PDZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0W1_LEIMU

TriTrypDb:

LmxM.29.1900

Length:

997

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0W1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0W1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	557	561	PF00656	0.511
CLV_C14_Caspase3-7	936	940	PF00656	0.375
CLV_C14_Caspase3-7	964	968	PF00656	0.454
CLV_C14_Caspase3-7	980	984	PF00656	0.544
CLV_NRD_NRD_1	150	152	PF00675	0.485
CLV_NRD_NRD_1	284	286	PF00675	0.535
CLV_NRD_NRD_1	427	429	PF00675	0.474
CLV_NRD_NRD_1	598	600	PF00675	0.458
CLV_NRD_NRD_1	894	896	PF00675	0.460
CLV_NRD_NRD_1	931	933	PF00675	0.489
CLV_PCSK_KEX2_1	150	152	PF00082	0.485
CLV_PCSK_KEX2_1	284	286	PF00082	0.535
CLV_PCSK_KEX2_1	41	43	PF00082	0.607
CLV_PCSK_KEX2_1	427	429	PF00082	0.474
CLV_PCSK_KEX2_1	598	600	PF00082	0.458
CLV_PCSK_KEX2_1	930	932	PF00082	0.476
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.607
CLV_PCSK_PC7_1	927	933	PF00082	0.485
CLV_PCSK_SKI1_1	299	303	PF00082	0.495
CLV_PCSK_SKI1_1	501	505	PF00082	0.445
CLV_PCSK_SKI1_1	598	602	PF00082	0.578
CLV_PCSK_SKI1_1	609	613	PF00082	0.480
CLV_PCSK_SKI1_1	688	692	PF00082	0.513
CLV_PCSK_SKI1_1	708	712	PF00082	0.338
CLV_PCSK_SKI1_1	829	833	PF00082	0.411
CLV_PCSK_SKI1_1	988	992	PF00082	0.648
DEG_APCC_DBOX_1	597	605	PF00400	0.516
DOC_CKS1_1	61	66	PF01111	0.535
DOC_CYCLIN_yClb3_PxF_3	181	187	PF00134	0.548
DOC_CYCLIN_yClb5_NLxxxL_5	571	580	PF00134	0.461
DOC_CYCLIN_yCln2_LP_2	183	189	PF00134	0.499
DOC_CYCLIN_yCln2_LP_2	241	247	PF00134	0.575
DOC_CYCLIN_yCln2_LP_2	836	842	PF00134	0.486
DOC_CYCLIN_yCln2_LP_2	916	922	PF00134	0.497
DOC_MAPK_gen_1	284	291	PF00069	0.494
DOC_MAPK_gen_1	705	715	PF00069	0.616
DOC_MAPK_HePTP_8	281	293	PF00069	0.486
DOC_MAPK_HePTP_8	779	791	PF00069	0.455
DOC_MAPK_MEF2A_6	166	174	PF00069	0.369
DOC_MAPK_MEF2A_6	284	293	PF00069	0.425
DOC_MAPK_MEF2A_6	453	460	PF00069	0.502
DOC_MAPK_MEF2A_6	782	791	PF00069	0.458
DOC_MAPK_RevD_3	272	285	PF00069	0.503
DOC_PP1_RVXF_1	116	122	PF00149	0.524
DOC_PP1_RVXF_1	827	833	PF00149	0.447
DOC_PP1_RVXF_1	986	992	PF00149	0.587
DOC_PP2B_LxvP_1	183	186	PF13499	0.486
DOC_PP2B_LxvP_1	836	839	PF13499	0.468
DOC_PP2B_LxvP_1	911	914	PF13499	0.500
DOC_PP2B_LxvP_1	916	919	PF13499	0.504
DOC_PP4_FxxP_1	159	162	PF00568	0.497
DOC_PP4_FxxP_1	91	94	PF00568	0.536
DOC_USP7_MATH_1	197	201	PF00917	0.655
DOC_USP7_MATH_1	248	252	PF00917	0.464
DOC_USP7_MATH_1	346	350	PF00917	0.538
DOC_USP7_MATH_1	369	373	PF00917	0.662
DOC_USP7_MATH_1	387	391	PF00917	0.759
DOC_USP7_MATH_1	473	477	PF00917	0.640
DOC_USP7_MATH_1	491	495	PF00917	0.407
DOC_USP7_MATH_1	496	500	PF00917	0.458
DOC_USP7_MATH_1	515	519	PF00917	0.446
DOC_USP7_MATH_1	524	528	PF00917	0.701
DOC_USP7_MATH_1	534	538	PF00917	0.611
DOC_USP7_MATH_1	551	555	PF00917	0.611
DOC_USP7_MATH_1	611	615	PF00917	0.538
DOC_USP7_MATH_1	757	761	PF00917	0.525
DOC_USP7_MATH_1	937	941	PF00917	0.367
DOC_USP7_UBL2_3	114	118	PF12436	0.477
DOC_USP7_UBL2_3	321	325	PF12436	0.516
DOC_WW_Pin1_4	136	141	PF00397	0.553
DOC_WW_Pin1_4	189	194	PF00397	0.646
DOC_WW_Pin1_4	530	535	PF00397	0.602
DOC_WW_Pin1_4	60	65	PF00397	0.509
DOC_WW_Pin1_4	840	845	PF00397	0.528
DOC_WW_Pin1_4	981	986	PF00397	0.629
LIG_14-3-3_CanoR_1	284	290	PF00244	0.527
LIG_14-3-3_CanoR_1	303	311	PF00244	0.329
LIG_14-3-3_CanoR_1	514	523	PF00244	0.437
LIG_14-3-3_CanoR_1	573	581	PF00244	0.476
LIG_14-3-3_CanoR_1	598	604	PF00244	0.515
LIG_14-3-3_CanoR_1	693	699	PF00244	0.392
LIG_14-3-3_CanoR_1	81	86	PF00244	0.543
LIG_14-3-3_CanoR_1	950	959	PF00244	0.500
LIG_Actin_WH2_2	139	155	PF00022	0.489
LIG_Actin_WH2_2	596	611	PF00022	0.525
LIG_Actin_WH2_2	776	792	PF00022	0.511
LIG_BIR_III_4	295	299	PF00653	0.461
LIG_BRCT_BRCA1_1	268	272	PF00533	0.500
LIG_BRCT_BRCA1_1	986	990	PF00533	0.714
LIG_EVH1_2	185	189	PF00568	0.612
LIG_FHA_1	190	196	PF00498	0.656
LIG_FHA_1	240	246	PF00498	0.717
LIG_FHA_1	286	292	PF00498	0.550
LIG_FHA_1	375	381	PF00498	0.522
LIG_FHA_1	401	407	PF00498	0.665
LIG_FHA_1	476	482	PF00498	0.481
LIG_FHA_1	506	512	PF00498	0.536
LIG_FHA_1	603	609	PF00498	0.610
LIG_FHA_1	699	705	PF00498	0.529
LIG_FHA_1	756	762	PF00498	0.493
LIG_FHA_1	864	870	PF00498	0.445
LIG_FHA_2	238	244	PF00498	0.579
LIG_FHA_2	374	380	PF00498	0.490
LIG_FHA_2	693	699	PF00498	0.476
LIG_FHA_2	725	731	PF00498	0.597
LIG_FHA_2	903	909	PF00498	0.418
LIG_FHA_2	940	946	PF00498	0.486
LIG_GBD_Chelix_1	563	571	PF00786	0.486
LIG_GBD_Chelix_1	958	966	PF00786	0.407
LIG_LIR_Apic_2	89	94	PF02991	0.552
LIG_LIR_Apic_2	967	972	PF02991	0.405
LIG_LIR_Gen_1	814	824	PF02991	0.460
LIG_LIR_Gen_1	99	108	PF02991	0.539
LIG_LIR_LC3C_4	167	172	PF02991	0.349
LIG_LIR_Nem_3	155	161	PF02991	0.461
LIG_LIR_Nem_3	658	663	PF02991	0.442
LIG_LIR_Nem_3	814	819	PF02991	0.490
LIG_LIR_Nem_3	987	993	PF02991	0.661
LIG_LIR_Nem_3	99	103	PF02991	0.564
LIG_MYND_1	181	185	PF01753	0.494
LIG_MYND_1	193	197	PF01753	0.646
LIG_MYND_1	230	234	PF01753	0.618
LIG_MYND_1	309	313	PF01753	0.534
LIG_MYND_3	221	225	PF01753	0.503
LIG_MYND_3	308	312	PF01753	0.516
LIG_REV1ctd_RIR_1	688	697	PF16727	0.464
LIG_REV1ctd_RIR_1	988	996	PF16727	0.634
LIG_SH2_CRK	100	104	PF00017	0.609
LIG_SH2_CRK	116	120	PF00017	0.413
LIG_SH2_NCK_1	100	104	PF00017	0.501
LIG_SH2_STAT3	651	654	PF00017	0.494
LIG_SH2_STAT5	116	119	PF00017	0.525
LIG_SH2_STAT5	144	147	PF00017	0.490
LIG_SH2_STAT5	646	649	PF00017	0.485
LIG_SH2_STAT5	651	654	PF00017	0.488
LIG_SH3_3	129	135	PF00018	0.408
LIG_SH3_3	169	175	PF00018	0.560
LIG_SH3_3	178	184	PF00018	0.621
LIG_SH3_3	190	196	PF00018	0.732
LIG_SH3_3	228	234	PF00018	0.584
LIG_SH3_3	361	367	PF00018	0.527
LIG_SH3_3	467	473	PF00018	0.462
LIG_SH3_3	541	547	PF00018	0.593
LIG_SH3_3	58	64	PF00018	0.521
LIG_SUMO_SIM_anti_2	349	355	PF11976	0.388
LIG_SUMO_SIM_anti_2	758	763	PF11976	0.573
LIG_SUMO_SIM_anti_2	957	964	PF11976	0.430
LIG_SUMO_SIM_par_1	599	606	PF11976	0.513
LIG_SUMO_SIM_par_1	957	964	PF11976	0.474
LIG_TRAF2_1	634	637	PF00917	0.531
LIG_TRAF2_1	752	755	PF00917	0.481
LIG_TYR_ITIM	765	770	PF00017	0.488
LIG_WRC_WIRS_1	249	254	PF05994	0.461
LIG_WRC_WIRS_1	881	886	PF05994	0.503
LIG_WW_2	181	184	PF00397	0.473
LIG_WW_2	193	196	PF00397	0.600
MOD_CDK_SPK_2	60	65	PF00069	0.534
MOD_CDK_SPxxK_3	981	988	PF00069	0.649
MOD_CK1_1	336	342	PF00069	0.537
MOD_CK1_1	374	380	PF00069	0.534
MOD_CK1_1	499	505	PF00069	0.456
MOD_CK1_1	509	515	PF00069	0.430
MOD_CK1_1	587	593	PF00069	0.570
MOD_CK1_1	602	608	PF00069	0.454
MOD_CK1_1	984	990	PF00069	0.613
MOD_CK2_1	217	223	PF00069	0.476
MOD_CK2_1	237	243	PF00069	0.622
MOD_CK2_1	291	297	PF00069	0.537
MOD_CK2_1	418	424	PF00069	0.541
MOD_CK2_1	551	557	PF00069	0.574
MOD_CK2_1	724	730	PF00069	0.505
MOD_CK2_1	902	908	PF00069	0.396
MOD_CK2_1	939	945	PF00069	0.499
MOD_CK2_1	954	960	PF00069	0.373
MOD_Cter_Amidation	148	151	PF01082	0.507
MOD_Cter_Amidation	596	599	PF01082	0.519
MOD_GlcNHglycan	108	111	PF01048	0.378
MOD_GlcNHglycan	269	272	PF01048	0.434
MOD_GlcNHglycan	3	6	PF01048	0.477
MOD_GlcNHglycan	330	333	PF01048	0.587
MOD_GlcNHglycan	347	351	PF01048	0.411
MOD_GlcNHglycan	36	39	PF01048	0.598
MOD_GlcNHglycan	383	386	PF01048	0.527
MOD_GlcNHglycan	498	501	PF01048	0.488
MOD_GlcNHglycan	51	54	PF01048	0.588
MOD_GlcNHglycan	526	529	PF01048	0.611
MOD_GlcNHglycan	536	539	PF01048	0.557
MOD_GlcNHglycan	553	556	PF01048	0.661
MOD_GlcNHglycan	576	579	PF01048	0.589
MOD_GlcNHglycan	593	596	PF01048	0.393
MOD_GlcNHglycan	609	612	PF01048	0.479
MOD_GlcNHglycan	613	616	PF01048	0.405
MOD_GlcNHglycan	88	91	PF01048	0.563
MOD_GlcNHglycan	885	889	PF01048	0.483
MOD_GlcNHglycan	973	976	PF01048	0.598
MOD_GlcNHglycan	979	982	PF01048	0.599
MOD_GSK3_1	102	109	PF00069	0.570
MOD_GSK3_1	117	124	PF00069	0.437
MOD_GSK3_1	185	192	PF00069	0.622
MOD_GSK3_1	248	255	PF00069	0.442
MOD_GSK3_1	257	264	PF00069	0.410
MOD_GSK3_1	303	310	PF00069	0.572
MOD_GSK3_1	369	376	PF00069	0.514
MOD_GSK3_1	387	394	PF00069	0.795
MOD_GSK3_1	429	436	PF00069	0.371
MOD_GSK3_1	456	463	PF00069	0.538
MOD_GSK3_1	505	512	PF00069	0.448
MOD_GSK3_1	530	537	PF00069	0.615
MOD_GSK3_1	558	565	PF00069	0.528
MOD_GSK3_1	587	594	PF00069	0.484
MOD_GSK3_1	599	606	PF00069	0.445
MOD_GSK3_1	607	614	PF00069	0.516
MOD_GSK3_1	724	731	PF00069	0.537
MOD_GSK3_1	880	887	PF00069	0.563
MOD_GSK3_1	935	942	PF00069	0.465
MOD_GSK3_1	977	984	PF00069	0.684
MOD_LATS_1	283	289	PF00433	0.512
MOD_N-GLC_1	121	126	PF02516	0.625
MOD_N-GLC_1	266	271	PF02516	0.526
MOD_N-GLC_1	574	579	PF02516	0.477
MOD_N-GLC_1	819	824	PF02516	0.424
MOD_NEK2_1	102	107	PF00069	0.588
MOD_NEK2_1	187	192	PF00069	0.635
MOD_NEK2_1	252	257	PF00069	0.436
MOD_NEK2_1	328	333	PF00069	0.489
MOD_NEK2_1	418	423	PF00069	0.582
MOD_NEK2_1	429	434	PF00069	0.531
MOD_NEK2_1	460	465	PF00069	0.536
MOD_NEK2_1	49	54	PF00069	0.468
MOD_NEK2_1	505	510	PF00069	0.435
MOD_NEK2_1	523	528	PF00069	0.573
MOD_NEK2_1	576	581	PF00069	0.421
MOD_NEK2_1	603	608	PF00069	0.446
MOD_NEK2_1	768	773	PF00069	0.412
MOD_NEK2_1	873	878	PF00069	0.585
MOD_NEK2_1	884	889	PF00069	0.449
MOD_NEK2_1	961	966	PF00069	0.447
MOD_NEK2_1	991	996	PF00069	0.625
MOD_NEK2_2	515	520	PF00069	0.403
MOD_NEK2_2	907	912	PF00069	0.448
MOD_PIKK_1	400	406	PF00454	0.506
MOD_PIKK_1	622	628	PF00454	0.555
MOD_PIKK_1	650	656	PF00454	0.562
MOD_PIKK_1	937	943	PF00454	0.373
MOD_PKA_2	152	158	PF00069	0.499
MOD_PKA_2	49	55	PF00069	0.469
MOD_PKA_2	692	698	PF00069	0.434
MOD_PKA_2	951	957	PF00069	0.510
MOD_PKA_2	977	983	PF00069	0.693
MOD_PKA_2	991	997	PF00069	0.510
MOD_Plk_1	204	210	PF00069	0.601
MOD_Plk_1	706	712	PF00069	0.514
MOD_Plk_1	768	774	PF00069	0.456
MOD_Plk_1	819	825	PF00069	0.424
MOD_Plk_1	873	879	PF00069	0.526
MOD_Plk_1	907	913	PF00069	0.485
MOD_Plk_1	923	929	PF00069	0.441
MOD_Plk_4	125	131	PF00069	0.480
MOD_Plk_4	248	254	PF00069	0.415
MOD_Plk_4	429	435	PF00069	0.441
MOD_Plk_4	439	445	PF00069	0.470
MOD_Plk_4	576	582	PF00069	0.394
MOD_Plk_4	599	605	PF00069	0.508
MOD_Plk_4	708	714	PF00069	0.495
MOD_Plk_4	757	763	PF00069	0.541
MOD_Plk_4	954	960	PF00069	0.517
MOD_Plk_4	961	967	PF00069	0.403
MOD_ProDKin_1	136	142	PF00069	0.546
MOD_ProDKin_1	189	195	PF00069	0.647
MOD_ProDKin_1	530	536	PF00069	0.605
MOD_ProDKin_1	60	66	PF00069	0.510
MOD_ProDKin_1	840	846	PF00069	0.525
MOD_ProDKin_1	981	987	PF00069	0.629
MOD_SUMO_for_1	704	707	PF00179	0.509
MOD_SUMO_rev_2	54	64	PF00179	0.652
MOD_SUMO_rev_2	553	559	PF00179	0.509
MOD_SUMO_rev_2	658	668	PF00179	0.347
MOD_SUMO_rev_2	684	690	PF00179	0.556
TRG_DiLeu_BaEn_1	297	302	PF01217	0.342
TRG_DiLeu_BaEn_1	425	430	PF01217	0.557
TRG_DiLeu_BaEn_3	923	929	PF01217	0.506
TRG_DiLeu_BaLyEn_6	228	233	PF01217	0.585
TRG_DiLeu_BaLyEn_6	544	549	PF01217	0.663
TRG_ENDOCYTIC_2	100	103	PF00928	0.569
TRG_ENDOCYTIC_2	116	119	PF00928	0.391
TRG_ENDOCYTIC_2	657	660	PF00928	0.473
TRG_ENDOCYTIC_2	767	770	PF00928	0.463
TRG_ER_diArg_1	130	133	PF00400	0.474
TRG_ER_diArg_1	150	153	PF00400	0.434
TRG_ER_diArg_1	302	305	PF00400	0.581
TRG_ER_diArg_1	427	429	PF00400	0.529
TRG_ER_diArg_1	598	600	PF00400	0.455
TRG_ER_diArg_1	674	677	PF00400	0.597
TRG_ER_diArg_1	929	932	PF00400	0.467
TRG_ER_diArg_1	949	952	PF00400	0.300
TRG_Pf-PMV_PEXEL_1	299	304	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBM5	Leptomonas seymouri	56%	88%
A0A1X0P1S7	Trypanosomatidae	35%	92%
A0A3Q8IEY3	Leishmania donovani	90%	98%
A4HIC4	Leishmania braziliensis	72%	98%
A4I5L6	Leishmania infantum	90%	98%
Q4Q7A5	Leishmania major	87%	100%