C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

C2H2 type zinc-finger (2 copies), putative

Species:

Leishmania mexicana

UniProt:

E9B0W9_LEIMU

TriTrypDb:

LmxM.29.1980

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0W9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0W9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.656
CLV_C14_Caspase3-7	279	283	PF00656	0.449
CLV_MEL_PAP_1	274	280	PF00089	0.513
CLV_NRD_NRD_1	218	220	PF00675	0.321
CLV_NRD_NRD_1	236	238	PF00675	0.279
CLV_NRD_NRD_1	276	278	PF00675	0.486
CLV_PCSK_KEX2_1	218	220	PF00082	0.321
CLV_PCSK_KEX2_1	236	238	PF00082	0.331
CLV_PCSK_KEX2_1	276	278	PF00082	0.486
CLV_PCSK_SKI1_1	10	14	PF00082	0.435
CLV_PCSK_SKI1_1	259	263	PF00082	0.321
DEG_COP1_1	309	321	PF00400	0.544
DOC_USP7_MATH_1	238	242	PF00917	0.544
DOC_USP7_MATH_1	326	330	PF00917	0.562
DOC_USP7_MATH_1	91	95	PF00917	0.483
DOC_USP7_UBL2_3	6	10	PF12436	0.504
DOC_WW_Pin1_4	139	144	PF00397	0.637
DOC_WW_Pin1_4	147	152	PF00397	0.699
LIG_14-3-3_CanoR_1	213	217	PF00244	0.506
LIG_14-3-3_CanoR_1	237	246	PF00244	0.553
LIG_14-3-3_CanoR_1	276	286	PF00244	0.534
LIG_14-3-3_CanoR_1	330	338	PF00244	0.567
LIG_APCC_ABBA_1	189	194	PF00400	0.399
LIG_APCC_ABBAyCdc20_2	219	225	PF00400	0.503
LIG_BIR_II_1	1	5	PF00653	0.511
LIG_eIF4E_1	226	232	PF01652	0.389
LIG_FHA_1	118	124	PF00498	0.427
LIG_FHA_1	28	34	PF00498	0.407
LIG_FHA_1	332	338	PF00498	0.563
LIG_FHA_2	164	170	PF00498	0.660
LIG_FHA_2	298	304	PF00498	0.492
LIG_FHA_2	318	324	PF00498	0.479
LIG_FHA_2	88	94	PF00498	0.563
LIG_Integrin_RGD_1	158	160	PF01839	0.647
LIG_LIR_Gen_1	167	178	PF02991	0.666
LIG_LIR_Gen_1	22	28	PF02991	0.321
LIG_LIR_Gen_1	224	234	PF02991	0.431
LIG_LIR_Gen_1	292	299	PF02991	0.468
LIG_LIR_Nem_3	167	173	PF02991	0.653
LIG_LIR_Nem_3	22	27	PF02991	0.402
LIG_LIR_Nem_3	224	229	PF02991	0.431
LIG_LIR_Nem_3	312	318	PF02991	0.495
LIG_NRBOX	66	72	PF00104	0.462
LIG_PCNA_PIPBox_1	36	45	PF02747	0.462
LIG_Pex14_2	77	81	PF04695	0.347
LIG_SH2_CRK	226	230	PF00017	0.430
LIG_SH2_GRB2like	109	112	PF00017	0.389
LIG_SH2_STAT5	192	195	PF00017	0.486
LIG_SH3_2	153	158	PF14604	0.473
LIG_SH3_3	126	132	PF00018	0.586
LIG_SH3_3	150	156	PF00018	0.580
LIG_SH3_3	284	290	PF00018	0.465
LIG_SH3_3	310	316	PF00018	0.561
LIG_SH3_3	55	61	PF00018	0.503
LIG_SH3_3	72	78	PF00018	0.335
LIG_TRAF2_1	161	164	PF00917	0.729
LIG_TRAF2_1	308	311	PF00917	0.644
LIG_TRAF2_1	320	323	PF00917	0.585
MOD_CDK_SPxxK_3	147	154	PF00069	0.456
MOD_CK1_1	117	123	PF00069	0.415
MOD_CK1_1	127	133	PF00069	0.680
MOD_CK1_1	94	100	PF00069	0.512
MOD_CK2_1	163	169	PF00069	0.657
MOD_CK2_1	297	303	PF00069	0.554
MOD_CK2_1	317	323	PF00069	0.483
MOD_CK2_1	87	93	PF00069	0.468
MOD_GlcNHglycan	126	129	PF01048	0.624
MOD_GlcNHglycan	194	198	PF01048	0.328
MOD_GlcNHglycan	300	303	PF01048	0.594
MOD_GSK3_1	117	124	PF00069	0.369
MOD_GSK3_1	293	300	PF00069	0.487
MOD_GSK3_1	332	339	PF00069	0.605
MOD_GSK3_1	66	73	PF00069	0.491
MOD_GSK3_1	87	94	PF00069	0.537
MOD_NEK2_1	102	107	PF00069	0.415
MOD_NEK2_1	137	142	PF00069	0.673
MOD_NEK2_1	145	150	PF00069	0.702
MOD_NEK2_1	212	217	PF00069	0.503
MOD_NEK2_1	297	302	PF00069	0.440
MOD_NEK2_1	5	10	PF00069	0.424
MOD_NEK2_1	70	75	PF00069	0.462
MOD_PIKK_1	27	33	PF00454	0.462
MOD_PKA_1	276	282	PF00069	0.491
MOD_PKA_2	102	108	PF00069	0.434
MOD_PKA_2	212	218	PF00069	0.503
MOD_PKA_2	276	282	PF00069	0.541
MOD_Plk_2-3	163	169	PF00069	0.767
MOD_Plk_4	66	72	PF00069	0.462
MOD_Plk_4	94	100	PF00069	0.490
MOD_ProDKin_1	139	145	PF00069	0.638
MOD_ProDKin_1	147	153	PF00069	0.698
TRG_DiLeu_BaLyEn_6	59	64	PF01217	0.472
TRG_ENDOCYTIC_2	226	229	PF00928	0.430
TRG_ER_diArg_1	218	220	PF00400	0.520
TRG_ER_diArg_1	235	237	PF00400	0.531
TRG_ER_diArg_1	275	277	PF00400	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8N5	Leptomonas seymouri	56%	100%
A0A0S4JM68	Bodo saltans	31%	100%
A0A3Q8IJF7	Leishmania donovani	91%	100%
A0A422P3H1	Trypanosoma rangeli	38%	100%
A4HID1	Leishmania braziliensis	81%	100%
A4I5M4	Leishmania infantum	90%	100%
C9ZQZ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4Q797	Leishmania major	89%	100%
Q9W1V7	Drosophila melanogaster	23%	75%
V5BYU5	Trypanosoma cruzi	38%	100%