LeishMANIAdb
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Putative splicing factor 3a

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative splicing factor 3a
Gene product:
splicing factor 3a, putative
Species:
Leishmania mexicana
UniProt:
E9B0V4_LEIMU
TriTrypDb:
LmxM.29.1830
Length:
621

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005681 spliceosomal complex 3 11
GO:0032991 protein-containing complex 1 11
GO:0140513 nuclear protein-containing complex 2 11
GO:1990904 ribonucleoprotein complex 2 11

Expansion

Sequence features

E9B0V4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0V4

Function

Biological processes
Term Name Level Count
GO:0000375 RNA splicing, via transesterification reactions 8 11
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 9 11
GO:0000398 mRNA splicing, via spliceosome 8 11
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006396 RNA processing 6 11
GO:0006397 mRNA processing 7 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0008380 RNA splicing 7 11
GO:0009987 cellular process 1 11
GO:0016070 RNA metabolic process 5 11
GO:0016071 mRNA metabolic process 6 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0043170 macromolecule metabolic process 3 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0046483 heterocycle metabolic process 3 11
GO:0071704 organic substance metabolic process 2 11
GO:0090304 nucleic acid metabolic process 4 11
GO:1901360 organic cyclic compound metabolic process 3 11
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 11
GO:0003723 RNA binding 4 11
GO:0005488 binding 1 11
GO:0008270 zinc ion binding 6 10
GO:0043167 ion binding 2 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11
GO:0046914 transition metal ion binding 5 10
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 431 435 PF00656 0.425
CLV_C14_Caspase3-7 593 597 PF00656 0.309
CLV_C14_Caspase3-7 599 603 PF00656 0.251
CLV_NRD_NRD_1 210 212 PF00675 0.326
CLV_NRD_NRD_1 235 237 PF00675 0.532
CLV_NRD_NRD_1 439 441 PF00675 0.563
CLV_NRD_NRD_1 470 472 PF00675 0.587
CLV_NRD_NRD_1 553 555 PF00675 0.279
CLV_NRD_NRD_1 587 589 PF00675 0.283
CLV_PCSK_KEX2_1 168 170 PF00082 0.418
CLV_PCSK_KEX2_1 235 237 PF00082 0.465
CLV_PCSK_KEX2_1 470 472 PF00082 0.587
CLV_PCSK_KEX2_1 553 555 PF00082 0.279
CLV_PCSK_KEX2_1 589 591 PF00082 0.286
CLV_PCSK_KEX2_1 619 621 PF00082 0.541
CLV_PCSK_PC1ET2_1 168 170 PF00082 0.418
CLV_PCSK_PC1ET2_1 589 591 PF00082 0.279
CLV_PCSK_PC7_1 615 621 PF00082 0.414
CLV_PCSK_SKI1_1 211 215 PF00082 0.250
CLV_PCSK_SKI1_1 408 412 PF00082 0.379
CLV_PCSK_SKI1_1 460 464 PF00082 0.610
DEG_COP1_1 113 120 PF00400 0.418
DEG_Nend_UBRbox_3 1 3 PF02207 0.619
DEG_SPOP_SBC_1 305 309 PF00917 0.703
DEG_SPOP_SBC_1 368 372 PF00917 0.595
DOC_CDC14_PxL_1 196 204 PF14671 0.229
DOC_CYCLIN_RxL_1 405 415 PF00134 0.377
DOC_CYCLIN_yClb1_LxF_4 187 192 PF00134 0.503
DOC_CYCLIN_yCln2_LP_2 218 224 PF00134 0.354
DOC_MAPK_DCC_7 340 349 PF00069 0.530
DOC_MAPK_MEF2A_6 197 204 PF00069 0.470
DOC_MAPK_MEF2A_6 310 319 PF00069 0.421
DOC_PP1_RVXF_1 187 193 PF00149 0.509
DOC_PP1_RVXF_1 210 217 PF00149 0.456
DOC_PP2B_LxvP_1 115 118 PF13499 0.502
DOC_PP2B_LxvP_1 329 332 PF13499 0.487
DOC_USP7_MATH_1 161 165 PF00917 0.558
DOC_USP7_MATH_1 277 281 PF00917 0.642
DOC_USP7_MATH_1 304 308 PF00917 0.803
DOC_USP7_MATH_1 358 362 PF00917 0.554
DOC_USP7_MATH_1 367 371 PF00917 0.722
DOC_WW_Pin1_4 116 121 PF00397 0.505
DOC_WW_Pin1_4 77 82 PF00397 0.545
LIG_14-3-3_CanoR_1 145 151 PF00244 0.466
LIG_14-3-3_CanoR_1 440 447 PF00244 0.454
LIG_14-3-3_CanoR_1 54 61 PF00244 0.558
LIG_Actin_WH2_2 444 462 PF00022 0.488
LIG_APCC_ABBA_1 61 66 PF00400 0.406
LIG_BIR_III_4 602 606 PF00653 0.297
LIG_CtBP_PxDLS_1 332 336 PF00389 0.504
LIG_FHA_1 1 7 PF00498 0.511
LIG_FHA_1 151 157 PF00498 0.487
LIG_FHA_1 381 387 PF00498 0.377
LIG_FHA_2 126 132 PF00498 0.412
LIG_FHA_2 153 159 PF00498 0.475
LIG_FHA_2 279 285 PF00498 0.627
LIG_FHA_2 399 405 PF00498 0.402
LIG_FHA_2 415 421 PF00498 0.340
LIG_FHA_2 593 599 PF00498 0.355
LIG_FHA_2 607 613 PF00498 0.211
LIG_KLC1_Yacidic_2 62 66 PF13176 0.406
LIG_LIR_Apic_2 343 348 PF02991 0.450
LIG_LIR_Apic_2 531 536 PF02991 0.258
LIG_LIR_Gen_1 100 109 PF02991 0.539
LIG_LIR_Gen_1 191 200 PF02991 0.297
LIG_LIR_Gen_1 257 268 PF02991 0.387
LIG_LIR_Gen_1 397 404 PF02991 0.383
LIG_LIR_Nem_3 100 104 PF02991 0.412
LIG_LIR_Nem_3 140 146 PF02991 0.338
LIG_LIR_Nem_3 191 196 PF02991 0.375
LIG_LIR_Nem_3 231 237 PF02991 0.458
LIG_LIR_Nem_3 257 263 PF02991 0.381
LIG_LIR_Nem_3 397 403 PF02991 0.396
LIG_LIR_Nem_3 563 567 PF02991 0.336
LIG_LIR_Nem_3 612 616 PF02991 0.355
LIG_NRBOX 394 400 PF00104 0.324
LIG_NRP_CendR_1 619 621 PF00754 0.637
LIG_Pex14_2 539 543 PF04695 0.279
LIG_SH2_CRK 234 238 PF00017 0.393
LIG_SH2_CRK 533 537 PF00017 0.410
LIG_SH2_SRC 229 232 PF00017 0.423
LIG_SH2_STAP1 146 150 PF00017 0.326
LIG_SH2_STAP1 414 418 PF00017 0.431
LIG_SH2_STAT5 229 232 PF00017 0.340
LIG_SH2_STAT5 400 403 PF00017 0.534
LIG_SH2_STAT5 613 616 PF00017 0.355
LIG_SH2_STAT5 64 67 PF00017 0.408
LIG_SH3_1 236 242 PF00018 0.425
LIG_SH3_3 114 120 PF00018 0.457
LIG_SH3_3 170 176 PF00018 0.531
LIG_SH3_3 236 242 PF00018 0.466
LIG_SH3_3 479 485 PF00018 0.728
LIG_TRAF2_1 417 420 PF00917 0.452
LIG_TRAF2_1 428 431 PF00917 0.472
LIG_TRAF2_1 435 438 PF00917 0.575
LIG_TRAF2_1 493 496 PF00917 0.593
LIG_TRFH_1 342 346 PF08558 0.383
LIG_TYR_ITIM 398 403 PF00017 0.378
LIG_WRC_WIRS_1 192 197 PF05994 0.417
LIG_WRPW_2 219 222 PF00400 0.353
MOD_CDK_SPK_2 116 121 PF00069 0.413
MOD_CK1_1 361 367 PF00069 0.707
MOD_CK1_1 443 449 PF00069 0.465
MOD_CK1_1 466 472 PF00069 0.669
MOD_CK2_1 125 131 PF00069 0.366
MOD_CK2_1 152 158 PF00069 0.469
MOD_CK2_1 251 257 PF00069 0.403
MOD_CK2_1 259 265 PF00069 0.473
MOD_CK2_1 398 404 PF00069 0.401
MOD_CK2_1 414 420 PF00069 0.360
MOD_CK2_1 432 438 PF00069 0.574
MOD_CK2_1 52 58 PF00069 0.455
MOD_CK2_1 592 598 PF00069 0.458
MOD_CK2_1 606 612 PF00069 0.355
MOD_GlcNHglycan 146 149 PF01048 0.483
MOD_GlcNHglycan 161 164 PF01048 0.610
MOD_GlcNHglycan 360 363 PF01048 0.656
MOD_GlcNHglycan 442 445 PF01048 0.483
MOD_GlcNHglycan 584 587 PF01048 0.343
MOD_GSK3_1 306 313 PF00069 0.712
MOD_GSK3_1 369 376 PF00069 0.496
MOD_GSK3_1 394 401 PF00069 0.427
MOD_GSK3_1 402 409 PF00069 0.377
MOD_GSK3_1 443 450 PF00069 0.454
MOD_LATS_1 338 344 PF00433 0.386
MOD_N-GLC_1 406 411 PF02516 0.454
MOD_NEK2_1 150 155 PF00069 0.390
MOD_NEK2_1 180 185 PF00069 0.546
MOD_NEK2_1 394 399 PF00069 0.344
MOD_NEK2_1 403 408 PF00069 0.370
MOD_NEK2_1 447 452 PF00069 0.525
MOD_NEK2_1 463 468 PF00069 0.596
MOD_NEK2_1 52 57 PF00069 0.245
MOD_NEK2_2 528 533 PF00069 0.258
MOD_NEK2_2 566 571 PF00069 0.279
MOD_PKA_1 340 346 PF00069 0.474
MOD_PKA_1 440 446 PF00069 0.482
MOD_PKA_2 144 150 PF00069 0.354
MOD_PKA_2 53 59 PF00069 0.553
MOD_PKB_1 590 598 PF00069 0.355
MOD_Plk_1 268 274 PF00069 0.578
MOD_Plk_1 406 412 PF00069 0.514
MOD_Plk_2-3 125 131 PF00069 0.491
MOD_Plk_2-3 251 257 PF00069 0.445
MOD_Plk_4 175 181 PF00069 0.510
MOD_Plk_4 19 25 PF00069 0.426
MOD_Plk_4 259 265 PF00069 0.541
MOD_Plk_4 394 400 PF00069 0.395
MOD_Plk_4 406 412 PF00069 0.380
MOD_Plk_4 528 534 PF00069 0.258
MOD_ProDKin_1 116 122 PF00069 0.500
MOD_ProDKin_1 77 83 PF00069 0.540
MOD_SUMO_for_1 111 114 PF00179 0.504
MOD_SUMO_for_1 167 170 PF00179 0.456
MOD_SUMO_for_1 266 269 PF00179 0.502
MOD_SUMO_rev_2 262 268 PF00179 0.440
MOD_SUMO_rev_2 377 384 PF00179 0.395
MOD_SUMO_rev_2 464 469 PF00179 0.546
MOD_SUMO_rev_2 90 96 PF00179 0.515
TRG_DiLeu_BaEn_1 497 502 PF01217 0.658
TRG_DiLeu_BaLyEn_6 118 123 PF01217 0.441
TRG_DiLeu_BaLyEn_6 345 350 PF01217 0.436
TRG_ENDOCYTIC_2 101 104 PF00928 0.543
TRG_ENDOCYTIC_2 105 108 PF00928 0.540
TRG_ENDOCYTIC_2 146 149 PF00928 0.328
TRG_ENDOCYTIC_2 219 222 PF00928 0.371
TRG_ENDOCYTIC_2 234 237 PF00928 0.406
TRG_ENDOCYTIC_2 400 403 PF00928 0.444
TRG_ENDOCYTIC_2 564 567 PF00928 0.337
TRG_ENDOCYTIC_2 613 616 PF00928 0.297
TRG_ER_diArg_1 234 236 PF00400 0.409
TRG_ER_diArg_1 37 40 PF00400 0.457
TRG_ER_diArg_1 470 473 PF00400 0.597
TRG_ER_diArg_1 552 554 PF00400 0.279
TRG_ER_diArg_1 587 590 PF00400 0.279
TRG_ER_diArg_1 619 621 PF00400 0.672
TRG_NES_CRM1_1 565 578 PF08389 0.410
TRG_NLS_MonoExtC_3 587 592 PF00514 0.297
TRG_Pf-PMV_PEXEL_1 10 15 PF00026 0.500
TRG_Pf-PMV_PEXEL_1 121 125 PF00026 0.452
TRG_Pf-PMV_PEXEL_1 154 158 PF00026 0.447
TRG_Pf-PMV_PEXEL_1 39 43 PF00026 0.459
TRG_Pf-PMV_PEXEL_1 416 420 PF00026 0.546
TRG_Pf-PMV_PEXEL_1 511 515 PF00026 0.357
TRG_PTS2 1 45 PF00400 0.382

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5M4 Leptomonas seymouri 63% 97%
A0A1X0P1R3 Trypanosomatidae 42% 100%
A0A3S7X3F0 Leishmania donovani 95% 100%
A0A422P3I2 Trypanosoma rangeli 45% 100%
A4H930 Leishmania braziliensis 84% 100%
A4I5K9 Leishmania infantum 94% 100%
C9ZQY7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
Q4Q7B2 Leishmania major 94% 100%
V5DQL3 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS