Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B0W2_LEIMU

TriTrypDb:

LmxM.29.1920

Length:

624

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0W2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0W2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	421	425	PF00656	0.600
CLV_NRD_NRD_1	147	149	PF00675	0.753
CLV_NRD_NRD_1	163	165	PF00675	0.443
CLV_NRD_NRD_1	200	202	PF00675	0.560
CLV_NRD_NRD_1	249	251	PF00675	0.490
CLV_NRD_NRD_1	322	324	PF00675	0.615
CLV_NRD_NRD_1	427	429	PF00675	0.637
CLV_NRD_NRD_1	468	470	PF00675	0.729
CLV_PCSK_KEX2_1	146	148	PF00082	0.770
CLV_PCSK_KEX2_1	162	164	PF00082	0.463
CLV_PCSK_KEX2_1	200	202	PF00082	0.560
CLV_PCSK_KEX2_1	249	251	PF00082	0.637
CLV_PCSK_KEX2_1	322	324	PF00082	0.615
CLV_PCSK_KEX2_1	427	429	PF00082	0.553
CLV_PCSK_KEX2_1	467	469	PF00082	0.611
CLV_PCSK_KEX2_1	52	54	PF00082	0.716
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.622
CLV_PCSK_PC7_1	142	148	PF00082	0.723
CLV_PCSK_PC7_1	245	251	PF00082	0.635
CLV_PCSK_SKI1_1	184	188	PF00082	0.594
DEG_APCC_DBOX_1	146	154	PF00400	0.570
DEG_APCC_DBOX_1	96	104	PF00400	0.630
DEG_COP1_1	5	13	PF00400	0.500
DOC_ANK_TNKS_1	54	61	PF00023	0.621
DOC_MAPK_gen_1	249	257	PF00069	0.744
DOC_MAPK_gen_1	467	475	PF00069	0.587
DOC_MAPK_gen_1	95	102	PF00069	0.632
DOC_MAPK_HePTP_8	378	390	PF00069	0.552
DOC_MAPK_MEF2A_6	249	257	PF00069	0.637
DOC_MAPK_MEF2A_6	381	390	PF00069	0.558
DOC_PP1_RVXF_1	436	443	PF00149	0.587
DOC_USP7_MATH_1	16	20	PF00917	0.620
DOC_USP7_MATH_1	217	221	PF00917	0.667
DOC_USP7_MATH_1	40	44	PF00917	0.633
DOC_USP7_MATH_1	520	524	PF00917	0.644
DOC_USP7_MATH_1	534	538	PF00917	0.510
DOC_USP7_MATH_1	568	572	PF00917	0.559
DOC_USP7_MATH_1	67	71	PF00917	0.669
DOC_WW_Pin1_4	151	156	PF00397	0.655
DOC_WW_Pin1_4	190	195	PF00397	0.603
DOC_WW_Pin1_4	213	218	PF00397	0.675
LIG_14-3-3_CanoR_1	146	151	PF00244	0.654
LIG_14-3-3_CanoR_1	184	190	PF00244	0.591
LIG_14-3-3_CanoR_1	213	217	PF00244	0.643
LIG_14-3-3_CanoR_1	347	351	PF00244	0.446
LIG_14-3-3_CanoR_1	427	435	PF00244	0.590
LIG_14-3-3_CanoR_1	90	98	PF00244	0.640
LIG_14-3-3_CanoR_1	99	103	PF00244	0.548
LIG_BIR_II_1	1	5	PF00653	0.504
LIG_BIR_III_4	355	359	PF00653	0.656
LIG_BRCT_BRCA1_1	221	225	PF00533	0.674
LIG_CaM_IQ_9	237	252	PF13499	0.477
LIG_FHA_1	22	28	PF00498	0.765
LIG_FHA_1	477	483	PF00498	0.553
LIG_FHA_1	494	500	PF00498	0.403
LIG_FHA_1	78	84	PF00498	0.618
LIG_FHA_2	295	301	PF00498	0.703
LIG_FHA_2	419	425	PF00498	0.641
LIG_FHA_2	451	457	PF00498	0.602
LIG_FHA_2	525	531	PF00498	0.744
LIG_LIR_Apic_2	226	232	PF02991	0.674
LIG_LIR_Gen_1	331	342	PF02991	0.655
LIG_LIR_Gen_1	34	40	PF02991	0.522
LIG_LIR_Gen_1	69	78	PF02991	0.660
LIG_LIR_LC3C_4	433	437	PF02991	0.581
LIG_LIR_Nem_3	331	337	PF02991	0.660
LIG_LIR_Nem_3	34	39	PF02991	0.523
LIG_LIR_Nem_3	69	75	PF02991	0.655
LIG_MYND_1	549	553	PF01753	0.484
LIG_NRBOX	253	259	PF00104	0.640
LIG_PCNA_PIPBox_1	172	181	PF02747	0.481
LIG_PCNA_yPIPBox_3	169	179	PF02747	0.474
LIG_PTAP_UEV_1	263	268	PF05743	0.649
LIG_SH2_CRK	315	319	PF00017	0.658
LIG_SH2_CRK	488	492	PF00017	0.563
LIG_SH2_GRB2like	351	354	PF00017	0.627
LIG_SH2_PTP2	229	232	PF00017	0.630
LIG_SH2_SRC	334	337	PF00017	0.598
LIG_SH2_SRC	351	354	PF00017	0.627
LIG_SH2_STAT3	417	420	PF00017	0.678
LIG_SH2_STAT3	556	559	PF00017	0.625
LIG_SH2_STAT5	167	170	PF00017	0.551
LIG_SH2_STAT5	185	188	PF00017	0.760
LIG_SH2_STAT5	229	232	PF00017	0.636
LIG_SH2_STAT5	334	337	PF00017	0.598
LIG_SH2_STAT5	351	354	PF00017	0.627
LIG_SH2_STAT5	474	477	PF00017	0.638
LIG_SH2_STAT5	488	491	PF00017	0.429
LIG_SH3_3	189	195	PF00018	0.517
LIG_SH3_3	261	267	PF00018	0.720
LIG_SH3_3	496	502	PF00018	0.583
LIG_SH3_3	61	67	PF00018	0.585
LIG_SH3_3	616	622	PF00018	0.691
LIG_SH3_CIN85_PxpxPR_1	618	623	PF14604	0.695
LIG_TRAF2_1	239	242	PF00917	0.661
LIG_WW_3	618	622	PF00397	0.692
MOD_CK1_1	114	120	PF00069	0.635
MOD_CK1_1	149	155	PF00069	0.663
MOD_CK1_1	216	222	PF00069	0.666
MOD_CK1_1	233	239	PF00069	0.494
MOD_CK1_1	426	432	PF00069	0.660
MOD_CK1_1	476	482	PF00069	0.612
MOD_CK1_1	533	539	PF00069	0.573
MOD_CK1_1	561	567	PF00069	0.597
MOD_CK1_1	6	12	PF00069	0.542
MOD_CK2_1	114	120	PF00069	0.671
MOD_CK2_1	31	37	PF00069	0.539
MOD_CMANNOS	170	173	PF00535	0.553
MOD_Cter_Amidation	50	53	PF01082	0.628
MOD_GlcNHglycan	113	116	PF01048	0.635
MOD_GlcNHglycan	232	235	PF01048	0.619
MOD_GlcNHglycan	264	267	PF01048	0.688
MOD_GlcNHglycan	280	283	PF01048	0.527
MOD_GlcNHglycan	29	32	PF01048	0.611
MOD_GlcNHglycan	401	404	PF01048	0.484
MOD_GlcNHglycan	521	525	PF01048	0.567
MOD_GlcNHglycan	532	535	PF01048	0.623
MOD_GlcNHglycan	536	539	PF01048	0.619
MOD_GlcNHglycan	553	556	PF01048	0.530
MOD_GlcNHglycan	563	566	PF01048	0.575
MOD_GlcNHglycan	69	72	PF01048	0.606
MOD_GSK3_1	12	19	PF00069	0.602
MOD_GSK3_1	180	187	PF00069	0.494
MOD_GSK3_1	2	9	PF00069	0.556
MOD_GSK3_1	207	214	PF00069	0.630
MOD_GSK3_1	23	30	PF00069	0.741
MOD_GSK3_1	233	240	PF00069	0.493
MOD_GSK3_1	262	269	PF00069	0.645
MOD_GSK3_1	290	297	PF00069	0.551
MOD_GSK3_1	314	321	PF00069	0.658
MOD_GSK3_1	324	331	PF00069	0.573
MOD_GSK3_1	336	343	PF00069	0.456
MOD_GSK3_1	450	457	PF00069	0.690
MOD_GSK3_1	520	527	PF00069	0.728
MOD_GSK3_1	529	536	PF00069	0.623
MOD_N-GLC_1	2	7	PF02516	0.503
MOD_NEK2_1	27	32	PF00069	0.753
MOD_NEK2_1	328	333	PF00069	0.604
MOD_NEK2_1	346	351	PF00069	0.637
MOD_NEK2_1	363	368	PF00069	0.469
MOD_NEK2_1	399	404	PF00069	0.535
MOD_NEK2_1	458	463	PF00069	0.686
MOD_NEK2_1	493	498	PF00069	0.566
MOD_NEK2_2	23	28	PF00069	0.660
MOD_NEK2_2	31	36	PF00069	0.591
MOD_PIKK_1	237	243	PF00454	0.490
MOD_PIKK_1	316	322	PF00454	0.673
MOD_PIKK_1	328	334	PF00454	0.593
MOD_PIKK_1	426	432	PF00454	0.576
MOD_PIKK_1	568	574	PF00454	0.553
MOD_PK_1	515	521	PF00069	0.641
MOD_PKA_1	146	152	PF00069	0.693
MOD_PKA_1	322	328	PF00069	0.612
MOD_PKA_2	125	131	PF00069	0.685
MOD_PKA_2	146	152	PF00069	0.693
MOD_PKA_2	212	218	PF00069	0.644
MOD_PKA_2	322	328	PF00069	0.625
MOD_PKA_2	346	352	PF00069	0.453
MOD_PKA_2	426	432	PF00069	0.660
MOD_PKA_2	89	95	PF00069	0.650
MOD_PKA_2	98	104	PF00069	0.546
MOD_Plk_1	165	171	PF00069	0.506
MOD_Plk_1	2	8	PF00069	0.532
MOD_Plk_1	515	521	PF00069	0.700
MOD_Plk_1	568	574	PF00069	0.553
MOD_Plk_2-3	336	342	PF00069	0.474
MOD_Plk_2-3	418	424	PF00069	0.640
MOD_Plk_4	185	191	PF00069	0.634
MOD_Plk_4	294	300	PF00069	0.650
MOD_Plk_4	31	37	PF00069	0.610
MOD_Plk_4	346	352	PF00069	0.621
MOD_Plk_4	45	51	PF00069	0.633
MOD_Plk_4	98	104	PF00069	0.634
MOD_ProDKin_1	151	157	PF00069	0.649
MOD_ProDKin_1	190	196	PF00069	0.603
MOD_ProDKin_1	213	219	PF00069	0.671
MOD_SUMO_for_1	83	86	PF00179	0.522
TRG_DiLeu_BaEn_1	341	346	PF01217	0.562
TRG_DiLeu_BaEn_1	59	64	PF01217	0.640
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.637
TRG_ENDOCYTIC_2	315	318	PF00928	0.669
TRG_ENDOCYTIC_2	334	337	PF00928	0.578
TRG_ENDOCYTIC_2	487	490	PF00928	0.550
TRG_ER_diArg_1	146	148	PF00400	0.766
TRG_ER_diArg_1	161	164	PF00400	0.471
TRG_ER_diArg_1	199	201	PF00400	0.602
TRG_ER_diArg_1	249	251	PF00400	0.492
TRG_ER_diArg_1	271	274	PF00400	0.607
TRG_ER_diArg_1	322	324	PF00400	0.615
TRG_ER_diArg_1	467	469	PF00400	0.571
TRG_ER_diArg_1	620	623	PF00400	0.702
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.648
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.653
TRG_PTS1	621	624	PF00515	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IRZ9	Leishmania donovani	86%	100%
A4HIC5	Leishmania braziliensis	68%	100%
A4I5L7	Leishmania infantum	86%	100%
Q4Q7A4	Leishmania major	85%	100%