Putative phosphatidylinositol kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol kinase, putative

Species:

Leishmania mexicana

UniProt:

E9B0V6_LEIMU

TriTrypDb:

LmxM.29.1850

Length:

1373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9B0V6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	3
GO:0006644	phospholipid metabolic process	4	3
GO:0006650	glycerophospholipid metabolic process	5	3
GO:0006661	phosphatidylinositol biosynthetic process	6	3
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0007165	signal transduction	2	7
GO:0008152	metabolic process	1	7
GO:0008610	lipid biosynthetic process	4	3
GO:0008654	phospholipid biosynthetic process	5	3

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004430	1-phosphatidylinositol 4-kinase activity	6	1
GO:0005488	binding	1	7
GO:0016301	kinase activity	4	7
GO:0016303	1-phosphatidylinositol-3-kinase activity	6	5
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	5
GO:0035004	phosphatidylinositol 3-kinase activity	5	5
GO:0043167	ion binding	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1033	1037	PF00656	0.340
CLV_C14_Caspase3-7	1110	1114	PF00656	0.431
CLV_C14_Caspase3-7	1353	1357	PF00656	0.439
CLV_C14_Caspase3-7	458	462	PF00656	0.576
CLV_C14_Caspase3-7	73	77	PF00656	0.609
CLV_C14_Caspase3-7	88	92	PF00656	0.554
CLV_MEL_PAP_1	1346	1352	PF00089	0.638
CLV_MEL_PAP_1	43	49	PF00089	0.420
CLV_NRD_NRD_1	105	107	PF00675	0.430
CLV_NRD_NRD_1	1348	1350	PF00675	0.551

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P583	Leptomonas seymouri	62%	97%
A0A3Q8IJE4	Leishmania donovani	93%	100%
A4H928	Leishmania braziliensis	84%	100%
A4I5L1	Leishmania infantum	93%	100%
Q4Q7B0	Leishmania major	93%	100%

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