	PF00397	0.408
DOC_WW_Pin1_4	83	88	PF00397	0.674
LIG_14-3-3_CanoR_1	290	294	PF00244	0.507
LIG_14-3-3_CanoR_1	423	432	PF00244	0.394
LIG_14-3-3_CanoR_1	532	538	PF00244	0.508
LIG_14-3-3_CanoR_1	54	62	PF00244	0.565
LIG_14-3-3_CanoR_1	82	87	PF00244	0.698
LIG_14-3-3_CanoR_1	95	99	PF00244	0.627
LIG_BIR_II_1	1	5	PF00653	0.396
LIG_BIR_III_2	346	350	PF00653	0.583
LIG_BIR_III_4	227	231	PF00653	0.409
LIG_CaM_NSCaTE_8	52	59	PF13499	0.481
LIG_Clathr_ClatBox_1	263	267	PF01394	0.323
LIG_CSL_BTD_1	416	419	PF09270	0.435
LIG_deltaCOP1_diTrp_1	259	266	PF00928	0.411
LIG_deltaCOP1_diTrp_1	455	464	PF00928	0.414
LIG_eIF4E_1	17	23	PF01652	0.467
LIG_FHA_1	154	160	PF00498	0.509
LIG_FHA_1	339	345	PF00498	0.661
LIG_FHA_1	59	65	PF00498	0.482
LIG_FHA_1	7	13	PF00498	0.441
LIG_FHA_2	16	22	PF00498	0.444
LIG_FHA_2	275	281	PF00498	0.498
LIG_Integrin_isoDGR_2	353	355	PF01839	0.679
LIG_LIR_Apic_2	119	125	PF02991	0.600
LIG_LIR_Apic_2	306	311	PF02991	0.570
LIG_LIR_Apic_2	415	419	PF02991	0.384
LIG_LIR_Gen_1	2	12	PF02991	0.461
LIG_LIR_Gen_1	27	37	PF02991	0.466
LIG_LIR_Gen_1	302	311	PF02991	0.431
LIG_LIR_Gen_1	496	504	PF02991	0.516
LIG_LIR_Gen_1	584	592	PF02991	0.595
LIG_LIR_Nem_3	167	172	PF02991	0.477
LIG_LIR_Nem_3	2	8	PF02991	0.395
LIG_LIR_Nem_3	259	264	PF02991	0.419
LIG_LIR_Nem_3	27	33	PF02991	0.409
LIG_LIR_Nem_3	302	308	PF02991	0.436
LIG_LIR_Nem_3	470	475	PF02991	0.477
LIG_LIR_Nem_3	496	500	PF02991	0.463
LIG_LIR_Nem_3	584	589	PF02991	0.496
LIG_NBox_RRM_1	266	276	PF00076	0.449
LIG_Pex14_2	257	261	PF04695	0.449
LIG_SH2_SRC	586	589	PF00017	0.520
LIG_SH2_STAP1	239	243	PF00017	0.328
LIG_SH2_STAT5	138	141	PF00017	0.505
LIG_SH2_STAT5	17	20	PF00017	0.495
LIG_SH2_STAT5	24	27	PF00017	0.491
LIG_SH2_STAT5	628	631	PF00017	0.448
LIG_SH3_2	126	131	PF14604	0.380
LIG_SH3_3	120	126	PF00018	0.428
LIG_SH3_3	357	363	PF00018	0.728
LIG_SH3_3	615	621	PF00018	0.486
LIG_SUMO_SIM_anti_2	26	35	PF11976	0.475
LIG_SUMO_SIM_anti_2	560	570	PF11976	0.457
LIG_SUMO_SIM_par_1	156	163	PF11976	0.526
LIG_SUMO_SIM_par_1	336	341	PF11976	0.554
LIG_SUMO_SIM_par_1	362	368	PF11976	0.488
LIG_SUMO_SIM_par_1	579	584	PF11976	0.508
LIG_SUMO_SIM_par_1	61	67	PF11976	0.459
LIG_TRAF2_1	249	252	PF00917	0.492
LIG_TRAF2_1	277	280	PF00917	0.565
LIG_TRAF2_1	600	603	PF00917	0.511
LIG_WW_3	124	128	PF00397	0.504
MOD_CDC14_SPxK_1	128	131	PF00782	0.542
MOD_CDK_SPK_2	394	399	PF00069	0.465
MOD_CDK_SPxK_1	125	131	PF00069	0.549
MOD_CDK_SPxxK_3	415	422	PF00069	0.456
MOD_CK1_1	111	117	PF00069	0.741
MOD_CK1_1	15	21	PF00069	0.508
MOD_CK1_1	187	193	PF00069	0.473
MOD_CK1_1	203	209	PF00069	0.460
MOD_CK1_1	26	32	PF00069	0.375
MOD_CK2_1	144	150	PF00069	0.526
MOD_CK2_1	151	157	PF00069	0.448
MOD_CK2_1	274	280	PF00069	0.593
MOD_CK2_1	330	336	PF00069	0.460
MOD_CK2_1	415	421	PF00069	0.415
MOD_CK2_1	581	587	PF00069	0.515
MOD_GlcNHglycan	1	4	PF01048	0.510
MOD_GlcNHglycan	14	17	PF01048	0.379
MOD_GlcNHglycan	146	149	PF01048	0.451
MOD_GlcNHglycan	186	189	PF01048	0.622
MOD_GlcNHglycan	215	218	PF01048	0.658
MOD_GlcNHglycan	233	236	PF01048	0.297
MOD_GlcNHglycan	371	374	PF01048	0.614
MOD_GlcNHglycan	56	59	PF01048	0.652
MOD_GlcNHglycan	569	572	PF01048	0.541
MOD_GlcNHglycan	583	586	PF01048	0.481
MOD_GlcNHglycan	593	597	PF01048	0.478
MOD_GlcNHglycan	66	69	PF01048	0.583
MOD_GlcNHglycan	90	93	PF01048	0.648
MOD_GSK3_1	104	111	PF00069	0.538
MOD_GSK3_1	180	187	PF00069	0.606
MOD_GSK3_1	365	372	PF00069	0.626
MOD_GSK3_1	394	401	PF00069	0.615
MOD_GSK3_1	54	61	PF00069	0.660
MOD_GSK3_1	62	69	PF00069	0.564
MOD_GSK3_1	77	84	PF00069	0.553
MOD_GSK3_1	94	101	PF00069	0.660
MOD_N-GLC_1	108	113	PF02516	0.739
MOD_N-GLC_1	394	399	PF02516	0.514
MOD_NEK2_1	12	17	PF00069	0.493
MOD_NEK2_1	179	184	PF00069	0.565
MOD_NEK2_1	220	225	PF00069	0.567
MOD_NEK2_1	231	236	PF00069	0.379
MOD_NEK2_1	424	429	PF00069	0.366
MOD_NEK2_1	526	531	PF00069	0.441
MOD_NEK2_1	567	572	PF00069	0.394
MOD_NEK2_1	71	76	PF00069	0.485
MOD_PIKK_1	433	439	PF00454	0.511
MOD_PIKK_1	462	468	PF00454	0.466
MOD_PIKK_1	480	486	PF00454	0.333
MOD_PKA_2	174	180	PF00069	0.503
MOD_PKA_2	184	190	PF00069	0.530
MOD_PKA_2	289	295	PF00069	0.513
MOD_PKA_2	354	360	PF00069	0.663
MOD_PKA_2	380	386	PF00069	0.646
MOD_PKA_2	398	404	PF00069	0.563
MOD_PKA_2	6	12	PF00069	0.447
MOD_PKA_2	81	87	PF00069	0.647
MOD_PKA_2	94	100	PF00069	0.536
MOD_Plk_1	108	114	PF00069	0.654
MOD_Plk_1	241	247	PF00069	0.452
MOD_Plk_1	26	32	PF00069	0.481
MOD_Plk_1	78	84	PF00069	0.622
MOD_Plk_4	190	196	PF00069	0.378
MOD_Plk_4	26	32	PF00069	0.481
MOD_Plk_4	467	473	PF00069	0.473
MOD_ProDKin_1	104	110	PF00069	0.668
MOD_ProDKin_1	125	131	PF00069	0.538
MOD_ProDKin_1	162	168	PF00069	0.532
MOD_ProDKin_1	187	193	PF00069	0.565
MOD_ProDKin_1	200	206	PF00069	0.330
MOD_ProDKin_1	365	371	PF00069	0.586
MOD_ProDKin_1	38	44	PF00069	0.495
MOD_ProDKin_1	394	400	PF00069	0.506
MOD_ProDKin_1	415	421	PF00069	0.455
MOD_ProDKin_1	58	64	PF00069	0.412
MOD_ProDKin_1	83	89	PF00069	0.669
MOD_SUMO_for_1	132	135	PF00179	0.485
MOD_SUMO_rev_2	465	471	PF00179	0.471
TRG_DiLeu_BaEn_1	135	140	PF01217	0.455
TRG_DiLeu_BaEn_1	259	264	PF01217	0.419
TRG_DiLeu_BaEn_4	279	285	PF01217	0.444
TRG_DiLeu_BaLyEn_6	168	173	PF01217	0.473
TRG_DiLeu_BaLyEn_6	420	425	PF01217	0.469
TRG_ENDOCYTIC_2	586	589	PF00928	0.452
TRG_ER_diArg_1	342	344	PF00400	0.647
TRG_ER_diArg_1	500	503	PF00400	0.531
TRG_NES_CRM1_1	282	294	PF08389	0.467
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P209	Trypanosomatidae	33%	100%
A0A3S5H7N2	Leishmania donovani	94%	100%
A4HIE2	Leishmania braziliensis	84%	100%
A4I5N9	Leishmania infantum	94%	100%
Q4Q783	Leishmania major	92%	100%
V5BL95	Trypanosoma cruzi	35%	100%