Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0W7_LEIMU

TriTrypDb:

LmxM.29.1970

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0W7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0W7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	144	146	PF00675	0.615
CLV_NRD_NRD_1	228	230	PF00675	0.434
CLV_NRD_NRD_1	241	243	PF00675	0.512
CLV_NRD_NRD_1	344	346	PF00675	0.566
CLV_NRD_NRD_1	395	397	PF00675	0.502
CLV_PCSK_FUR_1	226	230	PF00082	0.319
CLV_PCSK_KEX2_1	144	146	PF00082	0.708
CLV_PCSK_KEX2_1	228	230	PF00082	0.479
CLV_PCSK_KEX2_1	241	243	PF00082	0.522
CLV_PCSK_KEX2_1	288	290	PF00082	0.547
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.547
CLV_PCSK_SKI1_1	201	205	PF00082	0.606
CLV_PCSK_SKI1_1	24	28	PF00082	0.521
CLV_PCSK_SKI1_1	250	254	PF00082	0.404
CLV_PCSK_SKI1_1	365	369	PF00082	0.689
CLV_PCSK_SKI1_1	423	427	PF00082	0.567
CLV_PCSK_SKI1_1	47	51	PF00082	0.547
CLV_PCSK_SKI1_1	64	68	PF00082	0.509
CLV_PCSK_SKI1_1	73	77	PF00082	0.449
DEG_APCC_DBOX_1	340	348	PF00400	0.590
DEG_COP1_1	5	16	PF00400	0.567
DOC_CDC14_PxL_1	33	41	PF14671	0.512
DOC_CYCLIN_RxL_1	420	429	PF00134	0.674
DOC_MAPK_gen_1	288	296	PF00069	0.449
DOC_MAPK_gen_1	396	404	PF00069	0.566
DOC_MAPK_MEF2A_6	423	432	PF00069	0.641
DOC_PP1_RVXF_1	22	28	PF00149	0.550
DOC_USP7_MATH_1	81	85	PF00917	0.544
DOC_USP7_MATH_1	88	92	PF00917	0.596
DOC_WW_Pin1_4	147	152	PF00397	0.481
DOC_WW_Pin1_4	3	8	PF00397	0.704
DOC_WW_Pin1_4	352	357	PF00397	0.619
LIG_14-3-3_CanoR_1	144	154	PF00244	0.682
LIG_14-3-3_CanoR_1	201	210	PF00244	0.592
LIG_14-3-3_CanoR_1	242	252	PF00244	0.593
LIG_14-3-3_CanoR_1	365	375	PF00244	0.699
LIG_14-3-3_CanoR_1	73	79	PF00244	0.568
LIG_14-3-3_CanoR_1	89	93	PF00244	0.480
LIG_BIR_II_1	1	5	PF00653	0.666
LIG_deltaCOP1_diTrp_1	209	214	PF00928	0.595
LIG_FHA_1	202	208	PF00498	0.485
LIG_FHA_1	244	250	PF00498	0.609
LIG_FHA_1	296	302	PF00498	0.507
LIG_FHA_1	95	101	PF00498	0.528
LIG_FHA_2	107	113	PF00498	0.639
LIG_FHA_2	124	130	PF00498	0.725
LIG_FHA_2	137	143	PF00498	0.679
LIG_FHA_2	55	61	PF00498	0.621
LIG_LIR_Gen_1	176	185	PF02991	0.441
LIG_LIR_Gen_1	45	53	PF02991	0.541
LIG_LIR_Gen_1	74	81	PF02991	0.568
LIG_LIR_Nem_3	176	182	PF02991	0.444
LIG_LIR_Nem_3	263	267	PF02991	0.494
LIG_LIR_Nem_3	45	51	PF02991	0.536
LIG_LIR_Nem_3	74	78	PF02991	0.499
LIG_SH2_CRK	48	52	PF00017	0.574
LIG_SH2_NCK_1	179	183	PF00017	0.442
LIG_SH2_SRC	179	182	PF00017	0.406
LIG_SH2_SRC	28	31	PF00017	0.645
LIG_SH2_SRC	299	302	PF00017	0.447
LIG_SH2_STAP1	179	183	PF00017	0.442
LIG_SH2_STAP1	28	32	PF00017	0.570
LIG_SH2_STAP1	292	296	PF00017	0.545
LIG_SH2_STAP1	95	99	PF00017	0.600
LIG_SH2_STAT3	303	306	PF00017	0.484
LIG_SUMO_SIM_anti_2	326	331	PF11976	0.494
LIG_SUMO_SIM_par_1	152	161	PF11976	0.589
LIG_TRAF2_1	91	94	PF00917	0.557
LIG_TYR_ITSM	175	182	PF00017	0.328
LIG_UBA3_1	39	47	PF00899	0.563
LIG_WRC_WIRS_1	50	55	PF05994	0.610
MOD_CDK_SPK_2	3	8	PF00069	0.704
MOD_CDK_SPxK_1	352	358	PF00069	0.677
MOD_CK1_1	12	18	PF00069	0.690
MOD_CK1_1	147	153	PF00069	0.631
MOD_CK1_1	2	8	PF00069	0.768
MOD_CK1_1	54	60	PF00069	0.567
MOD_CK2_1	106	112	PF00069	0.356
MOD_CK2_1	123	129	PF00069	0.777
MOD_CK2_1	136	142	PF00069	0.554
MOD_CK2_1	287	293	PF00069	0.504
MOD_CK2_1	309	315	PF00069	0.506
MOD_CK2_1	387	393	PF00069	0.639
MOD_CK2_1	421	427	PF00069	0.652
MOD_CK2_1	49	55	PF00069	0.591
MOD_CK2_1	81	87	PF00069	0.517
MOD_CK2_1	88	94	PF00069	0.519
MOD_GlcNHglycan	109	112	PF01048	0.608
MOD_GlcNHglycan	117	120	PF01048	0.434
MOD_GlcNHglycan	132	135	PF01048	0.617
MOD_GlcNHglycan	360	363	PF01048	0.593
MOD_GlcNHglycan	382	385	PF01048	0.400
MOD_GlcNHglycan	404	407	PF01048	0.679
MOD_GlcNHglycan	413	418	PF01048	0.602
MOD_GlcNHglycan	44	47	PF01048	0.504
MOD_GlcNHglycan	64	67	PF01048	0.328
MOD_GSK3_1	103	110	PF00069	0.608
MOD_GSK3_1	132	139	PF00069	0.673
MOD_GSK3_1	2	9	PF00069	0.760
MOD_GSK3_1	350	357	PF00069	0.594
MOD_GSK3_1	366	373	PF00069	0.564
MOD_GSK3_1	409	416	PF00069	0.580
MOD_N-GLC_1	130	135	PF02516	0.694
MOD_N-GLC_1	79	84	PF02516	0.634
MOD_NEK2_1	114	119	PF00069	0.602
MOD_NEK2_1	319	324	PF00069	0.604
MOD_NEK2_1	380	385	PF00069	0.630
MOD_NEK2_1	402	407	PF00069	0.591
MOD_PKA_1	144	150	PF00069	0.614
MOD_PKA_2	144	150	PF00069	0.614
MOD_PKA_2	387	393	PF00069	0.569
MOD_PKA_2	88	94	PF00069	0.567
MOD_Plk_1	174	180	PF00069	0.408
MOD_Plk_1	20	26	PF00069	0.511
MOD_Plk_1	267	273	PF00069	0.515
MOD_Plk_1	363	369	PF00069	0.686
MOD_Plk_1	9	15	PF00069	0.653
MOD_Plk_2-3	309	315	PF00069	0.506
MOD_Plk_4	103	109	PF00069	0.632
MOD_Plk_4	174	180	PF00069	0.396
MOD_Plk_4	35	41	PF00069	0.492
MOD_Plk_4	81	87	PF00069	0.639
MOD_ProDKin_1	147	153	PF00069	0.474
MOD_ProDKin_1	3	9	PF00069	0.704
MOD_ProDKin_1	352	358	PF00069	0.624
MOD_SUMO_for_1	281	284	PF00179	0.604
MOD_SUMO_rev_2	257	267	PF00179	0.432
MOD_SUMO_rev_2	91	100	PF00179	0.554
TRG_DiLeu_BaEn_1	315	320	PF01217	0.610
TRG_DiLeu_BaEn_3	393	399	PF01217	0.349
TRG_ENDOCYTIC_2	179	182	PF00928	0.445
TRG_ENDOCYTIC_2	28	31	PF00928	0.604
TRG_ENDOCYTIC_2	48	51	PF00928	0.361
TRG_ER_diArg_1	143	145	PF00400	0.635
TRG_ER_diArg_1	228	230	PF00400	0.575
TRG_ER_diArg_1	289	292	PF00400	0.589
TRG_NLS_MonoExtC_3	287	293	PF00514	0.590
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	365	370	PF00026	0.674
TRG_Pf-PMV_PEXEL_1	423	427	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDD9	Leptomonas seymouri	59%	100%
A0A1X0P1Q4	Trypanosomatidae	37%	95%
A0A3S5H7N1	Leishmania donovani	90%	100%
A0A3S5ISM8	Trypanosoma rangeli	34%	93%
A4HIC9	Leishmania braziliensis	75%	100%
A4I5M2	Leishmania infantum	90%	100%
Q4Q799	Leishmania major	88%	100%
V5B8X3	Trypanosoma cruzi	36%	93%