Ferric reductase transmembrane protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ferric reductase transmembrane protein-like protein

Species:

Leishmania mexicana

UniProt:

E9B0X7_LEIMU

TriTrypDb:

LmxM.29.2050

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9B0X7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0X7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016491	oxidoreductase activity	2	10
GO:0140575	transmembrane monodehydroascorbate reductase activity	3	10
GO:0005488	binding	1	1
GO:0020037	heme binding	4	1
GO:0046906	tetrapyrrole binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	28	30	PF00675	0.261
CLV_NRD_NRD_1	44	46	PF00675	0.405
CLV_NRD_NRD_1	84	86	PF00675	0.312
CLV_PCSK_KEX2_1	166	168	PF00082	0.342
CLV_PCSK_KEX2_1	28	30	PF00082	0.260
CLV_PCSK_KEX2_1	84	86	PF00082	0.334
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.342
CLV_PCSK_PC7_1	80	86	PF00082	0.257
CLV_PCSK_SKI1_1	157	161	PF00082	0.383
CLV_PCSK_SKI1_1	74	78	PF00082	0.257
DEG_APCC_DBOX_1	19	27	PF00400	0.458
DOC_ANK_TNKS_1	28	35	PF00023	0.438
DOC_MAPK_gen_1	28	35	PF00069	0.482
DOC_MAPK_MEF2A_6	175	183	PF00069	0.281
DOC_MAPK_MEF2A_6	28	37	PF00069	0.448
DOC_PP1_SILK_1	153	158	PF00149	0.298
DOC_PP4_MxPP_1	202	205	PF00568	0.255
LIG_Actin_WH2_2	112	127	PF00022	0.181
LIG_Actin_WH2_2	143	159	PF00022	0.298
LIG_Actin_WH2_2	66	82	PF00022	0.349
LIG_EH1_1	56	64	PF00400	0.285
LIG_FHA_1	178	184	PF00498	0.361
LIG_FHA_1	208	214	PF00498	0.447
LIG_FHA_2	47	53	PF00498	0.279
LIG_LIR_Gen_1	120	129	PF02991	0.315
LIG_LIR_Nem_3	120	124	PF02991	0.262
LIG_LYPXL_yS_3	128	131	PF13949	0.257
LIG_MYND_2	204	208	PF01753	0.211
LIG_PCNA_PIPBox_1	187	196	PF02747	0.181
LIG_SH2_CRK	121	125	PF00017	0.257
LIG_SH2_CRK	56	60	PF00017	0.247
LIG_SH2_STAP1	198	202	PF00017	0.372
LIG_SH2_STAT5	121	124	PF00017	0.294
LIG_SH2_STAT5	158	161	PF00017	0.542
LIG_SH3_2	162	167	PF14604	0.494
LIG_SH3_3	156	162	PF00018	0.488
LIG_SUMO_SIM_par_1	178	184	PF11976	0.315
LIG_TRFH_1	158	162	PF08558	0.527
LIG_TYR_ITIM	119	124	PF00017	0.294
LIG_WRC_WIRS_1	103	108	PF05994	0.349
MOD_CK1_1	216	222	PF00069	0.298
MOD_CK2_1	114	120	PF00069	0.181
MOD_CK2_1	90	96	PF00069	0.593
MOD_GlcNHglycan	116	119	PF01048	0.254
MOD_GlcNHglycan	46	49	PF01048	0.546
MOD_GSK3_1	177	184	PF00069	0.331
MOD_GSK3_1	203	210	PF00069	0.294
MOD_GSK3_1	213	220	PF00069	0.252
MOD_GSK3_1	44	51	PF00069	0.480
MOD_NEK2_1	207	212	PF00069	0.358
MOD_NEK2_1	44	49	PF00069	0.432
MOD_PK_1	175	181	PF00069	0.246
MOD_PKA_2	44	50	PF00069	0.442
MOD_PKA_2	90	96	PF00069	0.388
MOD_Plk_1	6	12	PF00069	0.592
MOD_Plk_4	102	108	PF00069	0.522
MOD_Plk_4	142	148	PF00069	0.339
MOD_Plk_4	151	157	PF00069	0.268
MOD_Plk_4	203	209	PF00069	0.288
MOD_SUMO_for_1	4	7	PF00179	0.547
MOD_SUMO_rev_2	71	79	PF00179	0.298
TRG_ENDOCYTIC_2	121	124	PF00928	0.294
TRG_ENDOCYTIC_2	128	131	PF00928	0.245
TRG_ENDOCYTIC_2	56	59	PF00928	0.249
TRG_ER_diArg_1	28	30	PF00400	0.461
TRG_ER_diArg_1	84	86	PF00400	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JNM4	Bodo saltans	26%	95%
A0A1X0P2F3	Trypanosomatidae	26%	91%
A0A3Q8IC17	Leishmania donovani	87%	100%
A4HID6	Leishmania braziliensis	67%	100%
A4I5N2	Leishmania infantum	83%	100%
C9ZR03	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	95%
Q4Q789	Leishmania major	89%	100%
V5BPF8	Trypanosoma cruzi	24%	94%