AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0Y1_LEIMU

TriTrypDb:

LmxM.29.2080

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B0Y1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0Y1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	465	469	PF00656	0.508
CLV_MEL_PAP_1	211	217	PF00089	0.266
CLV_NRD_NRD_1	289	291	PF00675	0.266
CLV_NRD_NRD_1	295	297	PF00675	0.266
CLV_NRD_NRD_1	374	376	PF00675	0.471
CLV_NRD_NRD_1	380	382	PF00675	0.494
CLV_NRD_NRD_1	442	444	PF00675	0.579
CLV_NRD_NRD_1	453	455	PF00675	0.585
CLV_NRD_NRD_1	533	535	PF00675	0.539
CLV_PCSK_FUR_1	287	291	PF00082	0.266
CLV_PCSK_KEX2_1	289	291	PF00082	0.266
CLV_PCSK_KEX2_1	295	297	PF00082	0.266
CLV_PCSK_KEX2_1	374	376	PF00082	0.471
CLV_PCSK_KEX2_1	442	444	PF00082	0.523
CLV_PCSK_KEX2_1	455	457	PF00082	0.504
CLV_PCSK_KEX2_1	533	535	PF00082	0.605
CLV_PCSK_PC1ET2_1	455	457	PF00082	0.552
CLV_PCSK_SKI1_1	224	228	PF00082	0.360
CLV_PCSK_SKI1_1	382	386	PF00082	0.431
CLV_PCSK_SKI1_1	456	460	PF00082	0.491
DEG_APCC_DBOX_1	231	239	PF00400	0.331
DEG_MDM2_SWIB_1	74	81	PF02201	0.456
DEG_Nend_Nbox_1	1	3	PF02207	0.692
DEG_SPOP_SBC_1	34	38	PF00917	0.667
DEG_SPOP_SBC_1	509	513	PF00917	0.483
DOC_ANK_TNKS_1	181	188	PF00023	0.445
DOC_CYCLIN_RxL_1	442	453	PF00134	0.431
DOC_MAPK_gen_1	100	109	PF00069	0.393
DOC_MAPK_gen_1	12	20	PF00069	0.544
DOC_MAPK_gen_1	202	211	PF00069	0.358
DOC_MAPK_gen_1	402	411	PF00069	0.410
DOC_MAPK_gen_1	442	450	PF00069	0.504
DOC_MAPK_HePTP_8	399	411	PF00069	0.391
DOC_MAPK_MEF2A_6	204	213	PF00069	0.348
DOC_MAPK_MEF2A_6	402	411	PF00069	0.388
DOC_PP2B_LxvP_1	165	168	PF13499	0.382
DOC_USP7_MATH_1	3	7	PF00917	0.695
DOC_USP7_MATH_1	34	38	PF00917	0.684
DOC_USP7_MATH_1	84	88	PF00917	0.401
DOC_USP7_UBL2_3	455	459	PF12436	0.393
DOC_WW_Pin1_4	308	313	PF00397	0.281
DOC_WW_Pin1_4	388	393	PF00397	0.359
LIG_14-3-3_CanoR_1	128	137	PF00244	0.582
LIG_14-3-3_CanoR_1	197	201	PF00244	0.405
LIG_14-3-3_CanoR_1	264	268	PF00244	0.373
LIG_14-3-3_CanoR_1	381	385	PF00244	0.504
LIG_14-3-3_CanoR_1	387	392	PF00244	0.419
LIG_14-3-3_CanoR_1	507	517	PF00244	0.477
LIG_14-3-3_CanoR_1	534	543	PF00244	0.541
LIG_14-3-3_CanoR_1	66	74	PF00244	0.500
LIG_Actin_WH2_2	11	29	PF00022	0.579
LIG_Actin_WH2_2	113	130	PF00022	0.359
LIG_APCC_ABBAyCdc20_2	404	410	PF00400	0.348
LIG_BRCT_BRCA1_1	389	393	PF00533	0.409
LIG_CaM_IQ_9	288	303	PF13499	0.393
LIG_FHA_1	114	120	PF00498	0.409
LIG_FHA_1	168	174	PF00498	0.408
LIG_FHA_1	210	216	PF00498	0.266
LIG_FHA_1	244	250	PF00498	0.276
LIG_FHA_2	138	144	PF00498	0.483
LIG_FHA_2	167	173	PF00498	0.484
LIG_FHA_2	264	270	PF00498	0.281
LIG_FHA_2	320	326	PF00498	0.266
LIG_FHA_2	381	387	PF00498	0.413
LIG_FHA_2	536	542	PF00498	0.543
LIG_LIR_Apic_2	386	392	PF02991	0.498
LIG_LIR_Apic_2	511	517	PF02991	0.567
LIG_LIR_Gen_1	136	147	PF02991	0.366
LIG_LIR_Gen_1	311	321	PF02991	0.283
LIG_LIR_Gen_1	390	399	PF02991	0.400
LIG_LIR_Gen_1	490	497	PF02991	0.767
LIG_LIR_Gen_1	76	86	PF02991	0.433
LIG_LIR_Nem_3	103	107	PF02991	0.371
LIG_LIR_Nem_3	136	142	PF02991	0.361
LIG_LIR_Nem_3	143	149	PF02991	0.285
LIG_LIR_Nem_3	311	317	PF02991	0.283
LIG_LIR_Nem_3	390	396	PF02991	0.351
LIG_LIR_Nem_3	490	496	PF02991	0.768
LIG_LIR_Nem_3	540	546	PF02991	0.575
LIG_LIR_Nem_3	76	81	PF02991	0.393
LIG_NRBOX	347	353	PF00104	0.266
LIG_Pex14_2	74	78	PF04695	0.450
LIG_SH2_CRK	389	393	PF00017	0.452
LIG_SH2_CRK	493	497	PF00017	0.641
LIG_SH2_CRK	514	518	PF00017	0.521
LIG_SH2_NCK_1	139	143	PF00017	0.399
LIG_SH2_NCK_1	389	393	PF00017	0.402
LIG_SH2_NCK_1	514	518	PF00017	0.587
LIG_SH2_PTP2	408	411	PF00017	0.372
LIG_SH2_SRC	218	221	PF00017	0.411
LIG_SH2_SRC	314	317	PF00017	0.300
LIG_SH2_SRC	408	411	PF00017	0.372
LIG_SH2_STAP1	110	114	PF00017	0.442
LIG_SH2_STAP1	493	497	PF00017	0.564
LIG_SH2_STAP1	85	89	PF00017	0.489
LIG_SH2_STAT5	139	142	PF00017	0.501
LIG_SH2_STAT5	175	178	PF00017	0.498
LIG_SH2_STAT5	218	221	PF00017	0.300
LIG_SH2_STAT5	284	287	PF00017	0.411
LIG_SH2_STAT5	314	317	PF00017	0.281
LIG_SH2_STAT5	408	411	PF00017	0.328
LIG_SH2_STAT5	460	463	PF00017	0.488
LIG_SH2_STAT5	493	496	PF00017	0.724
LIG_SH2_STAT5	50	53	PF00017	0.388
LIG_SH3_3	257	263	PF00018	0.325
LIG_SH3_5	135	139	PF00018	0.374
LIG_Sin3_3	223	230	PF02671	0.281
LIG_SUMO_SIM_anti_2	234	239	PF11976	0.281
LIG_SUMO_SIM_par_1	234	239	PF11976	0.266
LIG_SUMO_SIM_par_1	4	11	PF11976	0.426
LIG_TRAF2_1	321	324	PF00917	0.331
LIG_TRAF2_1	370	373	PF00917	0.405
LIG_TRAF2_1	538	541	PF00917	0.507
LIG_UBA3_1	235	240	PF00899	0.336
LIG_UBA3_1	447	455	PF00899	0.448
LIG_WRC_WIRS_1	85	90	PF05994	0.420
MOD_CK1_1	391	397	PF00069	0.441
MOD_CK1_1	49	55	PF00069	0.560
MOD_CK1_1	505	511	PF00069	0.746
MOD_CK1_1	6	12	PF00069	0.627
MOD_CK1_1	70	76	PF00069	0.373
MOD_CK2_1	137	143	PF00069	0.409
MOD_CK2_1	267	273	PF00069	0.266
MOD_CK2_1	319	325	PF00069	0.281
MOD_CK2_1	367	373	PF00069	0.390
MOD_CK2_1	380	386	PF00069	0.458
MOD_CK2_1	535	541	PF00069	0.531
MOD_CK2_1	84	90	PF00069	0.421
MOD_GlcNHglycan	110	113	PF01048	0.198
MOD_GlcNHglycan	157	160	PF01048	0.607
MOD_GlcNHglycan	37	40	PF01048	0.693
MOD_GlcNHglycan	43	46	PF01048	0.568
MOD_GlcNHglycan	435	439	PF01048	0.451
MOD_GlcNHglycan	520	523	PF01048	0.720
MOD_GlcNHglycan	69	72	PF01048	0.501
MOD_GlcNHglycan	75	78	PF01048	0.467
MOD_GSK3_1	129	136	PF00069	0.376
MOD_GSK3_1	2	9	PF00069	0.566
MOD_GSK3_1	263	270	PF00069	0.319
MOD_GSK3_1	387	394	PF00069	0.391
MOD_GSK3_1	505	512	PF00069	0.759
MOD_GSK3_1	518	525	PF00069	0.650
MOD_GSK3_1	69	76	PF00069	0.389
MOD_GSK3_1	84	91	PF00069	0.322
MOD_N-GLC_1	20	25	PF02516	0.627
MOD_N-GLC_1	308	313	PF02516	0.281
MOD_N-GLC_1	377	382	PF02516	0.458
MOD_N-GLC_1	505	510	PF02516	0.785
MOD_NEK2_1	1	6	PF00069	0.557
MOD_NEK2_1	209	214	PF00069	0.323
MOD_NEK2_1	236	241	PF00069	0.271
MOD_NEK2_1	243	248	PF00069	0.274
MOD_NEK2_1	339	344	PF00069	0.266
MOD_NEK2_1	46	51	PF00069	0.423
MOD_NEK2_2	113	118	PF00069	0.443
MOD_PIKK_1	129	135	PF00454	0.515
MOD_PIKK_1	330	336	PF00454	0.281
MOD_PKA_2	155	161	PF00069	0.577
MOD_PKA_2	196	202	PF00069	0.363
MOD_PKA_2	231	237	PF00069	0.411
MOD_PKA_2	263	269	PF00069	0.411
MOD_PKA_2	380	386	PF00069	0.311
MOD_PKA_2	535	541	PF00069	0.651
MOD_PKB_1	375	383	PF00069	0.437
MOD_Plk_1	434	440	PF00069	0.363
MOD_Plk_1	46	52	PF00069	0.555
MOD_Plk_1	505	511	PF00069	0.521
MOD_Plk_2-3	319	325	PF00069	0.411
MOD_Plk_4	118	124	PF00069	0.328
MOD_Plk_4	196	202	PF00069	0.369
MOD_Plk_4	231	237	PF00069	0.272
MOD_Plk_4	244	250	PF00069	0.246
MOD_Plk_4	263	269	PF00069	0.266
MOD_Plk_4	3	9	PF00069	0.608
MOD_Plk_4	380	386	PF00069	0.410
MOD_Plk_4	46	52	PF00069	0.551
MOD_Plk_4	491	497	PF00069	0.789
MOD_Plk_4	84	90	PF00069	0.540
MOD_ProDKin_1	308	314	PF00069	0.281
MOD_ProDKin_1	388	394	PF00069	0.361
MOD_SUMO_rev_2	539	549	PF00179	0.578
TRG_DiLeu_BaEn_1	115	120	PF01217	0.299
TRG_DiLeu_BaEn_1	435	440	PF01217	0.517
TRG_ENDOCYTIC_2	139	142	PF00928	0.501
TRG_ENDOCYTIC_2	314	317	PF00928	0.281
TRG_ENDOCYTIC_2	408	411	PF00928	0.313
TRG_ENDOCYTIC_2	493	496	PF00928	0.643
TRG_ENDOCYTIC_2	543	546	PF00928	0.629
TRG_ENDOCYTIC_2	85	88	PF00928	0.486
TRG_ER_diArg_1	201	204	PF00400	0.382
TRG_ER_diArg_1	287	290	PF00400	0.266
TRG_ER_diArg_1	374	377	PF00400	0.469
TRG_ER_diArg_1	441	443	PF00400	0.284
TRG_ER_diArg_1	533	536	PF00400	0.630
TRG_NLS_Bipartite_1	442	460	PF00514	0.299
TRG_NLS_MonoExtC_3	454	459	PF00514	0.389
TRG_NLS_MonoExtN_4	454	460	PF00514	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P0	Leptomonas seymouri	66%	98%
A0A0S4JQC6	Bodo saltans	53%	100%
A0A1X0P383	Trypanosomatidae	50%	100%
A0A3Q8IFP8	Leishmania donovani	91%	100%
A0A422P3G0	Trypanosoma rangeli	52%	100%
A4HIE0	Leishmania braziliensis	82%	100%
A4I5N7	Leishmania infantum	92%	100%
C9ZR06	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
Q4Q785	Leishmania major	92%	100%
V5DQJ7	Trypanosoma cruzi	63%	94%