Succinyl-CoA:3-ketoacid-coenzyme A transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

succinyl-coa:3-ketoacid-coenzyme a transferase- like protein

Species:

Leishmania mexicana

UniProt:

E9B0W4_LEIMU

TriTrypDb:

LmxM.29.1940

Length:

499

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043231	intracellular membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

E9B0W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0W4

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	14
GO:0006629	lipid metabolic process	3	14
GO:0008152	metabolic process	1	14
GO:0009056	catabolic process	2	14
GO:0009987	cellular process	1	14
GO:0016042	lipid catabolic process	4	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0044248	cellular catabolic process	3	14
GO:0044281	small molecule metabolic process	2	14
GO:0044282	small molecule catabolic process	3	14
GO:0046950	cellular ketone body metabolic process	3	14
GO:0046952	ketone body catabolic process	4	14
GO:0071704	organic substance metabolic process	2	14
GO:1901568	fatty acid derivative metabolic process	4	14
GO:1901569	fatty acid derivative catabolic process	5	14
GO:1901575	organic substance catabolic process	3	14
GO:1902224	ketone body metabolic process	4	14

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0008260	succinyl-CoA:3-oxo-acid CoA-transferase activity	5	13
GO:0008410	CoA-transferase activity	4	14
GO:0016740	transferase activity	2	14
GO:0016782	transferase activity, transferring sulphur-containing groups	3	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.529
CLV_NRD_NRD_1	256	258	PF00675	0.537
CLV_NRD_NRD_1	278	280	PF00675	0.305
CLV_NRD_NRD_1	6	8	PF00675	0.569
CLV_PCSK_KEX2_1	189	191	PF00082	0.398
CLV_PCSK_KEX2_1	248	250	PF00082	0.538
CLV_PCSK_KEX2_1	278	280	PF00082	0.319
CLV_PCSK_KEX2_1	6	8	PF00082	0.569
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.327
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.403
CLV_PCSK_SKI1_1	208	212	PF00082	0.403
CLV_PCSK_SKI1_1	279	283	PF00082	0.334
CLV_PCSK_SKI1_1	390	394	PF00082	0.334
CLV_PCSK_SKI1_1	408	412	PF00082	0.207
CLV_PCSK_SKI1_1	53	57	PF00082	0.333
CLV_PCSK_SKI1_1	6	10	PF00082	0.574
CLV_PCSK_SKI1_1	80	84	PF00082	0.309
CLV_PCSK_SKI1_1	95	99	PF00082	0.328
DEG_APCC_DBOX_1	433	441	PF00400	0.451
DEG_MDM2_SWIB_1	164	171	PF02201	0.614
DEG_SPOP_SBC_1	259	263	PF00917	0.440
DEG_SPOP_SBC_1	59	63	PF00917	0.527
DOC_CKS1_1	125	130	PF01111	0.591
DOC_MAPK_DCC_7	229	238	PF00069	0.614
DOC_MAPK_gen_1	186	195	PF00069	0.538
DOC_MAPK_gen_1	278	284	PF00069	0.513
DOC_MAPK_gen_1	95	105	PF00069	0.429
DOC_MAPK_HePTP_8	282	294	PF00069	0.614
DOC_MAPK_MEF2A_6	229	238	PF00069	0.614
DOC_MAPK_MEF2A_6	285	294	PF00069	0.614
DOC_MAPK_MEF2A_6	362	370	PF00069	0.537
DOC_MAPK_NFAT4_5	285	293	PF00069	0.614
DOC_PP4_FxxP_1	125	128	PF00568	0.591
DOC_USP7_MATH_1	146	150	PF00917	0.425
DOC_USP7_MATH_1	16	20	PF00917	0.494
DOC_USP7_MATH_1	259	263	PF00917	0.520
DOC_USP7_MATH_1	269	273	PF00917	0.624
DOC_USP7_MATH_1	494	498	PF00917	0.522
DOC_WW_Pin1_4	124	129	PF00397	0.591
LIG_14-3-3_CanoR_1	167	172	PF00244	0.550
LIG_14-3-3_CanoR_1	196	204	PF00244	0.591
LIG_14-3-3_CanoR_1	488	493	PF00244	0.535
LIG_CSL_BTD_1	385	388	PF09270	0.614
LIG_FHA_1	228	234	PF00498	0.625
LIG_FHA_1	287	293	PF00498	0.589
LIG_FHA_1	3	9	PF00498	0.421
LIG_FHA_1	377	383	PF00498	0.565
LIG_FHA_1	487	493	PF00498	0.464
LIG_FHA_1	50	56	PF00498	0.527
LIG_FHA_1	67	73	PF00498	0.568
LIG_FHA_1	81	87	PF00498	0.566
LIG_FHA_2	108	114	PF00498	0.537
LIG_FHA_2	413	419	PF00498	0.560
LIG_FHA_2	430	436	PF00498	0.577
LIG_FHA_2	467	473	PF00498	0.543
LIG_Integrin_isoDGR_2	165	167	PF01839	0.389
LIG_LIR_Apic_2	154	158	PF02991	0.593
LIG_LIR_Apic_2	302	306	PF02991	0.561
LIG_LIR_Apic_2	384	388	PF02991	0.614
LIG_LIR_Gen_1	178	187	PF02991	0.524
LIG_LIR_Gen_1	356	366	PF02991	0.544
LIG_LIR_LC3C_4	400	403	PF02991	0.494
LIG_LIR_Nem_3	178	182	PF02991	0.524
LIG_LIR_Nem_3	356	361	PF02991	0.525
LIG_MAD2	422	430	PF02301	0.516
LIG_PDZ_Class_1	494	499	PF00595	0.477
LIG_Pex14_2	164	168	PF04695	0.591
LIG_Pex14_2	181	185	PF04695	0.591
LIG_Pex14_2	97	101	PF04695	0.599
LIG_SH2_PTP2	303	306	PF00017	0.560
LIG_SH2_SRC	303	306	PF00017	0.589
LIG_SH2_STAT5	126	129	PF00017	0.505
LIG_SH2_STAT5	237	240	PF00017	0.505
LIG_SH2_STAT5	303	306	PF00017	0.562
LIG_SH2_STAT5	85	88	PF00017	0.519
LIG_SH3_3	228	234	PF00018	0.521
LIG_SH3_3	239	245	PF00018	0.481
LIG_SUMO_SIM_anti_2	307	312	PF11976	0.509
LIG_TRAF2_1	469	472	PF00917	0.557
LIG_UBA3_1	43	50	PF00899	0.477
MOD_CK1_1	262	268	PF00069	0.692
MOD_CK1_1	338	344	PF00069	0.543
MOD_CK1_1	347	353	PF00069	0.535
MOD_CK1_1	354	360	PF00069	0.481
MOD_CK1_1	90	96	PF00069	0.516
MOD_CK2_1	12	18	PF00069	0.473
MOD_CK2_1	412	418	PF00069	0.603
MOD_CK2_1	429	435	PF00069	0.418
MOD_CK2_1	466	472	PF00069	0.523
MOD_CK2_1	60	66	PF00069	0.573
MOD_GlcNHglycan	14	17	PF01048	0.328
MOD_GlcNHglycan	205	208	PF01048	0.375
MOD_GlcNHglycan	346	349	PF01048	0.358
MOD_GlcNHglycan	353	356	PF01048	0.311
MOD_GlcNHglycan	375	379	PF01048	0.355
MOD_GlcNHglycan	483	486	PF01048	0.501
MOD_GlcNHglycan	62	65	PF01048	0.388
MOD_GSK3_1	12	19	PF00069	0.338
MOD_GSK3_1	126	133	PF00069	0.516
MOD_GSK3_1	258	265	PF00069	0.490
MOD_GSK3_1	338	345	PF00069	0.575
MOD_GSK3_1	347	354	PF00069	0.537
MOD_GSK3_1	455	462	PF00069	0.473
MOD_GSK3_1	49	56	PF00069	0.527
MOD_N-GLC_1	335	340	PF02516	0.262
MOD_NEK2_1	12	17	PF00069	0.384
MOD_NEK2_1	195	200	PF00069	0.505
MOD_NEK2_1	299	304	PF00069	0.620
MOD_NEK2_1	344	349	PF00069	0.566
MOD_NEK2_1	366	371	PF00069	0.539
MOD_NEK2_1	374	379	PF00069	0.509
MOD_NEK2_2	146	151	PF00069	0.429
MOD_PIKK_1	196	202	PF00454	0.591
MOD_PKA_2	158	164	PF00069	0.560
MOD_PKA_2	195	201	PF00069	0.519
MOD_Plk_1	366	372	PF00069	0.519
MOD_Plk_1	87	93	PF00069	0.527
MOD_Plk_1	99	105	PF00069	0.442
MOD_Plk_2-3	466	472	PF00069	0.502
MOD_Plk_4	107	113	PF00069	0.582
MOD_Plk_4	299	305	PF00069	0.550
MOD_Plk_4	347	353	PF00069	0.552
MOD_Plk_4	366	372	PF00069	0.386
MOD_Plk_4	381	387	PF00069	0.537
MOD_Plk_4	455	461	PF00069	0.464
MOD_Plk_4	53	59	PF00069	0.537
MOD_Plk_4	81	87	PF00069	0.519
MOD_ProDKin_1	124	130	PF00069	0.591
MOD_SUMO_for_1	475	478	PF00179	0.514
MOD_SUMO_for_1	97	100	PF00179	0.429
MOD_SUMO_rev_2	222	231	PF00179	0.614
MOD_SUMO_rev_2	252	259	PF00179	0.619
MOD_SUMO_rev_2	413	421	PF00179	0.603
MOD_SUMO_rev_2	466	475	PF00179	0.500
TRG_ER_diArg_1	6	8	PF00400	0.567
TRG_NES_CRM1_1	435	450	PF08389	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P584	Leptomonas seymouri	52%	100%
A0A0N1I0F3	Leptomonas seymouri	47%	100%
A0A0S4JH09	Bodo saltans	53%	100%
A0A1X0NIU4	Trypanosomatidae	49%	100%
A0A1X0P425	Trypanosomatidae	48%	100%
A0A3Q8IC07	Leishmania donovani	84%	100%
A0A3Q8IMK1	Leishmania donovani	48%	100%
A0A3R7LBN6	Trypanosoma rangeli	50%	100%
A0A3S7X3G0	Leishmania donovani	88%	100%
A4HLU7	Leishmania braziliensis	47%	100%
A4I5L8	Leishmania infantum	84%	100%
A4I5L9	Leishmania infantum	87%	100%
B2GV06	Rattus norvegicus	47%	96%
D0A680	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AHQ2	Leishmania infantum	48%	100%
E9B0W3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B473	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
F1CYZ5	Acetobacterium woodii	27%	95%
P37766	Escherichia coli (strain K12)	25%	94%
P55809	Homo sapiens	47%	96%
Q09450	Caenorhabditis elegans	45%	96%
Q29551	Sus scrofa	48%	96%
Q4Q3V3	Leishmania major	48%	100%
Q4Q7A2	Leishmania major	87%	100%
Q4Q7A3	Leishmania major	83%	100%
Q54JD9	Dictyostelium discoideum	48%	98%
Q5XIJ9	Rattus norvegicus	47%	96%
Q8X5X6	Escherichia coli O157:H7	25%	94%
Q9BYC2	Homo sapiens	47%	97%
Q9D0K2	Mus musculus	47%	96%
Q9ESL0	Mus musculus	46%	96%
Q9JJN4	Mus musculus	46%	96%
Q9W058	Drosophila melanogaster	47%	97%
V5DQB8	Trypanosoma cruzi	48%	100%