BILBO1_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0W8_LEIMU

TriTrypDb:

LmxM.29.1975

Length:

418

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0W8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.614
CLV_PCSK_KEX2_1	264	266	PF00082	0.808
CLV_PCSK_KEX2_1	396	398	PF00082	0.677
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.630
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.668
CLV_PCSK_SKI1_1	212	216	PF00082	0.651
CLV_PCSK_SKI1_1	349	353	PF00082	0.693
CLV_PCSK_SKI1_1	396	400	PF00082	0.652
CLV_PCSK_SKI1_1	87	91	PF00082	0.503
DEG_Nend_UBRbox_2	1	3	PF02207	0.495
DEG_SCF_FBW7_1	20	27	PF00400	0.233
DEG_SPOP_SBC_1	134	138	PF00917	0.504
DEG_SPOP_SBC_1	24	28	PF00917	0.395
DEG_SPOP_SBC_1	241	245	PF00917	0.672
DEG_SPOP_SBC_1	277	281	PF00917	0.698
DOC_CYCLIN_RxL_1	403	414	PF00134	0.513
DOC_CYCLIN_RxL_1	84	92	PF00134	0.395
DOC_MAPK_DCC_7	163	171	PF00069	0.482
DOC_MAPK_gen_1	215	223	PF00069	0.619
DOC_MAPK_gen_1	370	379	PF00069	0.484
DOC_MAPK_MEF2A_6	163	171	PF00069	0.541
DOC_MAPK_MEF2A_6	372	381	PF00069	0.479
DOC_MAPK_RevD_3	249	265	PF00069	0.514
DOC_PP4_FxxP_1	164	167	PF00568	0.649
DOC_PP4_FxxP_1	224	227	PF00568	0.497
DOC_SPAK_OSR1_1	163	167	PF12202	0.757
DOC_USP7_MATH_1	134	138	PF00917	0.785
DOC_USP7_MATH_1	157	161	PF00917	0.620
DOC_USP7_MATH_1	180	184	PF00917	0.550
DOC_USP7_MATH_1	242	246	PF00917	0.581
DOC_USP7_MATH_1	276	280	PF00917	0.748
DOC_USP7_MATH_1	307	311	PF00917	0.611
DOC_USP7_MATH_2	333	339	PF00917	0.696
DOC_WW_Pin1_4	127	132	PF00397	0.618
DOC_WW_Pin1_4	136	141	PF00397	0.610
DOC_WW_Pin1_4	20	25	PF00397	0.233
DOC_WW_Pin1_4	222	227	PF00397	0.659
DOC_WW_Pin1_4	278	283	PF00397	0.577
DOC_WW_Pin1_4	301	306	PF00397	0.706
DOC_WW_Pin1_4	329	334	PF00397	0.766
DOC_WW_Pin1_4	75	80	PF00397	0.406
LIG_14-3-3_CanoR_1	207	212	PF00244	0.707
LIG_14-3-3_CanoR_1	25	30	PF00244	0.415
LIG_14-3-3_CanoR_1	265	275	PF00244	0.706
LIG_14-3-3_CanoR_1	290	300	PF00244	0.638
LIG_14-3-3_CanoR_1	31	40	PF00244	0.328
LIG_14-3-3_CanoR_1	397	404	PF00244	0.584
LIG_Actin_WH2_2	381	398	PF00022	0.648
LIG_BRCT_BRCA1_1	167	171	PF00533	0.475
LIG_BRCT_BRCA1_1	215	219	PF00533	0.656
LIG_BRCT_BRCA1_1	36	40	PF00533	0.503
LIG_deltaCOP1_diTrp_1	158	164	PF00928	0.497
LIG_eIF4E_1	84	90	PF01652	0.395
LIG_FHA_1	136	142	PF00498	0.736
LIG_FHA_1	24	30	PF00498	0.411
LIG_FHA_1	256	262	PF00498	0.618
LIG_FHA_1	390	396	PF00498	0.568
LIG_FHA_2	182	188	PF00498	0.709
LIG_Integrin_RGD_1	361	363	PF01839	0.636
LIG_LIR_Apic_2	258	263	PF02991	0.585
LIG_LIR_Apic_2	269	275	PF02991	0.665
LIG_LIR_Gen_1	158	169	PF02991	0.489
LIG_LIR_Gen_1	37	47	PF02991	0.346
LIG_LIR_Gen_1	65	73	PF02991	0.315
LIG_LIR_Gen_1	78	86	PF02991	0.457
LIG_LIR_Nem_3	158	164	PF02991	0.497
LIG_LIR_Nem_3	2	6	PF02991	0.447
LIG_LIR_Nem_3	37	43	PF02991	0.391
LIG_LIR_Nem_3	65	71	PF02991	0.315
LIG_LIR_Nem_3	78	83	PF02991	0.457
LIG_Pex14_2	86	90	PF04695	0.474
LIG_SH2_CRK	272	276	PF00017	0.708
LIG_SH2_NCK_1	272	276	PF00017	0.674
LIG_SH2_STAT5	22	25	PF00017	0.392
LIG_SH2_STAT5	260	263	PF00017	0.674
LIG_SH2_STAT5	59	62	PF00017	0.406
LIG_SH2_STAT5	84	87	PF00017	0.406
LIG_SH3_1	272	278	PF00018	0.697
LIG_SH3_3	272	278	PF00018	0.708
LIG_SH3_3	283	289	PF00018	0.577
LIG_SH3_3	327	333	PF00018	0.730
LIG_SH3_3	97	103	PF00018	0.233
LIG_TRAF2_1	282	285	PF00917	0.529
MOD_CDC14_SPxK_1	139	142	PF00782	0.646
MOD_CDK_SPK_2	20	25	PF00069	0.233
MOD_CDK_SPK_2	301	306	PF00069	0.706
MOD_CDK_SPK_2	329	334	PF00069	0.612
MOD_CDK_SPxK_1	136	142	PF00069	0.655
MOD_CDK_SPxxK_3	301	308	PF00069	0.708
MOD_CK1_1	133	139	PF00069	0.669
MOD_CK1_1	183	189	PF00069	0.589
MOD_CK1_1	210	216	PF00069	0.595
MOD_CK1_1	240	246	PF00069	0.650
MOD_CK1_1	296	302	PF00069	0.602
MOD_CK1_1	310	316	PF00069	0.641
MOD_CK1_1	324	330	PF00069	0.721
MOD_CK1_1	34	40	PF00069	0.461
MOD_CK1_1	402	408	PF00069	0.608
MOD_CK2_1	278	284	PF00069	0.647
MOD_CK2_1	329	335	PF00069	0.642
MOD_GlcNHglycan	132	135	PF01048	0.558
MOD_GlcNHglycan	152	155	PF01048	0.447
MOD_GlcNHglycan	203	206	PF01048	0.668
MOD_GlcNHglycan	239	242	PF01048	0.628
MOD_GlcNHglycan	247	250	PF01048	0.563
MOD_GlcNHglycan	309	312	PF01048	0.631
MOD_GlcNHglycan	323	326	PF01048	0.728
MOD_GlcNHglycan	33	36	PF01048	0.357
MOD_GlcNHglycan	358	361	PF01048	0.694
MOD_GlcNHglycan	55	58	PF01048	0.449
MOD_GSK3_1	101	108	PF00069	0.558
MOD_GSK3_1	121	128	PF00069	0.714
MOD_GSK3_1	130	137	PF00069	0.659
MOD_GSK3_1	183	190	PF00069	0.636
MOD_GSK3_1	20	27	PF00069	0.233
MOD_GSK3_1	237	244	PF00069	0.551
MOD_GSK3_1	292	299	PF00069	0.627
MOD_GSK3_1	307	314	PF00069	0.570
MOD_GSK3_1	335	342	PF00069	0.651
MOD_N-GLC_1	301	306	PF02516	0.544
MOD_NEK2_1	132	137	PF00069	0.695
MOD_NEK2_1	150	155	PF00069	0.536
MOD_NEK2_1	171	176	PF00069	0.552
MOD_NEK2_1	268	273	PF00069	0.757
MOD_NEK2_1	399	404	PF00069	0.624
MOD_NEK2_2	242	247	PF00069	0.513
MOD_PIKK_1	101	107	PF00454	0.529
MOD_PIKK_1	227	233	PF00454	0.665
MOD_PIKK_1	312	318	PF00454	0.690
MOD_PIKK_1	339	345	PF00454	0.673
MOD_PIKK_1	389	395	PF00454	0.506
MOD_PIKK_1	72	78	PF00454	0.503
MOD_PK_1	361	367	PF00069	0.584
MOD_PKA_2	115	121	PF00069	0.521
MOD_PKA_2	171	177	PF00069	0.484
MOD_PKA_2	187	193	PF00069	0.653
MOD_PKA_2	24	30	PF00069	0.395
MOD_PKA_2	296	302	PF00069	0.767
MOD_PKA_2	307	313	PF00069	0.657
MOD_PKB_1	337	345	PF00069	0.697
MOD_Plk_1	157	163	PF00069	0.536
MOD_Plk_1	72	78	PF00069	0.503
MOD_Plk_4	121	127	PF00069	0.679
MOD_Plk_4	165	171	PF00069	0.659
MOD_Plk_4	324	330	PF00069	0.664
MOD_Plk_4	361	367	PF00069	0.599
MOD_ProDKin_1	127	133	PF00069	0.622
MOD_ProDKin_1	136	142	PF00069	0.610
MOD_ProDKin_1	20	26	PF00069	0.233
MOD_ProDKin_1	222	228	PF00069	0.661
MOD_ProDKin_1	278	284	PF00069	0.578
MOD_ProDKin_1	301	307	PF00069	0.705
MOD_ProDKin_1	329	335	PF00069	0.770
MOD_ProDKin_1	75	81	PF00069	0.406
TRG_DiLeu_BaEn_2	1	7	PF01217	0.555
TRG_DiLeu_BaEn_4	390	396	PF01217	0.655
TRG_ENDOCYTIC_2	61	64	PF00928	0.438
TRG_ER_diArg_1	305	308	PF00400	0.734
TRG_ER_diArg_1	370	373	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	339	343	PF00026	0.698
TRG_Pf-PMV_PEXEL_1	397	401	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	87	92	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IML8	Leptomonas seymouri	33%	93%
A0A3Q8IEA2	Leishmania donovani	79%	97%
A4HID0	Leishmania braziliensis	55%	100%
A4I5M3	Leishmania infantum	79%	97%