RNA pseudouridylate synthase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA pseudouridylate synthase-like protein

Species:

Leishmania mexicana

UniProt:

E9B0W6_LEIMU

TriTrypDb:

LmxM.29.1960

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0W6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0W6

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	8
GO:0006396	RNA processing	6	8
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	8
GO:0034470	ncRNA processing	7	8
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	8
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0000154	rRNA modification	6	1
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	1
GO:0031118	rRNA pseudouridine synthesis	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0009982	pseudouridine synthase activity	4	11
GO:0016853	isomerase activity	2	11
GO:0016866	intramolecular transferase activity	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0106029	tRNA pseudouridine synthase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.671
CLV_C14_Caspase3-7	49	53	PF00656	0.563
CLV_NRD_NRD_1	11	13	PF00675	0.548
CLV_NRD_NRD_1	117	119	PF00675	0.487
CLV_NRD_NRD_1	438	440	PF00675	0.611
CLV_NRD_NRD_1	466	468	PF00675	0.512
CLV_PCSK_FUR_1	436	440	PF00082	0.569
CLV_PCSK_FUR_1	9	13	PF00082	0.541
CLV_PCSK_KEX2_1	11	13	PF00082	0.548
CLV_PCSK_KEX2_1	116	118	PF00082	0.466
CLV_PCSK_KEX2_1	438	440	PF00082	0.611
CLV_PCSK_KEX2_1	466	468	PF00082	0.369
CLV_PCSK_SKI1_1	24	28	PF00082	0.469
CLV_PCSK_SKI1_1	341	345	PF00082	0.275
CLV_PCSK_SKI1_1	467	471	PF00082	0.334
CLV_PCSK_SKI1_1	486	490	PF00082	0.522
CLV_PCSK_SKI1_1	515	519	PF00082	0.279
CLV_Separin_Metazoa	113	117	PF03568	0.434
CLV_Separin_Metazoa	279	283	PF03568	0.497
DEG_SCF_FBW7_2	352	358	PF00400	0.372
DOC_CKS1_1	205	210	PF01111	0.436
DOC_CKS1_1	352	357	PF01111	0.397
DOC_CYCLIN_RxL_1	464	473	PF00134	0.480
DOC_MAPK_gen_1	223	233	PF00069	0.458
DOC_MAPK_MEF2A_6	438	447	PF00069	0.563
DOC_PP1_RVXF_1	472	478	PF00149	0.464
DOC_PP2B_LxvP_1	71	74	PF13499	0.447
DOC_PP4_FxxP_1	477	480	PF00568	0.392
DOC_PP4_FxxP_1	65	68	PF00568	0.414
DOC_USP7_MATH_1	14	18	PF00917	0.525
DOC_USP7_MATH_1	193	197	PF00917	0.791
DOC_USP7_MATH_1	198	202	PF00917	0.760
DOC_USP7_MATH_1	235	239	PF00917	0.543
DOC_USP7_MATH_1	258	262	PF00917	0.584
DOC_USP7_MATH_1	271	275	PF00917	0.417
DOC_USP7_MATH_1	319	323	PF00917	0.588
DOC_USP7_MATH_1	348	352	PF00917	0.556
DOC_USP7_MATH_1	524	528	PF00917	0.663
DOC_USP7_MATH_1	74	78	PF00917	0.483
DOC_WW_Pin1_4	174	179	PF00397	0.777
DOC_WW_Pin1_4	201	206	PF00397	0.807
DOC_WW_Pin1_4	211	216	PF00397	0.495
DOC_WW_Pin1_4	351	356	PF00397	0.550
DOC_WW_Pin1_4	415	420	PF00397	0.457
DOC_WW_Pin1_4	480	485	PF00397	0.631
DOC_WW_Pin1_4	490	495	PF00397	0.498
LIG_14-3-3_CanoR_1	129	133	PF00244	0.600
LIG_14-3-3_CanoR_1	199	203	PF00244	0.759
LIG_14-3-3_CanoR_1	474	478	PF00244	0.329
LIG_14-3-3_CanoR_1	486	491	PF00244	0.494
LIG_AP2alpha_2	442	444	PF02296	0.455
LIG_BIR_III_4	166	170	PF00653	0.687
LIG_BRCT_BRCA1_1	22	26	PF00533	0.499
LIG_BRCT_BRCA1_1	273	277	PF00533	0.548
LIG_BRCT_BRCA1_1	509	513	PF00533	0.448
LIG_eIF4E_1	106	112	PF01652	0.396
LIG_eIF4E_1	84	90	PF01652	0.491
LIG_EVH1_1	352	356	PF00568	0.440
LIG_FHA_1	137	143	PF00498	0.682
LIG_FHA_1	205	211	PF00498	0.399
LIG_FHA_1	226	232	PF00498	0.470
LIG_FHA_1	254	260	PF00498	0.472
LIG_FHA_1	291	297	PF00498	0.548
LIG_FHA_1	303	309	PF00498	0.548
LIG_FHA_1	516	522	PF00498	0.542
LIG_FHA_1	86	92	PF00498	0.526
LIG_FHA_2	108	114	PF00498	0.432
LIG_FHA_2	133	139	PF00498	0.662
LIG_FHA_2	161	167	PF00498	0.668
LIG_FHA_2	47	53	PF00498	0.435
LIG_KLC1_Yacidic_2	430	435	PF13176	0.528
LIG_LIR_Apic_2	4	10	PF02991	0.443
LIG_LIR_Apic_2	476	480	PF02991	0.331
LIG_LIR_Gen_1	140	149	PF02991	0.460
LIG_LIR_Gen_1	23	30	PF02991	0.463
LIG_LIR_Gen_1	274	285	PF02991	0.461
LIG_LIR_Gen_1	291	300	PF02991	0.510
LIG_LIR_Nem_3	140	146	PF02991	0.460
LIG_LIR_Nem_3	23	29	PF02991	0.440
LIG_LIR_Nem_3	274	280	PF02991	0.475
LIG_LIR_Nem_3	291	295	PF02991	0.458
LIG_LIR_Nem_3	360	366	PF02991	0.529
LIG_LIR_Nem_3	441	447	PF02991	0.546
LIG_LYPXL_yS_3	406	409	PF13949	0.378
LIG_SH2_CRK	143	147	PF00017	0.456
LIG_SH2_CRK	292	296	PF00017	0.514
LIG_SH2_CRK	7	11	PF00017	0.434
LIG_SH2_SRC	84	87	PF00017	0.450
LIG_SH2_STAP1	292	296	PF00017	0.548
LIG_SH2_STAT5	106	109	PF00017	0.515
LIG_SH2_STAT5	124	127	PF00017	0.565
LIG_SH2_STAT5	21	24	PF00017	0.336
LIG_SH2_STAT5	28	31	PF00017	0.383
LIG_SH2_STAT5	292	295	PF00017	0.476
LIG_SH2_STAT5	414	417	PF00017	0.459
LIG_SH2_STAT5	433	436	PF00017	0.343
LIG_SH2_STAT5	55	58	PF00017	0.435
LIG_SH2_STAT5	7	10	PF00017	0.512
LIG_SH3_3	176	182	PF00018	0.616
LIG_SH3_3	202	208	PF00018	0.695
LIG_SH3_3	350	356	PF00018	0.552
LIG_SH3_3	401	407	PF00018	0.523
LIG_SH3_3	440	446	PF00018	0.561
LIG_SH3_3	518	524	PF00018	0.557
LIG_SUMO_SIM_anti_2	110	116	PF11976	0.419
LIG_SUMO_SIM_anti_2	227	235	PF11976	0.458
LIG_SUMO_SIM_anti_2	85	93	PF11976	0.505
LIG_SUMO_SIM_par_1	85	93	PF11976	0.499
LIG_TRAF2_1	135	138	PF00917	0.531
LIG_TYR_ITIM	404	409	PF00017	0.379
LIG_UBA3_1	18	25	PF00899	0.495
LIG_UBA3_1	280	284	PF00899	0.460
LIG_WRC_WIRS_1	487	492	PF05994	0.444
LIG_WW_3	66	70	PF00397	0.469
MOD_CDC14_SPxK_1	483	486	PF00782	0.542
MOD_CDK_SPxK_1	351	357	PF00069	0.372
MOD_CDK_SPxK_1	415	421	PF00069	0.584
MOD_CDK_SPxK_1	480	486	PF00069	0.517
MOD_CDK_SPxxK_3	174	181	PF00069	0.749
MOD_CK1_1	127	133	PF00069	0.573
MOD_CK1_1	177	183	PF00069	0.676
MOD_CK1_1	188	194	PF00069	0.686
MOD_CK1_1	201	207	PF00069	0.617
MOD_CK1_1	240	246	PF00069	0.497
MOD_CK1_1	351	357	PF00069	0.534
MOD_CK1_1	511	517	PF00069	0.381
MOD_CK1_1	527	533	PF00069	0.534
MOD_CK2_1	107	113	PF00069	0.428
MOD_CK2_1	132	138	PF00069	0.578
MOD_CK2_1	243	249	PF00069	0.507
MOD_GlcNHglycan	166	170	PF01048	0.739
MOD_GlcNHglycan	191	194	PF01048	0.786
MOD_GlcNHglycan	195	198	PF01048	0.805
MOD_GlcNHglycan	227	231	PF01048	0.285
MOD_GlcNHglycan	239	242	PF01048	0.287
MOD_GlcNHglycan	448	454	PF01048	0.599
MOD_GlcNHglycan	457	460	PF01048	0.636
MOD_GlcNHglycan	526	529	PF01048	0.461
MOD_GSK3_1	124	131	PF00069	0.541
MOD_GSK3_1	132	139	PF00069	0.634
MOD_GSK3_1	173	180	PF00069	0.742
MOD_GSK3_1	185	192	PF00069	0.675
MOD_GSK3_1	193	200	PF00069	0.605
MOD_GSK3_1	20	27	PF00069	0.512
MOD_GSK3_1	243	250	PF00069	0.473
MOD_GSK3_1	284	291	PF00069	0.519
MOD_GSK3_1	486	493	PF00069	0.581
MOD_GSK3_1	507	514	PF00069	0.455
MOD_GSK3_1	515	522	PF00069	0.511
MOD_GSK3_1	524	531	PF00069	0.675
MOD_NEK2_1	29	34	PF00069	0.407
MOD_NEK2_1	343	348	PF00069	0.558
MOD_NEK2_1	366	371	PF00069	0.570
MOD_NEK2_1	380	385	PF00069	0.484
MOD_NEK2_1	413	418	PF00069	0.424
MOD_NEK2_1	470	475	PF00069	0.445
MOD_PIKK_1	247	253	PF00454	0.410
MOD_PIKK_1	29	35	PF00454	0.356
MOD_PIKK_1	325	331	PF00454	0.561
MOD_PIKK_1	358	364	PF00454	0.451
MOD_PK_1	284	290	PF00069	0.497
MOD_PKA_1	117	123	PF00069	0.426
MOD_PKA_1	24	30	PF00069	0.327
MOD_PKA_2	117	123	PF00069	0.513
MOD_PKA_2	128	134	PF00069	0.621
MOD_PKA_2	198	204	PF00069	0.758
MOD_PKA_2	473	479	PF00069	0.332
MOD_Plk_1	107	113	PF00069	0.460
MOD_Plk_1	14	20	PF00069	0.559
MOD_Plk_1	302	308	PF00069	0.497
MOD_Plk_1	507	513	PF00069	0.501
MOD_Plk_1	84	90	PF00069	0.510
MOD_Plk_4	107	113	PF00069	0.393
MOD_Plk_4	14	20	PF00069	0.461
MOD_Plk_4	486	492	PF00069	0.522
MOD_Plk_4	508	514	PF00069	0.429
MOD_Plk_4	51	57	PF00069	0.518
MOD_Plk_4	85	91	PF00069	0.478
MOD_ProDKin_1	174	180	PF00069	0.778
MOD_ProDKin_1	201	207	PF00069	0.807
MOD_ProDKin_1	211	217	PF00069	0.495
MOD_ProDKin_1	351	357	PF00069	0.550
MOD_ProDKin_1	415	421	PF00069	0.465
MOD_ProDKin_1	480	486	PF00069	0.631
MOD_ProDKin_1	490	496	PF00069	0.504
MOD_SUMO_rev_2	70	80	PF00179	0.400
TRG_DiLeu_BaEn_1	85	90	PF01217	0.490
TRG_DiLeu_BaEn_2	301	307	PF01217	0.490
TRG_DiLeu_BaEn_2	439	445	PF01217	0.486
TRG_ENDOCYTIC_2	143	146	PF00928	0.455
TRG_ENDOCYTIC_2	292	295	PF00928	0.458
TRG_ENDOCYTIC_2	406	409	PF00928	0.378
TRG_ER_diArg_1	115	118	PF00400	0.455
TRG_ER_diArg_1	181	184	PF00400	0.769
TRG_ER_diArg_1	370	373	PF00400	0.472
TRG_ER_diArg_1	436	439	PF00400	0.521
TRG_ER_diArg_1	9	12	PF00400	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IME7	Leptomonas seymouri	48%	100%
A0A0S4JCR9	Bodo saltans	30%	89%
A0A3Q8IFN9	Leishmania donovani	88%	100%
A0A3R7MB50	Trypanosoma rangeli	37%	100%
A4HIC8	Leishmania braziliensis	73%	100%
A4I5M1	Leishmania infantum	88%	100%
C9ZQZ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4Q7A0	Leishmania major	87%	100%
V5DQK8	Trypanosoma cruzi	35%	100%